Polymers for Pharmaceutical and Biomedical Applications
Fundamentals, Selection, and Preparation
- 1st Edition - January 16, 2024
- Imprint: Elsevier
- Editors: Vandana Patravale, John I. Disouza, Aliasgar Shahiwala
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 4 9 6 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 4 9 7 - 6
Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the… Read more
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Request a sales quotePolymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are highlighted, with chapters explaining the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, and more. Throughout the book, the aim is to provide accessible, step-by-step coverage supported by diagrams and case studies. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting.
- Explains fundamental concepts relating to the synthesis, modification, and characterization of polymers
- Guides the reader towards successful selection of polymer systems for specific target applications
- Addresses key challenges in this field that are supported by case studies and regulatory information
Researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, Scientists and R&D professionals working in drug delivery systems, and materials for pharmaceutical applications
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1 Pharmaceutical and biomedical polymers: Basics, modifications, and applications
- Abstract
- 1.1 Introduction
- 1.2 Advantages of polymers
- 1.3 Classification of polymers
- 1.4 Chemistry, properties, and applications of pharmaceutical and biomedical polymers
- 1.5 Conclusions
- References
- Chapter 2 Polymer synthesis and modification
- Abstract
- 2.1 Introduction
- 2.2 Methods of polymer synthesis
- 2.3 Polymer simulation and artificial intelligence in polymer synthesis
- 2.4 Conclusions
- References
- Further reading
- Chapter 3 Characterization of polymers
- Abstract
- 3.1 Introduction to essential characteristics of the polymers to be revealed
- 3.2 Solid-state characterization of polymers
- 3.3 Solution phase characterization
- 3.4 Interpenetrating polymer network
- 3.5 Biological characterization of polymers
- 3.6 Polymer-based biomaterial interaction with cells: In vitro characterization
- 3.7 Other methods in the characterization of polymers
- 3.8 Summary and future perspectives
- References
- Chapter 4 Polymer dissolution
- Abstract
- 4.1 Introduction to polymer dissolution and its importance
- 4.2 Mechanism of polymer dissolution
- 4.3 Factors affecting polymer dissolution
- 4.4 Polymer solubility and solubility parameters
- 4.5 Polymer dissolution models
- 4.6 Techniques to study polymer dissolution
- 4.7 Conclusions
- References
- Chapter 5 Pharmaceutical polymers in conventional dosage forms
- Abstract
- 5.1 Solid oral dosage forms
- 5.2 Solutions and liquid disperse systems
- 5.3 Semisolids
- 5.4 Transdermal drug delivery systems (TDDS)
- 5.5 Parenterals
- 5.6 Ophthalmics
- 5.7 Other dosage forms including nasal, buccal, rectal, and vaginal dosage forms
- 5.8 Polymers in cosmetic formulations
- References
- Chapter 6 Pharmaceutical polymers for modified drug delivery and controlled release
- Abstract
- 6.1 Introduction
- 6.2 Mechanisms of modified release
- 6.3 Polymers for oral, modified drug release systems
- 6.4 Mucoadhesive polymers for modified drug delivery
- 6.5 In situ gelling and depot/implant forming systems for controlled drug delivery
- References
- Chapter 7 Polymer conjugates
- Abstract
- 7.1 Polymer therapeutics
- 7.2 Polymer-drug conjugates
- 7.3 Nanoparticle-drug conjugates
- 7.4 Protein-polymer conjugates
- References
- Chapter 8 Polymers in advanced drug and gene delivery
- Abstract
- 8.1 Introduction to polymers
- 8.2 Classification of polymers for drug and gene delivery
- 8.3 Source of polymers
- 8.4 Polymeric NPs for drug and gene delivery
- 8.5 Engineered polymers and novel polymeric architectures
- 8.6 Amphiphilic polysaccharides as delivery systems
- 8.7 Polymer-drug conjugates
- 8.8 Smart polymers for cell therapy
- 8.9 Conclusions
- References
