Pancreatobiliary Pathology, An Issue of Surgical Pathology Clinics
- 1st Edition, Volume 15-3 - September 2, 2022
- Imprint: Elsevier
- Editor: Aatur D. Singhi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 9 7 3 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 9 7 4 - 6
In this issue of Surgical Pathology Clinics, guest editor Dr. Aatur D. Singhi brings his considerable expertise to the topic of Pancreatobiliary Neoplastic Pathology. To… Read more
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Request a sales quoteIn this issue of Surgical Pathology Clinics, guest editor Dr. Aatur D. Singhi brings his considerable expertise to the topic of Pancreatobiliary Neoplastic Pathology. Top experts in the field discuss precursor and malignant neoplasms (with mimics) such as molecular discoveries (e.g., IOPNs), neoadjuvant treatment histopathology (e.g., grading), immunohistochemical biomarkers (e.g., prognostic markers for neuroendocrine tumors), and more.
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Contains 13 relevant, practice-oriented topics including the diagnostic challenge of evaluating small biopsies from the pancreatobiliary system; integrating molecular analysis to the pathologic evaluation of pancreatic cysts; the cytomorphologic and molecular assessment of bile duct brushing specimens; advances in the surgical approach to pancreatobiliary neoplasms; and more.
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Provides in-depth clinical reviews on pancreatobiliary neoplastic pathology, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Diagnostic Challenge of Evaluating Small Biopsies from the Pancreatobiliary System
- Introduction
- Solid cellular neoplasms
- Cystic lesions
- Extrapancreatic lesions
- Summary
- Disclosure
- Integrating Molecular Analysis into the Pathologic Evaluation of Pancreatic Cysts
- Overview
- The utility of molecular analysis in pancreatic cyst management
- The impact of molecular analysis on pancreatic cyst lesion management
- Clinics care points
- Summary
- The Cytomorphologic and Molecular Assessment of Bile Duct Brushing Specimens
- Overview
- Sampling techniques of bile duct strictures
- Tissue triage of bile duct brushing specimens and small tissue biopsies
- Cytomorphology of bile duct brushings
- Reporting bile duct brushing cytology and risk of malignancy
- Fluorescence in-situ hybridization
- Mutational analysis and next-generation sequencing
- Other methodologies
- Summary
- Clinics care points
- Disclosure
- Advances in the Surgical Treatment of Pancreatic Cancer
- Overview
- Minimally invasive pancreatectomy
- Neoadjuvant therapy
- Irreversible electroporation
- Summary
- The Evolving Paradigm of Germline Testing in Pancreatic Ductal Adenocarcinoma and Implications for Clinical Practice
- Overview
- Germline mutation in pancreatic ductal adenocarcinoma
- Impact of multigene panel testing
- Targeted therapy in patients with germline mutations
- Impact of germline mutations on screening for pancreatic ductal adenocarcinoma
- Summary
- Clinics care points
- Appendix
- Total Pancreatectomy with Islet Autotransplantation: New Insights on the Pathology and Pathogenesis of Chronic Pancreatitis from Tissue Research
- Introduction
- Total pancreatectomy with islet autotransplantation
- Early observations and theories on the pathophysiology of chronic pancreatitis using tissue specimens
- Deciphering unique pathways based on the cause of chronic pancreatitis
- Advancements in diagnosis of chronic pancreatitis, guided by access to histopathology
- Summary
- Clinics care points
- The Histopathology of Neoadjuvant-Treated (NAT) Pancreatic Ductal Adenocarcinoma
- Overview
- Handling neoadjuvant-treated pancreatectomy specimens
- Microscopic findings
- Evans grading system
- College of American Pathologists system
- MD Anderson TRG system
- Summary
- The Molecular Pathogenesis and Targeted Therapies for Cholangiocarcinoma
- Introduction
- Molecular pathogenesis of cholangiocarcinoma
- Signaling pathways
- The cholangiocarcinoma microenvironment
- Molecular classifications
- Targeting the mutational landscape of cholangiocarcinoma
- Epigenetics of cholangiocarcinoma
- Summary
- Clinics care points
- Disclosure
- Prognostic and Predictive Biomarkers for Pancreatic Neuroendocrine Tumors
- Introduction
- Established prognostic biomarkers
- General principles of clinical management and prognosis
- Genetic alterations with prognostic and/or predictive potential
- Epigenetic signatures
- Summary and perspective
- Clinics care points
- Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms of the Pancreas
- Introduction
- Gross features
- Microscopic features
- Differential diagnosis
- Diagnosis
- Molecular pathology features
- Prognosis
- Summary
- Clinics care points/diagnostic pitfalls
- Disclosure
- The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder
- Overview
- Demographic features
- Symptomatology and preoperative evaluation
- Gross features
- Microscopic features
- Molecular features
- Prognosis
- Differential diagnosis and diagnostic challenges
- Special precautions to be taken during pathologic examination
- Future directions
- Edition: 1
- Volume: 15-3
- Published: September 2, 2022
- Imprint: Elsevier
- No. of pages: 240
- Language: English
- Hardback ISBN: 9780323919739
- eBook ISBN: 9780323919746
AS
Aatur D. Singhi
Affiliations and expertise
Associate Professor of Pathology, Director and Coordinator, Anatomic Pathology Research, Director, UPMC Developmental Laboratory, University of Pittsburgh