Polymeric Nanosystems

Theranostic Nanosystems, Volume 1

1st Edition - March 22, 2023
Editors: Md Saquib Hasnain, Amit Kumar Nayak, Tejraj M. Aminabhavi
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 6 5 6 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 5 7 7 - 5

Polymeric Nanosystems: Theranostic Nanosystems, Volume One examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the la… Read more

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Polymeric Nanosystems: Theranostic Nanosystems, Volume One examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glycolide, polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials.

It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Polymer-based nanotheranostics: current status and challenges
Abstract
Abbreviations
1.1 Introduction
1.2 Polymeric theranostics
1.3 Polymers for nanotheranostics
1.4 Concluding remarks, future implications, and prospects
References
Chapter 2. Poly(lactic acid) and poly(lactic-co-glycolic acid)-based nanocarrier systems for theranostic applications
Abstract
2.1 Introduction
2.2 Chemistry of polylactic acid and poly(lactic-co-glycolic acid)
2.3 Polylactic acid-based nanocarrier systems for theranostic applications
2.4 PLGA-based nanocarrier systems for theranostic applications
2.5 Conclusion and future prospects
References
Chapter 3. Polycaprolactone-based nanoparticles for advanced therapeutic applications
Abstract
3.1 Introduction
3.2 Physicochemical properties of poly-ε-caprolactone
3.3 Methods for preparation of poly-ε-caprolactone nanoparticles
3.4 Poly-ε-caprolactone nanoparticles for various advanced therapeutic applications
3.5 Conclusion
References
Chapter 4. Acrylate-based polymeric nanotheranostics
Abstract
4.1 Introduction
4.2 Mechanism of targeted drug delivery systems in cancer
4.3 Passive targeting
4.4 Active targeting
4.5 Polymeric nanomedicines and nanotheranostics systems for drug delivery
4.6 Acrylate-based polymers for theranostic applications
4.7 Final remarks and conclusions
References
Chapter 5. Cellulose and cellulose derivatives-based nanosystems as therapeutic platform
Abstract
5.1 Introduction
5.2 Types of cellulose
5.3 Application of cellulose and its derivatives-based nanosystems on nanotheranostics
5.4 Limitations and prospects
5.5 Conclusion
References
Chapter 6. Alginate-based nanosystems for therapeutic use
Abstract
6.1 Introduction
6.2 Alginate delivery system
6.3 Conclusion
References
Further reading
Chapter 7. Chitin- and chitosan-based nanomaterials for therapeutic applications
Abstract
7.1 Introduction
7.2 Sources and chemical structure of chitin and chitosan
7.3 Extraction of chitin and chitosan
7.4 Therapeutic applications
7.5 Conclusion
References
Chapter 8. Gellan gumbased nanosystems for therapeutic applications
Abstract
8.1 Introduction
8.2 The history of Gellan gum
8.3 General principals of Gellan
8.4 Properties of Gellan gum
8.5 Advantages and disadvantages of Gellan gum
8.6 Factors affected by Gellan gum drug delivery
8.7 Gellan gum drug route administration
8.8 Gellan gum used as nanosystem drug delivery
8.9 Applications of Gellan gum
8.10 In vitro evaluation of Gellan gum formulations
8.11 Gellan gum nanosystem drug delivery in comparison with conventional drugs
8.12 New approaches to Gellan gum-based nanosystems for therapeutic applications
References
Chapter 9. Chondroitin sulfate-derived theranostic nanosystems
Abstract
9.1 Introduction
9.2 Chondroitin sulfate-based nanosystems
9.3 Conclusion and perspective
References
Chapter 10. Hyaluronic acid-based nanosystems for theranostic delivery and imaging
Abstract
10.1 Introduction
10.2 Properties of hyaluronic acid
10.3 Hyaluronic acid-drug conjugates
10.4 Hyaluronic acid-based hydrogel
10.5 Hyaluronic acid-based drug delivery systems
10.6 The role of hyaluronic acid-based nanosystems in imaging
