Pancreatic B Cell Biology in Health and Disease

1st Edition, Volume 359 - April 6, 2021
Imprint: Academic Press
Editors: Izortze Santin Gomez, Lorenzo Galluzzi
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 7 5 5 - 7
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 7 5 6 - 4

Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in… Read more

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Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more.

Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter One: Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes
Abstract
1: Introduction
2: Type I interferons
3: Pancreatic β-cell dysfunction in T1D
4: Viruses as triggers of IFNα response in β-cells
5: Candidate genes and type I IFN signaling pathway
6: Type I IFNs in T1D pathogenesis
7: Targeting type I IFN production and/or signaling as potential therapeutic approaches
8: Concluding remarks
Chapter Two: Sexual hormones and diabetes: The impact of estradiol in pancreatic β cell
Abstract
1: Introduction
2: Receptors and modulation
3: Estrogen receptors in pancreatic β cells
4: Knock-out mice models: A useful tool in the study of estrogens impact in pancreatic β cells
5: Menopause, hormone replacement therapy and diabetes
6: Summary and concluding remarks
Acknowledgment
Chapter Three: Molecular mechanisms of β-cell dysfunction and death in monogenic forms of diabetes
Abstract
1: Introduction
2: Monogenic forms of diabetes associated with mutations in transcription factors and transcriptional regulators
3: Monogenic forms of diabetes associated with impaired glucose metabolism and insulin secretion
4: Monogenic forms of diabetes associated with endoplasmic reticulum stress
5: Monogenic forms of diabetes associated with mitochondrial dysfunction
6: Monogenic forms of diabetes associated with impaired tRNA methylation
7: Concluding remarks
Chapter Four: Role of microRNA in pancreatic beta cell function
Abstract
1: Introduction
2: miRNAs in pancreatic beta cell physiology
3: Deregulation of beta cell miRNAs during diabetes
4: Conclusions and perspectives
Chapter Five: Physiology of pancreatic β-cells: Ion channels and molecular mechanisms implicated in stimulus-secretion coupling
Abstract
1: Introduction
2: Ion channels in pancreatic β-cells
3: Stimulus-secretion coupling in pancreatic β-cells
4: Paracrine regulation of insulin secretion in pancreatic β-cells
5: Ion channels and insulin secretion: Implications in Type 2 diabetes mellitus
6: Concluding remarks
Chapter Six: Long non-coding RNA-regulated pathways in pancreatic β cells: Their role in diabetes
Abstract
1: Introduction
2: The non-coding transcriptome of pancreatic β cells
3: The implication of LncRNAs in pancreas development and β cell differentiation
4: LncRNAs and pancreatic β cell function
5: Micropeptides encoded by LncRNAs and their potential role in pancreatic β cells
6: LncRNAs and diabetes
7: Concluding remarks
Chapter Seven: Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction
Abstract
1: Introduction
2: FFA-induced lipotoxicity
3: Lipid signaling pathways involved in the FFA modulation of GSIS
4: Lipid metabolites involved in FFA-mediated lipotoxicity
5: Molecular mechanism leading to lipotoxic β-cell dysfunction
6: Conclusions

Izortze Santin Gomez

Izortze Santin is assistant professor and researcher in the Department of Biochemistry and Molecular Biology of the University of the Basque Country (Leioa, Spain). She obtained her PhD in Genetics of autoimmune diseases in 2004, and then, she moved to the ULB Center for Diabetes Research (Brussels, Belgium) where she completed her formation in diabetes with functional studies in in vitro models of pancreatic beta cell and in vivo models of type 1 diabetes. Izortze Santin is best known for major experimental and conceptual contributions to the research of pancreatic beta cell dysfunction in type 1 diabetes. Indeed, her work has highlighted the implication of type 1 diabetes candidate genes in the regulation of several pathways related to pancreatic beta cell inflammation and death. Currently her main research line aims to characterize how T1D genes (coding and non-coding) and viral infections interact to trigger the autoimmune destruction of pancreatic beta cells in type 1 diabetes. To this aim, she has several ongoing funded projects related to type 1 diabetes pathogenesis, in which the study of pancreatic beta cell acquired a central role.

Affiliations and expertise

University of the Basque Country, Department of Biochemistry and Molecular Biology, Leioa; Biocruces Bizkaia Health Research Institute, Bilbao; Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

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