Pathogenic Viruses and Armamentarium Design
- 1st Edition - June 15, 2024
- Imprint: Academic Press
- Editors: Awanish Kumar, Kumud Pant
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 4 1 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 4 2 - 9
Pathogenic Viruses and Armamentarium Design covers the latest developments in viral target elucidation and viral control using wet and dry lab strategies. The control and combat st… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quotePathogenic Viruses and Armamentarium Design covers the latest developments in viral target elucidation and viral control using wet and dry lab strategies. The control and combat strategies and their implementation compiled in this book are invaluable in aiding the understanding of viral disease progression and for designing new strategies against existing and evolving viruses.
This important resource is a comprehensive compilation of antiviral approaches designed and devised using computational and other laboratory techniques. This book is a useful reference for scientists, researchers, industry professionals, advanced students, and postgraduates in virology, biotechnology, infection biology, biochemistry, and pharmaceutical sciences who engaged in the study of pathogenic virus and the development of prophylactics and therapeutics against viral infection.
- Provides an overview of human pathogenic viruses, viral entry and disease progression, and strategic approaches to
combating existing and evolving viruses - Explores available techniques for clinical diagnostics, virology, and viral immune diagnostics
- Comprehensively discusses antiviral drugs, their targets, mechanism of action, design, and development challenges
Researchers and investigators working in pathogenic human viruses. Researchers in applied microbiology, molecular biology, biotechnology, biochemistry, pharmaceutical industry, Medicinal Chemistry, Drug Discovery etc. Basic and applied scientists of different disciplines (microbiologist, molecular biologists, medicinal chemists,) specialists in different sub-disciplines of phytomedicines, and students in postgraduate and PhD programs, The incorporation of software and tools will help both experienced and new bioinformaticians and students
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1. Human pathogenic viruses and tissue virology
- 1. Introduction
- 2. History
- 3. Types of human pathogenic viruses
- 4. Severity and mortality
- 5. Genomics and proteomics
- 6. Phylogeny
- 7. Tissue virology
- 8. Conclusions
- Chapter 2. Past, present, and future of pathogenic viruses
- 1. Introduction
- 2. Viruses in historical records
- 3. Dawn of ancient pathogenic viruses in plants and animals
- 4. Why study viruses?
- 5. New emerging and evolving viruses
- 6. Reason for emergence of new viruses
- 7. Reasons for reemerging viruses
- 8. Adaptation of viruses to human hosts
- 9. Challenges
- 10. Detecting emergence of pandemics
- 11. Prediction of emergence of novel zoonotic pathogens from wild life
- 12. Future prospect for pathogenic virus
- Chapter 3. Viral cell annexation strategies: Cell surface receptor interfaces, infection, and host range
- 1. Introduction
- 2. Invasion, routes of infection, and viral shedding
- 3. Tissue tropism, receptor interactions, and host range
- 4. Proviral determinants and host restriction factors in viral pathogenesis
- 5. Conclusion
- Chapter 4. Host immune response against viruses
- 1. Introduction
- 2. Viral entry in the host cell
- 3. Host immune defense system
- 4. Innate immunity against viruses
- 5. Adaptive immunity against viruses
- 6. Host immune response against SARS-CoV-2
- 7. Host immune response against human papilloma virus
- 8. Conclusion
- Conflict of interest
- Chapter 5. Antiviral drugs: Types and mechanism of action
- 1. Introduction
- 2. Virus infection cycle
- 3. Classification of antiviral drugs based on viral targets
- 4. Future of antiviral drugs
- 5. Conclusion
- Chapter 6. Identifying antiviral targets: Dry lab experimentation
- 1. Virtual screening
- 2. Viral targets and identification
- 3. A table reflecting antiviral targets of hosts and virus
- 4. Antiviral targets and in silico studies
- 5. Step I—hit and lead identification
- 6. Lead optimization
- 7. Drug likeliness
- Chapter 7. Clinic viral diagnostics, viral vaccines, and advanced immunology
- 1. Introduction
- 2. Viral diagnostic techniques
- 3. Various vaccine candidates
