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Oxygen Sensing
- 1st Edition, Volume 381 - May 10, 2004
- Editors: Gregg L. Semenza, Chandan K. Sen
- Language: English
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 4 9 7 1 9 - 8
The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a… Read more
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Request a sales quoteThe ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.
Biochemists, cell biologists, molecular biologists, and geneticists
LUNG AND THE AIRWAYS
1. Assessment of oxygen sensing by model airway and arterial chemoreceptors
P. J. Kemp, C.Peers
2. Methods to study neuroepithelial bodies as airway oxygen sensors.
E. Cutz, X.W. Fu, H. Yeger
3. Role of glutathione redox state in oxygen sensing by carotid body chemoreceptor cells.
C. Gonzalez, G. Sanz-Alfayate, A. Obeso, M. T. Agapito
4. Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: use of the small vessel myograph
J. P.T. Ward, V. A. Snetkov
5. Oxygen-dependent regulation of pulmonary circulation
R.M. Tuder, S. McGrath, N. F. Voelkel, M. W. Geraci
6. Detection of oxygen sensing during intermittent hypoxia
N. R. Prabhakar,Y.J. Peng, J. L. Overholt, G K. Kumar
7. Functional analysis of the role of HIF-1 in the pathogenesis of hypoxic pulmonary hypertension
G. L. Semenza, L. A. Shimoda
CARDIOVASCULAR AND BLOOD
8. Perceived hyperoxia: oxygen regulated signal transduction pathways in the heart
S. Roy, S. Khanna, C. K. Sen
9. Evaluation of Cytochrome P450-4A omega-Hydroxylase and 20-HETE as an O2 Sensing Mechnism in the Microcirculation
10. Assessment of roles for oxidant mechanisms in vascular oxygen sensing
M. S. Wolin, P. M. Kaminski, M. Ahmad, S. A. Gupte
Department of Physiology, New York Medical College, Valhalla, USA.
11. Survival surgery for coronary occlusion and reoxygenation in a rodent model
W. A. Wallace, A. J. Cardounel, S. Khanna, C. K. Sen
12. Measurement of in vivo oxidative stress regulated by the Rac1 GTPase
K. Irani, M. Ozaki
13. Proteomic analysis of the mammalian cell nucleus
A. K. Tewari, S. Roy, S. Khanna, Chandan K. Sen
14. Oxygen-dependent regulation of erythropoiesis
J. T. Prchal, J. Jelinek
15. Physiological responses to chronic anemia in fetal sheep
L. Davis, R. Hohimer
16. Hypoxia-Inducible Factor 1 alpha-Deficient Chimeric Mice as a Model to Study Abnormal B Lymphocyte Development and Autoimmunity
ION CHANNELS
17. Molecular strategies for studying oxygen-sensitive K+ channels
E. Honore, K. Buckler
18. Oxygen sensing by human recombinant K(+) channel: assessment of the use of stable cell lines
P. J. Kemp, D. Iles, C. Peers
19. Methods to study oxygen-sensing sodium channels
A. K. M. Hammarstrom, P. W. Gage
20. Analysis of oxygen-sensitive human cardiac L-type Ca(2+) channel alpha(1C) subunit (hHT isoform)
C. Peers, J. L. Scragg, I. M. Fearon, S. G. Ball, A. Schwartz, G. Varadi
TUMOR BIOLOGY
21. Analysis of von Hippel-Lindau tumour suppressor as mediator of cellular oxygen sensing P. J. Ratcliffe, N. Masson
22. Analysis of the von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing
W. G. Kaelin Jr., H. Yang, M. Ivan, J-H. Min, W. Kim
23. Tumor hypoxia and malignant progression
P. Vaupel, A. Mayer, M. Hockel
METABOLISM
24. Oxygen dependent regulation of hepatic glucose metabolism
T. Kietzmann
25. Assessing oxygen sensitivity of the multiple drug resistance (MDR1) gene
S. P. Colgan, K. M. Comerford
26. Oxygen-dependent regulation of adipogenesis
A. J. Giaccia, L. M. Swiersz, Z. Yun
NERVOUS SYSTEM
27. Methods to detect hypoxia-induced ischemic tolerance in the brain
F. R. Sharp, M. Bernaudin
28. Proximal middle cerebral artery occlusion surgery for the study of ischemia-reoxygenation injury in the brain
A.J. Cardounel, W. A. Wallace, C. K. Sen
