Oxides for Medical Applications

1st Edition - March 17, 2023
Imprint: Woodhead Publishing
Editors: Piyush Kumar, Ganeshlenin Kandasamy, Jitendra Pal Singh, Pawan Kumar Maurya
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 5 3 8 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 6 4 2 - 5

Oxides for Medical Applications reviews the most important advances of oxides with optical, magnetic and electronic properties for biomedical applications. Owing to their unusual p… Read more

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Oxides for Medical Applications reviews the most important advances of oxides with optical, magnetic and electronic properties for biomedical applications. Owing to their unusual properties, oxides are expected to play a significant role in the prevention or early treatment of diseases. In addition to catalytically active artificial enzymes based on oxide materials—the book provides comprehensive coverage of the most relevant categories of oxide materials and their properties and applications. Since magnetic oxides are used extensively for a wide range of medical applications, there are numerous chapters that address these materials, including LSMO nanoparticles, ferrites, nanocatalysts, and more.

Finally, practical considerations for the translation of these materials from the lab to the clinic are reviewed, including biocompatibility and toxicity of oxide nanoparticles, making this a suitable resource for researchers and practitioners in materials science and engineering in academia and the clinic.

Cover image
Title page
Table of Contents
Copyright
List of contributors
1. An overview of biomedical applications of oxide materials
1.1. Introduction
1.2. Iron oxide nanoparticles
1.3. Zinc oxide nanoparticles
1.4. Titanium oxide nanoparticles
1.5. Silicon oxide nanoparticles
1.6. Cerium oxide nanoparticles
1.7. Graphene oxide nanoparticles and nanosheets
1.8. Conclusion
2. Particle specifications of oxide materials for biomedical applications
2.1. Introduction
2.2. Particles specifications of oxide materials
2.3. Ultrafine size and shape
2.4. Band gap
2.5. Surface multifunctionalization
2.6. Specific surface area
2.7. Dispersibility
2.8. Magnetic behavior
2.9. Cytotoxicity
2.10. Conclusion
3. Synthesis of graphene and graphene oxide and their medical applications
3.1. Introduction
3.2. Preparation methods for graphene and graphene oxide
3.3. Structure and properties of two-dimensional graphitic materials
3.4. Interactions between two-dimensional graphitic materials and biomolecules
3.5. Biomedical applications of graphene, graphene oxide, and other two-dimensional graphitic materials
3.6. Degradation and toxicity of graphene-based materials
3.7. Conclusion and future prospects
4. Synthesis of silica oxide nanoparticles and their medical applications
4.1. Introduction
4.2. Synthesis
4.3. Medical applications
4.4. Conclusion
5. Synthesis of TiO2 nanostructures and their medical applications
5.1. Introduction
5.2. Commonly applied metallic biomaterials
5.3. Titanium oxide nanostructures on metallic materials
5.4. Conclusions
6. Synthesis of ZnO nanostructures and their medical applications
6.1. Introduction
6.2. Methods for synthesis
6.3. Biomedical applications
6.4. Conclusion
7. Synthesis of iron-based nanoparticles by chemical methods and their biomedical applications
7.1. Introduction
7.2. Iron-based nanoparticles
7.3. Chemical synthesis technique
7.4. Biomedical applications
7.5. Toxicity assessment
7.6. Conclusion
8. Core-shell oxide nanoparticles and their biomedical applications
8.1. Introduction
8.2. Synthesis methods for CSNPs
8.3. Characterization methods of nanoparticles
8.4. Biomedical applications
8.5. Challenges and future perspectives
9. Zinc ferrite nanoparticles and their biomedical applications
9.1. Introduction
9.2. ZnFe2O4
9.3. Magnetism
9.4. Theory of superparamagnetism
9.5. Biomedical applications
9.6. Conclusion
10. Iron oxide and enzyme interface
10.1. Introduction
10.2. Methods of preparation
10.3. Novel enzyme mimetic activity of iron oxide nanoparticle
10.4. Iron oxide-enzyme mimetic activity-based biomedical application
10.5. Conclusion
11. Magnetic recyclable nanocatalysts for cancer treatment
11.1. Introduction
11.2. Synthesis of magnetic nanoparticles
11.3. Regulation of cellular signaling pathways by nanocatalyst complexes
11.4. Catalytic Fenton reaction
11.5. Enhanced chemo dynamic therapy for cancer by MNPs
11.6. Photonic cancer therapy by iron-based catalysts
11.7. Rhodium nanocomposites in cancer phototherapy
11.8. Silver nanocomposites in cancer therapy
11.9. Conclusions and perspectives
12. Catalytically active nanomaterials as artificial enzymes
12.1. Introduction
12.2. Types of nanoparticles used as nano-catalyst
12.3. Catalytic modulation methods for enzyme nanoparticles
12.4. Application of nanomaterial as an artificial enzyme
12.5. Biomimetic activity of nanoparticles as artificial enzymes
12.6. Nanoparticles in green catalysis
12.7. Challenges of oxides nanoparticle as an artificial enzyme
12.8. Conclusion
12.9. Future perspective
13. Oxides, oxidative stress, and cellular aging
13.1. Introduction
13.2. Unique properties of metal oxide nanoparticles
13.3. Oxidative stress during cellular aging
13.4. Role of oxidative stress in age-related disorders
13.5. Biomedical-based abilities of metal oxide nanoparticles
13.6. Conclusion
14. Clinical role of oxides in Neuropsychiatric and Neurodegenerative disorders
14.1. Introduction
14.2. Nitric oxide
14.3. Peroxynitrite
14.4. Heme oxygenase and brain dysfunction
14.5. Carbon monoxide and impaired brain functioning
14.6. Disruption of regular pathways in the case of neuropsychiatric disorders role of oxides
14.7. Implications to Alzheimer's disease
14.8. MicroRNA in neuropsychiatric disorders
14.9. MicroRNA and schizophrenia
14.10. Role of miRNA in neuropsychosis
14.11. Bringing MiR137 to highlight
14.12. miRNA biogenesis and its impact on schizophrenia
14.13. Interaction between miRNA and neuroleptic drugs
14.14. MiRNA as depression biomarkers
14.15. Future perspectives
15. Medical applications of zirconia and its derivatives
15.1. Introduction
15.2. Chemical synthesis
15.3. Preparation of nanoparticles
15.4. Hydrothermal treatment routes
15.5. Other synthesis methods
15.6. Zirconia derivatives for biomedical applications
15.7. Conclusion
16. ROS-mediated pathogen control by ZnO and MgO nanoparticles
16.1. Introduction
16.2. Antibacterial activity of ZnO nanoparticles
16.3. Antibacterial activity of MgO nanoparticles
16.4. Combined antibacterial effect of ZnO and MgO nanoparticles
16.5. Factors affecting antimicrobial property of ZnO and MgO nanoparticles
16.6. Future prospectus
17. Surface Enhanced Raman Spectroscopy (SERS) based graphene oxide nanocomposites in biomedical applications
17.1. Introduction
17.2. SERS mechanism
17.3. Medical applications of SERS
17.4. Recent trends and future applications
17.5. Role of SERS based graphene oxide (GO) nanocomposites in DNA detection
17.6. Conclusion
18. Nanotechnology laying new foundations for combating COVID-19 pandemic
18.1. Introduction to nanotechnology
18.2. The COVID-19 pandemic
18.3. Role of nanotechnology in COVID-19 diagnosis
18.4. Role of nanotechnology in COVID-19 therapeutics
18.5. Role of nanotechnology in COVID-19 prevention
18.6. Conclusion and future perspectives
19. Biocompatibility of oxide nanoparticles
19.1. Introduction
19.2. Biocompatibility of iron oxide nanoparticles
19.3. Biocompatibility of zinc oxide nanoparticles
19.4. Biocompatibility of silica nanoparticles
19.5. Conclusion
Index

