Organic Nanomaterials for Cancer Phototheranostics

1st Edition - August 26, 2023
Editors: Manzar Abbas, Atia Atiq, Muhammad Ovais, Michael R Hamblin
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 7 5 8 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 7 5 9 - 5

Organic Nanomaterials for Cancer Phototheranostics highlights the use of biocompatible building blocks to make nanomaterials that can aid in medical treatment through better di… Read more

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Organic Nanomaterials for Cancer Phototheranostics highlights the use of biocompatible building blocks to make nanomaterials that can aid in medical treatment through better diagnostic and antitumor efficacy. The book synthesizes the current literature on synthetic strategies and designs based on peptides, proteins, polymers, lipids, and their conjugates, as well as composites and complexes with metals and inorganic components used to form the nanomaterials. Mechanistic approaches, clinical problems, and therapeutic and diagnostics mechanisms are covered in each chapter. Cellular interactions and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and safety concerns of these types of nanomaterials are also discussed. Other topics cover photostability, clearance, metabolism, in-vitro and in-vivo mechanisms, therapeutic efficacy, imaging, and toxicology.

Cover image
Title page
Copyright
Table of Contents
List of Contributors
Introduction
Chapter 1 Contemporary developments, trends, and challenges in cancer phototheranostics
1.1 Introduction
1.2 Overview of organic nanomaterials
1.3 Fundamentals parameters of phototheranostics
1.4 Jablonski diagram
1.5 Recent developments in organic nanomaterials
1.6 Conclusion and future perspectives
References
Chapter 2 The role of nanotechnology: Organic nanomaterials and the mechanism of cancer phototheranostics
2.1 Introduction
2.2 Parameters of nanomaterials influencing cancer phototheranostics
2.3 Therapeutic mechanism of molecular drugs in assembled state
2.4 FDA-approved organic nanomaterials
2.5 Challenges for clinical translation
2.6 Conclusion and future perspectives
References
Chapter 3 Synthetic strategies of short peptide-modified nanomaterials for diagnostics and phototherapy
3.1 Introduction
3.2 Physicochemical properties needed for phototheranostics
3.3 Molecular design of amino acid and short peptide-based phototheranostics agent
3.4 Conclusion and future perspectives
Acknowledgment
References
Chapter 4 Development of metal– peptide composite nanomaterials for diagnosis and phototherapy
4.1 Introduction
4.2 Molecular design of phototheranostics agents
4.3 Molecular design of short peptides with metals for phototheranostics
4.4 Conclusion and future perspectives
Acknowledgments
References
Chapter 5 Fabrication of protein-based nanomaterials as photonanomedicine agents
5.1 Introduction
5.2 Types of proteins used to produce protein nanomaterials
5.3 Fabrication of protein-based nanomaterials
5.4 Protein-based nanomaterials for PDT and PTT
5.5 Protein-based nanomaterials for photoimmunotherapy
5.6 Protein-AIEgens nanocomposites
5.7 Protein-based nanomaterials for photoacoustic imaging
5.8 Conclusion and future perspectives
References
Chapter 6 Synthetic strategies of protein–metal nanomaterials as photonanomedicine agents
6.1 Introduction
6.2 Protein-based nanoparticles
6.3 Synthetic strategies of metal–protein-based nanomaterials
6.4 Proteins types used to harvest protein–metal nanohybrids
6.5 Metal–protein-based nanomaterials as photonanomedicine agents
6.6 Conclusion and future perspectives
References
Chapter 7 Fabrication of polymeric nanomaterials for phototheranostics of cancer
7.1 Introduction
7.2 Polymer-based nanoparticles
7.3 Polymeric micelles
7.4 Liposomes
7.5 Nanogels
7.6 Dendrimers
7.7 Types of phototheragnostic
7.8 Conclusion and future perspectives
References
Chapter 8 Development of metal–polymer composite nanomaterials for diagnosis and phototherapy
8.1 Introduction
8.2 Conventional phototherapy methods and their limitations
8.3 Recent advances in metal–polymer nanocomposites for diagnosis applications
8.4 Recent advances in metal–polymer nanocomposites for phototherapy applications
8.5 Challenges and future translational opportunities
8.6 Conclusion and future perspectives
Acknowledgment
References
Chapter 9 Lipid-based nanomaterials as phototheranostic agents
Abbreviations
9.1 Introduction
9.2 Development and classification of lipidic nanomaterials
9.3 Cancer-targeted delivery of lipid nanoparticles
9.4 Application of lipid nanoparticles in cancer therapy and imaging
9.5 Phototheranostic agent
9.6 Application of lipidic nanomaterials in photodynamic therapy
9.7 Application of PTA as nanomedicines in clinical trials
9.8 Lipidic nanocarriers as phototheranostic agent
9.9 Conclusion and future perspectives
References
Chapter 10 Safety considerations of organic nanomaterials for phototheranostics
10.1 Introduction
10.2 Organic nanomaterials as phototheranostic agents: current trends
10.3 Safety considerations of organic nanomaterials
10.4 Factors affecting the biocompatibility of organic nanomaterials
10.5 Conclusion and future perspectives
References
Index

