
Patent Foramen Ovale, An Issue of Cardiology Clinics
- 1st Edition, Volume 42-4 - September 25, 2024
- Imprint: Elsevier
- Editor: Jonathan M. Tobis
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 2 9 6 9 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 2 9 7 0 - 4
In this issue of Cardiology Clinics, guest editors Drs. Jonathan M. Tobis and Ali Emami bring their considerable expertise to the topic of Patent Foramen Ovale. Top experts discu… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteIn this issue of Cardiology Clinics, guest editors Drs. Jonathan M. Tobis and Ali Emami bring their considerable expertise to the topic of Patent Foramen Ovale. Top experts discuss key topics such as embryology, anatomy, and physiology: diagnosis of PFO: TTE, TEE, TCD, RHC; PFO-associated stroke: a neurologist’s perspective; migraine and PFO; hypoxemia and PFO; and more.
- Contains 10 relevant, practice-oriented topics including altitude sickness; decompression illness; practical aspects of PFO closure: ultrasound and fluoroscopic guidance; a cardiologist’s perspective on PFO-associated conditions; and more.
- Provides in-depth clinical reviews on patent foramen ovale, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Cardiology
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Dedication
- Preface
- Some Practical Points About Patent Foramen Ovale Conditions that May Not Be Covered in the Rest of the Book
- Key points
- Introduction
- Clinics care points
- Patent Foramen Ovale Embryology, Anatomy, and Physiology
- Key points
- Introduction
- Patent foramen ovale embryology
- Anatomy
- Imaging anatomy
- Fluoroscopy during patent foramen ovale closure
- Radiation exposure considerations
- Transesophageal echocardiography
- Intracardiac echocardiography
- Hemodynamics
- Unusual anatomic considerations
- Summary
- Clinics care points
- Techniques for Identifying a Patent Foramen Ovale: Transthoracic Echocardiography, Transesophageal Echocardiography, Transcranial Doppler, Right Heart Catheterization
- Key points
- Introduction
- Ultrasonography
- Contrast agent for bubble study
- Choosing an injection site for bubble study (brachial or femoral)
- Provocation maneuvers during a bubble study
- Diagnostic criteria for intracardiac right-to-left shunt
- Transthoracic echocardiography for the diagnosis of patent foramen ovale
- Transesophageal echocardiography for the diagnosis of patent foramen ovale
- Transcranial Doppler for the diagnosis of patent foramen ovale
- Intracardiac echocardiography for the diagnosis of patent foramen ovale
- Ear oximetry for the diagnosis of patent foramen ovale
- Cardiac computed tomography for the diagnosis of patent foramen ovale
- MRI for the diagnosis of patent foramen ovale
- Summary and recommendations
- Clinics care points
- Patent Foramen Ovale–Associated Stroke: A Neurologist’s Perspective
- Key points
- Introduction
- Clinical epidemiology
- Evidential basis for treatment
- Summary
- Clinical care points
- Migraine Headache and Patent Foramen Ovale: Observational Studies, the Randomized Clinical Trials, and the GORE RELIEF Clinical Study
- Key points
- Background
- Initial observations
- The early migraine–patent foramen ovale trials
- Why did the early patent foramen ovale–migraine trials fail?
- Platelets and migraine headaches
- The GORE RELIEF clinical study
- Summary
- Clinics care points
- Patent Foramen Ovale and Hypoxemia
- Key points
- Part 1: platypnea-orthodeoxia syndrome
- Part 2: obstructive sleep apnea
- Part 3: chronic obstructive pulmonary disease with hypoxemia out of proportion to pulmonary disease
- Clinics care points
- Supplementary data
- Patent Foramen Ovale and Acute Mountain Sickness
- Key points
- Clinics care points
- Patent Foramen Ovale and Decompression Illness: The Present and Future
- Key points
- Introduction
- Pathophysiology of decompression illness
- Subtypes and symptomatology
- Decompression illness and patent foramen ovale
- Asymptomatic brain lesions and patent foramen ovale
- Patient selection for investigating patent foramen ovale in divers
- Imaging tests for detection of patent foramen ovale
- Interventions for patent foramen ovale-mediated decompression illness
- Treatment: current recommendations
- Supportive management
- Future directions
- Clinics care points
- Practical Aspects of Patent Foramen Ovale Closure: Ultrasound and Fluoroscopic Guidance
- Key points
- Introduction
- Guidance during PFO closure
- 2D/3D transesophageal echocardiography with (or without) fluoroscopy
- 2D/3D intracardiac echocardiography with (or without) fluoroscopy
- Fluoroscopy guidance alone
- Summary and key learning points
- Clinics care points
- Supplementary data
- A Cardiologist’s Perspective on Patent Foramen Ovale-Associated Conditions
- Key points
- Introduction
- Scope of the problem
- Discussion
- Summary
- Clinics care points
- Supplementary data
- Patent Foramen Ovale and Coronary Artery Spasm: A New Patent Foramen Ovale-associated Condition that May Explain the Mechanism of Vasospastic Angina
- Key points
- Introduction
- Angina with nonobstructive coronary arteries
- Patent foramen ovale and vasospastic angina
- Takotsubo syndrome and coronary vasospasm
- Clinics care points
- Edition: 1
- Volume: 42-4
- Published: September 25, 2024
- Imprint: Elsevier
- No. of pages: 240
- Language: English
- Hardback ISBN: 9780443129698
- eBook ISBN: 9780443129704
JT
Jonathan M. Tobis
Dr. Jonathan M. Tobis is the Director of Interventional Cardiology Research at UCLA and Clinical Professor of Medicine in Cardiology at the University of California, Los Angeles. He performed the world’s first digital left ventricular and coronary angiograms and contributed to the advancements of intravascular ultrasound early in his career. His recent work is devoted to understanding the role of PFO closure in relation to several medical conditions including stroke and migraine. He was voted one of the 10 Most Highly Regarded Heart Doctors in the United States.
Affiliations and expertise
Division of Cardiology, Department of Medicine,
University of California, Los Angeles, Los Angeles,
California, USA