29. Carotid chemodenervation approach to study oxygen sensing in brainstem
O. Pascual, J-C. Roux, C. Soulage, M-P. Morin-Surun, M. Denavit-Saubie, J-M. Pequignot
30. Discovery of oxygen responsive genes in pheochromocytoma cells
D. E. Millhorn, K. A. Seta, T. K. Ferguson
GENERAL
31. Oxygen-dependent asparagines hydroxylation
J. Gorman, D. J. Peet, D. Lando, D. A. Whelan, M. L. Whitelaw
32. Deciphering of the oxygen sensing pathway by microscopy
H. Acker, C. Huckstorf, H. Sauer, T. Streller, M. Wartenberg
33. Identification of CREB-dependent transcriptional responses in hypoxia by microarray analysis
C. T. Taylor, M. O. Leonard, S. O’Reilly, K. M. Comerford
WOUND HEALING
34. Determination of the role of HIF-1 in wound healing
J. E. Albina, J. S. Reichner
35. Measuring oxygen in wounds
H. W. Hopf, T. K. Hunt, H. Scheuenstuh., J. M. West, L. M. Humphrey, M.D. Rollins
36. Regulatory role of lactate in wound repair
M. Z. Hussain, Q. P. Ghani, S. Wagner, H. D. Becker, T. K. Hunt
37. Protocols for Topical and Systemic Oxygen Treatments in Wound Healing
G. M. Gordillo, R. Schlanger, W. A. Wallace, V. Bergdall, R. Bartlett
UNICELLULAR SYSTEMS
38. Measurement of oxidative stress in cells exposed to hypoxia or other changes in oxygen concentration
R. O. Poyton, R. Dirmeier, K. O’Brien, M. Engle, A. Dodd, E. Spears
39. Evaluation of oxygen response involving differential gene expression in Chlamydomonas reinhardtii
J. del Campo, J. M. Quinn, S. Merchant
40. Resonance Raman and ligand binding analysis of the oxygen-sensing signal transducer protein HemAT from Bacillus subtilis
S. Aono, H. Nakajima, T. Ohta, T. Kitagawa
41. Analysis of FNR as oxygen sensor in Escherichia coli
R. A. Schmitz, S. Achebach, G. Unden
42. Experimental strategies for analyzing oxygen sensing in yeast
R.O. Poyton, R. Dirmeier, K. O’Brien, P. David, A. Dodd
PHYSICAL DETECTION OF OXYGEN
43. Measuring tissue pO2 with microelectrodes
D. G. Buerk
44. Identifying oxygen sensors by their photochemical action spectra
D. F. Wilson
45. Fabrication and in vivo evaluation of NO-releasing electrochemical oxygen sensing catheters
M. E. Meyerhoff, M. C. Frost
46. Methods in optical oxygen sensing: protocols and critical analyses
D. B. Papkovsky
47. Concurrent 31P NMR spectroscopy and fiber-optic oxygen consumption measurements in perfused rat hearts
P. Pantano, P. Zhao, Y. Zhao, A. D. Sherry
48. MICROXYMETRY: An EPR Spectroscopy Based Method for Simultaneous Measurements of Oxygen Utilization and Free Radicals Production in Enzymatic Reactions
G. Ilangovan, J. L. Zweier, P. Kuppusamy
1. Assessment of oxygen sensing by model airway and arterial chemoreceptors
P. J. Kemp, C.Peers
2. Methods to study neuroepithelial bodies as airway oxygen sensors.
E. Cutz, X.W. Fu, H. Yeger
3. Role of glutathione redox state in oxygen sensing by carotid body chemoreceptor cells.
C. Gonzalez, G. Sanz-Alfayate, A. Obeso, M. T. Agapito
4. Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: use of the small vessel myograph
J. P.T. Ward, V. A. Snetkov
5. Oxygen-dependent regulation of pulmonary circulation
R.M. Tuder, S. McGrath, N. F. Voelkel, M. W. Geraci
6. Detection of oxygen sensing during intermittent hypoxia
N. R. Prabhakar,Y.J. Peng, J. L. Overholt, G K. Kumar
7. Functional analysis of the role of HIF-1 in the pathogenesis of hypoxic pulmonary hypertension
G. L. Semenza, L. A. Shimoda
CARDIOVASCULAR AND BLOOD
8. Perceived hyperoxia: oxygen regulated signal transduction pathways in the heart
S. Roy, S. Khanna, C. K. Sen
9. Evaluation of Cytochrome P450-4A omega-Hydroxylase and 20-HETE as an O2 Sensing Mechnism in the Microcirculation
10. Assessment of roles for oxidant mechanisms in vascular oxygen sensing
M. S. Wolin, P. M. Kaminski, M. Ahmad, S. A. Gupte
Department of Physiology, New York Medical College, Valhalla, USA.