Piyush Kumar

Dr. Piyush Kumar is an Associate Professor at School of Health Sciences & Technology, UPES, Dehradun, India. He did his M.Sc. in Biophysics (2003-2005, Govind Ballabh Pant University of Agriculture and Technology) and Ph.D. in Biochemistry (2006-2010, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand). He has worked as a Research Associate at Indian Institute of Technology Roorkee, India, during 2010-2014 and as a MHRD post-doc researcher at the same institute during 2014-2017 and as Assistant Professor at Department of Biochemistry, Central University of Haryana, India, during 2017-2020. Dr. Kumar’s research contributions are highly interdisciplinary. His research interests are Nanobiosensors, functionalized nanomaterials, and applications of probiotic enzymes in value addition of food. He has actively worked in the designing and constructing of Aptasensors and nanoengineered surface modification strategies for pathogenic bacteria and hazardous xenobiotic molecules, nano and natural products based combinatorial strategies to control pathogens and therapeutic applications probiotic enzymes.

Affiliations and expertise

Associate Professor, UPES Dehradun, India

Ganeshlenin Kandasamy

Dr. Ganeshlenin Kandasamy has completed his Masters in Nanotechnology from Karunya University, Coimbatore & PhD from Shiv Nadar University, Delhi NCR in 2019 with specialization in “Nanotechnology for Biomedical Applications”. He is currently working as an Assistant. Professor in the Department Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India. He has published several papers in reputable journals like J. Coll. & Inter. Sci., J. Mol. Liq., ACS Omega, RSC Adv., and has reviewed manuscripts for well-known publishers. His research interests include the synthesis, characterization, and optimization of multifunctional nanoparticles – especially spinel ferrite nanoparticles and carbon quantum dots (CQDs), their polymeric co-encapsulation with potential CTDs, and subsequent application in MRI, fluorescence imaging, MFH based thermotherapy, and combined thermo-/chemo-therapies for the treatment of different type of cancers.

Affiliations and expertise

Assistant Professor, Department Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India

Jitendra Pal Singh

Jitendra Pal Singh is the Ramanujan Fellow at the Manav Rachna University, Faridabad, India. His research interests are irradiation studies in nanoferrites, thin films, and magnetic multilayers, including the synthesis of ferrite nanoparticles and thin films, determining the magnetic, optical, and dielectric response of ferrites, and irradiation and implantation effects in ferrite thin films and nanoparticles.

Affiliations and expertise

Ramanujan Fellow, Department of Sciences, Manav Rachna University, Faridabad, Haryana, India

Pawan Kumar Maurya

Prof. Pawan Kumar Maurya is Dean, School of Life Long Learning & Head of Department of Biochemistry, Central University of Haryana, India. He has done a PhD from the University of Allahabad (A Central University), India & post-doctoral training from Universidade Federal de Sao Paulo-UNIFESP, Brazil; Taipei Medical University (TMU) and National Taiwan University (NTU), Taiwan. He has more than 14 years of teaching and research experience. He is working on biochemical diagnostics, nanomedicine, and clinical biochemistry. He has published over 75 research articles in reputed journals. He has also edited of six books published from Elsevier, USA and Springer-Nature, Singapore. He is recipient of prestigious fellowships: Science without Borders (Government of Brazil) and National Science Council, Taiwan.

Affiliations and expertise

Central University of Haryana, Mahendergarh (Haryana), INDIA

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Oxides for Medical Applications

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Piyush Kumar

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Pawan Kumar Maurya

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