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Elsevier

Post-transcriptional Gene Regulation in Human Disease

  • 1st Edition, Volume 32 - August 12, 2022
  • Latest edition
  • Editors: Buddhi Prakash Jain, Shyamal K Goswami, Tapan Sharma
  • Language: English

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcri… Read more

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Description

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.

Key features

  • Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation
  • Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats
  • Features a summary and conclusion at the end of each chapter

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, and immunology; life science researchers; biotechnologists; developmental biologists. Clinicians and graduate students in the biosciences

Table of contents

1. Regulation of Gene Expression in Mammals: An Overview
Shyamal K. Goswami.

2. Post Transcriptional Gene Regulation: An Overview
Shweta Pandey, Smriti Shreya, and Buddhi Prakash Jain

3. Methods to Study Post-Transcriptional Regulation of Gene Expression
Tapan Sharma

4. Epigenetic Regulation of Post-Transcriptional Machinery
Saddam Hussain, Anindita Dutta, and Rohini Muthuswami

5. Post-Transcriptional Regulation: A Less Explored Territory in the World of Neurodegenerative Diseases
Ayeman Amanullah

6. Role of Post-Transcriptional Gene Regulation in Hematological Malignancies
Hafiz M Ahmad

7. Post-Transcriptional Gene Regulation in Solid Tumors
Saba Tabasum and Monika Yadav

8. A Comprehensive View of the Prostate Cancer Metastasis and Role of Androgen Receptor Splice Variants
Yashika Jawa, Sangeeta Kumari, Gargi Bagchi, and Rakesh K. Tyagi

9. Post-Transcriptional Gene Regulation in Cardiorenal Syndrome
Ramandeep Singh, Anupam Mittal, Ajay Bahl, and Madhu Khullar

10. Noncoding RNAs as Modulators of Post-Transcriptional Changes and Their Role in CVDs
Swati Sharma, Shankar Chanchal, Yasir Khan, and Zahid Ashraf

11. microRNAs as Critical Regulators in Heart Development and Diseases
Vibha Rani

12. MicroRNA Regulation in Autoimmune Diseases
Ishani Dasgupta

13. Post-Transcriptional Regulation of Inflammatory Disorder
Savita Devi

14. Post-Transcriptional Gene Regulation in Metabolic Syndrome
Rashmi Pathak and Avinash Kumar

15. Post-Transcriptional Regulation of HIV-1 Gene Expression: Role of Viral and Host Factors
Anjali Tripathi, Alapani Mitra, Anindita Dasgupta, and Debashis Mitra

16. Post-Transcriptional Regulation of Gene Expression in Entamoeba histolytica
Sandeep Ojha and Sudha Bhattacharya

17. Post-Transcriptional Regulation of Gene Expression in the Human Malaria Parasite Plasmodium falciparum
Karina Simantov and Manish Goyal

18. Hepcidin-Induced Degradation of Iron Exporter Ferroportin Determines Anemia of Chronic Diseases
Chinmay K. Mukhopadhyay, Pragya Mishra, Ayushi Aggarwal, and Sameeksha Yadav

19. Post-Transcriptional Regulation of Genes and Mitochondrial Disorder
Ankit Sabharwal, and Bibekananda Kar

Product details

  • Edition: 1
  • Latest edition
  • Volume: 32
  • Published: August 16, 2022
  • Language: English

About the editors

BP

Buddhi Prakash Jain

Dr. Buddhi Prakash Jain is an Assistant Professor at the Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India. He completed his doctoral studies at the School of Life Sciences, Jawaharlal Nehru University (JNU) New Delhi, India. His research interests include gene expression regulation and endoplasmic reticulum stress in cancer. He is the recipient of several awards including a gold medal in Master Programme (M.Sc.), EMBO travel award, DST (Department of Science and Technology) Govt of India, Young Scientist travel award, and has published several papers in reputed international journals and a number of books and book chapters.
Affiliations and expertise
Assistant Professor, Department of Zoology, School of Life Sciences, Mahatma Ghandi Central University, Motihari, Bihar, India

SK

Shyamal K Goswami

Shyamal Goswami has a research career spanning 35 years. He has experience teaching in biochemistry, cellular and molecular biology and redox biology at the postgraduate level. He served as Associate Professor and Professor in the School of Life Sciences at Jawaharlal Nehru University, India, from 1998 to 2020. Prior to this he was a Research Assistant Professor in the Department of Anatomy and Cell Biology at the State University of New York-Health Science Centre at Brooklyn, New York, USA. Dr. Goswami has contributed numerous publications across his field. He also co-authored Protocols in Biochemistry and Clinical Biochemistry and co-edited Post-transcriptional Gene Regulation in Human Disease, both published by Academic Press/Elsevier. His main areas of research are cell signaling and gene expression in the cardiovascular system; redox biology of degenerative diseases; and signal scaffolds and cell functions.
Affiliations and expertise
Professor (retired), School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

TS

Tapan Sharma

Dr. Tapan Sharma is a Postdoctoral Research Scientist at the University of Massachusetts Medical School, Worcester, MA, USA. His research focuses on understanding the epigenetic mechanisms involved in the regulation of skeletal muscle differentiation, with more than nine years of laboratory experience in the field of ATP-dependent chromatin remodelers. He has worked with mouse models and multiple primary and immortalized cell lines, having led projects independently during Ph.D. and post-doctoral associateships.
Affiliations and expertise
Postdoctoral Research Scientist, University of Massachusetts Medical School, Worcester, MA, USA

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