Polymeric Materials for Biomedical Implants

Characterization, Properties, and Applications

1st Edition - October 3, 2023
Editors: Sabu Thomas, Abhimanyu Tharayil
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 6 9 0 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 6 9 1 - 4

Polymeric Materials for Biomedical Implants: Characterization, Properties, and Applications offers a comprehensive guide to the various polymers utilized in the developme… Read more

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Polymeric Materials for Biomedical Implants: Characterization, Properties, and Applications offers a comprehensive guide to the various polymers utilized in the development and application of biomedical implants. These materials possess unique properties which make them ideal for use in biomedical implants, including their high degree of flexibility, ease of fabrication, non-magnetic and radio transparent properties for medical imaging, and ease of engineering for biocompatibility. The book thoroughly reviews the properties, characterization and a broad range of applications of polymeric materials in biomedical implants, bringing all key information on this important topic together under a single reference.

The book's chapters cover vital topics for the development of polymeric biomedical implants, including biomaterial-tissue interactions, mechanical and surface property requirements for different implants, as well as market and ethical issues. This will be a useful reference for academics and researchers working in materials science, biomedical engineering, regenerative medicine and pharmacology, as well as R&D groups developing biomedical implants.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter 1: Introduction to polymer materials for implants
Abstract
1.1: Introduction
1.2: Polymers
1.3: Conclusion
References
Chapter 2: Characterization of polymer nanocomposites in biomedical implants
Abstract
2.1: Introduction
2.2: Characterization techniques
References
Chapter 3: Polymer nanocomposites in biomedical implants
Abstract
3.1: Introduction
3.2: Polymers
3.3: Nanocomposites
3.4: Fabrication
3.5: Application
3.6: Conclusion of studies
References
Chapter 4: Introduction to immune responses toward medical implants
Abstract
Graphical abstract
4.1: Introduction
4.2: Provisional matrix formation
4.3: Acute inflammation
4.4: Chronic inflammation
4.5: Conclusion
References
Chapter 5: Polymer implants for gene and drug delivery
Abstract
Acknowledgments
5.1: Introduction
5.2: Polymers in implantable drug/gene delivery systems
5.3: Biomedical applications of polymeric implants
5.4: Conclusion
References
Chapter 6: Polymers in wound dressing
Abstract
6.1: Introduction
6.2: Polymers used in wound management
6.3: Physicochemical characterization and the biological studies
6.4: Conclusions and future trends
References
Chapter 7: Polymers as medical adhesives and sutures
Abstract
7.1: Introduction
7.2: Polymer-based surgical sutures
7.3: Polymer-based tissue adhesives
7.4: Conclusion
References
Chapter 8: Polymeric nanoparticles in cancer therapy
Abstract
8.1: Introduction
8.2: Polymeric nanoparticles in cancers
8.3: Challenges in polymeric nanoparticle-based cancer therapy
8.4: Regulatory issues
8.5: Clinical and preclinical studies
8.6: Conclusions
References
Chapter 9: Polymers in dentistry
Abstract
9.1: Introduction
9.2: Polymers in dental adhesion
9.3: Restorative composite resin polymers
9.4: Denture base polymers
9.5: Polymers for treatment of dental caries
9.6: Polymers for assisted remineralization of carious dentin
9.7: Digital dentistry polymers
9.8: Conclusion
References
Chapter 10: Polymers for IOL systems
Abstract
10.1: Introduction
10.2: Polymeric materials in IOL
10.3: Future perspective
References
Chapter 11: Polymer implants for cardiovascular application
Abstract
11.1: Type of cardiovascular implants
11.2: Cardiovascular biomaterials
11.3: Risk factors for developing cardiovascular device-associated infections (CVDAI)
11.4: Microbial agents and pathogenesis in CVDAI
11.5: Biofilm
11.6: Microorganisms most commonly involved in CVDAI
References
Chapter 12: Polymers in maxillofacial prosthodontics
Abstract
12.1: Introduction
12.2: History of maxillofacial prosthetic reconstruction
12.3: Maxillofacial materials
12.4: Testing procedures of silicone polymers
12.5: Digital maxillofacial prosthodontics
References
Chapter 13: Polymers for burn dressings and skin substitutes
Abstract
13.1: Introduction
13.2: Nonpolymeric burn treatment
13.3: Polymers in burns wound dressings and skin substitutes
13.4: Conclusions
References
Chapter 14: Polymers for implantable bioartificial pancreas
Abstract
Acknowledgments
Declaration of interests
14.1: Introduction
14.2: Polymers for fabricating a bioartificial pancreas
14.3: Functionalization of polymeric materials to boost bioactivity and biocompatibility
14.4: Different designs of polymeric constructs for a BAP
14.5: Conclusion
References
Chapter 15: Polymers and composites for peripheral nerve repair
Abstract
15.1: Clinical challenge: Peripheral nerve injury (PNI)
15.2: Nerve anatomy and progression of PNI
15.3: PNI treatment strategies
15.4: Functional recovery of PNI
15.5: Conclusions
References
Chapter 16: Polymer interactions with blood
Abstract
16.1: Introduction
16.2: Polymer-blood components interactions
16.3: Platelets
16.4: Plasma components
16.5: Architecture of polymers and effects on blood interactions
16.6: Specific blood compatibility tests
16.7: Nanofibers and microparticulate-type polymeric devices
16.8: Physicochemistry and degradability of polymers related to blood compatibility
16.9: Polymeric devices with increased blood compatibility
16.10: Final considerations
References
Chapter 17: Market access of implants: Regulatory framework and ethical issues
Abstract
17.1: Introduction
17.2: Global regulatory framework
17.3: Market access of implants in the European Union
17.4: Market access of implants in the United States of America
17.5: Ethical issues of implants
17.6: Conclusions
References
Chapter 18: Additive manufacturing of polymeric implants
Abstract
18.1: Introduction
18.2: Additive-manufactured implants
18.3: 3D Printing of bio-structures
18.4: Conclusions
References
Chapter 19: Strategies for the sterilization of polymeric biomaterials
Abstract
Acknowledgments
19.1: Introduction
19.2: Sterilization techniques
19.3: Sterilization of polymeric biomaterials
19.4: Supercritical CO2 sterilization
References
Chapter 20: Toxicity and degradation of polymeric implants
Abstract
20.1: Introduction
20.2: Polymeric implants
20.3: Types of polymeric implants
20.4: Toxicity and degradation assessments of polymeric implants in different applications
20.5: Conclusion
References
Further reading
Index

