Physiology of the Gastrointestinal Tract
- 4th Edition - March 30, 2006
- Editors: Leonard R. Johnson, Kim E. Barrett, Fayez K. Ghishan, Juanita L. Merchant, Hamid M. Said, Jackie D. Wood
- Language: English
FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensi… Read more
Description
Description
FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.
Key features
Key features
· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology
· Information presented in a style that is both readable and understandable
· Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student
· Features an entirely new section on Immunology and Inflammation
· Each section edited by the preeminent scientist in the field
· Information presented in a style that is both readable and understandable
· Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student
· Features an entirely new section on Immunology and Inflammation
· Each section edited by the preeminent scientist in the field
Readership
Readership
Clinical gastroenterologists, Grad-level lecturer, American College of Gastroenterology members, Internists, and Physiologists
Table of contents
Table of contents
Section I: Basic Cell Physiology and Growth of the GI Tract
1. Transcription and Epigenetic Regulation
Juanita L. Merchant and Longchuan Bai
2. Translation and Posttranslational Processing of GI Peptides
Cheryl E. Gariepy and Chris J. Dickinson
3. Transmembrane Receptors for Endogenous Ligands and Associated Signals
Nigel Bunnett
4. Gastrointestinal Hormones: Gastrin, CCK, Somatostatin, Ghrelin
Graham J. Dockray
5. Post-Pyloric Gastrointestinal Peptides
Ella W. Englander and George H. Greeley
6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis
Daniel J. Drucker
7. Growth Factors in the GI Tract
John Barnard and Kirk McHugh
8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway
Eric Fearon
9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
Gijs R. van den Brink, Maikel P. Peppelenbosch, and Drucilla J. Roberts
10. Developmental Signaling Networks: The Notch Pathway
Guy R. Sander, Hanna Krysinska, and Barry Powell
11. Physiology of Gastrointestinal Stem Cells
Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn
12. Apoptosis in the Gastrointestinal Tract
Leonard R. Johnson
13. Molecular Aspects and Regulation of Gastrointestinal Function During Post-Natal Development
James F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan
14. Effect of Aging on the Gastrointestinal Tract
Adhip P.N. Majumdar and Marc D. Basson
15. Regulation of Gastrointestinal Normal Cell Growth
Mark R. Hellmich and B. Mark Evers
16. Mucosal Repair and Restitution
Mark R. Frey and D. Brent Polk
17. Mechanisms of GI Malignancies
John P. Lynch and Anil K. Rustgi
Section II: Neural Gastroenterology and Motility
18. Development of Enteric Nervous System
Michael Gershon
19. Cellular Physiology of Gastrointestinal Smooth Muscle
Gabriel M. Makhlouf and Karnam S. Murthy
20. Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract
Kenton M. Sanders, Sang Don Koh, and Sean M. Ward
21. Functional Histoanatomy of the Enteric Nervous System
Simon JH Brookes and Marcello Costa
22. Physiology of Prevertebral Sympathetic Ganglia
Joseph H. Szurszewski and Steven M. Miller
23. Cellular Neurophysiology of Enteric Neurons
Jackie Wood
24. Integrative Functions of the Enteric Nervous System
Jackie D. Wood
25. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
Michael J. Beyak, David C.E. Bulmer, Wen Jiang, Christopher D. Keating, Weifang Rong, and David Grundy
26. Processing of Gastrointestinal Sensory Signals in the Brain
Anthony R. Hobson and Qasim Aziz
27. Enteric Neural Regulation of Mucosal Secretion
Helen J. Cooke and Fievos L. Christofi
28. Effect of Stress on Intestinal Mucosal Function
Johan D. Söderholm and Mary H. Perdue
29. Effect of Stress on Gastrointestinal Motility
Michèle Gué
30. HPA-Axis In Gastrointestinal Physiology
Yvette Taché
31. Neural Regulation of Gastrointestinal Blood Flow
Peter Holzer
32. Neural Control of the Gallbladder and Sphincter of Oddi
Gary M. Mawe, Gino T.P. Saccone, and Maria J. Pozo
33. Brainstem Control of the Gastric Function
Richard C. Rodgers, Gerlinda E. Hermann, and R. Alberto Travagli
34. Neural and Hormonal Controls of Food Intake and Satiety
Timothy H. Moran
35. Pharyngeal Motor Function
Reza Shaker
36. Motor Function of the Esophagus
Ray E. Clouse and Nicholas E. Diamant
37. Neurophysiological Mechanisms of Gastric Reservoir Function
Jan Tack
38. Small Intestinal Motility
William L. Hasler
39. Large Intestinal Motility
Sushil Sarna
40. Neural Control of Pelvic Floor Muscles
David B. Vodusek and Paul Enck
41. Pathophysiology Underlying the Irritable Bowel Syndrome
Jackie D. Wood
Section III. Gastrointestinal Immunology and Inflammation
42. Innate Immune Responses in the GI Tract: Sensors and Effectors
Lars Eckmann
43. Biology of Gut Immunoglobulins
Finn-Eirik Johansen, Elizabeth Yen, Bonny Dickinson, Massaru Yoshida, Steve Claypool, Richard S. Blumberg, and Wayne I. Lencer
44. Mechanisms of Helicobacter pylori-induced Gastric Inflammation
Dawn A. Israel and Richard M. Peek Jr.
