Polysaccharide Nanoparticles

Preparation and Biomedical Applications

1st Edition - January 11, 2022
Editors: Jayachandran Venkatesan, Se-Kwon Kim, Sukumaran Anil, Rekha P. D
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 3 5 1 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 3 5 6 - 7

Polysaccharide Nanoparticles: Preparation and Biomedical Applications provides detailed information on polysaccharides nanoparticles in terms of their synthesis and applicati… Read more

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Polysaccharide Nanoparticles: Preparation and Biomedical Applications provides detailed information on polysaccharides nanoparticles in terms of their synthesis and applications. Naturally occurring polysaccharides are widely used as food materials, particularly in Asia. Different kinds of polysaccharide materials are available from nature with various resources such as crustaceans and algae. The exploration and exploitation of polysaccharides nanoparticles from natural resource is at the heart of this book, which also explores the synthesis, preparation and applications of polysaccharides nanoparticles for tissue engineering and food applications.

This is an important reference for materials scientists and bioengineers who are looking to gain a greater understanding on how polysaccharides nanoparticles are being used for a variety of biomedical applications.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Chapter 1 Dextran nanoparticles: Preparation and applications
Abstract
1.1 Introduction
1.2 Synthesis of dextran and dextran-based nanoparticles
1.3 Applications of dextran and dextran-based nanoparticles
1.4 Toxicity studies of dextran and dextran-based nanoparticles
1.5 Conclusions
References
Chapter 2 The encapsulation of probiotics by polysaccharides
Abstract
2.1 Introduction
2.2 Microencapsulation materials (polysaccharides)
2.3 Techniques for microencapsulation of probiotics
2.4 Probiotics encapsulation by different polysaccharides
2.5 Concluding remarks
Reference
Chapter 3 Emerging trend of chondroitin sulfate in nanoparticles preparation, targeting, and pharmaceutical applications
Abstract
3.1 Introduction
3.2 Structural and physicochemical properties
3.3 Magnetic nanoparticles
3.4 Chondroitin sulfate based polymeric nanoparticles
3.5 Applications
Acknowledgement
References
Chapter 4 Fucoidan based nanoparticles: Structure and applications
Abstract
4.1 Introduction
4.2 Structures of fucoidans
4.3 Fucoidan-based nanoparticle creation
4.4 Nanoparticle creation by complex formation method
4.5 Molecular mass influence on nanoparticle parameters
4.6 Metallic nanoparticles coated by fucoidan
4.7 Application of fucoidan nanoparticles
4.8 Conclusion
References
Chapter 5 Guar gum nanoparticles: A new paradigm in biomedical applications
Abstract
5.1 Introduction
5.2 Methods of preparation of guar gum nanoparticles
5.3 Characterization parameters for guar gum nanoparticles
5.4 Surface modification of guar gum nanoparticles
5.5 Biomedical applications of guar gum nanoparticles
5.6 Conclusions
References
Chapter 6 Chitosan and cellulose particles for drug sequestration
Abstract
6.1 Introduction
6.2 Experimental
6.3 Methods
6.4 Instrumental
6.5 Results and discussion
6.6 Conclusions
Acknowledgments
References
Chapter 7 Pectin nanoparticles: Fabrication and uses
Abstract
7.1 Introduction
7.2 Pectin nanoparticles fabrication
7.3 Applications and perspectives of pectin nanoparticles
7.4 Conclusion
References
