Pancreas and Beta Cell Replacement
- 1st Edition, Volume 1 - April 21, 2022
- Editor: Wayne Hawthorne
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 0 1 1 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 0 1 2 - 0
Pancreas and Beta Cell Replacement is the inaugural volume of the Regenerative and Transplant Medicine series. The idea for this new book series spawned from the observati… Read more
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Request a sales quotePancreas and Beta Cell Replacement is the inaugural volume of the Regenerative and Transplant Medicine series. The idea for this new book series spawned from the observation that the regenerative medicine field is progressing at such a fast pace that the way we currently think and practice transplant medicine is rapidly changing, faster than we could ever imagine. This series was therefore conceived to bring together experts from both the transplant and regenerative medicine fields, to share knowledge first, but also to introduce the transplant audience to the remarkable progress that has occurred in regenerative medicine over the past few decades. At the same time, we intend to illustrate to researchers and operators in the regenerative medicine field the numerous platforms that transplant medicine offers for the application of their technologies. To the publisher and the editors of this series and volumes there is no doubt that regenerative medicine will shape and define the future of transplant medicine.
This volume focuses on pancreas and beta cell replacement and illustrates how progress in biomaterial sciences, stem cell biology, gene editing, cell, tissue and organ bioengineering and regeneration, along with advances in xenotransplantation are revolutionizing the field. Written by the world’s experts in the fields of pancreas, islet and xenotransplantation, as well as regenerative medicine, it represents a valuable educational tool for those in the fields of clinical transplantation, researchers in the field of regenerative medicine, transplant medicine, diabetes and immunology, as well as for medical and health science students, those in academia, the biotech industry and regulatory agencies working to advance the field. At the end of the book, it will become clear to the reader that beta cell replacement offers a vast array of platforms for the application of regenerative medicine technologies to transplant medicine.
- First volume in the Regenerative and Transplant Medicine series, focusing on the pancreas
- Includes an overview of the field, including developments of transplantation methods and techniques
- Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals
Transplant operators, regenerative medicine operators, tissue engineering operators, biotech operators, Academia, Industry and Regulatory agencies and operators
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1: Pancreas and beta cell replacement: An overview
- Abstract
- Acknowledgments
- Introduction
- Significant improvements to isolation outcomes
- The donor and donor pancreas
- Effect of cold ischemic time (CIT)
- Organ donor age effects
- Surgical retrieval
- Effect of organ preservation and transport
- Machine perfusion and persufflation
- In review
- References
- Chapter 2: Whole pancreas transplantation: Advantages and disadvantages, and an overview of new technologies in organ resuscitation
- Abstract
- Introduction
- Advantages of pancreas transplantation
- Diabetic nephropathy
- Retinopathy
- Peripheral neuropathy/autonomic neuropathy
- Macrovascular disease: Peripheral, cardiac, and neurovascular
- Disadvantages of pancreas transplantation
- Vascular thrombosis
- Pancreatic exocrine leakage and re-laparotomy
- Peri-pancreatic collections, mycotic aneurysms, and other complications
- New technology in pancreas resuscitation
- Hypothermic machine perfusion
- Normothermic machine perfusion
- Conclusion
- References
- Chapter 3: Pancreas resuscitation for whole pancreas transplantation
- Abstract
- Introduction
- History and current strategies of pancreas preservation for transplantation
- The impact of ischemia and ischemia–reperfusion in the pancreas
- Resuscitation of the pancreas for whole organ transplantation
- The future of perfusion in pancreas transplantation: What needs to happen and what difference will it make?
- Concluding remarks
- References
- Chapter 4: Normothermic regional perfusion for whole pancreas and islet transplantation
- Abstract
- Introduction
- Donors after circulatory death
- DCD pancreas and islet cell transplant
- Normothermic regional perfusion: Methodology
- Mechanistic insights into how normothermic regional perfusion works
- Donor selection for DCD-NRP: Transplant organ utilization
- Evidence for use of NRP
- Liver transplant outcomes from DCD-NRP
- Kidney transplant outcomes from DCD-NRP
- Pancreas outcomes and future directions for NRP and the pancreas
- References
- Chapter 5: Allogeneic islet isolation: Methods to improve islet cell transplantation with new technologies in organ transplant retrieval and isolation techniques
- Abstract
- Acknowledgments
- Introduction
- Allogeneic islet transplantation
- Clean room facility and equipment
- Donor selection
- Pancreas procurement
- Organ preservation
- Human islet isolation procedure
- Tissue-dissociation enzyme blends for human islet isolation
- Purification
- Islet release criteria
- Future perspectives
- References
- Chapter 6: Auto islet isolation: Methods in removal and isolation from fibrosed and autolyzed pancreata
- Abstract
- Introduction
- Clinical islet transplant facility requirements reduce disease transmission, increase safety, standardize procedures, and maximize patient outcomes
- Auto islet transplantation
- References
- Chapter 7: Oxygenation of the pancreas
- Abstract
- Introduction
- Hypoxia in islets: Structural, biochemical, and molecular considerations
- Fundamental concepts of organ oxygenation
- Commonly used and alternative pancreas preservation methods to improve oxygenation
- Conclusion
- References
- Chapter 8: Encapsulation devices to enhance graft survival: The latest in the development of micro and macro encapsulation devices to improve clinical, xeno, and stem cell transplantation outcomes
- Abstract
- Introduction
- Design of reactors and transplantation devices
- Microencapsulation
- Macroencapsulation
- Biocompatibility
- Site of implantation
- Immune protection of encapsulated transplants
- Allograft protection
- Xenograft protection
- Autoimmune protection
- Device vascularisation
- Efficacy
- Conclusion
- References
- Chapter 9: Transgenic pigs for islet xenotransplantation
- Abstract
- Introduction
- Protecting porcine islet xenografts from the innate immune response
- Protecting porcine islet xenografts from adaptive immunity
- Improving the compatibility and function of porcine islets
- Reducing infectious risk
- The next generation of highly modified donor pigs
- Which transgenes are relevant for alternative transplant sites and modalities?
- Can genetic modification to protect islet xenografts have a detrimental impact on islet function?
- Summary
- References
- Chapter 10: Xenogeneic pancreatic islet cell transplantation—Application of pig cells and techniques for clinical islet cell xenotransplantation
- Abstract
- Acknowledgment
- Introduction
- Sources of porcine xenoislets
- Hurdles to successful transplantation
- Techniques to control IBMIR and immunological rejection
- Clinical application of xenoislet cell transplantation
- Future perspectives
- References
- Chapter 11: The development of stem cell therapies to treat diabetes utilizing the latest science and medicine have to offer
- Abstract
- Introduction to stem cells—What they are and how they can help treat disease
- Human-induced pluripotent stem cells
- Pancreatic embryological structure and cell signaling
- Pancreatic beta-cells physiology in relation to stem cells
- Stem cell differentiation strategies—An overview of the past two decades
- Strategies behind developing a pancreatic differentiation protocol
- State of the art for the pancreatic differentiation
- Final considerations
- References
- Chapter 12: Regeneratively speaking: Reflections on organ transplantation and beta cell replacement in the regenerative medicine era
- Abstract
- A historical perspective
- Organ transplantation: A halfway technology
- Regenerative medicine technologies
- Final remarks
- References
- Index
- No. of pages: 224
- Language: English
- Edition: 1
- Volume: 1
- Published: April 21, 2022
- Imprint: Academic Press
- Hardback ISBN: 9780128240113
- eBook ISBN: 9780128240120
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