Plant Polysaccharides as Pharmaceutical Excipients

1st Edition - November 20, 2022
Imprint: Elsevier
Editors: Amit Kumar Nayak, Md Saquib Hasnain, Dilipkumar Pal
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 8 0 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 8 1 - 1

Plant Polysaccharides as Pharmaceutical Excipients explores innovative techniques and applications of plant-derived polysaccharides as pharmaceutical excipients. Plant polysacch… Read more

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Plant Polysaccharides as Pharmaceutical Excipients explores innovative techniques and applications of plant-derived polysaccharides as pharmaceutical excipients. Plant polysaccharides are sustainable, renewable and abundantly available, offering attractive properties in terms of water solubility, swelling ability, non-toxicity and biodegradability. These qualities have resulted in extensive exploration into their applications as excipients in a variety of pharmaceutical dosage forms. This book takes a comprehensive, application-oriented approach, drawing on the very latest research that includes sources, classification and extraction methods of plant polysaccharides. Subsequent chapters focus on plant polysaccharides for individual pharmaceutical applications, enabling the reader to understand their preparation for specific targeted uses.

Throughout the book, information is supported by illustrations, chemical structures, flow charts and data tables, providing a clear understanding. Finally, future perspectives and challenges are reviewed and discussed.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Plant polysaccharides: sources, classifications, and extraction methods
Abstract
1.1 Introduction
1.2 Classification of plant polysaccharides based on their sources
1.3 The extraction of polysaccharides from plant sources
1.4 Conclusion
References
Chapter 2. Properties of plant polysaccharides used as pharmaceutical excipients
Abstract
Abbreviations
2.1 Introduction
2.2 Sources
2.3 Plant natural sources
2.4 Gum and mucilages
2.5 Cellulose
2.6 Starch
2.7 Conclusion
References
Chapter 3. Natural products as pharmaceutical additives in drug delivery systems
Abstract
Graphical abstract
3.1 Introduction
3.2 Sources of natural polysaccharide excipients
3.3 Classification of pharmaceutical excipients
3.4 Conclusion
Acknowledgments
Conflict of interest
Author contributions
References
Chapter 4. Plant polysaccharides in pharmaceutical tablets
Abstract
4.1 Introduction
4.2 Advantages of plant polysaccharides as excipients in tablet formulations
4.3 Drawbacks associated with plant polysaccharides as tableting excipients
4.4 Chemical nature of plant polysaccharides
4.5 Plant polysaccharides used in tablet formulations
4.6 Semisynthetic plant polysaccharides
4.7 Conclusion
References
Chapter 5. Plant polysaccharides as suspending agents in pharmaceutical suspensions
Abstract
5.1 Introduction
5.2 Sources of natural polysaccharides
5.3 Plant polysaccharides
5.4 Plant polysaccharides in pharmaceuticals
5.5 Plant polysaccharides as a suspending agent in pharmaceuticals
5.6 Theory of pharmaceutical suspensions
5.7 Application of plant polysaccharides as suspending agents
5.8 Conclusions
References
Chapter 6. Plant polysaccharides as emulsifiers in pharmaceutical emulsions
Abstract
6.1 Introduction
6.2 Pectin
6.3 Arabinogalactans
6.4 Arabinoxylans
6.5 β-Glucan
6.6 Psyllium husk gum
6.7 Algins
6.8 Agars
6.9 Carrageenan
6.10 Furcellaran
6.11 Guar gum
6.12 Locust bean gum
6.13 Tara gum
6.14 Tamarind seed gum
6.15 Quince seed
6.16 Inulin
6.17 Gum arabic
6.18 Gum ghatti
6.19 Gum karaya
6.20 Gum tragacanth
6.21 Aloe gel
6.22 Conclusion
References
Chapter 7. Role of plant polysaccharides in pharmaceutical hydrogels
Abstract
Abbreviations
7.1 Introduction
7.2 Pharmaceutical applications of cellulose-derived HDG
7.3 Pharmaceutical applications of starch-derived HDG