45. Mechanisms and Consequences of Intestinal Inflammation in the Gut
Wallace MacNaughton
46. Recruitment of Inflammatory and Immune Cells in the Gut: Physiology and Pathophysiology
D. Neil Granger, Christopher Kevil, and Matthew B. Grisham
47. Physiology of Host-Pathogen Interactions
Kim Hodges, V.K. Viswanathan and Gail Hecht
Section IV. Physiology of Secretion
48. Salivary Secretion
David Cook
49. Regulation of Gastric Acid Secretion
Arthur Shulkes, Graham S. Baldwin, and Andrew S. Giraud
50. Gastroduodenal Mucosal Defense
Marshall H. Montrose, Yasutada Akiba, Koji Takeuchi, and Jonathan D. Kaunitz
51. Genetically Engineered Mouse Models of Gastric Physiology
Linda C. Samuelson
52. Structure-Function Relationships in the Pancreatic Acinar Cell
Fred S. Gorelick and James D. Jamieson
53. Stimulus-Secretion Coupling in Pancreatic Acinar Cells
John A. Williams and David I. Yule
54. Cell Physiology of Pancreatic Ducts
B.E. Argent, M.A. Gray, M.C. Steward, and R.M. Case
55. Regulation of Pancreatic Secretion
Rodger A. Liddle
56. Bile Formation and the Enterohepatic Circulation
Paul Dawson, Ben Shneider and Alan Hofmann
57. Mechanisms of Hepatocyte Organic Anion Transport
Allan W. Wolkoff
58. Mechanisms of Hepatocyte Detoxification
Karen F. Murray, Donald J. Messner, and Kris V. Kowdley
59. Physiology of Cholangiocytes
Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso
60. Gallbladder Function
Sum P. Lee and Rahul Kuver
Section V. Digestion and Absorption
61. Tight Junctions and the Intestinal Barrier
Thomas Y. Ma, and James M. Anderson
62. Protein Sorting in the Exocytic and Endocytic Pathways in Polarized Epithelial Cells
Stephen J. Hunt and W. James Nelson
63. Physiology of the Circulation of the Small Intestine
Philip T. Nowicki
64. Sugar Absorption
Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama, and Eric Turk
65. Protein Digestion and Absorption
Vadivel Ganapathy, Naren Gupta, and Robert G. Martindale
66. Lipid Digestion and Absorption
Judy Storch and Nada Abumurad
67. Genetic Regulation of Intestinal Lipid Transport and Metabolism
Zhouji Chen and Nicholas O. Davidson
68. Digestion and Intestinal Absorption of Dietary Carotenoids & Vitamin A
Alexandrine During and Earl H. Harrison
69. Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon
J. Wesley Pike, Makoto Watanuki, and Nirupama K. Shevde
70. Vitamin E and Vitamin K Metabolism
Ronald J. Sokol, Richard Bruno, and Maret Traber
71. Intestinal Absorption of Water-Soluble Vitamins
Hamid M. Said and Bellur Seetharam
72. Water Transport in the Gastrointestinal Tract
Jay R. Thiagarajah and Alan S. Verkman
73. Na+/H+ Exchange in Mammalian Digestive Tract
Pawel R. Kiela and Fayez K. Ghishan
74. Intestinal Anion Absorption
Pradeep K. Dudeja and Krishnamurthy Ramaswamy
75. Ion Channels of the Epithelia of the Gastrointestinal Tract
John Cuppoletti and Danuta H. Malinowska
76. Integrated Physiology of Intestinal Electrolyte Transport
Kim Barrett and Stephen Keely
77. Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium
James F. Collins and Fayez K. Ghishan
78. Iron Absorption
Nancy C. Andrews
79. Trace Element Absorption and Transport
Robert J. Cousins
1. Transcription and Epigenetic Regulation
Juanita L. Merchant and Longchuan Bai
2. Translation and Posttranslational Processing of GI Peptides
Cheryl E. Gariepy and Chris J. Dickinson
3. Transmembrane Receptors for Endogenous Ligands and Associated Signals
Nigel Bunnett
4. Gastrointestinal Hormones: Gastrin, CCK, Somatostatin, Ghrelin
Graham J. Dockray
