Post-transcriptional Gene Regulation in Human Disease
- 1st Edition, Volume 32 - August 12, 2022
- Editors: Buddhi Prakash Jain, Shyamal K Goswami, Tapan Sharma
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 3 0 5 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 4 2 4 - 6
Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcri… Read more
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Request a sales quotePost-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.
- Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation
- Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats
- Features a summary and conclusion at the end of each chapter
Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, and immunology; life science researchers; biotechnologists; developmental biologists. Clinicians and graduate students in the biosciences
- Cover image
- Title page
- Table of Contents
- Translational Epigenetics Series
- Copyright
- List of contributors
- A note from the editor
- Chapter 1. Regulation of gene expression in mammals: an overview
- Introduction
- The genome, genes, and the regulatory elements: how many genes do we have?
- Promoters, enhancers, and their regulation
- The role of long noncoding and enhancer RNA in gene expression
- Epigenetic regulation of gene expression
- MicroRNA and post-transcriptional gene silencing
- Post-transcriptional processing of the pre-mRNA transcripts
- Concluding remarks
- Chapter 2. Post-transcriptional gene regulation: an overview
- Introduction
- Summary
- Chapter 3. Methods to study post-transcriptional regulation of gene expression
- Introduction
- Methods for determining mRNA stability
- Understanding the results from mRNA turnover studies
- RNA-binding proteins
- Methods to study post-transcriptional gene regulation due to RNA–protein interactions
- Summary
- Chapter 4. Epigenetic regulation of post-transcriptional machinery
- Introduction
- Post-transcriptional regulation of gene expression
- Regulation of alternative splicing by chromatin
- DNA methylation and alternative splicing
- Alternative splicing in cancer
- Summary
- Chapter 5. Post-transcriptional regulation: a less explored territory in the world of neurodegenerative diseases
- Introduction
- Post-transcriptional gene regulation in neurodegenerative disorders
- Alzheimer's disease
- Parkinson's disease
- Spinocerebral ataxia
- Huntington's disease
- Amyotrophic lateral sclerosis
- Discussion
- Chapter 6. Role of post-transcriptional gene regulation in hematological malignancies
- Introduction
- IRES
- Modifications of RNA
- RNA-binding proteins
- Alternative splicing
- MicroRNAs
- Summary
- Chapter 7. Post-transcriptional gene regulation in solid tumors
- Introduction
- Breast cancer
- Lung cancer
- Colorectal cancer
- Gastric cancer
- Oral squamous cell carcinoma
- Ovarian cancer
- Summary
- Chapter 8. A comprehensive view of the prostate cancer metastasis and role of androgen receptor splice variants
- Prostate cancer: origin and metastasis
- Androgen receptor
- AR splice variants
- Role of AR splice variants in CRPC
- AR variants as clinical biomarkers
- AR variants as therapeutic targets
- Summary
- Chapter 9. Post-transcriptional gene regulation in Cardiorenal syndrome
- Introduction
- Histone modifications
- RNA-based modifications
- DNA-based modifications
- SUMOylation
- Summary
- Chapter 10. Noncoding RNAs as modulators of post-transcriptional changes and their role in CVDs
- Introduction
- Noncoding RNAs
- ncRNA in CVD
- RNA-binding protein and CVD
- Summary
- Chapter 11. microRNAs as critical regulators in heart development and diseases
- Introduction
- microRNAs: small RNA molecules with enormous potential
- Journey of microRNAs research
- MicroRNA biogenesis
- Dicer, a microRNA biogenesis component in cardiac development and disease
- MicroRNAs in cardiac development and diseases
- microRNAs in cardiac hypertrophy
- Involvement of microRNAs in various pathways leading to cardiac hypertrophy
- MicroRNAs in ECM remodeling
- microRNAs as a therapeutic target
- Limitation in microRNA-based therapy in the cardiovascular system
- Conclusion
- Chapter 12. MicroRNA regulation in autoimmune diseases
- Introduction
- miRNA in autoimmunity
- miRNA in autoimmune diseases
- miRNAs as therapeutic targets
- Summary
- Chapter 13. Post-transcriptional regulation of inflammatory disorder
- Introduction
- Regulation: post-transcriptionally
- Mechanism of miRNA-mediated cytokine regulation
- MiRNA as a regulator of NLRP3 inflammasome in RA
- Chromatin-mediated inflammatory gene regulation
- Coregulators
- Inflammatory transcript regulation via negative regulators
- Summary
- Chapter 14. Post-transcriptional gene regulation in metabolic syndrome
- Introduction to metabolic syndrome
- Post-transcriptional gene regulation in metabolic pathways
- Role of noncoding RNAs in metabolic regulation
- Role of RNA-binding proteins in metabolic regulation
