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Organ Repair and Regeneration
Preserving Organs in the Regenerative Medicine Era
- 1st Edition - January 14, 2021
- Editors: Giuseppe Orlando, Shaf Keshavjee
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 4 5 1 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 9 4 5 2 - 2
Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intest… Read more
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Request a sales quoteOrgan Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation.
- Covers all aspects of organ preservation, repair and regeneration
- Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ
- Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine
Physicians, surgeons and PhDs in the field of organ transplantation and regenerative medicine as well as anyone interested in organ preservation techniques
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Foreword
- Preface
- Chapter 1. Ischemia-reperfusion injury
- Concepts and molecular mechanisms of ischemia reperfusion injury
- Ischemia-reperfusion injury in acute kidney injury and transplantation
- Future directions
- Chapter 2. Machine perfusion for donor organ repair: from vision to everyday clinical practice
- Strategies for donor pool expansion
- Machine perfusion and liver anatomy
- Mechanisms of preservation injury and graft protection
- Graft viability assessment
- Clinical practices of ex situ machine perfusion
- Chapter 3. Assessing and reconditioning kidneys using normothermic machine perfusion
- Introduction
- Development of NMP for renal grafts
- Perfusion solutions
- Clinical normothermic machine perfusion
- Quality assessment and conditioning
- Repair mechanisms and potential for reconditioning
- Future developments
- Conclusion
- Chapter 4. Autologous cells for renal allograft repair
- Introduction
- Cell therapy in solid organ transplantation
- The rationale and potential advantages for the use of autologous cells for transplant organ regenerative therapy
- Candidate cell types for regenerative peri-transplant therapy
- Sources of autologous regenerative cells
- Cellular makeup, properties, and mechanisms of action of adipose-derived regenerative cells
- Review of literature on the effect of systemic/organ dysfunction on fat SVR cellular composition and efficacy
- Bedside production of ADRCs
- Efficacy of ADRC's in preventing IRI/promoting tissue regeneration in kidney and other organ systems
- Adipose-derived regenerative cell model of renal regenerative therapy
- Mechanism of ADRC action in promoting renal allograft repair
- Synergistic repair with novel ex vivo perfusion technologies
- Chapter 5. Repairing organs with MSC
- Stem cell–mediated regeneration of damaged renal allografts: the hope and the reality
- Inherent regenerative potential and limitations
- The role of the immune system in regeneration
- Association of delayed graft function with chronic rejection
- Stem cells
- Source of stem cells
- The role of prolonged ex vivo perfusion platforms for tissue engineering
- Evidence supporting the potential to regenerate renal allografts
- HREC
- Potential of MSC-mediated renal regeneration
- Optimal source of MSC
- MSC-derived products
- MSC clinical trials
- Renal regeneration during ex vivo warm perfusion
- Chapter 6. Resuscitation of the pancreas: whole organ and islet cell technologies into the machine era
- Abbreviations
- Pancreas and islet cell transplantation—the need, current indications, and organ acceptance criteria
- Current methods of static preservation of the pancreas
- Defining the “marginal” pancreas
- Utilization and outcomes of pancreas and islet cell transplantation from marginal or expanded criteria donors
- Resuscitation and regeneration of the whole pancreas before transplantation
- Resuscitation and regeneration of the pancreas before islet cell transplantation
- Concluding remarks
- Chapter 7. Assessment of extended criteria liver grafts during machine perfusion. How far can we go?
- Background
- Liver function
- Animal models
- Clinical studies
- Regional perfusion
- Future considerations
- Chapter 8. RNA interference in organ transplantation: next-generation medicine?
- Abbreviations
- Introduction
- Gene silencing with RNA interference
- RNAi in organ transplantation
- Conclusions
- Chapter 9. Repairing cardiac allografts on ex situ perfusion devices
- Introduction
- Current state of heart transplantation
- MP and heart transplantation
- Standard criteria brain-dead donors
- Marginal criteria brain-dead donors
- Donation after circulatory death donors
- Future directions
- Conclusions
- Chapter 10. Repairing cardiac allografts in situ
- What is organ repair?
- How does the donor heart gets damaged?
- Why fuss about donor heart repair?
- Utilization of organs and the emerging resource of DCD hearts
- Donation after circulatory determined death
- In situ reanimation of cardiac allografts
- How do we assess function in DCD hearts?
