LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical… Read more
LIMITED OFFER
Immediately download your ebook while waiting for your print delivery. No promo code needed.
List of Contributors
Introduction: Pushing the Boundary Toward Clinical Application: After 35 Years, PAK Research Comes of Age
Acknowledgments
References
1. Functional Maturation of PAKs from Unicellular to Multicellular Organisms
Abbreviations
1.1 Introduction
1.2 MIHCKs/PAKs and Myosin I in Unicellular Acanthamoeba and Multicellular Dictyostelium
1.3 PAK Evolution Among Metazoans (Unicellular Versus Multicellular)
1.4 PIX in Fruit Fly Drosophila and Nematode C. elegans
1.5 FYN/ETK-Dependent Activation of PAK1
1.6 Evolution of Merlin, Nischarin, and LBK1 (PAK Inhibitors)
1.7 Concluding Remarks
Acknowledgment
References
2. Oncogenicity of PAKs and Their Substrates
Abbreviations
2.1 Introduction
2.2 Loss of Contact Inhibition of Growth
2.3 Serum-Independent Growth
2.4 Anchorage-Independent Growth
2.5 Tumor-Induced Angiogenesis
2.6 Metastasis/Invasion
2.7 PAK1/PAK4-Dependent Solid Tumors
2.8 Oncogenic Targets of PAKs
2.9 Concluding Remarks
Acknowledgments
References
3. Natural or Synthetic Therapeutics That Block PAKs
Abbreviations
3.1 Introduction
3.2 Synthetic Chemical Therapeutics
3.3 Natural PAK1 Blockers
3.4 PAK1 Blockers = AMPK Activators
Acknowledgments
References
4. PAK1–3 in Infectious Diseases
4.1 Malaria Infection
4.2 Enterobacterial Infection
4.3 Viral Infection
Acknowledgments
References
5. PAK1 in Brain Diseases or Disorders
Abbreviations
5.1 Introduction
5.2 Tumorigenesis: NF, TSC, Retinoblastoma, and Gliomas
5.3 Epilepsy
5.4 Mental Retardation
5.5 Schizophrenia
5.6 Depression
References
6. PAK1 in Alzheimer’s and Huntington’s Diseases
Abbreviations
6.1 Alzheimer’s Disease
6.2 Huntington’s Disease
Acknowledgments
References
7. PAK1 Controls the Lifespan
Abbreviations
7.1 Introduction
7.2 Snell Dwarf Mice
7.3 RAC-Deficient Drosophila
7.4 PAK1 Blockers Extend the Lifespan of Tiny Animals
7.5 Crosstalk Between PI-3 kinase-PAK1 and TOR-S6K Signaling Pathways
7.6 The Nematode Caenorhabditis japonica as a Quicker Animal Model for Elixir Screening
7.7 Antiaging (Methuselah) Venture
Acknowledgments
References
8. 3D Structure and Physiological Regulation of PAKs
8.1 The PAK Family of Protein Kinases
8.2 Structural Mechanisms of PAK Regulation
8.3 Alternative Mechanisms Leading to PAK Activation
8.4 PAK Substrate Specificity and Downstream Signaling Events
Acknowledgments
References
Epilogue: “Lateral Thinking” Is the Key to a Great Leap in Biomedical Sciences
References
About the Authors