10.7 The role of hyaluronic acid-based nanosystems in therapy
10.8 Theranostic delivery for hyaluronic acid-based nanosystems
10.9 Conclusion
References
Chapter 11. Pullulan-based nanocarriers for therapeutic applications
Abstract
11.1 Introduction
11.2 Therapeutic applications of pullulan and its derivatives
References
Chapter 12. Xanthan gum-based nanocarriers for therapeutic delivery
Abstract
12.1 Introduction
12.2 Xanthan gum: source, chemical composition, properties, and uses
12.3 Synthesis of xanthan gum-based hydrogels
12.4 Application of xanthan gum-based hydrogels in therapeutic delivery
12.5 Miscellaneous applications of xanthan gum-based systems
12.6 Conclusion and future perspectives
Acknowledgments
Conflicts of interest
References
Chapter 13. Gum tragacanth-based nanosystems for therapeutic applications
Abstract
13.1 Nanomedicine
13.2 Gum tragacanth
13.3 Production and collection of gum tragacanth
13.4 Structure of gum tragacanth
13.5 Rheological characteristics
13.6 Degradation
13.7 Cytotoxicity
13.8 Applications of gum tragacanth
13.9 Nanotechnology
13.10 Nanoparticle applications
13.11 Nanohydrogels
13.12 Nanoencapsulation
13.13 Nanofibers
13.14 Conclusion
References
Chapter 14. Pectin-based nanoformulations for therapeutic applications
Abstract
14.1 Introduction
14.2 Nanoformulation of pectin
14.3 Therapeutic applications of nano-pectin
14.4 Conclusions
References
Chapter 15. Guar-gum-based nanocarriers for drug delivery and targeting
Abstract
15.1 Introduction
15.2 Extraction of guar-gum
15.3 Guar gum productions
15.4 Various properties of natural Guar-gum polymer
15.5 Guar-gum-based nanocarriers for drug delivery applications
15.6 Conclusions and prospects
Acknowledgment
References
Chapter 16. Carrageenan-based nanosystems for therapeutic applications
Abstract
16.1 Introduction
16.2 Carrageenan-based nanosystems
16.3 Therapeutic application of carrageenan-based nanosystem
16.4 Conclusion and future perspective
References
Chapter 17. Starch-based nanosystems for theranostic applications
Abstract
17.1 Introduction
17.2 Starch-based nanosystems
17.3 Starch nanoparticles
17.4 Starch nanocrystals
17.5 Nutrients and nutraceutical encapsulation
17.6 Encapsulation of pharmaceuticals
17.7 Conclusion
References
Chapter 18. Gelatin-based nanosystems for therapeutic applications
Abstract
18.1 Introduction
18.2 Gelatin nanosystems: methods of production
18.3 Gelatin-based nanosystems applications
18.4 Conclusions and future perspectives
References
Chapter 19. Albumin-based nanocarriers for therapeutic applications
Abstract
19.1 Introduction
19.2 Albumin-types and structures
19.3 Albumin-based nanocarriers
19.4 Surface functionalization of albumin nanocarriers and applications
19.5 Applications of albumin nanocarriers
19.6 Clinical translation of albumin-based nanocarriers
19.7 Conclusion
Acknowledgments
References
Chapter 20. Silk protein-based nanoparticles for therapeutic applications
Abstract
20.1 Introduction
20.2 Therapeutic presentations of sericin nanoparticles
20.3 Sericin nanoparticles in wound healing and corneal wound healing
20.4 Sericin nanoparticle in cancer therapy
20.5 Sericin nanoparticles in cardiotherapy
20.6 Sericin nanoparticles in CNS disorders
20.7 Sericin nanoparticles as potential antioxidant
20.8 Sericin nanoparticles as potential drug carriers
20.9 Therapeutic presentations of fibroin nanoparticles
20.10 Fibroin-based nanoparticles for drug delivery
20.11 Fibroin nanoparticles in tissue engineering
20.12 Fibroin nanoparticles for protein delivery
20.13 Fibroin nanoparticles in gene delivery
20.14 Fibroin nanoparticles in enzyme immobilization
20.15 Fibroin nanocomposites for biomedical applications
20.16 Fibroin nanoparticles for nerve regeneration
20.17 Fibroin nanoparticles for biosensing and bioimaging
20.18 Conclusions and future perspectives
References