- Chapter 9 Polymers in medical devices and pharmaceutical packaging
- Abstract
- 9.1 Introduction
- 9.2 Polymers in medical devices
- 9.3 Polymers in pharmaceutical container closure systems
- 9.4 Conclusions
- References
- Chapter 10 Polymers for 3D cell culture and tissue engineering applications
- Abstract
- 10.1 Introduction
- 10.2 Techniques for developing 3D cell culture
- 10.3 Native ECM-based 3D cell culture for mimicking the native tissues
- 10.4 Polymers for manufacturing scaffolds
- 10.5 Polymer-based microspheres
- 10.6 Polymer-based hydrogels as bioinks for bioprinting
- 10.7 Standardization and quality control of bioinks
- 10.8 Conclusion
- References
- Chapter 11 Regulation of pharmaceutical polymers
- Abstract
- 11.1 Introduction
- 11.2 Polymeric biomaterial forms
- 11.3 Polymers as excipients
- 11.4 Impurity testing in polymers
- 11.5 Global regulatory assessment of polymers
- 11.6 The global pharmaceutical market
- 11.7 Emerging market overview
- 11.8 Registration requirements for emerging markets
- 11.9 Registration requirements for regulated markets like EU/UK/US
- 11.10 Polymers for packaging
- 11.11 Novel excipients and their regulatory status
- 11.12 Current regulatory status of novel excipients
- 11.13 Medical polymers
- 11.14 Medical device materials
- 11.15 Conclusions
- References
- Index
- Edition: 1
- Published: January 16, 2024
- Imprint: Elsevier
- No. of pages: 500
- Language: English
- Paperback ISBN: 9780323954969
- eBook ISBN: 9780323954976
VP
Vandana Patravale
Dr. Vandana B. Patravale is currently a Professor of Pharmaceutics at the Institute of Chemical Technology, Mumbai, India. She has 30 years of teaching and research experience. Prof. Patravale has over 200 refereed publications, 11 granted patents, 24 patents in the pipeline, and 2 trademark registries, and has published 2 books and 25 book chapters. She is an international advisory committee member of AAPS and Vice President of the CRS Indian chapter. She has acted as an editorial board member or guest editor for numerous journals, and has active collaborations with researchers and industries within the country and abroad. Prof. Patravale has successfully transferred many technologies to industry, the most recent being drug-eluting stents which are currently marketed in more than 60 countries.
Affiliations and expertise
Professor of Pharmaceutics, Institute of Chemical Technology, Mumbai, IndiaJD
John I. Disouza
Dr. John I. Disouza is a Professor in Pharmaceutics, and Principal, at Tatyasaheb Kore College of Pharmacy, Warananagar, India. He has 20 years of teaching and research experience. Prof. Disouza has published more than 100 research papers, 3 books, and 8 book chapters. He is chief editor of the journal ‘Pharmacumconsequat’ and editor for Centum, and has also served as a guest editor for DDTR. Prof. Disouza is the chairperson of the IPA-Education division for Maharashtra state, a member of the Executive Board of the national IPA-Education division, and EC member of Controlled Release Society- Indian Chapter.
Affiliations and expertise
Professor in Pharmaceutics, and Principal, Tatyasaheb Kore College of Pharmacy, Warananagar, IndiaAS
Aliasgar Shahiwala
Dr. Aliasgar Shahiwala is currently serving as a Professor in the Department of Pharmaceutics, and Graduate Program Director, at Dubai Pharmacy College, Dubai, UAE. He received his MA and PhD in pharmaceutics and pharmaceutical technology from the Maharaja Sayajirao University of Baroda, India, with a particular research focus on the area of novel drug delivery. His postdoctoral research at Northeastern University, USA, centered on applications of nanotechnology in the field of drug delivery and drug targeting. With more than 20 years of teaching and research experience, Prof. Shahiwala has published several articles in international peer-reviewed journals, edited 4 books, and authored many book chapters, as well as being an active reviewer and editorial board member.
Affiliations and expertise
Dubai Pharmacy College for Girls, United Arab EmiratesRead Polymers for Pharmaceutical and Biomedical Applications on ScienceDirect