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Pocket Companion to Robbins & Cotran Pathologic Basis of Disease
- 10th Edition - November 19, 2022
- Authors: Richard N Mitchell, Vinay Kumar, Abul K. Abbas, Jon C. Aster
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 6 5 3 9 0 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 2 5 6 3 - 4
Offering rapid, portable access to key concepts and principles of pathology from Robbins and Cotran Pathologic Basis of Disease, 10th Edition, this up-to-date Pocket Compan… Read more
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Institutional subscription on ScienceDirect
Request a sales quoteOffering rapid, portable access to key concepts and principles of pathology from Robbins and Cotran Pathologic Basis of Disease, 10th Edition, this up-to-date Pocket Companion makes it easy to locate essential information on the go. The condensed, at-a-glance format, organized to parallel the parent text, is ideal for quick review—anytime, anywhere.
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Features cutting-edge information on important topics such as novel therapies for hepatitis C, personalized medicine, the role of microbiome and metabolome in non-communicable disease, and much more.
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Includes new gross and microscopic figures for clarity of morphology and new artwork depicting the latest advances in molecular pathogenesis of cancers.
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Reflects updated page references and content changes found in to Robbins and Cotran Pathologic Basis of Disease, 10th Edition.
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Contains all the key data and principles needed for the USMLE Step 1, in-course exams, and rotations.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Medical Students ; Pathology residents and practitioners
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- General Pathology
- 1. The Cell as a Unit of Health and Disease
- The Genome (p. 1)
- Cellular Housekeeping (p. 6)
- Cellular Metabolism and Mitochondrial Function (p. 15)
- Cellular Activation (p. 16)
- Signal Transduction Pathways (p. 17)
- Growth Factors and Receptors (p. 20)
- Extracellular Matrix (p. 21)
- Maintaining Cell Populations (p. 25)
- 2. Cell Injury, Cell Death, and Adaptations
- Introduction to Pathology (p. 33)
- Overview of Cellular Responses to Stress and Noxious Stimuli (p. 34)
- Causes of Cell Injury (p. 36)
- The Progression of Cell Injury and Death (p. 36)
- Necrosis (p. 39)
- Apoptosis (p. 42)
- Other Mechanisms of Cell Death (p. 47)
- Mechanisms of Cell Injury (p. 49)
- Examples of Cell Injury and Death (p. 55)
- Adaptations of Cellular Growth and Differentiation (p. 57)
- Intracellular Accumulations (p. 62) (Fig. 2.18)
- Pathologic Calcification (p. 65)
- Cellular Aging (p. 66)
- 3. Inflammation and Repair
- Overview of Inflammation: Definitions and General Features (p. 71)
- Acute Inflammation (p. 75)
- Mediators of Inflammation (p. 85)
- Morphologic Patterns of Acute Inflammation (p. 93)
- Outcomes of Acute Inflammation (p. 95; Fig. 3.11)
- Summary of Acute Inflammation (p. 95)
- Chronic Inflammation (p. 96)
- Systemic Effects of Inflammation (p. 101)
- Tissue Repair (p. 103)
- 4. Hemodynamic Disorders, Thromboembolic Disease, and Shock
- Edema and Effusions (p. 115)
- Hyperemia and Congestion (p. 117)
- Hemostasis, Hemorrhagic Disorders, and Thrombosis (p. 118)
