Perinatal and Developmental Epigenetics
- 1st Edition, Volume 35 - December 2, 2022
- Editor: Garima Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 8 5 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 8 6 - 3
Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental an… Read more
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Request a sales quotePerinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming.
Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood.
- Examines disease onset stemming from epigenetic changes during the perinatal periods
- Features contributions from international experts in the field, including basic biology, disease research and drug discovery
- Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes
Human geneticists, human genomicists, translational researchers in genomic medicine, epigenetics, reproductive biology, endocrinology, molecular biology, and developmental biology
- Cover image
- Title page
- Table of Contents
- Translational Epigenetics Series
- Copyright
- Contributors
- Section 1. The ever-growing complexity of epigenetic regulation of gene expression
- Chapter 1. Epigenetic regulation of gene expression: an overview of classical and recently discovered novel players
- Introduction
- DNA methylation
- Genomic imprinting
- Histone modifications
- Noncoding RNAs
- Effect of different conditions on Epigenetic mechanisms and programming of human health and disease risk
- Impact of prenatal stress on epigenetic modifications
- Chapter 2. Histone modifications in germline development and maintenance
- Cécile Bedet, Francesca Palladino, Valérie J. Robert
- Dynamic reorganization of histone PTMs supports germ cell development, identity, and functions in mammals
- Histone PTMs distribution and function in Caenorhabditis elegans hermaphrodite germ cells
- Concluding remarks
- Chapter 3. Epigenetic regulation of cis-regulatory elements and transcription factors during development
- Epigenetic mechanisms govern developmental processes via Genome regulation
- cis-regulatory elements and trans-acting factors orchestrate Cell type–specific gene transcription
- Identification and characterization of cis-regulatory elements and trans-acting factors
- Epigenetic programming in perinatal and early development
- Conclusion
- Chapter 4. Genomic imprinting and developmental physiology: intrauterine growth and postnatal period
- Genomic imprinting: discovery and early work
- Imprinted gene functions converge on neuronal and metabolic processes that govern early development: The cost of altered imprinted gene dosage
- Genomic imprinting-mediated control of fetal growth and placental resources
- Genomic imprinting and human imprinting disorders
- Imprinted genes regulate multiple maternal–fetal interactions and are essential for early survival
- Postnatal control of growth and development is mediated by imprinted genes via key metabolic systems and is crucial for preserving adult metabolic health
- Final comments
- Chapter 5. Role of RNA epigenetics in development
- Introduction
- RNA modifications
- Conclusion and future perspective
- Section 2. Epigeneticprogramming ofplacenta regulatesshort-term andlong-term healthoutcomes
- Chapter 6. Epigenetic regulation of placental function
- Introduction
- Epigenetic regulation during placentation
- Conclusion
- Chapter 7. Role of placenta in developmental programming of sex-specific adult outcomes
- Mechanisms of developmental programming
- Section 3. Epigenetics, hormones, sex, and developmental programming
- Chapter 8. Role of epigenetics in shaping sex differences in brain development and behavior
- Introduction
- Introduction to epigenetics
- Gonadal steroid hormones drive sexual differentiation and are epigenetic modifiers
- An extreme sex difference in epigenetic regulation: X chromosome inactivation
- Sex differences in the human epigenome: normal development
- Implications for neurological disorders and diseases
- Sex differences in the brain epigenome: rodent studies
- Sex differences in the epigenetic writers, erasers, and readers
- Manipulating epigenetic marks during development: effects on sexual differentiation of neural morphology and behavior
- Manipulating epigenetic marks during development: sexual differentiation of neurochemistry
- Future directions
- Section 4. Epigenetic programming by adverse perinatal influences
- Chapter 9. Early-life stress exposure and epigenetic programming
- Introduction to epigenetics
- Mechanisms of stress
- Candidate early-life stress–mediated epigenetic markers
- Conclusion
- Chapter 10. Early life substance abuse and epigenetic programming
- Substance abuse and substance use disorders
- Epigenetics and gene expression regulation
- Early drug use and epigenetic modifications
- Molecular strategies targeting epigenetic modifications as novel therapeutics for treatment
- Conclusions
- Chapter 11. Paternal and maternal environmental influences on offspring health: inter- and transgenerational epigenetic inheritance
- Introduction
- Germline epigenome and reprogramming
- Germline epigenetic inheritance in mammals
- Inheritance of paternal environmental exposure effects
- Inheritance of maternal environmental exposure effects
- Signaling environmental information to germline
- Conclusions and future perspective
- Chapter 12. Modeling early-life adversity in the laboratory: animal models, their advantages, and future directions in extrapolating findings to humans
- Introduction
- The advantage of animal models
- Recovery interventions
- Summary
- Section 5. Pharmacological and nonpharmacological approaches to reprogram the developmental programming to improve the health outcomes
- Chapter 13. The Emerging field of epigenetic editing: implication for translational purposes for diseases with developmental origin
- Summary of the epigenetic editing field
- Targeted epigenetic editing
- Developmental disease that have the potential to be treated with epigenetic editing
- Imprinting disorders
- X-linked intellectual disability
- Insights for the Application of epigenetic editing in the treatment of these developmental diseases
- Index
- No. of pages: 404
- Language: English
- Edition: 1
- Volume: 35
- Published: December 2, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780128217856
- eBook ISBN: 9780128217863
GS
Garima Singh
Dr. Singh is working as Assistant Professor at Pachhunga University College (PUC) campus of Mizoram Central University, Mizoram, India. She has completed her doctorate in 2018 from Mizoram University, India in plant sciences and worked on the pharmaceutical potential of selected traditional medicinal plants. Dr. Singh has 8 years of research experience and has published several research papers in national and international journals having high impact factor like Scientific reports, BMC complementary and alternative medicine, frontiers in plant sciences, etc. Dr. Singh has awarded for her work by several agencies while presenting her research work in India and abroad. Her expertise lies in the areas of utilization of traditional medicinal plants for sustainable development, secondary metabolites extraction and documentation of traditional medicinal pants. Dr. Singh is running one externally funded project to explore the pharmaceutical potential of some selected traditional medicinal plants located in North East India.
Affiliations and expertise
Department of Botany, Pachhunga University College (PUC) campus, Mizoram University, Aizawl, Mizoram, IndiaRead Perinatal and Developmental Epigenetics on ScienceDirect