7.4 Pharmaceutical applications of Pectin-derived HDG
7.5 Pharmaceutical applications of gum (Acacia/Arabic/Ghatti/Karaya/Tragacanth/Locust bean/Sterculia)-derived HDG
7.6 Conclusion
References
Chapter 8. Plant polysaccharides-based multiple-units for oral drug delivery
Abstract
8.1 Introduction
8.2 Advantages of multiple-unit oral drug delivery systems
8.3 Advantages of plant polysaccharides for fabrication of multiple-unit oral drug delivery
8.4 Plant polysaccharides used in fabrication of multiple-unit oral drug delivery
8.5 Conclusion
References
Chapter 9. Plant polysaccharides-based nanoparticles for drug delivery
Abstract
9.1 Introduction
9.2 Classification of plant polysaccharides
9.3 Applications of polysaccharides-based nanoparticles
9.4 Conclusion
Acknowledgment
Conflict of interest
References
Chapter 10. Plant polysaccharides as excipients in oral drug delivery
Abstract
10.1 Introduction
10.2 Classification of plant polysaccharides
10.3 Oral drug delivery systems
10.4 Plant polysaccharides in oral formulations
10.5 Conclusion
References
Further reading
Chapter 11. Plant polysaccharides in ocular drug delivery
Abstract
11.1 Introduction
11.2 Role of anatomy and physiology of the eye in ocular drug delivery
11.3 Ocular drug delivery and methods
11.4 Role of plant polysaccharides in ocular drug delivery
11.5 Advantages and disadvantages of plant polysaccharides
11.6 Summary and conclusion
References
Chapter 12. Plant polysaccharides for nasal drug delivery
Abstract
12.1 Introduction
12.2 Polysaccharides for nasal delivery
12.3 Conclusions
Acknowledgment
References
Chapter 13. Plant polysaccharides in transdermal drug delivery
Abstract
13.1 Introduction
13.2 Plant polysaccharides used in transdermal drug delivery
13.3 Applications of plant polysaccharides in the transdermal drug delivery system
13.4 Conclusion and future prospective
References
Chapter 14. Plant polysaccharides in buccal drug delivery
Abstract
14.1 Introduction
14.2 Delivery systems for buccal drug delivery
14.3 The buccal mucosa
14.4 Buccal drug delivery systems based on mucoadhesive plant polysaccharides
14.5 Conclusion
References
Chapter 15. Plant polysaccharides for colon-targeted drug delivery
Abstract
15.1 Introduction
15.2 Rationale behind colon-specific targeting
15.3 Factors involved in colon-specific drug delivery
15.4 Different strategies/approaches for colon-specific targeting
15.5 Plant polysaccharides in colon targeting
15.6 Current limitations
15.7 Perspectives and future directions
15.8 Conclusion
References
Chapter 16. Plant polysaccharide-based conjugates for anticancer drug delivery
Abstract
16.1 Introduction
16.2 Conjugation in pharmaceutical science
16.3 Pharmaceutical conjugate for cancer management
16.4 Nanoconjugate technology for cancer management
16.5 Polysaccharide-based conjugates for drug delivery
16.6 Plant polysaccharides and plant polysaccharides conjugates
16.7 Plant polysaccharide-based conjugates for drug delivery
16.8 Preparation of plant polysaccharide-based conjugates
16.9 Plant polysaccharide-based conjugates for anticancer drug delivery
16.10 Conclusion
Conflict of interest
References
Further reading
Chapter 17. Plant polysaccharides in formulation coating
Abstract
17.1 Introduction
17.2 Food coating
17.3 Pharmaceutical applications
17.4 Tissue engineering
17.5 Concluding remarks
References
Chapter 18. Plant polysaccharides for protein binding
Abstract
18.1 Introduction
18.2 The physiological role of polysaccharides
18.3 Types and sources of polysaccharides
18.4 Plant-derived polysaccharides
18.5 Potential utilization and applications of polysaccharides
18.6 Stability of protein emulsion
18.7 Emulsion and emulsifiers
18.8 Emulsion stability theory
18.9 Coalescence
18.10 Flocculation
18.11 Creaming
18.12 Thermodynamic and interaction theory
18.13 Properties of food emulsifier
18.14 Protein as emulsifier
18.15 Protein-polysaccharides complexes