- Embolism (p. 130)
- Infarction (p. 133)
- Shock (p. 134)
- 5. Genetic Disorders
- Genes and Human Diseases (p. 141)
- Mendelian Disorders (p. 144)
- Complex Multigenic Disorders (p. 163)
- Chromosomal Disorders (p. 164)
- Single-Gene Disorders With Nonclassic Inheritance (p. 173)
- Molecular Genetic Diagnosis (p. 180)
- 6. Diseases of the Immune System
- The Normal Immune Response (p. 190)
- Hypersensitivity: Immunologically Mediated Tissue Injury (p. 204)
- Rejection of Tissue Transplants (p. 234)
- Immunodeficiency Diseases (p. 240)
- Amyloidosis (p. 259)
- 7. Neoplasia
- Nomenclature (p. 268)
- Characteristics of Benign and Malignant Neoplasms (p. 270)
- Epidemiology of Cancer (p. 277)
- Molecular Basis of Cancer: Role of Genetic and Epigenetic Alterations (p. 281)
- Molecular Basis of Multistep Carcinogenesis (p. 320)
- Carcinogenic Agents and Their Cellular Interactions (p. 320)
- Clinical Aspects of Neoplasia (p. 328)
- 8. Infectious Diseases
- General Principles of Microbial Pathognesis (p. 399)
- Viral Infections (p. 349; Table 8.4)
- Bacterial Infections (p. 359; Table 8.5)
- Fungal Infections (p. 383)
- Parasitic Infections (p. 388; Table 8.6)
- Sexually Transmitted Infections (STIs; p. 399; see also Chapters 21 and 22)
- Special Techniques for Diagnosing Infectious Agents (p. 401)
- 9. Environmental and Nutritional Diseases
- Health Effects of Climate Change (p. 406)
- Toxicity of Chemical and Physical Agents (p. 407)
- Environmental Pollution (p. 408)
- Occupational Health Risks: Industrial and Agricultural Exposures (p. 414)
- Effects of Tobacco (p. 415)
- Effects of Alcohol (p. 418)
- Injury by Therapeutic Drugs and Drugs of Abuse (p. 420)
- Injury by Physical Agents (p. 426)
- Nutritional Diseases (p. 433)
- 10. Diseases of Infancy and Childhood
- Congenital Anomalies (p. 453)
- Prematurity and Fetal Growth Restriction (p. 457)
- Perinatal Infections (p. 461)
- Fetal Hydrops (p. 462)
- Inborn Errors of Metabolism and Other Genetic Disorders (p. 464)
- Sudden Infant Death Syndrome (SIDS; p. 473)
- Tumors and Tumorlike Lesions of Infancy and Childhood (p. 475)
- Systemic Pathology: Diseases of Organ Systems
- 11. Blood Vessels
- Vascular Structure and Function (p. 485)
- Vascular Anomalies (p. 487)
- Vascular Wall Response to Injury (p. 487)
- Hypertensive Vascular Disease (p. 489)
- Arteriosclerosis (p. 493)
- Atherosclerosis (p. 493)
- Aneurysms and Dissection (p. 504)
- Vasculitis (p. 508)
- Antiendothelial Cell Antibodies (p. 511)
- Disorders of Blood Vessel Hyper-Reactivity (p. 516)
- Veins (p. 517)
- Vascular Tumors (p. 518)
- Pathology of Vascular Intervention (p. 523)
- 12. The Heart
- Cardiac Structure and Specializations (p. 527)
- Effects of Aging on the Heart (p. 528)
- Overview of Cardiac Pathophysiology (p. 529)
- Heart Failure (p. 530)
- Cardiac Development (p. 534)
- Congenital Heart Disease (CHD; p. 534)
- Ischemic Heart Disease (p. 542)
- Arrhythmias (p. 554)
- Hypertensive Heart Disease (p. 555)
- Valvular Heart Disease (p. 557)
- Cardiomyopathies (p. 567)
- Pericardial Disease (p. 577)
- Tumors of the Heart (p. 579)
- Cardiac Transplantation (p. 580)
- Cardiac Devices (p. 580)
- 13. Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus
- Normal Hematopoiesis (p. 584)
- Disorders of White Cells (p. 586)
- Leukopenia (p. 586)
- Reactive Proliferations of White Cells and Lymph Nodes (p. 587)
- Neoplastic Proliferations of White Cells (p. 590)