Chapter 21. Zein-based nanoparticles for drug delivery and targeting
Abstract
21.1 Introduction
21.2 Preparation methods of zein NPs and their stability
21.3 Oral administration of zein NPs to the intestinal tract
21.4 Zein-based nanoformulations in cancer treatment
21.5 Polysaccharide modification of zein NPs to deliver drugs to cancer cells
21.6 Zein-modification with other proteins to develop anticancer drug delivery means
21.7 Zein-based delivery of active substances against diabetes type II
21.8 Zein-based NPs as antiinflammatory delivery means
21.9 Zein-based nanoformulations as antimicrobial means
21.10 Analysis of α-zein peptides reveals some extra features
21.11 Conclusion
Acknowledgement
References
Chapter 22. Casein-based nanosystems for therapeutic applications
Abstract
22.1 Introduction to nanotechnology
22.2 Protein-based nanoparticles
22.3 Background of casein
22.4 Structural aspects of casein
22.5 Casein-based nanoparticles
22.6 Synthesis of casein-based nanoparticles
22.7 Therapeutic applications of casein-based nanoparticles
22.8 Toxicity of casein-based nanoparticles
22.9 Future perspectives and challenges
22.10 Conclusion
Acknowledgment
References
Chapter 23. Polymeric nanosystems for cancer theranostics
Abstract
23.1 Introduction
23.2 Polymer-based nanosystems for theranostic application
23.3 Multifunctionality of polymers nanostructures for theranostic application
23.4 Actively targeted polymer nanoparticles for theranostic application
23.5 Polymeric nanoparticles for both therapy and imaging application
23.6 Conclusion
References
Chapter 24. Polymeric nanosystems for cardiovascular therapeutics
Abstract
24.1 Introduction
24.2 Polymeric nanosystem
24.3 Potential biocompatibility
24.4 Easy functionality
24.5 Passive and active targeting
24.6 Polymeric nanosystems for the treatment of cardiovascular system
24.7 Liposomes
24.8 Dendrimers
24.9 Polymeric nanoparticles
24.10 Nanoparticles
24.11 Nanotechnology and hypertensive disease
24.12 Application of nanotechnology in pulmonary hypertension
24.13 Application of nanotechnology in acute myocardial infarction treatment
24.14 Future perspective and conclusion
Acknowledgments
Author disclosure statement
References
Chapter 25. Polymeric nanosystems for neurological therapeutics
Abstract
25.1 Introduction
25.2 Polymeric nanosystems
25.3 Conclusions and future perspective
References
Chapter 26. Polymeric nanosystems for antidiabetic therapeutics
Abstract
26.1 Introduction
26.2 Conclusions
References
Chapter 27. Molecular imprinting and surface grafting of glycoprotein fragments in polymeric nanosystems: from cancer diagnosis to virus targeting
Abstract
27.1 Introduction
27.2 Glycoproteins, glycans, and monosaccharides and their roles in biology
27.3 Tailoring of polymers to medical applications
27.4 Molecular imprinting and grafting in synthetic materials
27.5 Application with labeling, imaging, and development of cancer therapies
27.6 Application with antiviral polymers
Acknowledgments
References
Index

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Marwadi University, Rajkot, Gujarat, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Tejraj M. Aminabhavi

Tejraj M. Aminabhavi is the Director of Research at the Center for Energy and Environment , School of Advanced Sciences, KLE Technological University, Hubballi, India. He works in the area of membrane transport processes, molecular modeling of polymer surfaces, wastewater treatment technologies, drug delivery polymers and sustainable environmental engineering.

Affiliations and expertise

Director of Research, Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Polymeric Nanosystems

Theranostic Nanosystems, Volume 1

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Md Saquib Hasnain

Amit Kumar Nayak

Tejraj M. Aminabhavi

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