5. Post-Pyloric Gastrointestinal Peptides
Ella W. Englander and George H. Greeley
6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis
Daniel J. Drucker
7. Growth Factors in the GI Tract
John Barnard and Kirk McHugh
8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway
Eric Fearon
9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
Gijs R. van den Brink, Maikel P. Peppelenbosch, and Drucilla J. Roberts
10. Developmental Signaling Networks: The Notch Pathway
Guy R. Sander, Hanna Krysinska, and Barry Powell
11. Physiology of Gastrointestinal Stem Cells
Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn
12. Apoptosis in the Gastrointestinal Tract
Leonard R. Johnson
13. Molecular Aspects and Regulation of Gastrointestinal Function During Post-Natal Development
James F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan
14. Effect of Aging on the Gastrointestinal Tract
Adhip P.N. Majumdar and Marc D. Basson
15. Regulation of Gastrointestinal Normal Cell Growth
Mark R. Hellmich and B. Mark Evers
16. Mucosal Repair and Restitution
Mark R. Frey and D. Brent Polk
17. Mechanisms of GI Malignancies
John P. Lynch and Anil K. Rustgi
Section II: Neural Gastroenterology and Motility
18. Development of Enteric Nervous System
Michael Gershon
19. Cellular Physiology of Gastrointestinal Smooth Muscle
Gabriel M. Makhlouf and Karnam S. Murthy
20. Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract
Kenton M. Sanders, Sang Don Koh, and Sean M. Ward
21. Functional Histoanatomy of the Enteric Nervous System
Simon JH Brookes and Marcello Costa
22. Physiology of Prevertebral Sympathetic Ganglia
Joseph H. Szurszewski and Steven M. Miller
23. Cellular Neurophysiology of Enteric Neurons
Jackie Wood
24. Integrative Functions of the Enteric Nervous System
Jackie D. Wood
25. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
Michael J. Beyak, David C.E. Bulmer, Wen Jiang, Christopher D. Keating, Weifang Rong, and David Grundy
26. Processing of Gastrointestinal Sensory Signals in the Brain
Anthony R. Hobson and Qasim Aziz
27. Enteric Neural Regulation of Mucosal Secretion
Helen J. Cooke and Fievos L. Christofi
28. Effect of Stress on Intestinal Mucosal Function
Johan D. Söderholm and Mary H. Perdue
29. Effect of Stress on Gastrointestinal Motility
Michèle Gué
30. HPA-Axis In Gastrointestinal Physiology
Yvette Taché
31. Neural Regulation of Gastrointestinal Blood Flow
Peter Holzer
32. Neural Control of the Gallbladder and Sphincter of Oddi
Gary M. Mawe, Gino T.P. Saccone, and Maria J. Pozo
33. Brainstem Control of the Gastric Function
Richard C. Rodgers, Gerlinda E. Hermann, and R. Alberto Travagli
34. Neural and Hormonal Controls of Food Intake and Satiety
Timothy H. Moran
35. Pharyngeal Motor Function
Reza Shaker
36. Motor Function of the Esophagus
Ray E. Clouse and Nicholas E. Diamant
37. Neurophysiological Mechanisms of Gastric Reservoir Function
Jan Tack
38. Small Intestinal Motility
William L. Hasler
39. Large Intestinal Motility
Sushil Sarna
40. Neural Control of Pelvic Floor Muscles
David B. Vodusek and Paul Enck
41. Pathophysiology Underlying the Irritable Bowel Syndrome
Jackie D. Wood
Section III. Gastrointestinal Immunology and Inflammation
42. Innate Immune Responses in the GI Tract: Sensors and Effectors
Lars Eckmann
43. Biology of Gut Immunoglobulins
Finn-Eirik Johansen, Elizabeth Yen, Bonny Dickinson, Massaru Yoshida, Steve Claypool, Richard S. Blumberg, and Wayne I. Lencer
44. Mechanisms of Helicobacter pylori-induced Gastric Inflammation
Dawn A. Israel and Richard M. Peek Jr.
