Parathyroid Hormone

1st Edition, Volume 120 - August 9, 2022
Editor: Gerald Litwack
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 2 5 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 2 6 - 8

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of au… Read more

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Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Cover image
Title page
Table of Contents
Copyright
Former Editors
Contributors
Preface
Chapter One: Structural pharmacology of PTH and PTHrP
Abstract
1: Evolutionary biology of PTH and PTHrP
2: PTH mutations
3: PTHrP mutations
4: PTH and PTHrP pharmacology
Acknowledgments
References
Chapter Two: Salt inducible kinases and PTH1R action
Abstract
1: Parathyroid hormone and PTH1R biology
2: PTH as anabolic therapies for osteoporosis
3: PTH action in osteocytes
4: Salt inducible kinases
5: Role of salt inducible kinases in responses to PTH in bone
6: Role of salt inducible kinases in responses to PTH in cartilage
7: Do salt inducible kinases participate in the renal actions of PTH?
8: PTH stimulates Cyp27b1 expression
9: PTH decreases phosphate reabsorption in proximal tubule
10: PTH increases calcium reabsorption in distal tubule
11: Summary and future directions
References
Chapter Three: Physiological regulation of phosphate homeostasis
Abstract
1: Introduction
2: An overview of phosphate homeostasis
3: Intestinal phosphate absorption
4: Transcellular intestinal phosphate absorption and the role of NaPi-IIb
5: Renal phosphate reabsorption
6: Phosphate imbalance
References
Chapter Four: The parathyroid glands and parathyroid hormone: Insights from PTH gene mutations
Abstract
1: History of the parathyroid gland and parathyroid hormone
2: Sequence and structure of the PTH gene
3: Synthesis, processing, and secretion of PTH
4: Chromosomal rearrangement of the PTH gene
5: Intragenic polymorphisms of the PTH gene
6: Mutations in the PTH signal peptide
7: PTH exon skipping mutation
8: Mutations in the mature PTH peptide
9: Conclusions and future directions
References
Chapter Five: Modulation of PTH1R signaling by an extracellular binding antibody
Abstract
1: Introduction
2: Results
3: Discussion
Acknowledgments
References
Chapter Six: Parathyroid hormone-related protein (PTHrP) and malignancy
Abstract
1: Background
2: Characterization of MAH
3: Role of PTHrP in tumor progression
4: Clinical implications of MAH
5: Conclusion
References
Further reading
Chapter Seven: Parathyroid hormone-related protein (PTHrP)-dependent modulation of gene expression signatures in cancer cells
Abstract
1: Parathyroid hormone-related protein (PTHrP): A brief insight into its structure and function
2: Bone cancer cells
3: Breast cancer cells
4: Cancer cells of the digestive system
5: Leukema/lymphoma adult T-cells
6: Prostate cancer cells
7: Conclusions
References
Chapter Eight: Parathyroid hormone-related protein in breast cancer bone metastasis
Abstract
1: Introduction
2: Discovery and nature of PTHrP
3: Breast cancer and bone metastases before PTHrP
4: Breast biology, breast cancer and PTHrP
5: Regulation of PTHrP in tumor-induced bone disease
6: Crosstalk with the microenvironment regulation of PTHrP
Funding information
References
Chapter Nine: Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3
Abstract
1: Introduction
2: Pathogenetic mechanisms causing increased bone resorption in glucocorticoid-induced osteoporosis
3: Glucocorticoid receptor
4: Interaction between glucocorticoids and calcium regulating hormones
5: Concluding remarks/summary
References
Chapter Ten: Evolution of intra-operative parathyroid hormone and its application in parathyroid surgery
Abstract
1: Discovery of the parathyroid gland
2: History of parathyroid hormone
3: Early parathyroid surgery
4: Evolution of intraoperative parathyroid hormone
5: Dissemination of intraoperative parathyroid hormone
6: Use of parathyroid hormone testing in reoperative cases
7: Elevated parathyroid hormone levels postsurgery
8: Future directions
References
Chapter Eleven: Gene expression profiles in parathyroid adenoma and normal parathyroid tissue
Abstract
1: Introduction
2: Summary of germline and somatic genetics in sporadic parathyroid adenoma
3: Comparative genomic expression
Acknowledgment
References
Chapter Twelve: Renal hyperparathyroidism
Abstract
1: Pathophysiology of renal hyperparathyroidism
2: Causes of renal hyperparathyroidism
3: Medical treatment of renal hyperparathyroidism (Table 1)
4: Renal bone disease
Acknowledgments
References
Further reading
Chapter Thirteen: Primary cilia and PTH1R interplay in the regulation of osteogenic actions
Abstract
1: Introduction to primary cilia structure, biogenesis, intra-ciliary transport and molecular mechanotransducers in bone
2: Role of primary cilia in bone
3: Primary cilia-depending signaling pathways associated with activation of PTH1R in osteogenesis: Hedgehog and TGF-β/BMPs pathways
4: Primary cilia and PTH1R interactions in osteogenesis
5: Conclusions
Acknowledgments
References

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Gerald Litwack