- Adverse health conditions associated with metabolic syndromes
- Summary
- Chapter 15. Post-transcriptional regulation of HIV-1 gene expression: role of viral and host factors
- Introduction
- HIV-1 transcription
- Co- and post-transcriptional modifications of HIV-1 pre mRNAs
- Post-transcriptional regulation of HIV-1 mRNAs
- Regulation of HIV-1 protein translation
- Post-translational modifications of HIV-1 proteins
- Post-translational regulation of HIV-1: protein degradation and maturation
- Summary
- Acknowledgements
- Chapter 16. Post-transcriptional regulation of gene expression in Entamoeba histolytica
- Introduction
- Small RNA-mediated gene regulation in E. histolytica
- LncRNAs in E.histolytica
- Post-transcriptional regulation of ribosome biogenesis in Entamoeba
- Regulation via mRNA stability in E. histolytica
- Post-transcriptional regulation through RNA homeostasis mechanisms
- Chapter 17. Post-transcriptional regulation of gene expression in human malaria parasite Plasmodium falciparum
- Introduction
- Alternative splicing and gene expression in Plasmodium
- mRNA degradation and gene expression
- mRNA export and gene regulation
- Noncoding RNAs roles in Plasmodium
- Translational repression
- Concluding remarks
- Chapter 18. Hepcidin-induced degradation of iron exporter ferroportin determines anemia of chronic diseases
- Introduction
- Requirement of iron
- Recycling of iron
- Iron homeostasis: cellular and systemic
- Ferroportin—the unique iron exporter
- Structure of ferroportin
- Regulation of ferroportin by inflammation
- Ferroportin regulation by iron
- Regulation of ferroportin by hypoxia
- Hepcidin—the master controller of iron homeostasis
- Structure of hepcidin
- Regulation of hepcidin
- Inflammation augments hepcidin synthesis by IL-6
- Hepcidin promotes ferroportin degradation
- Hepcidin-induced ferroportin degradation results in anemia
- Summary
- Chapter 19. Post-transcriptional regulation of genes and mitochondrial disorder
- Introduction
- Mitochondrial genome
- Mitochondrial transcription
- Processing of mitochondrial primary transcript
- Post-transcriptional modification and mitochondrial disorders
- Summary
- Index
- No. of pages: 394
- Language: English
- Edition: 1
- Volume: 32
- Published: August 12, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323913058
- eBook ISBN: 9780323914246
BP
Buddhi Prakash Jain
Dr. Buddhi Prakash Jain is an Assistant Professor at the Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India. He completed his doctoral studies at the School of Life Sciences, Jawaharlal Nehru University (JNU) New Delhi, India. His research interests include gene expression regulation and endoplasmic reticulum stress in cancer. He is the recipient of several awards including a gold medal in Master Programme (M.Sc.), EMBO travel award, DST (Department of Science and Technology) Govt of India, Young Scientist travel award, and has published several papers in reputed international journals and a number of books and book chapters.
Affiliations and expertise
Assistant Professor, Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University, Motihari, Bihar, IndiaSK
Shyamal K Goswami
Shyamal Goswami has a research career spanning 35 years. He has experience teaching in biochemistry, cellular and molecular biology and redox biology at the postgraduate level. He served as Associate Professor and Professor in the School of Life Sciences at Jawaharlal Nehru University, India, from 1998 to 2020. Prior to this he was a Research Assistant Professor in the Department of Anatomy and Cell Biology at the State University of New York-Health Science Centre at Brooklyn, New York, USA.
Dr. Goswami has contributed numerous publications across his field and has more than 1500 citations. He also co-authored Protocols in Biochemistry and Clinical Biochemistry and co-edited Post-transcriptional Gene Regulation in Human Disease, both published by Academic Press/Elsevier. His main areas of research are cell signaling and gene expression in the cardiovascular system; redox biology of degenerative diseases; and signal scaffolds and cell functions.
Affiliations and expertise
Professor (retired), School of Life Sciences, Jawaharlal Nehru University, New Delhi, IndiaTS
Tapan Sharma
Dr. Tapan Sharma is a Postdoctoral Research Scientist at the University of Massachusetts Medical School, Worcester, MA, USA. His research focuses on understanding the epigenetic mechanisms involved in the regulation of skeletal muscle differentiation, with more than nine years of laboratory experience in the field of ATP-dependent chromatin remodelers. He has worked with mouse models and multiple primary and immortalized cell lines, having led projects independently during Ph.D. and post-doctoral associateships.
Affiliations and expertise
Postdoctoral Research Scientist, University of Massachusetts Medical School, Worcester, MA, USARead Post-transcriptional Gene Regulation in Human Disease on ScienceDirect