- 4. Mechanism of action of different vaccine candidates
- 5. Conclusion
- Conflict of interest
- Chapter 8. Selecting target stages in the viral life cycle for antiviral vaccine design
- 1. Introduction
- 2. Various phases of the virus life cycle
- 3. Strategies for designing of antiviral vaccines
- 4. Antiviral effects of nanomaterials
- 5. Properties of nanoparticles that influence the production of an immune response
- 6. Current methods for researching the immunological reactions brought on by antiviral vaccinations
- 7. Case study of targeting various proteins and development stages for development of antiviral drugs
- 8. Conclusions
- Chapter 9. Reverse vaccinology and applications as prophylactics
- 1. Introduction
- 2. From Pasteur to reverse vaccinology
- 3. The breakthrough of the MenB vaccine
- 4. Reverse vaccinology approach for designing SARS-COV-2 vaccine
- 5. Reverse vaccinology and cellular immunity
- 6. Modification in reverse vaccinology
- 7. The contribution of epitope prediction in reverse vaccinology
- 8. Advantages of reverse vaccinology over conventional vaccine development approaches
- 9. Bioinformatics tools for reverse vaccinology
- 10. The use of omics as complementary tools
- 11. Recent applications to vaccines against pathogens
- 12. Challenges and future perspectives for reverse vaccinology
- Chapter 10. SARS-CoV2 and SARS-CoV2 vaccinology
- 1. Introduction
- 2. Features of coronavirus
- 3. Pathogenicity
- 4. Various vaccine designing strategies for COVID-19
- 5. Combination vaccines (mix and match vaccines)
- 6. Infodemic
- 7. Challenges and future prospects
- 8. Conclusion
- Chapter 11. Challenges in development of antiviral drugs and vaccines
- 1. Introduction
- 2. WHO list of current global health threats
- 3. Known viral diseases affecting humans and animals
- 4. Most notorious disease causing microbes
- 5. Viruses are obligate parasite
- 6. Types of drugs given to combat virus
- 7. Virucides: Also known as microbicides
- 8. Immunomodulators
- 9. Anti-virals
- 10. Steps in development of antiviral drugs
- 11. Target identification and screening
- 12. Lead generation and optimization
- 13. Preclinical and clinical trials
- 14. Final registration of the drug
- 15. Conclusion
- Index
- Edition: 1
- Published: June 15, 2024
- No. of pages (Paperback): 192
- No. of pages (eBook): 225
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443152412
- eBook ISBN: 9780443152429
AK
Awanish Kumar
Dr. Awanish Kumar is currently an Associate Professor in the Department of Biotechnology at the National Institute of Technology, Raipur (CG), India. He has more than 13 years of research experience. He received his PhD in Molecular Parasitology from the CSIR-Central Drug Research Institute, Lucknow, India, and Jawaharlal Nehru University, Delhi, India, and completed his postdoctoral studies at McGill University, Montreal, Canada. His research interests are infection biology, drug targeting, and drug discovery. Dr. Kumar has served on various national and international organizations in different academic and research capacities. He has also served on many national committees and scientific advisory panels, as a member of many international professional research societies, and as a reviewer and editorial board member of reputed and refereed journals. He has authored or edited several monographs, books, and book chapters.
Affiliations and expertise
Associate Professor, Department of Biotechnology, National Institute of Technology Raipur, IndiaKP
Kumud Pant
Dr. Kumud Pant is an Associate Professor at Graphic Era (Deemed to be University) where she teaches both undergraduate and postgraduate students. She received her master’s degree in Biotechnology from Jiwaji University, Gwalior, Madhya Pradesh, India and her PhD in Bioinformatics from NIT, Bhopal, India. Dr. Pant has more than 10 years of experience and her major research interests are drug design, metagenomic data analysis, and data mining. Dr. Pant currently serves on many national committees, scientific societies, and advisory panels and is a member of many international professional research societies. She has also been a contributor to many book chapters and is a reviewer and editorial board member for reputed and refereed journals.
Affiliations and expertise
Department of Biotechnology, Graphic Era University, Uttarakhand, IndiaRead Pathogenic Viruses and Armamentarium Design on ScienceDirect