Pharmaceutical Biotechnology in Drug Development
- 1st Edition - April 21, 2023
- Authors: Muhammad Sajid Hamid Akash, Kanwal Rehman, Kanwal Irshad, Shuqing Chen
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 3 5 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 3 6 - 7
Pharmaceutical Biotechnology in Drug Development summarizes key concepts and the latest developments of biotechnology applied to the development of biopharmaceuticals. Chapters… Read more
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Request a sales quotePharmaceutical Biotechnology in Drug Development summarizes key concepts and the latest developments of biotechnology applied to the development of biopharmaceuticals. Chapters present a comprehensive collection of introductory biotechnology technologies and their modern concepts and cover pharmacokinetic and pharmacodynamic behavior of biopharmaceuticals and modification techniques of amino acids and nucleic acid. Other sections focus on topics such as gene therapy, immunological preparations and nanoparticles which are the major contributions of pharmaceutical biotechnology. Final chapters discuss emerging techniques in the field of pharmaceutical biotechnology to meet current patient and health care demand.
This book is an essential reference useful for pharmaceutical scientists, clinicians and academic researchers who want easy access to up-to-date practices of pharmaceutical biotechnology. Corporate researchers will also benefit from this book’s succinct and objective content structure.
- Includes key concepts at the foundation of the technology and relevant for protein therapeutics
- Explains how advances in other areas such as genomics, proteomics and high-throughput screening have paved the way for exploring new avenues of drug discovery
- Covers the importance of biotechnology in the development of new biopharmaceuticals, along with their pharmacodynamics and pharmacokinetics
Researchers and scientists in Pharmaceutical Sciences, Biochemistry and biotechnology, Drug development corporate researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Chapter 1. Modern concepts of pharmaceutical biotechnology in drug development
- Introduction
- Branches of biotechnology
- Color classification of branches of biotechnology
- Techniques used in biotechnology
- Applications of biotechnology in drug development
- Current trends and challenges
- Conclusion
- Chapter 2. Pharmacokinetics and pharmacodynamics of biotech products
- Introduction
- Pharmacokinetics of biotech products
- Pharmacodynamics of biotech products
- Current trends and challenges to study PK/PD of biotech products
- Conclusion
- Chapter 3. Amino acid transporters as drug targets in disease modification
- Introduction
- Membrane transporters
- Inhibition of transporters
- Targeted type investigation
- Ion channels
- Kinases
- G protein-coupled receptors
- Proteases
- Identification of transporter inhibitors
- Scintillation proximity assay
- Membrane potential sensitive dyes
- Deposition of radiolabeled substrate
- Role of a transporter in immune disorders
- Role of transporters in metabolic disorders
- LAT1 and cancer
- Development of LAT1 inhibitor for the treatment of cancer
- Conclusion and future perspective
- Chapter 4. Nucleic acids as therapeutic targets in disease modification
- Introduction
- Gene therapy
- Gene therapy techniques
- Ex vivo
- In situ
- In vivo
- Germ-line gene therapy
- DNA microarrays
- Antisense technology
- Challenge and future prospects
- Conclusion
- Chapter 5. Development and therapeutic applications of monoclonal antibodies
- Introduction
- Monoclonal antibodies and polyclonal
- Classes of antibodies
- Monoclonal antibodies
- New approaches and developments
- Therapeutic applications of monoclonal antibodies
- Future perspective
- Conclusion
- Chapter 6. Nano-based drug delivery: a promising targeted system for delivery of biotech products
- Introduction
- Nanoparticles and drug delivery
- Nano-based drug delivery system
- Types of nanoparticles
- Designing of nanoparticles
- Applications of nanoparticles
- Future perspectives
- Conclusion
- Chapter 7. Production of biopharmaceuticals from transgenic animals
- Introduction
- Methods for the production of biopharmaceuticals in plants
- Application of transgenic plants
- Benefits and applications of transgenic animals
- Techniques for the production of transgenic animals
- Gene transfer through artificial chromosomes
- Modern techniques for production of transgenic animals
- Recent developments in transgenic biotechnology
- Possible risks of human health and environment through transgenic animals
- Future perspectives
- Conclusion
- Chapter 8. Metabolomics as bioanalytical approach for pharmaceutical biotechnology in drug development
- Introduction
- Analytical approaches to metabolomics
- Applications of metabolomics
- New insights into disease processes and future perspectives
- Conclusion
- Chapter 9. New biological targets for drug discovery and development
- Introduction
- Lead discovery
- Lead modification
- Conclusion
- Chapter 10. Signaling pathways of membrane-spanning receptors for drug development
- Introduction
- Enzyme-linked receptors
- GPCRs as a drug target
- Conventional drug discovery approaches of GPCRs
- Chemical libraries and structure-based drug design
- Novel approaches and orphan GPCRs
- Conclusion
- Index
- No. of pages: 236
- Language: English
- Edition: 1
- Published: April 21, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443191350
- eBook ISBN: 9780443191367
MA
Muhammad Sajid Hamid Akash
Dr. Akash is currently working as associate professor and chairman at Department of Pharmaceutical Chemistry, Government College University Faisalabad (GCUF), Pakistan. He got his bachelor and master’s degrees in pharmacy from Bahauddin Zakariya University Multan, Pakistan and PhD degree in Pharmaceutical Analysis from Zhejiang University, China. Currently, he is focusing on investigating the effect of EDCs on various molecular and metabolic pathways that are involved in metabolic disorders and the treatment strategies of these EDCs-induced metabolic disorders funded by Higher Education Commission (HEC) of Pakistan. His Research work is the cutting edge and worthy of extension in developing countries like Pakistan, where it can be most beneficial and cost-effective especially for diabetic patients. Based on his significant scientific contributions in the field of Pharmaceutical Sciences, he has been awarded “Research Productivity Award” from Pakistan Council for Science and Technology (PCST), PAS Gold Medal from Pakistan Academy of Sciences and A.R. Shakoori Gold Medal from Zoological Society of Pakistan.