- Spleen (p. 628)
- Thymus (p. 631; see also Chapter 6)
- 14. Red Blood Cell and Bleeding Disorders
- Anemias (p. 635)
- Polycythemia (p. 662)
- Bleeding Disorders: Hemorrhagic Diatheses (p. 662)
- 15. The Lung
- Congenital Anomalies (p. 674)
- Atelectasis (Collapse) (p. 674)
- Pulmonary Edema (p. 675)
- Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage) (p. 676)
- Obstructive and Restrictive Lung Diseases (p. 678)
- Obstructive Lung Diseases (p. 678)
- Chronic Diffuse Interstitial (Restrictive) Diseases (p. 688)
- Diseases of Vascular Origin (p. 700)
- Lung Transplantation (p. 714)
- Tumors (p. 715)
- 16. Head and Neck
- Oral Cavity (p. 731)
- Upper Airways (p. 739)
- Neck p. 745)
- Salivary Glands (p. 747)
- 17. The Gastrointestinal Tract
- Congenital Abnormalities (p. 754)
- Diaphragmatic Hernia, Omphalocele, and Gastroschisis (p. 754)
- Ectopia (p. 755)
- Pyloric Stenosis (p. 755)
- Hirschsprung Disease (p. 755)
- Esophagus (p. 757)
- Achalasia (p. 757)
- Esophagitis and Related Disorders (p. 758)
- Barrett Esophagus (p. 761)
- Esophageal Tumors (p. 762)
- Stomach (p. 764)
- Chronic Gastritis and Its Complications (p. 766)
- Other Complications of Chronic Gastritis
- Hypertrophic Gastropathies (p. 771; Table 17.1)
- Gastric Polyps and Tumors (p. 773; Table 17.1)
- Small Intestine and Colon (p. 780)
- Intestinal Obstruction (p. 780)
- Ischemic Bowel Disease (p. 781)
- Angiodysplasia (p. 783)
- Malabsorption and Diarrhea (p. 783)
- Infectious Enterocolitis (p. 787)
- Irritable Bowel Syndrome (IBS; p. 798)
- Inflammatory Bowel Disease (IBD; p. 798)
- Other Causes of Chronic Colitis (p. 805)
- Graft-Versus-Host Disease (GVHD; p. 805)
- Sigmoid Diverticular Disease (p. 806)
- Polyps (p. 807)
- Adenocarcinoma (p. 813)
- Hemorrhoids (p. 818)
- Acute Appendicitis (p. 818)
- Tumors of the Appendix (p. 819)
- Peritoneal Cavity (p. 820)
- Tumors (p. 820)
- 18. Liver and Gallbladder
- The Liver and Bile Ducts (p. 823)
- Infectious Disorders (p. 831)
- Autoimmune Hepatitis (AIH; p. 839)
- Drug- and Toxin-Induced Liver Injury (p. 841)
- Fatty Liver Disease (p. 842)
- Inherited Liver Disease (p. 848)
- Autoimmune Cholangiopathies (p. 857)
- Circulatory Disorders (p. 861; Fig. 18.10)
- Hepatic Disease Associated With Pregnancy (p. 864)
- Nodules and Tumors (p. 865)
- Gallbladder (p. 872)
- 19. The Pancreas
- Congenital Anomalies (p. 881)
- Pancreatitis (p. 882)
- Non-Neoplastic Cysts (p. 888)
- Neoplasms (p. 886)
- 20. The Kidney
- Clinical Manifestations of Renal Diseases (p. 896)
- Glomerular Diseases (p. 897)
- Tubular and Interstitial Diseases (p. 924)
- Vascular Diseases (p. 935)
- Congenital and Developmental Anomalies (p. 940)
- Cystic Diseases of the Kidney (p. 941)
- Urolithiasis (Renal Calculi, Stones) (p. 947)
- Neoplasms of the Kidney (p. 948)
- 21. The Lower Urinary Tract and Male Genital System
- The Lower Urinary Tract (p. 953)
- Urinary Bladder (p. 955)
- Urethra (p. 963)
- The Male Genital Tract (p. 963)
- Prostate (p. 975)
- 22. The Female Genital Tract
- Infections (p. 986)
- Vulva (p. 989)
- Vagina (p. 994)
- Cervix (p. 995)
- Body of Uterus and Endometrium (p. 1001)
- Fallopian Tubes (p. 1015)
- Ovaries (p. 1016)
- Gestational and Placental Disorders (p. 1028)
- 23. The Breast
- Disorders of Development (p. 1038)
- Clinical Presentation of Breast Disease (p. 1038)
- Inflammatory Disorders (p. 1040)
- Benign Epithelial Lesions (p. 1042)
- Carcinoma of the Breast (p. 1046)