Sabu Thomas

Prof. Sabu Thomas is a Professor of Polymer Science and Engineering and the Director of the School of Energy Materials at Mahatma Gandhi University, India. Additionally, he is the Chairman of the Trivandrum Engineering Science & Technology Research Park (TrEST Research Park) in Thiruvananthapuram, India. He is the founder director of the International and Inter-university Centre for Nanoscience and Nanotechnology at Mahatma Gandhi University and the former Vice-Chancellor of the same institution.

Prof. Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields. Dr. Thomas has been conferred with Honoris Causa (DSc) by the University of South Brittany, France.

Affiliations and expertise

Professor and Director, International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, India

Abhimanyu Tharayil

Abhimanyu Tharayil completed his Ph. D from IIT Kanpur, India in the field of medical implants. Prior to his doctoral studies he worked on electrospinning of polymers in his Master’s. He has published research articles, review articles in peer reviewed journals and book chapters with reputed publishers. He has given invited lectures in the field of biomaterials and has conducted and attended conferences in that field. He is also an independent and certified operator of SEM, XRD, DMA, Micro injection molding, UTM, Electrospinning apparatus etc. He has served as the student president of Indian Institute of metals, Kanpur chapter during his doctoral studies. Presently, he is working as a researcher with Dr Sabu Thomas. His specialized areas of research are biomaterials for medical implants, polymer synthesis, polymer nanocomposites and electrospinning.

Affiliations and expertise

Postdoc Researcher, Mahatma Gandhi University, Kottayam, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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