11. Survival surgery for coronary occlusion and reoxygenation in a rodent model
W. A. Wallace, A. J. Cardounel, S. Khanna, C. K. Sen
12. Measurement of in vivo oxidative stress regulated by the Rac1 GTPase
K. Irani, M. Ozaki
13. Proteomic analysis of the mammalian cell nucleus
A. K. Tewari, S. Roy, S. Khanna, Chandan K. Sen
14. Oxygen-dependent regulation of erythropoiesis
J. T. Prchal, J. Jelinek
15. Physiological responses to chronic anemia in fetal sheep
L. Davis, R. Hohimer
16. Hypoxia-Inducible Factor 1 alpha-Deficient Chimeric Mice as a Model to Study Abnormal B Lymphocyte Development and Autoimmunity
ION CHANNELS
17. Molecular strategies for studying oxygen-sensitive K+ channels
E. Honore, K. Buckler
18. Oxygen sensing by human recombinant K(+) channel: assessment of the use of stable cell lines
P. J. Kemp, D. Iles, C. Peers
19. Methods to study oxygen-sensing sodium channels
A. K. M. Hammarstrom, P. W. Gage
20. Analysis of oxygen-sensitive human cardiac L-type Ca(2+) channel alpha(1C) subunit (hHT isoform)
C. Peers, J. L. Scragg, I. M. Fearon, S. G. Ball, A. Schwartz, G. Varadi
TUMOR BIOLOGY
21. Analysis of von Hippel-Lindau tumour suppressor as mediator of cellular oxygen sensing P. J. Ratcliffe, N. Masson
22. Analysis of the von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing
W. G. Kaelin Jr., H. Yang, M. Ivan, J-H. Min, W. Kim
23. Tumor hypoxia and malignant progression
P. Vaupel, A. Mayer, M. Hockel
METABOLISM
24. Oxygen dependent regulation of hepatic glucose metabolism
T. Kietzmann
25. Assessing oxygen sensitivity of the multiple drug resistance (MDR1) gene
S. P. Colgan, K. M. Comerford
26. Oxygen-dependent regulation of adipogenesis
A. J. Giaccia, L. M. Swiersz, Z. Yun
NERVOUS SYSTEM
27. Methods to detect hypoxia-induced ischemic tolerance in the brain
F. R. Sharp, M. Bernaudin
28. Proximal middle cerebral artery occlusion surgery for the study of ischemia-reoxygenation injury in the brain
A.J. Cardounel, W. A. Wallace, C. K. Sen
29. Carotid chemodenervation approach to study oxygen sensing in brainstem
O. Pascual, J-C. Roux, C. Soulage, M-P. Morin-Surun, M. Denavit-Saubie, J-M. Pequignot
30. Discovery of oxygen responsive genes in pheochromocytoma cells
D. E. Millhorn, K. A. Seta, T. K. Ferguson
GENERAL
31. Oxygen-dependent asparagines hydroxylation
J. Gorman, D. J. Peet, D. Lando, D. A. Whelan, M. L. Whitelaw
32. Deciphering of the oxygen sensing pathway by microscopy
H. Acker, C. Huckstorf, H. Sauer, T. Streller, M. Wartenberg
33. Identification of CREB-dependent transcriptional responses in hypoxia by microarray analysis
C. T. Taylor, M. O. Leonard, S. O’Reilly, K. M. Comerford
WOUND HEALING
34. Determination of the role of HIF-1 in wound healing
J. E. Albina, J. S. Reichner
35. Measuring oxygen in wounds
H. W. Hopf, T. K. Hunt, H. Scheuenstuh., J. M. West, L. M. Humphrey, M.D. Rollins
36. Regulatory role of lactate in wound repair
M. Z. Hussain, Q. P. Ghani, S. Wagner, H. D. Becker, T. K. Hunt
37. Protocols for Topical and Systemic Oxygen Treatments in Wound Healing
G. M. Gordillo, R. Schlanger, W. A. Wallace, V. Bergdall, R. Bartlett
UNICELLULAR SYSTEMS
38. Measurement of oxidative stress in cells exposed to hypoxia or other changes in oxygen concentration
R. O. Poyton, R. Dirmeier, K. O’Brien, M. Engle, A. Dodd, E. Spears
39. Evaluation of oxygen response involving differential gene expression in Chlamydomonas reinhardtii
J. del Campo, J. M. Quinn, S. Merchant
40. Resonance Raman and ligand binding analysis of the oxygen-sensing signal transducer protein HemAT from Bacillus subtilis
S. Aono, H. Nakajima, T. Ohta, T. Kitagawa
41. Analysis of FNR as oxygen sensor in Escherichia coli
R. A. Schmitz, S. Achebach, G. Unden
42. Experimental strategies for analyzing oxygen sensing in yeast
R.O. Poyton, R. Dirmeier, K. O’Brien, P. David, A. Dodd
PHYSICAL DETECTION OF OXYGEN
43. Measuring tissue pO2 with microelectrodes
D. G. Buerk
44. Identifying oxygen sensors by their photochemical action spectra
D. F. Wilson
45. Fabrication and in vivo evaluation of NO-releasing electrochemical oxygen sensing catheters
M. E. Meyerhoff, M. C. Frost
46. Methods in optical oxygen sensing: protocols and critical analyses
D. B. Papkovsky
47. Concurrent 31P NMR spectroscopy and fiber-optic oxygen consumption measurements in perfused rat hearts
P. Pantano, P. Zhao, Y. Zhao, A. D. Sherry
48. MICROXYMETRY: An EPR Spectroscopy Based Method for Simultaneous Measurements of Oxygen Utilization and Free Radicals Production in Enzymatic Reactions
G. Ilangovan, J. L. Zweier, P. Kuppusamy
- No. of pages: 824
- Language: English
- Edition: 1
- Volume: 381
- Published: May 10, 2004
- Imprint: Academic Press
- eBook ISBN: 9780080497198
GS
Gregg L. Semenza
Affiliations and expertise
John Hopkins University School of Medicine, Baltimore, MarylandCS
Chandan K. Sen
Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants & Redox Signaling(www.liebertpub.com/ars) with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.
Affiliations and expertise
Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center, Columbus, Ohio, USA