Pathophysiological Aspects of Proteases in Cancer
- 1st Edition - October 22, 2024
- Imprint: Academic Press
- Editors: Sajal Chakraborti, Srijit Das, Cheorl-Ho Kim
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 0 0 9 8 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 0 0 9 9 - 8
Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recent… Read more
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Request a sales quotePathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.
Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
- Gives insight into the spectrum of proteases, protease inhibitors, and protease interactors involved at the cellular and molecular level in cancer development
- Gives a comprehensive overview of the role of proteases in modulating cellular metabolism and chemoresistance to better understand how proteases play in early to the end point in cancer development and metastasis
- Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases
- Highlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitors
- Bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry
Researchers/scholars working in cancer biology
Section I: General Aspects
1. Pathophysiological aspects of calpains in cancer
2. Mitochondrial proteases in cancer development and progression
3. Proteases in Head and Neck Cancer
4. Matrix metalloproteases and uveal melanomas
5. Proteases in DNA damage, repair and radio resistance: Cellular and Molecular aspects
6. Radiotherapy, proteases and gastric cancer: a complex interplay
7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma
8. Exploring synthetic and natural compounds for Cathepsin B: Mechanisms and therapy
9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer
10. Ubiquitin –specific protease 3,7 in bone cancer and squamous cell carcinoma
11. Serine protease: structure, classification, mechanism and role in breast cancer
Section II: Proteases as Diagnostics and Prognostics Biomarkers
12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and novel therapeutic targets for gastric cancer
13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer
14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis
15. Cathepsins as a diagnostic and prognostic marker in Oral cancer
16. Role of Kallikreins in Prostate Cancer
17. Mechanistic aspects of Serine Protease as biomarkers in wound healing of lung cancer
18. The role of acetylcholinesterase in cancer development and possible therapeutic applications
19. Therapeutics of animal derived compounds in proteases induced cancer
20. Molecular Warriors: Proteases as Sentinels in the War Against Cancer Diagnosis and Prognosis
Section III: Proteases, Chemoresistance and Cancer
21. Serine proteases, chemoresistance and cancer
22. Cathepsins, chemoresistance and cancer
23. ix metalloproteases, chemoresistance and cancer
24. MMPs (-2 and -9) mediated drug resistance and their reversal in gynecological cancer
25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer
26. Role of the proteasome in the development of chemoresistance in multiple myeloma
27. Role of cysteine cathepsin and matrix metalloproteases in progression and chemoresistance in ovarian and breast cancer
28. Proteases, chemoresistance and cancer
29. Breaking Barriers: Proteases as Key Players in Cancer Chemoresistance
Section IV: Other Aspects
30. Matrix metalloproteases-targeting low molecular weight compound
31. Synthetic protease inhibitors in oral, head and neck cancer: evidence from clinical trials.
32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: results of clinical trials
33. Side effects of synthetic protease inhibitors used in gynecology cancers
34. Role of synthetic compounds with protease inhibitory activity in breast cancer
35. Cathepsin responsive nanomaterials for targeted delivery of malignant tumors
1. Pathophysiological aspects of calpains in cancer
2. Mitochondrial proteases in cancer development and progression
3. Proteases in Head and Neck Cancer
4. Matrix metalloproteases and uveal melanomas
5. Proteases in DNA damage, repair and radio resistance: Cellular and Molecular aspects
6. Radiotherapy, proteases and gastric cancer: a complex interplay
7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma
8. Exploring synthetic and natural compounds for Cathepsin B: Mechanisms and therapy
9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer
10. Ubiquitin –specific protease 3,7 in bone cancer and squamous cell carcinoma
11. Serine protease: structure, classification, mechanism and role in breast cancer
Section II: Proteases as Diagnostics and Prognostics Biomarkers
12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and novel therapeutic targets for gastric cancer
13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer
14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis
15. Cathepsins as a diagnostic and prognostic marker in Oral cancer
16. Role of Kallikreins in Prostate Cancer
17. Mechanistic aspects of Serine Protease as biomarkers in wound healing of lung cancer
18. The role of acetylcholinesterase in cancer development and possible therapeutic applications
19. Therapeutics of animal derived compounds in proteases induced cancer
20. Molecular Warriors: Proteases as Sentinels in the War Against Cancer Diagnosis and Prognosis
Section III: Proteases, Chemoresistance and Cancer
21. Serine proteases, chemoresistance and cancer
22. Cathepsins, chemoresistance and cancer
23. ix metalloproteases, chemoresistance and cancer
24. MMPs (-2 and -9) mediated drug resistance and their reversal in gynecological cancer
25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer
26. Role of the proteasome in the development of chemoresistance in multiple myeloma
27. Role of cysteine cathepsin and matrix metalloproteases in progression and chemoresistance in ovarian and breast cancer
28. Proteases, chemoresistance and cancer
29. Breaking Barriers: Proteases as Key Players in Cancer Chemoresistance
Section IV: Other Aspects
30. Matrix metalloproteases-targeting low molecular weight compound
31. Synthetic protease inhibitors in oral, head and neck cancer: evidence from clinical trials.
32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: results of clinical trials
33. Side effects of synthetic protease inhibitors used in gynecology cancers
34. Role of synthetic compounds with protease inhibitory activity in breast cancer
35. Cathepsin responsive nanomaterials for targeted delivery of malignant tumors
- Edition: 1
- Published: October 22, 2024
- No. of pages (Paperback): 648
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443300981
- eBook ISBN: 9780443300998
SC
Sajal Chakraborti
Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 40 years teaching and independent research experience in biochemistry, molecular physiology and cell biology. He has published over 110 original research articles, dozens of review articles and book chapters, and also edited fifteen books.
Affiliations and expertise
Professor, Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, IndiaSD
Srijit Das
Dr. Srijit Das is currently Professor of Anatomy at the Sultan Quaboos University in Oman. He has decades teaching experience in Anatomy including Embryology, Histology, Gross Anatomy, Neuroanatomy, Radiological Anatomy, Clinical Anatomy, and Surface Anatomy. He is member of World Association of Medical Editors. He published 500 articles in world-renowned journals, published 5 books and is editorial board member of numerous globally respected journals.
Affiliations and expertise
Professor of Anatomy, Department of Human and Clinical Anatomy, Sultan Qaboos University, OmanCK
Cheorl-Ho Kim
Prof/Dr Cheorl-Ho Kim has received his MS and PhD in The University of Tokyo during the period of 1985-1990. Currently, since 2006 he is professor and chair of Department of Biological Sciences, College of Science, Sungkyunkwan University and Samsung Advanced Institute of Health Science and Technology (SAIHST), Korea. He has successfully completed his Administrative responsibilities as Genome Program Head, Korea Research Institute of Bioscience and Biotechnology on 1990-1996 and Chairman, Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University during 1996-2006. His research has included the molecular biology of gene expression, ER-Golgi glycosyltransferases, oncogenesis, cancer metastasis and angiogenesis. He has authored more than 350 research articles/books with H-index 66. He is a member of International Scientific Advisory Board Member, International Symposium for Glycosyltransferases (GlycoT 2006), IUBMB symposium, Tsukuba and International Symposium for Glycosyltransferases (GlycoT 2008), Emory University, GA, USA, 2010 Tokai University GlycoResearch Center and 2015 Visiting Professor, The Ohio State University
Affiliations and expertise
Professor and Chair, Department of Biological Sciences, College of Science, Sungkyunkwan University and Samsung Advanced Institute of Health Science and Technology (SAIHST), KoreaRead Pathophysiological Aspects of Proteases in Cancer on ScienceDirect