References
Further reading
Chapter 19. Pharmacokinetics of bioactive plant-derived polysaccharides for enhanced drug release, stability, bioavailability and target specificity
Abstract
19.1 Introduction
19.2 Some bioactive plant-based polysaccharrides, their bioavalability, stability, drug release, and target specificities
19.3 Pharmacokinetics of polyssacharides during drug release
19.4 Conclusion
References
Chapter 20. Plant polysaccharides for cancer theranostics
Abstract
20.1 Introduction
20.2 Types of plant polysaccharides
20.3 Plant polysaccharides in cancer applications
20.4 Future perspective
20.5 Conclusion
References
Further reading
Chapter 21. Plant polysaccharides in pharmaceutical 3D printing
Abstract
21.1 Introduction
21.2 3D printing in pharmaceuticals field
21.3 3D printing process
21.4 3D printing technologies
21.5 Plant polysaccharides in 3D printing for pharmaceutical applications
21.6 Conclusion and future perspectives
Acknowledgments
References
Chapter 22. Plant polysaccharides for drug delivery in wound healing
Abstract
22.1 Introduction
22.2 Sources of plant polysaccharides
22.3 Structure activity relationship of plant polysaccharides for wound healing
22.4 Role of plant polysaccharides in wound healing
22.5 Various drug delivery systems made of plant polysaccharides for wound healing
22.6 Conclusion
References
Chapter 23. Plant polysaccharides for orthopedic drug delivery
Abstract
23.1 Natural and plant polysaccharides
23.2 Significance of polysaccharides in pharmaceutics
23.3 Drug delivery and its importance in pharmacology
23.4 Applications of plant polysaccharides in drug delivery and orthopedics
23.5 Applications of orthopedics in medicinal treatment and its relationships with drug delivery
23.6 Future of polysaccharides in drug delivery and orthopedics
Acknowledgment
References
Chapter 24. Polysaccharides for biomedical implants
Abstract
24.1 Introduction
24.2 Polysaccharides’ properties and structure
24.3 Applications of polysaccharides
24.4 Advantages of polysaccharides
24.5 Conclusions
References
Chapter 25. Antioxidant effects of polysaccharides derivatives of various plants
Abstract
25.1 Introduction
25.2 Methods
25.3 Results
25.4 Discussion and conclusion
References
Chapter 26. Biological and pharmaceutical activities of polysaccharides
Abstract
26.1 Introduction
26.2 Application of polysaccharides in nutrition and food items
26.3 Applications of polysaccharides in the field of medicine
References
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Marwadi University, Rajkot, Gujarat, India

Dilipkumar Pal

Dr. Dilipkumar Pal is an Associate Professor at the Department of Pharmaceutical Sciences, Guru Ghasidash Vishwavidyalaya, Bilaspur, India. He received his master and PhD degree from Jadavpur Universty, Kolkata, and performed post-doctoral research as Endeavour research fellow in University of Sydney, Australia. His research interests include phytochemical pharmacological evaluation of indigenous plants and natural biopolymers. He has published 177 full research papers in peer-reviewed national and international scientific journals, and contributed 115 abstracts in different national and international conferences. He has written one book and 68 book chapters and edited seven books published by reputed international publishers. Dr. Pal had received 13 national and international professional awards and has guided seven PhD and 39 master students for their dissertation thesis. He is the reviewer and Editorial Board member of 27 and 29 scientific journals, respectively. Dr Pal is the Editor-in-Chief of the research journal SPER Journal of Pharmaceutical and Biological Research.

Affiliations and expertise

Guru Ghasidash Vishwavidyalaya

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Plant Polysaccharides as Pharmaceutical Excipients

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