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Parathyroid Hormone
- 1st Edition, Volume 120 - August 9, 2022
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 2 2 5 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 2 2 6 - 8
Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of au… Read more
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Request a sales quoteVitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in Vitamins and Hormones serials
- Updated release includes the latest information on Parathyroid Hormone
Undergraduates, graduates, academics, and researchers in the field of vitamins and hormones
- Cover image
- Title page
- Table of Contents
- Copyright
- Former Editors
- Contributors
- Preface
- Chapter One: Structural pharmacology of PTH and PTHrP
- Abstract
- 1: Evolutionary biology of PTH and PTHrP
- 2: PTH mutations
- 3: PTHrP mutations
- 4: PTH and PTHrP pharmacology
- Acknowledgments
- References
- Chapter Two: Salt inducible kinases and PTH1R action
- Abstract
- 1: Parathyroid hormone and PTH1R biology
- 2: PTH as anabolic therapies for osteoporosis
- 3: PTH action in osteocytes
- 4: Salt inducible kinases
- 5: Role of salt inducible kinases in responses to PTH in bone
- 6: Role of salt inducible kinases in responses to PTH in cartilage
- 7: Do salt inducible kinases participate in the renal actions of PTH?
- 8: PTH stimulates Cyp27b1 expression
- 9: PTH decreases phosphate reabsorption in proximal tubule
- 10: PTH increases calcium reabsorption in distal tubule
- 11: Summary and future directions
- References
- Chapter Three: Physiological regulation of phosphate homeostasis
- Abstract
- 1: Introduction
- 2: An overview of phosphate homeostasis
- 3: Intestinal phosphate absorption
- 4: Transcellular intestinal phosphate absorption and the role of NaPi-IIb
- 5: Renal phosphate reabsorption
- 6: Phosphate imbalance
- References
- Chapter Four: The parathyroid glands and parathyroid hormone: Insights from PTH gene mutations
- Abstract
- 1: History of the parathyroid gland and parathyroid hormone
- 2: Sequence and structure of the PTH gene
- 3: Synthesis, processing, and secretion of PTH
- 4: Chromosomal rearrangement of the PTH gene
- 5: Intragenic polymorphisms of the PTH gene
- 6: Mutations in the PTH signal peptide
- 7: PTH exon skipping mutation
- 8: Mutations in the mature PTH peptide
- 9: Conclusions and future directions
- References
- Chapter Five: Modulation of PTH1R signaling by an extracellular binding antibody
- Abstract
- 1: Introduction
- 2: Results
- 3: Discussion
- Acknowledgments
- References
- Chapter Six: Parathyroid hormone-related protein (PTHrP) and malignancy
- Abstract
- 1: Background
- 2: Characterization of MAH
- 3: Role of PTHrP in tumor progression
- 4: Clinical implications of MAH
- 5: Conclusion
- References
- Further reading
- Chapter Seven: Parathyroid hormone-related protein (PTHrP)-dependent modulation of gene expression signatures in cancer cells
- Abstract
- 1: Parathyroid hormone-related protein (PTHrP): A brief insight into its structure and function
- 2: Bone cancer cells
- 3: Breast cancer cells
- 4: Cancer cells of the digestive system
- 5: Leukema/lymphoma adult T-cells
- 6: Prostate cancer cells
- 7: Conclusions
- References
- Chapter Eight: Parathyroid hormone-related protein in breast cancer bone metastasis
- Abstract
- 1: Introduction
- 2: Discovery and nature of PTHrP
- 3: Breast cancer and bone metastases before PTHrP
- 4: Breast biology, breast cancer and PTHrP
- 5: Regulation of PTHrP in tumor-induced bone disease
- 6: Crosstalk with the microenvironment regulation of PTHrP
- Funding information
- References
- Chapter Nine: Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3
- Abstract
- 1: Introduction
- 2: Pathogenetic mechanisms causing increased bone resorption in glucocorticoid-induced osteoporosis
- 3: Glucocorticoid receptor
- 4: Interaction between glucocorticoids and calcium regulating hormones
- 5: Concluding remarks/summary
- References
- Chapter Ten: Evolution of intra-operative parathyroid hormone and its application in parathyroid surgery
- Abstract
- 1: Discovery of the parathyroid gland
- 2: History of parathyroid hormone
- 3: Early parathyroid surgery
- 4: Evolution of intraoperative parathyroid hormone
- 5: Dissemination of intraoperative parathyroid hormone
- 6: Use of parathyroid hormone testing in reoperative cases
- 7: Elevated parathyroid hormone levels postsurgery
- 8: Future directions
- References
- Chapter Eleven: Gene expression profiles in parathyroid adenoma and normal parathyroid tissue
- Abstract
- 1: Introduction
- 2: Summary of germline and somatic genetics in sporadic parathyroid adenoma
- 3: Comparative genomic expression
- Acknowledgment
- References
- Chapter Twelve: Renal hyperparathyroidism
- Abstract
- 1: Pathophysiology of renal hyperparathyroidism
- 2: Causes of renal hyperparathyroidism
- 3: Medical treatment of renal hyperparathyroidism (Table 1)
- 4: Renal bone disease
- Acknowledgments
- References
- Further reading
- Chapter Thirteen: Primary cilia and PTH1R interplay in the regulation of osteogenic actions
- Abstract
- 1: Introduction to primary cilia structure, biogenesis, intra-ciliary transport and molecular mechanotransducers in bone
- 2: Role of primary cilia in bone
- 3: Primary cilia-depending signaling pathways associated with activation of PTH1R in osteogenesis: Hedgehog and TGF-β/BMPs pathways
- 4: Primary cilia and PTH1R interactions in osteogenesis
- 5: Conclusions
- Acknowledgments
- References
- No. of pages: 390
- Language: English
- Edition: 1
- Volume: 120
- Published: August 9, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780323992251
- eBook ISBN: 9780323992268
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United StatesRead Parathyroid Hormone on ScienceDirect