45. Mechanisms and Consequences of Intestinal Inflammation in the Gut
Wallace MacNaughton
46. Recruitment of Inflammatory and Immune Cells in the Gut: Physiology and Pathophysiology
D. Neil Granger, Christopher Kevil, and Matthew B. Grisham
47. Physiology of Host-Pathogen Interactions
Kim Hodges, V.K. Viswanathan and Gail Hecht
Section IV. Physiology of Secretion
48. Salivary Secretion
David Cook
49. Regulation of Gastric Acid Secretion
Arthur Shulkes, Graham S. Baldwin, and Andrew S. Giraud
50. Gastroduodenal Mucosal Defense
Marshall H. Montrose, Yasutada Akiba, Koji Takeuchi, and Jonathan D. Kaunitz
51. Genetically Engineered Mouse Models of Gastric Physiology
Linda C. Samuelson
52. Structure-Function Relationships in the Pancreatic Acinar Cell
Fred S. Gorelick and James D. Jamieson
53. Stimulus-Secretion Coupling in Pancreatic Acinar Cells
John A. Williams and David I. Yule
54. Cell Physiology of Pancreatic Ducts
B.E. Argent, M.A. Gray, M.C. Steward, and R.M. Case
55. Regulation of Pancreatic Secretion
Rodger A. Liddle
56. Bile Formation and the Enterohepatic Circulation
Paul Dawson, Ben Shneider and Alan Hofmann
57. Mechanisms of Hepatocyte Organic Anion Transport
Allan W. Wolkoff
58. Mechanisms of Hepatocyte Detoxification
Karen F. Murray, Donald J. Messner, and Kris V. Kowdley
59. Physiology of Cholangiocytes
Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso
60. Gallbladder Function
Sum P. Lee and Rahul Kuver
Section V. Digestion and Absorption
61. Tight Junctions and the Intestinal Barrier
Thomas Y. Ma, and James M. Anderson
62. Protein Sorting in the Exocytic and Endocytic Pathways in Polarized Epithelial Cells
Stephen J. Hunt and W. James Nelson
63. Physiology of the Circulation of the Small Intestine
Philip T. Nowicki
64. Sugar Absorption
Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama, and Eric Turk
65. Protein Digestion and Absorption
Vadivel Ganapathy, Naren Gupta, and Robert G. Martindale
66. Lipid Digestion and Absorption
Judy Storch and Nada Abumurad
67. Genetic Regulation of Intestinal Lipid Transport and Metabolism
Zhouji Chen and Nicholas O. Davidson
68. Digestion and Intestinal Absorption of Dietary Carotenoids & Vitamin A
Alexandrine During and Earl H. Harrison
69. Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon
J. Wesley Pike, Makoto Watanuki, and Nirupama K. Shevde
70. Vitamin E and Vitamin K Metabolism
Ronald J. Sokol, Richard Bruno, and Maret Traber
71. Intestinal Absorption of Water-Soluble Vitamins
Hamid M. Said and Bellur Seetharam
72. Water Transport in the Gastrointestinal Tract
Jay R. Thiagarajah and Alan S. Verkman
73. Na+/H+ Exchange in Mammalian Digestive Tract
Pawel R. Kiela and Fayez K. Ghishan
74. Intestinal Anion Absorption
Pradeep K. Dudeja and Krishnamurthy Ramaswamy
75. Ion Channels of the Epithelia of the Gastrointestinal Tract
John Cuppoletti and Danuta H. Malinowska
76. Integrated Physiology of Intestinal Electrolyte Transport
Kim Barrett and Stephen Keely
77. Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium
James F. Collins and Fayez K. Ghishan
78. Iron Absorption
Nancy C. Andrews
79. Trace Element Absorption and Transport
Robert J. Cousins
Product details
Product details
- Edition: 4
- Published: May 10, 2006
- Language: English
About the editors
About the editors
LJ
Leonard R. Johnson
Leonard R. Johnson received a Ph.D. in physiology from the University of Michigan and then trained with Dr. Morton I. Grossman at UCLA. He spent 17 years as a Professor of Physiology at the University of Texas Medical School in Houston before moving to the University of Tennessee Health Science Center as the Thomas A. Gerwin Professor and Chairman of the Department of Physiology. He is the author or coauthor of over 250 papers on gastrointestinal physiology and holds an NIH MERIT Award. Currently he is the Vice Chancellor for Research at Tennessee.
Affiliations and expertise
Thomas A. Gerwin Professor and Chairman, Department of Physiology, The University of Tennessee Health Sciences Center, Memphis, TN, USAKB
Kim E. Barrett
Affiliations and expertise
Professor of Medicine and Vice-Chair for Research, Department of Medicine, University of California, San Diego, San Diego, California, USAFG
Fayez K. Ghishan
Affiliations and expertise
Horace W. Steele Endowed Chair in Pediatric Research Head, Department of Pediatrics and
Director, Steele Children's Research Center, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona, USAJM
Juanita L. Merchant
Affiliations and expertise
Professor of Internal Medicine and Integrative and Molecular Physiology, University of Michigan, Ann Arbor, Michigan, USAHS
Hamid M. Said
Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit).
He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals.
Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.
Affiliations and expertise
Professor of Medicine, Physiology and Biophysics, Departments of Medicine and Physiology/Biophysics, University of California School of Medicine, Irvine, CA, USAJW
Jackie D. Wood
Affiliations and expertise
Professor of Physiology and Cell Biology and Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USAView book on ScienceDirect
View book on ScienceDirect
Read Physiology of the Gastrointestinal Tract on ScienceDirect