Chapter 8 Chitosan nanoparticles for therapeutic delivery of anticancer drugs
Abstract
8.1 Introduction
8.2 Available anticancer drugs and their limiting factors
8.3 Nanomedicine and chitosan nanoparticles
8.4 Fabrication methods of chitosan nanoparticles
8.5 Advantage of chitosan nanoparticles
8.6 Improve delivery and bioavailability of the aqueous insoluble drug
8.7 Improved pharmacokinetics in nonparenteral delivery
8.8 Enhanced drug penetration
8.9 Sustained release with the low-dose requirement
8.10 Reversal of multidrug resistance
8.11 Crossing the blood-brain barrier
8.12 Codelivery of multiple drugs
8.13 Embolic effect
8.14 Targeted delivery of chitosan nanoparticles
8.15 Passive targeting
8.16 Active targeting
8.17 Stimuli-sensitive targeting
8.18 Chitosan nanoparticles for targeting cancer stem cells and tumor microenvironment
8.19 Challenges with chitosan nanoparticles
8.20 Conclusion and prospects
References
Chapter 9 Plant based polysaccharide nanoparticles for anticancer applications
Abstract
GLOSSARY
9.1 Introduction
9.2 Polysaccharides derived from plants and their anticancer properties
9.3 Conclusion
Acknowledgements
References
Chapter 10 Alginate derived nanoassemblies in drug delivery and tissue engineering
Abstract
10.1 Introduction
10.2 Synthesis aspects of sodium alginate derived nanoparticles
10.3 Advantages of sodium alginate derived nanoparticles
10.4 Sodium alginate derived nanoparticles in drug delivery
10.5 Alginate nanoparticles for tissue engineering
10.6 Conclusions
Abbreviations
Acknowledgment
References
Chapter 11 Applications of hyaluronic acid and its derivatives-based nanoparticles in drug delivery
Abstract
11.1 Introduction
11.2 General properties of hyaluronic acid
11.3 Chemical modification of hyaluronic acid
11.4 Hyaluronic acid and its derivatives-based nanocarriers on delivery of various types of drugs
11.5 Routes of administration of hyaluronic acid and its derivatives-based nanoparticles
11.6 Conclusions and perspective
References
Chapter 12 Biomedical applications of alginate nanoparticles
Abstract
12.1 Introduction
12.2 Polymeric nanoparticles
12.3 Alginate in regeneration of cartilage
12.4 Alginate in repair of bone
12.5 Alginate nanoparticles and oxidative stress
12.6 Alginate nanoparticles as adjuvant/carrier in vaccine delivery system
12.7 Conclusion
References
Chapter 13 Polysaccharide-based nanoparticles for dentistry applications
Abstract
Keywords
13.1 Introduction
13.2 Chitosan nanoparticles for dental applications
13.3 Alginate nanoparticles for dental applications
13.4 Polysaccharide containing gelatin nanoparticles for dental applications
13.5 Starch nanoparticles for dental applications
13.6 Conclusion
Acknowledgments
References
Chapter 14 Starch-based nanoparticles for fabrication of nutraceutical delivery system
Abstract
Keywords
14.1 Introduction
14.2 Preparation of starch nanoparticles
14.3 Wettability and surface charge of starch nanoparticles
14.4 Modification of starch nanoparticles
14.5 Fabrication of starch nanoparticle-stabilized Pickering emulsions
14.6 Conclusions and perspectives
References
Chapter 15 Polysaccharide-based metal nanoparticles
Abstract
Keywords
15.1 Background
15.2 Superiority of polysaccharides for synthesis of nanostructures
15.3 Classification of polysaccharides
15.4 Mechanism for synthesis of nanostructures using polysaccharides
15.5 Strategies for exploitation polysaccharides in synthesizing of nanostructures
15.6 Polysaccharides for synthesis of monometallic nanostructures
15.7 Polysaccharides for synthesis of bimetallic and multimetallic nanostructures
