Pathophysiology and Treatment of Atherosclerotic Disease in Peripheral Arteries
- 1st Edition - June 12, 2024
- Imprint: Elsevier
- Editor: Aloke Virmani Finn
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 5 9 3 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 5 9 4 - 1
Pathophysiology and Treatment of Atherosclerotic Disease in Peripheral Arteries is a thorough review of the disease written by experts studying its detection and treatment. These… Read more
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Request a sales quotePathophysiology and Treatment of Atherosclerotic Disease in Peripheral Arteries is a thorough review of the disease written by experts studying its detection and treatment. These state-of-the-art chapters summarize emerging knowledge about this important area of medicine. The pathophysiology and treatment of peripheral artery (PAD) disease remains poorly understood even by practitioners. Often it is assumed that PAD should be treated in a similar fashion to coronary artery disease (CAD), when in fact recent data suggest a distinct pathophysiology with genetic risk having some but not complete overlap with CAD.
This is a novel reference of emerging data on the factors behind its development and progression, detection, and treatment suggest an emerging paradigm for this disease.
This is a novel reference of emerging data on the factors behind its development and progression, detection, and treatment suggest an emerging paradigm for this disease.
- Provides understanding for the pathophysiology of PAD from pathologic and molecular perspectives
- Reviews state-of-the art modalities for its detection as well as the data surrounding new medical and interventional treatment for PAD
- Elucidates the impact of new treatment modalities such as drug coated balloons and atherectomy devices such a lithotripsy
Researchers and physicians interested in the field of PAD Vascular Medicine specialists, Cardiologists, Vascular Surgeons, Interventional radiology and cardiology specialists, students, Industry who makes some of the devices discussed
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- 1. Introduction
- 2. Epidemiology of peripheral artery disease
- Introduction
- Prevalence
- Risk factors
- Natural history of PAD
- Limb outcomes in PAD
- Conclusion
- 3. Atherosclerosis—Pathology of lower extremity atherosclerosis
- Introduction
- General understanding of progression of atherosclerosis
- Nonatherosclerotic intimal lesions
- Progressive atherosclerotic lesions
- Lesion with thrombus formation
- Other lesions including healed plaque and fibrocalcific plaque
- Differences of cause of acute thrombotic event between CAD and LEAD
- Differences of manifestation of calcifications between PAD and CAD
- Perspective of histology of LEAD
- 4. Pathology of below-the-knee occlusions and chronic limb ischemia
- Introduction
- Atherosclerosis in below-the-knee arteries
- Medial arterial calcification
- Summary of pathological findings in below-the-knee arteries
- Conclusion
- 5. Calcium and atherosclerosis in lower extremities
- Introduction
- Prevalence of calcification
- Development of intimal and medial calcification and its contribution to PAD
- Mechanisms of medial arterial calcification
- Clinical implications
- 6. Current molecular understanding of peripheral arterial disease
- Introduction
- Genomics
- Cellular pathophysiology
- Conclusion
- 7. Clinical presentation and diagnosis of PAD
- Introduction
- Who are high risk groups for PAD?
- Clinical presentation
- Claudication
- Chronic limb-threatening Ischemia
- Acute limb ischemia
- Clinical evaluation of peripheral arterial disease
- Definition
- Physiology
- Vascular ultrasound
- Conclusion
- 8. Medical therapy of PAD
- Medical therapies that reduce major adverse cardiovascular and limb events in PAD
- Noninvasive therapies that improve symptoms in PAD
- Conclusions
- 9. Intravascular ultrasound: Role in PAD
- Introduction
- The basics of IVUS in peripheral vascular interventions
- IVUS in peripheral arterial interventions
- Outcomes in peripheral arterial interventions
- Indications for IVUS in peripheral arterial interventions
- IVUS in peripheral venous interventions
- Outcomes in peripheral venous interventions
- Indications for IVUS in peripheral venous interventions
- Controversies and concerns
- Conclusion
- 10. Atherectomy in endovascular procedures
- Introduction
- Atherectomy device utilization
- Scientific statements on atherectomy
- Evidence base supporting atherectomy
- Conclusion
- 11. Interventional treatment of PAD: Drug-coated balloons and stents
- Introduction
- Current chemotherapy medications
- DES
- Full drug jacket?
- Restenosis and the use of DES
- Tibial DES
- DCB
- Comparative DCB versus DES data
- Treatment of in-stent restenosis with DCB/DES
- Vessel prep and DCB
- Tibial DCB
- Economic impact of drug-based technologies
- Summary
- 12. Surgical treatment of PAD: Open and endovascular repair
- Introduction
- Aortoiliac lesions
- Femoropopliteal lesions
- Infrapopliteal lesions
- Conclusion
- 13. PAD: Future directions
- Index
- Edition: 1
- Published: June 12, 2024
- Imprint: Elsevier
- No. of pages: 320
- Language: English
- Paperback ISBN: 9780443135934
- eBook ISBN: 9780443135941
AF
Aloke Virmani Finn
Dr. Aloke Virmani Finn is a physician-scientist whose focus is on the pathology of cardiovascular disease and its treatment. He serves as the Medical Director and Chief Scientific Officer for CVPath Institute where he oversees device development research and runs a molecular lab with focus on the molecular understanding of vascular wall injury and healing, genetics of sudden cardiac death and molecular basis of coronary artery disease. When not running CVPath, he performs interventional cardiology procedures at University of Maryland.
Affiliations and expertise
Director and Chief Scientific Officer, CVPathRead Pathophysiology and Treatment of Atherosclerotic Disease in Peripheral Arteries on ScienceDirect