- Types of Breast Carcinoma (p. 1053)
- 24. The Endocrine System
- Pituitary Gland (p. 1066)
- Thyroid Gland (p. 1075)
- Parathyroid Glands (p. 1093)
- The Endocrine Pancreas (p. 1097)
- Adrenal Glands (p. 1114)
- Pineal Gland (p. 1130)
- 25. The Skin
- The Skin: More Than a Mechanical Barrier (p. 1133)
- Disorders of Pigmentation and Melanocytes (p. 1135)
- Benign Epithelial Tumors (p. 1102)
- Premalignant and Malignant Epidermal Tumors (p. 1145)
- Tumors of the Dermis (p. 1149)
- Tumors of Cellular Migrants to the Skin (p. 1151)
- Disorders of Epidermal Maturation (p. 1152)
- Acute Inflammatory Dermatoses (p. 1153)
- Chronic Inflammatory Dermatoses (p. 1157)
- Blistering (Bullous) Diseases (p. 1159)
- Disorders of Epidermal Appendages (p. 1165)
- Panniculitis (p. 1166)
- Infection (p. 1166)
- 26. Bones, Joints, and Soft Tissue Tumors
- Bones (p. 1171)
- Joints (p. 1197)
- Soft Tissue Tumors (p. 1208)
- 27. Peripheral Nerves and Skeletal Muscles
- Diseases of Peripheral Nerves (p. 1217)
- Specific Peripheral Neuropathies (p. 1220)
- Diseases of the Neuromuscular Junction (p. 1225)
- Diseases of Skeletal Muscle (p. 1227)
- Peripheral Nerve Sheath Tumors (p. 1236)
- 28. The Central Nervous System
- Cellular Pathology of the Central Nervous System (p. 1242)
- Cerebral Edema, Hydrocephalus, Raised Intracranial Pressure, and Herniation (p. 1244)
- Malformations and Developmental Disorders (p. 1245)
- Perinatal Brain Injury (p. 1248)
- Trauma (p. 1249)
- Cerebrovascular Disease (p. 1253)
- Infections (p. 1261)
- Demyelinating Diseases (p. 1269)
- Neurodegenerative Diseases (p. 1273)
- Genetic Metabolic Diseases (p. 1289)
- Toxic and Acquired Metabolic Diseases (p. 1291)
- Tumors (p. 1293)
- 29. The Eye
- Orbit (p. 1306)
- Eyelid (p. 1307)
- Conjunctiva (p. 1308)
- Sclera (p. 1310)
- Cornea (p. 1310)
- Anterior Segment (p. 1313)
- Uvea (p. 1315)
- Retina and Vitreous (p. 1318)
- Optic Nerve (p. 1325)
- The End-Stage Eye: Phthisis Bulbi (p. 1328)
- Index
- No. of pages: 1040
- Language: English
- Edition: 10
- Published: November 19, 2022
- Imprint: Elsevier
- Paperback ISBN: 9780323653909
- eBook ISBN: 9780323825634
RM
Richard N Mitchell
Richard N Mitchell, MD, PhD, Lawrence J. Henderson Professor of Pathology and Health Sciences and Technology, Department of Pathology, Harvard Medical School, Staff Pathologist, Brigham and Women's Hospital, Boston, Massachusetts
Affiliations and expertise
Lawrence J. Henderson Professor of Pathology and Health Sciences and Technology, Department of Pathology, Harvard Medical School, Staff Pathologist, Brigham and Women's Hospital, Boston, MassachusettsVK
Vinay Kumar
Vinay Kumar, MBBS, MD, FRCPath, Alice Hogge and Arthur A. Baer Distinguished Service Professor of Pathology, Biologic Sciences Division and the Pritzker Medical School, The University of Chicago, Chicago, Illinois, USA
Affiliations and expertise
Professor and Chairman, Department of Pathology, University of Chicago, Pritzker School of Medicine, Chicago, ILAA
Abul K. Abbas
Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California
Affiliations and expertise
Emeritus Professor, Department of Pathology, University of California San FranciscoJA
Jon C. Aster
Jon C. Aster, MD, PhD, Professor of Pathology, Harvard Medical School; Brigham and Women's Hospital, Boston, Massachusetts
Affiliations and expertise
Professor, Department of Pathology, Harvard Medical School; Brigham and Women's Hospital, Boston, Massachusetts