Manzar Abbas

Dr. Abbas started working as an assistant professor of chemistry at Khalifa University of Science and Technology, Abu Dhabi, UAE in 2022. He holds a Ph.D. degree in material chemistry from the Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China. After graduating in 2017, he was a post-doctoral researcher at King Abdullah University of Science and Technology, Saudi Arabia. Later in 2019, he was awarded the Marie Curie Individual Fellowship from European Foundation and he joined the Institute for Molecules and Materials at Radboud University, Netherlands. By training, he is a chemist with work experience in organic synthesis, peptide chemistry, and material science with a focus on the multidisciplinary cutting-edge research direction in advanced drug delivery, and synthetic cells. He is the recipient of the 2017 UCAS Excellent International Graduate award and has published high-impact articles in peer-reviewed journals like the Journal of American Chemical Society/ACS, Nature Chemistry, Advanced Materials-Wiley, and Chemical Society Review/RSC. His group research is focused on the design and synthesis of small functional molecules including short peptides, and self-assembled nano-micro level materials for anticancer and protocell applications. His research work has been cited over 1900 times and he is serving as guest editor for a joint special collection on “peptide-based supramolecular systems” in Chemistry – A European Journal, ChemBioChem, and Journal of Peptide Science for Wiley-VCH publisher. He is an active reviewer for reputed journals including Nano Today, Advanced Science, ChemBioChem, Chemistry-An Asian Journal, and Colloid and Surfaces A; Physicochemical and Engineering Aspects.

Affiliations and expertise

Department of Chemistry, Khalifa University of Science and Technology, P.O. Box 127788 Abu Dhabi, United Arab Emirates. Advanced Materials Chemistry Center, Khalifa University of Science and Technology, P.O. Box 127788 Abu Dhabi, United Arab Emirates.

Atia Atiq

Dr. Atiq completed her Ph.D. in physics in 2019 from the Institute of Physics, The Islamia University of Bahawalpur, Pakistan. She is currently working as an Assistant Professor in the Multan campus of the University of Education, Lahore, Pakistan. Her research interests are nanomaterials for biomedical applications, photon dose calculations, treatment planning, and quality assurance programs in radiotherapy.

Affiliations and expertise

Assistant Professor, University of Education, Lahore, Pakistan

Muhammad Ovais

Muhammad Ovais is a Research Scientist at the CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), China. His research focuses on nanomedicine and cancer theranostics. Dr. Ovais received his Ph.D. with distinction from CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China. His research interests are in nanomedicines, biomaterials, immuno-engineering, and nanocatalytic medicine. He is the recipient of over 30 international awards, has authored over 50 journal articles and book chapters in journals such as Advanced Materials, NanoToday, Nanomedicine-Future Medicine, and Science China Chemistry.

Affiliations and expertise

Research Scientist, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), China

Michael R Hamblin

Michael Hamblin was a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, and Associate Professor of Dermatology, Harvard Medical School. He is now a Visiting Professor at the University of Johannesburg, South Africa. His research interests include photodynamic therapy and photobiomodulation. He has published more than 530 peer-reviewed articles and 25 textbooks. His work has been cited more than 49k times and he is Editor-in-Chief of Photobiomodulation, Photomedicine, and Laser Surgery.

Affiliations and expertise

Professor, Laser Research Centre, University of Johannesburg, South Africa