15.8 Various applications of polysaccharides-based nanostructures
References
Chapter 16 Fucoidans as nanoparticles: pharmaceutical and biomedical applications
Abstract
Keywords
16.1 Introduction
16.2 Physicochemical properties of fucoidans
16.3 Fucoidans and nanotechnology
16.4 Conclusion
References
Chapter 17 Recent patents and current emergence of polysaccharides- based nanoparticles in medicine and drug delivery
Abstract
Keywords
17.1 Polysaccharide-based nanoparticle—an introduction
17.2 Biomedical applications of polysaccharide-based nanoparticle
17.3 Paradigm shifting of polysaccharide-based nanoparticles
17.4 Perspective
Acknowledgments
Authors’ contribution
Conflict of interest
References
Chapter 18 Multifunctional cyclodextrin nanoparticles: A promising theranostic tool for strategic targeting of cancer
Abstract
Keywords
18.1 Introduction
18.2 Source, structure, and physicochemical properties of multifunctional cyclodextrins
18.3 Cyclodextrin nanoparticles
18.4 Cyclodextrins as theranostic tool for targeting of cancer
18.5 Cyclodextrin-based nanoparticles
18.6 Case studies of CDT NPs in cancer targeting
18.7 Conclusion and future perspectives
References
Chapter 19 Chitosan nanoparticles: Integration of computational simulation, modeling, and artificial neural network techniques for augmenting drug delivery in biomedical applications
Abstract
Keywords
19.1 Introduction
19.2 Overview of CADD tools and Artificial Neural Network
19.3 Application of computational tools in preformulation studies
19.4 Role of computational tools in ADMET studies
19.5 Application of ANN in process optimization for preparation of nanoparticles
19.6 Application of ANN in characterization
19.7 Applications of chitosan nanoparticles
19.8 Limitation, challenges, and future perspective
19.9 Summary
References
Chapter 20 Biosynthesis of polysaccharides-stabilized metal nanoparticles for chemical and biosensing applications
Abstract
Keywords
20.1 Introduction
20.2 Synthesis of polysaccharide-stabilized metal NPs for sensing applications
20.3 Parameters affecting the synthesis of metal nanoparticles
20.4 Chemical sensors for environmental monitoring
20.5 Detection of food contents and adulterants
20.6 Sensors for clinical and biomedical applications
20.7 Future scope
References
Chapter 21 Modulation of fluorescence of fluorophores by cyclodextrins forming supported suprastructures to nanoparticles
Abstract
Keywords
21.1 Introduction
21.2 Control of guest structure and host size on the formation of CD architecture
21.3 Cyclodextrin suprastructures with embedded gold nanoclusters
21.4 Cyclodextrin nanoparticle formation that induces surface hovering to a guest molecule
Acknowledgments
References
Chapter 22 Polysaccharides-based nanoparticles for bone tissue engineering
Abstract
Keywords
22.1 Introduction
22.2 Tissue engineering
22.3 Bone tissue engineering
22.4 Cellular attachments at the nanoscale
22.5 Effect of the nanoenvironment for the bone tissue engineering
22.6 Potential of the polysaccharide-based nanoparticles for bone tissue engineering
22.7 Conclusion
Acknowledgment
References
Chapter 23 Cellulose and starch nanoparticles: Function and surface modifications for biomedical application
Abstract
Keywords
23.1 Introduction
23.2 Preparation of nanoparticles from starch or cellulose
23.3 Techniques for optimization of nanoparticles and nanocomposites
23.4 Chemical modification of nanobiopolymers
23.5 Biomedical applications
23.6 Conclusions
References
Index