- So, is it worth the effort? Outcomes of DCD heart transplants
- How to improve? The importance of time
- So where next? Future directions
- Chapter 11. Steatotic livers for transplantation: improving utilization of a prevalent resource through organ repair
- Introduction
- Limitations of steatotic grafts for liver transplantation
- Historic uses of steatotic livers for transplant
- Current use of machine perfusion for steatotic livers
- Future therapies for repairing steatotic livers
- Conclusion
- Chapter 12. Implementing the vision: the organ repair center
- Chapter 13. Mitochondria transplantation in organ damage and repair
- Introduction
- Technical considerations
- Conclusion
- Chapter 14. How the transplant landscape is changing in the regenerative medicine era
- Abbreviations
- A historical perspective
- Organ transplantation: a halfway technology
- Pursuit of immunosuppression-free transplantation
- RM applications in current organ transplantation
- Developing regenerative medicine technologies
- What the immediate future holds
- Index
- No. of pages: 304
- Language: English
- Edition: 1
- Published: January 14, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128194515
- eBook ISBN: 9780128194522
GO
Giuseppe Orlando
Giuseppe Orlando, MD, PhD, Marie Curie Fellow, is an Associate Professor and a kidney and pancreas transplant surgeon scientist at the Wake Forest University School of Medicine, in Winston Salem, USA. His research aims at developing platforms for the bioengineering and regeneration of transplantable organs, and at developing therapies to enhance the innate ability of the human body to repair itself after damage. His literature output aims at bridging organ transplantation to regenerative medicine.
Affiliations and expertise
Section of Transplantation, Wake Forest University Baptist Medical Center Medical Center Boulevard Winston-Salem, NC, USASK
Shaf Keshavjee
Dr. Shaf Keshavjee completed his medical training at the University of Toronto in 1985, and subsequently trained in General Surgery, Cardiac Surgery and Thoracic Surgery at the University of Toronto followed by fellowship training at Harvard University and the University of London for airway surgery and heart-lung transplantation, respectively. He currently leads a team whose studies in transplantation will have a significant impact on treatment outcomes for patients with lung disease at UHN and around the world. Dr. Keshavjee was appointed UHN’s Surgeon-in-Chief in 2010.
An integral part of the Division of Thoracic Surgery at UHN, Dr. Keshavjee has taken on leadership roles in all facets of this specialized area of care: as a skilled surgeon and Director of the Toronto Lung Transplant Program; and as a researcher and Director of the Latner Thoracic Surgery Research Laboratories. To improve lung function after transplantation, Dr. Keshavjee has developed a lung preservation solution to preserve donor lungs en route to transplant. This solution has become the standard technique used by transplantation programs around the world. Dr.Keshavjee has further attracted worldwide attention for his pioneering research to recondition and repair injured human donor lungs using a combination the Toronto XVIVO Lung Perfusion System, making them suitable for transplantation into patients and enhancing the number of donor lungs that are available.
Dr. Keshavjee has served on the Board of Directors of the International Society for Heart and Lung Transplantation, The Canadian Society of Transplantation and on the Governing Council of the American Association for Thoracic Surgery. He has received numerous awards for his continuing contributions to his field, including the George Armstrong Peters Young Investigator Award, Canada’s Top 40 Under 40Award, the Colin Woolf Award for Excellence in Continuing Medical Education and the highest award for research achievement in the Department of Surgery: the Lister Prize in Surgery.Dr. Shaf Keshavjee completed his medical training at the University of Toronto in 1985, and subsequently trained in General Surgery, Cardiac Surgery and Thoracic Surgery at the University of Toronto followed by fellowship training at Harvard University and the University of London for airway surgery and heart-lung transplantation, respectively. He currently leads a team whose studies in transplantation will have a significant impact on treatment outcomes for patients with lung disease at UHN and around the world. Dr. Keshavjee was appointed UHN’s Surgeon-in-Chief in 2010.
An integral part of the Division of Thoracic Surgery at UHN, Dr. Keshavjee has taken on leadership roles in all facets of this specialized area of care: as a skilled surgeon and Director of the Toronto Lung Transplant Program; and as a researcher and Director of the Latner Thoracic Surgery Research Laboratories. To improve lung function after transplantation, Dr. Keshavjee has developed a lung preservation solution to preserve donor lungs en route to transplant. This solution has become the standard technique used by transplantation programs around the world. Dr.Keshavjee has further attracted worldwide attention for his pioneering research to recondition and repair injured human donor lungs using a combination the Toronto XVIVO Lung Perfusion System, making them suitable for transplantation into patients and enhancing the number of donor lungs that are available.
Dr. Keshavjee has served on the Board of Directors of the International Society for Heart and Lung Transplantation, The Canadian Society of Transplantation and on the Governing Council of the American Association for Thoracic Surgery. He has received numerous awards for his continuing contributions to his field, including the George Armstrong Peters Young Investigator Award, Canada’s Top 40 Under 40Award, the Colin Woolf Award for Excellence in Continuing Medical Education and the highest award for research achievement in the Department of Surgery: the Lister Prize in Surgery.
Affiliations and expertise
Faculty of Medicine, University of Toronto, Toronto, ON CanadaRead Organ Repair and Regeneration on ScienceDirect