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Elsevier

Plasma Membrane Shaping

  • 1st Edition - September 8, 2022
  • Latest edition
  • Editor: Shiro Suetsugu
  • Language: English

Plasma Membrane Shaping summarizes current knowledge on how cells shape their membrane. Organized in four sections, the book opens with a broad overview of the plasma membrane,… Read more

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Description

Plasma Membrane Shaping summarizes current knowledge on how cells shape their membrane. Organized in four sections, the book opens with a broad overview of the plasma membrane, its composition, usual shapes and substructures, Actin/WASP/arp2/3 structures, BAR domains, and Ankyrin repeat domains, dynamin, and phospholipid signaling. Other sections cover the shaping of the plasma membrane for transport processes, discussions on exosomes, microvesicles, and endosomes, clathrin-coated pits, caveolae, and other endocytic pits, membrane deformation for cell movement, and some of the most current dry and wet lab research techniques to investigate cellular membrane shaping.

This is an ideal resource for new researchers coming into this area as well as for graduate students. The methods section will be of interest to both microscopists and computer scientists dedicated to the visualization, data collection, and analysis of plasma membrane shaping experiments.

Key features

  • Covers membrane shaping for both cytosis and cell movement
  • Includes dry and wet lab research methods of plasma membrane shaping
  • Describes the molecular machinery involved with protein and lipid balance in the plasma membrane
  • Presents the coordination of cellular structures involved in cell deformation and motion

Readership

Graduate students, postdocs, academics in life science. Graduate students in Biophysics and membrane biology in general

Table of contents

1. Introduction and overview of the book

Part 1: Building blocks and the shape builders

2. Membrane lipid compositions and the difference between subcellular structures

3. Wiskott4. BAR domains

5. Ankyrin repeat domains with an amphipathic helix for membrane deformation

6. Ankyrin repeat domains

7. Dynamin: molecular scissors for membrane fission

8. Phospholipid signaling, lipase

9. Phospholipid signaling: phosphoinositide kinases and phosphatases

10. Plasma membrane shaping by protein phase separation

11. Synthetic mimics of membrane-active proteins and peptides

Part 2: The functions of the plasma membrane substance and derived vesicles

12. The extracellular vesicles

13. Regulation of membrane traffic through recycling endosomes by membrane phospholipid phosphatidylserine

14. Membrane shaping for clathrin-coated pits and endocytosis

15. Caveolae biogenesis and lipid sorting at the plasma membrane

16. Non-vesicular lipid transport at membrane contact sites between the endoplasmic reticulum and the plasma membrane

17. Lamellipodia and filopodia

18. Membrane structures, dynamics, and shaping in invadopodia and podosomes

Part 3: Force around the plasma membrane and imaging

19. Membrane tension and mechanobiology of cell migration

20. Brownian ratchet force sensor at the contacting point between F-actin barbed end and lamellipodium tip plasma membrane

21. Biophysics of cellular membrane shaping on fiber networks

22. Reconstitution of membrane symmetry breaking

Part 4: The microscopy and image analysis for understanding the shaping of the membrane

23. Imaging three-dimensional dynamics of plasma membrane structures using ultrathin plane illumination microscopy

24. Deep learning for cell shape analysis

Part 5: The essentiality of the membrane shaping by theory and reconstitution

25. Physical principles of cellular membrane shapes

26. Modeling cellular shape changes in the presence of curved membrane proteins and active cytoskeletal forces

27. Molecular dynamics

Product details

  • Edition: 1
  • Latest edition
  • Published: September 8, 2022
  • Language: English

About the editor

SS

Shiro Suetsugu

Dr. Suetsugu is currently Professor at Nara Institute of Science and Technology, Japan. He received his Ph.D and M.Sc in Cell Biology from the Department of Biochemistry and Biophysics, Graduate school of Sciences, The University of Tokyo. His research is focused on the cellular plasma membrane and its essential role of distinguishing the inside and the outside of the cells. He and his team focus on the mechanisms connecting the membrane to the cytoskeleton, and the membrane-binding proteins connecting the membrane to the intracellular and intercellular signaling for varieties of cellular functions including proliferation and morphological changes. They pioneered the membrane shaping protein of the plasma membrane and proposed the mechanisms of the membrane shaping. Notably, they contributed to the mechanisms of the concept of membrane shaping by the proteins having the BAR domains including the I-BAR domain. Throughout his career, Dr. Suetsugu received awards international and national awards such as FEBS Letters Young Group Leader Award, the Young Scientists’ Prize by the Minister of Education, Culture, Sports, Science and Technology, Young Investigator Award, the Japanese Biochemical Society, and the 2015 Kazato Prize.
Affiliations and expertise
Professor, Nara Institute of Science and Technology, Japan

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