Jayachandran Venkatesan

Dr. Jayachandran Venkatesan M.Sc., M.Phil., Ph.D. is an assistant professor in Yenepoya Research Centre (YRC), Yenepoya (Deemed to be University), India. He worked as a postdoctoral researcher in the Division of Bioengineering, Incheon National University, and Hanyang University, South Korea. Previously, he worked as a Research Professor at the Department of Chemistry and Marine Bioprocess Research Center (MBPRC) at Pukyong National University, South Korea. He received his Master of Science in chemistry from Thiruvalluvar University in 2005. Further, He received his Ph.D. from Pukyong National University in 2011. His primary research interests are the investigation and development of naturally derived polymers, ceramics, and protein-based materials for biomedical applications. Furthermore, he works on natural biomaterials for tissue engineering and drug delivery applications.

Affiliations and expertise

Assistant Professor, Yenepoya Research Centre, Mangaluru, Karnataka, India

Se-Kwon Kim

Se-Kwon Kim, Ph.D., is presently working as a Distinguished Professor at Department of Marine-Bio Convergence Science, Specialized Graudate School Science & Technology Convergence and Director of Marine Bioprocess Research Center (MBPRC) at Pukyong National University, Yongdang Campus, 10 floor, Hanmiregwan Building, Room No: 1006, 365, Sinseon-ro, Nam-Gu, Busan, 608-739, South Korea.

He received his M.Sc. and Ph.D. degrees from Pukyong National University and conducted his postdoctoral studies at the Laboratory of Biochemical Engineering, University of Illinois, Urbana-Champaign, Illinois, USA. Later, he became a visiting scientist at the Memorial University of Newfoundland in Canada.

Dr. Kim served as president of the ‘Korean Society of Chitin and Chitosan’ in 1986-1990, and the ‘Korean Society of Marine Biotechnology’ in 2006-2007. To the credit for his research, he won the best paper award from the American Oil Chemists’ Society In 2002. Dr. Kim was also the chairman for ‘7th Asia-pacific Chitin and Chitosan Symposium’, which was held in South Korea in 2006. He was the chief-editor in the ‘Korean Society of Fisheries and Aquatic Science’ during 2008-2009. Also, he is the board member of International Society of Marine Biotechnology (IMB) and International Society of Nutraceuticals and Functional Food (ISNFF).

His major research interests are investigation and development of bioactive substances from seafood processing wastes and other marine sources. His immense experience of marine bio-processing and mass-production technologies for marine bio-industry is the key asset of holding majorly funded Marine Bio projects in Korea. Furthermore, he expended his research fields up to the development of bioactive materials from marine organisms for their applications in oriental medicine, cosmeceuticals and nutraceuticals. To date, he has authored around 650 research papers, has edited more than 70 books and holds 120 patents.

Affiliations and expertise

Pukyong National University, Busan, South Korea

Sukumaran Anil

Prof. Sukumaran Anil, BDS, MDS, PhD, FDS RCPS (Glas), FICD, FPFA, is currently serving as professor and consultant in Division of Periodontics, College of Dentistry, Prince Sattam Bin Abdulaziz University, Riyadh and Saudi Arabia. He received his Doctoral Degree in Dentistry (PhD), from University of Hong Kong in 2002. Further, he underwent one year advanced training at the UK center for Oral HIV research, Guys’ and St. Thomas’s hospital, London. Based on the contribution to the field Prof. Sukumaran received honorary fellowship from the Royal College of Physicians and Surgeons, Glasgow (FDS, RCPS), International College of Dentist (FICD) and Pierre Fauchard Academy (FPFA). He was a recipient of several awards for excellence in the field, Gold-medal winner (BDS-India), Ratan H. Doctor National Award (INDIA), Wang Gungwu Scholarship for Research Students (Hong Kong), Golden Quill award for research excellence from King Saud University, Riyadh. He has more than 30 years of undergraduate, postgraduate teaching experience and PhD supervision in various countries such as India, Hong Kong, Saudi Arabia, United Kingdom, The Netherlands, South Korea and USA. Previously, he served as full Professor at King Saud University, Riyadh for the past 10 years and worked as chairman and member of the National Accreditation (NCAAA), European and US accreditation for the courses at King Saud University. He is having a major role in developing a medical research facility (Biomaterials and Dental) for the medical division of the ministry of defense in Riyadh. He has published more than 350 research papers in high-impact journals-chapters and books in the field.

Affiliations and expertise

Prince Sattam Bin Abdulaziz University

Rekha P. D

Rekha P.D. is Deputy Director and Professor of Biomaterials at Yenepoya Research Center, India. Her research focuses on the isolation and applications of biomaterials, polymeric substances, from natural resources, particularly marine bacteria for biomedical application, including, skin graft development, wound management, tissue engineering and drug delivery.

Affiliations and expertise

Yenepoya Research Center, India

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Polysaccharide Nanoparticles

Preparation and Biomedical Applications

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Jayachandran Venkatesan

Se-Kwon Kim

Sukumaran Anil

Rekha P. D