Peptide and Protein Drug Delivery Using Polysaccharides

1st Edition - October 5, 2023
Imprint: Academic Press
Editors: Aakanchha Jain, Sonia Malik
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 2 5 - 8
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 2 6 - 5

Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider… Read more

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Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding.

Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editors
Chapter 1. Peptide and protein in therapeutics
Abstract
List of abbreviations
1.1 Introduction
1.2 Classification of protein based on its pharmacological activity
1.3 Challenges for peptide and protein therapeutics
1.4 Peptides and proteins therapeutics in neurological disorders
1.5 Peptide and proteins therapeutics in diabetes mellitus
1.6 Peptides and proteins therapeutics in cancer
1.7 Peptides and protein therapeutics in cardiovascular diseases
1.8 Peptides and protein therapeutics in vaccine
1.9 Application of peptides as antimicrobial agent
1.10 Peptides application in COVID lab on chip
1.11 Conclusion and future perspective
References
Chapter 2. Hairy root culture: a reliable bioreactor from transgenic plants
Abstract
2.1 Introduction
2.2 Pharmaceutical production, metabolites engineering, and phytoremediation applications of hairy root cultures
2.3 Biotechnological tools applied in hairy root culture systems
2.4 Strategies to improve hairy root culture system productions
2.5 Potential issues and recalcitrant
2.6 Future perspective
References
Chapter 3. Strategies for the ameliorated production of pharmaceutically important glycosides via plant cell culture
Abstract
Abbreviations
3.1 Introduction
3.2 Cell suspension culture
3.3 Conclusion and prospects
Declarations
Acknowledgments
Conflict of interest
Ethical approval
Funding
References
Chapter 4. Peptide and protein delivery through cellulose, hyaluronic acid, and heparin
Abstract
Abbreviations
4.1 Introduction
4.2 Polysaccharide-based systems for the protein and peptide delivery
4.3 Protein and peptide delivery through cellulose
4.4 Protein and peptide delivery through hyaluronic acid
4.5 Heparin-based nanoparticles for protein and peptide delivery
4.6 Conclusion and prospects
Acknowledgment
References
Chapter 5. Peptide and protein delivery through carrageenan, alginic acid, agar, and myrrh
Abstract
Abbreviations
5.1 Introduction
5.2 Basics of protein/peptide transport
5.3 Advance drug delivery systems through carrageenan, alginic acid, agar, and myrrh
5.4 Recent patents/clinical trials targeted on protein and peptide drug delivery through carrageenan, alginic acid, agar, and myrrh
5.5 Conclusion
5.6 Future prospectus
Acknowledgment
References
Chapter 6. Peptide and protein delivery through acacia, tragacanth, and ghatti gum
Abstract
6.1 Introduction
6.2 Categorization of natural polymers
6.3 Future prospects and conclusion
Acknowledgement
References
Chapter 7. Protein and peptide delivery through chitin, chitosan, and starch
Abstract
List of abbreviations
7.1 Introduction
7.2 Proteins and peptides: properties and significance in drug delivery
7.3 Proteins and peptides as therapeutics and current limitations with respect to routes of administration
7.4 The emergence of nanotechnology in peptide delivery
7.5 Therapeutic applications of chitin and chitosan derivatives-based peptide delivery
7.6 Therapeutic applications of starch and starch derivatives-based peptide delivery
7.7 Challenges for protein and peptide delivery
7.8 Conclusion
References
Chapter 8. Protein and peptide delivery through glycogen and dextran
Abstract
Abbreviations
8.1 Introduction
8.2 Properties of protein and peptides in drug delivery applications
8.3 Glycogen-based drug delivery through protein and peptide
8.4 Dextran-based drug delivery of protein and peptides
8.5 Characterization of glycogen and dextran-based systems for protein and peptides
8.6 Conclusion
References
Chapter 9. Peptide and protein in vaccine delivery
Abstract
Abbreviations
9.1 Introduction
9.2 Peptide-based vaccines
9.3 Application of bioinformatics in vaccine designing
9.4 Delivery methods used for peptide-based vaccines
9.5 Efficient vaccination
9.6 Protein vaccines
9.7 Recent research work in peptide-based and protein vaccines
9.8 Future prospects
9.9 Conclusion
Acknowledgment
References
Chapter 10. Analytical methods in the detection of proteins and peptides in tissue fluids and homogenates
Abstract
10.1 Introduction
10.2 The structure of proteins
10.3 Protein identification and visualization
10.4 Protein purification and separation
10.5 Tissue preparation
10.6 Tissue homogenates
10.7 Modern protein analysis techniques
10.8 Light scattering
10.9 Multi-detection gel permeation chromatography/ size-exclusion chromatography
10.10 Circular dichroism spectrometry
10.11 Isothermal titration calorimetry
10.12 Precipitation and differential solubilization
10.13 Ultracentrifugation
10.14 High-performance liquid chromatography and fast protein liquid chromatography
10.15 Immunohistochemistry
10.16 Western blotting
10.17 Sequence analysis by matrix-assisted laser desorption/ionization-time of flight mass spectrometry
10.18 Conclusion
References
Chapter 11. Factors affecting peptide and protein absorption, metabolism, and excretion
Abstract
11.1 Introduction
11.2 Challenges in protein and peptide delivery
11.3 Recent advances in peptide, including protein drug delivery
11.4 Factors affecting peptide including protein absorption, metabolism, or excretion
11.5 Approaches for delivery of proteins and peptides
11.6 Conclusion
References
Index

Aakanchha Jain

Dr. Aakanchha Jain is an Assistant Professor at the National Institute of Pharmaceutical Education and Research (NIPER) in Gandhinagar, Gujarat, India. Her research focuses on anticancer drug delivery, the role of caspase in cancer treatment, colon targeting, development of novel delivery systems of proteins and drugs for different diseases, and tropical and transdermal drug delivery. Dr. Jain has served as an editorial board member for EC Gastroenterology and Digestive System, and a guest reviewer for Carbohydrate Polymers, Pharmaceutical Development and Technology, and ACS Omega. She has received various awards and recognition for research, and has published widely in such peer reviewed journals as the Journal of Microencapsulation, Pharmaceutical Biotechnology, Journal of Biomaterial and Tissue Engineering, Journal of Pharmacognosy and Phytochemistry, Journal of Molecular Liquids, Drug Delivery and Translational Research, Journal of Controlled Release, and the Journal of Pharmaceutical Sciences and Pharmacology.

Affiliations and expertise

Assistant Professor, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad Palaj, Opp Air Force Station, Gandhinagar, Gujarat, India

Sonia Malik

Dr. Sonia Malik is a senior researcher at LBLGC, University of Orleans, France. After holding various research positions at Brazil, Czech Republic and Australia, she joined University of Orleans, France, as a Senior Researcher. Her research work is focused on enhanced and sustainable production of bioactive compounds from plants using different biotechnological approaches. She publishes regularly in peer-reviewed journals, and has served as a journals special issue and book editor on topics related to her area of expertise. She is the editorial board member and reviewer of many International scientific journals including Protoplasma, The Journal of Horticultural Science and Biotechnology, New Forests. She has visited many world leading cross-disciplinary research and teaching Institutions as a visiting researcher.

Affiliations and expertise

Senior Researcher, Laboratory of Woody Plants and Crops Biology (LBLGC) University of Orleans, Orleans, France

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