Affiliations and expertise
Associate Professor and Chairman at Department of Pharmaceutical Chemistry, Government College University Faisalabad (GCUF), PakistanKR
Kanwal Rehman
Dr. Kanwal Rehman PhD is working as Associate Professor at Department of Pharmacy in The Women University, Multan, Pakistan. Dr. Kanwal Rehman received her PhD in Pharmacology and Toxicology from Zhejiang University, Hangzhou, China in 2015. She nurtures a keen interest in pathogenesis of metabolic disorders like diabetes mellitus, obesity, and new therapeutic modalities for its treatment. Other work includes detection of environmental pollutants and their cytotoxic effects. She has published about 135 articles. She has also published 50 book chapters with international publishers and 4 books with Springer-Nature. Currently, she is focusing on the investigation of role of pharmacogenomics based upon gene polymorphism on various molecular and metabolic pathways that are involved in mitogenic disorders and treatment strategies like natural biogenic compounds against different risk factors of metabolic disorders including pancreatitis, cardiometabolic disorders and hormonal imbalance. Dr. Kanwal Rehman has also been awarded Research productivity award by Pakistan Council for Science and Technology (PCST), Pakistan.
Affiliations and expertise
Associate Professor, Department of Pharmacy in The Women University, Multan, PakistanKI
Kanwal Irshad
Dr. Kanwal Irshad is working as PhD scholar at Department of Pharmaceutical Chemistry in Government College University Faisalabad, Pakistan. She has done her MPhil from Government College University Faisalabad, Pakistan. She completed her bachelor’s (Doctor of Pharmacy) from University of Agriculture, Faisalabad. She has done excellent work on exploring the effect of arsenic on hepatoxicity and nephrotoxicity and their amelioration by bioactive compounds. She has published 5 articles and 8 book chapters with international book publishers. She has received HEC PhD indigenous scholarship for completion of PhD by Higher Education Commission (HEC) of Pakistan. Currently, she is focusing on the investigation of different molecular pathways of arsenic in neurological disorders and their treatment strategies by naturally occurring bioactive compounds.
Affiliations and expertise
PhD scholar at Department of Pharmaceutical Chemistry in Government College University Faisalabad, Pakistan.SC
Shuqing Chen
Professor Chen was graduated from Zhejiang Medical University in 1983, got his Ph.D. degree in Zhejiang University and had his post-doctor training in Cornell University USA. Professor Chen now is a professor of Zhejiang University, head of the Precision Medicine & Biopharmaceuticals Laboratory, director of International Center for Precision Medicine, Zhejiang-California International NanoSystems Institute, standing committee member of the Division of Pharmacogenomics of the Chinese Pharmacological Society, committee member of the Division of Biochemical and Biotechnological Drugs of the Chinese Pharmaceutical Association, honorary chairman of the Biochemical Drugs Professional Committee of Zhejiang Pharmaceutical Association, director of Zhejiang Bioengineering Society, deputy editor-in-chief of Chinese Journal of Biochemical Pharmacy, editor of Chinese Journal of Pharmaceutical Sciences, international editor of Medical Science Monitor. Dr. Shuqing Chen published 269 articles including Cell, Advanced Materials, Biomaterials, SMALL, Clinical Cancer Research of which 148 are included in SCI/EI. He is the chief editor or editor of 16 books and textbooks. He has presided over five National Natural Science Foundation of China (including two of the State Key Program), two major sub-projects of the National Major Scientific and Technological Special Project for “Significant New Drugs Development”, and one key project of the National Key R & D Plan “Precision Medical Research”. Dr. Shuqing Chen has chaired and accomplished three scientific research, got one Second Prize award and two Third Prize award of Science & Technology Progress of Zhejiang Province.
Affiliations and expertise
Professor, Zhejiang University; Head, Precision Medicine and Biopharmaceuticals Laboratory and Director, International Center for Precision Medicine, Zhejiang-California International NanoSystems Institute, ChinaRead Pharmaceutical Biotechnology in Drug Development on ScienceDirect