Oncogenic Viruses Volume 2
Medical Applications of Viral Oncology Research
- 1st Edition - September 14, 2022
- Imprint: Academic Press
- Editor: Moulay Mustapha Ennaji
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 1 5 6 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 1 6 - 5
Oncogenic Viruses: Medical Applications of Viral Oncology Research, Volume Two builds on the introductory overview of Volume One, Oncogenic Viruses: Fundamentals of Oncogenic… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteOncogenic Viruses: Medical Applications of Viral Oncology Research, Volume Two builds on the introductory overview of Volume One, Oncogenic Viruses: Fundamentals of Oncogenic Viruses. It looks at recent advances and medical application of research studies on oncoviruses, including examining oncoviruses on a molecular level, covers diagnostic and prognostic viral biomarkers and identifying biomarkers in specific human cancers, and delves into prevention, treatment and the future of cancer therapy of oncoviruses, antiviral activities and vaccination strategies. Advanced topics and the future direction of oncovirology round out the book.
This book is a comprehensive reference for researchers and practitioners engaged in learning more about the role of oncogenic viruses in the pathogenesis of human cancers and how that information can be applied to identify strategies for prevention and treatment.
- Explores the biology of oncoviruses and mechanisms of action on a cellular level
- Examines recent advances in oncoviruses prevention and curative treatments
- Discusses the use of modeling and bioinformatics in research studies on oncoviruses
Experts in the role of oncoviruses in tumorgenesis mechanisms; specialized researchers in viruses and human tumors; researchers in the molecular biology of cancer; researchers of fundamental virology studies; lecturers of virology, cancer in medicine, and microbiology
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface—Oncogenic Viruses: Up To Recent Knowledge
- Acknowledgments
- Chapter 1. Vitamin D new therapy for breast cancer prevention
- Abstract
- 1.1 Introduction
- 1.2 Breast cancer
- 1.3 Viral etiology of breast cancer
- 1.4 Mouse mammary tumor virus like
- 1.5 Human papilloma virus
- 1.6 Epstein–Barr virus
- 1.7 Vitamin D
- 1.8 Food needs and sources
- 1.9 Storage sites
- 1.10 Vitamin D receptors
- 1.11 Vitamin D new therapy for breast cancers prevention
- 1.12 Mechanism of action
- 1.13 Vitamin D and breast cancer prevention
- 1.14 Conclusion
- References
- Chapter 2. Molecular diagnosis of human papillomavirus related to cervical cancer
- Abstract
- 2.1 Introduction
- 2.2 Etiopathogenesis of human papillomavirus infection
- 2.3 Diagnosis of human papillomavirus viral genome
- 2.4 Conclusion
- Acknowledgment
- References
- Chapter 3. Risk of the development of cancers induced by the consumption of mussels accumulating metallic trace elements
- Abstract
- 3.1 Introduction
- 3.2 Trace metal elements
- 3.3 Bivalve molluscs
- 3.4 Oxidative stress and cancer
- 3.5 Conclusion
- Acknowledgments
- References
- Chapter 4. Oncolytic virus cancer therapeutic options and integration of artificial intelligence into virus cancer research
- Abstract
- 4.1 Introduction
- 4.2 History
- 4.3 General properties of oncovirus
- 4.4 Oncolytic viral therapy: a new era of treatment
- 4.5 Applications of oncolytic viral therapy
- 4.6 Limitations
- 4.7 Integration of artificial intelligence or machine learning into cancer research
- 4.8 Future concerns
- 4.9 Conclusion
- Acknowledgment
- References
- Chapter 5. Oncoviruses: future prospects of molecular mechanisms and therapeutic strategies
- Abstract
- 5.1 Introduction
- 5.2 Mechanism of oncovirus
- 5.3 Types and mechanism of oncoviruses
- 5.4 Genetics of virus
- 5.5 Types of treatment
- 5.6 Stem cell transplant therapy
- 5.7 Future of oncotherapy
- 5.8 Conclusion
- Acknowledgment
- References
- Chapter 6. Multi-omics methods and tools in dissecting the oncovirus behavior in human host
- Abstract
- 6.1 Introduction
- 6.2 Types of omics
- 6.3 Conclusions
- References
- Chapter 7. Role of viral human oncogenesis: recent developments in molecular approaches
- Abstract
- 7.1 Introduction
- 7.2 Prevalence of oncovirus
- 7.3 Classification of oncovirus
- 7.4 Molecular tools used for oncovirus detection
- 7.5 Vaccines available for oncovirus
- 7.6 Statistical analysis of oncovirus
- 7.7 Oncovirus and cancer progression
- 7.8 Oncolytic virotherapy
- 7.9 Conclusion
- Acknowledgment
- References
- Chapter 8. Strategies for the development of hepatitis B virus vaccines
- Abstract
- 8.1 Introduction
- 8.2 Virus-like particle-based hepatitis B vaccines
- 8.3 Therapeutic vaccines
- 8.4 DNA-based vaccines
- 8.5 mRNA-based vaccines
- 8.6 Proteins/peptides vaccines
- 8.7 Cell-based vaccines
- 8.8 Nanovaccines
- 8.9 Efficacy of therapeutic vaccines
- 8.10 Harmlessness
- 8.11 Immunization coverage
- 8.12 Conclusion
- References
- Chapter 9. MYC oncogenes as potential anticancer targets
- Abstract
- 9.1 Introduction
- 9.2 Biological role of MYC genes
- 9.3 MYC in normal tissues and cancer
- 9.4 MYC signal transduction pathway
- 9.5 Structure of MYC
- 9.6 The MYC–Max interaction
- 9.7 MYC as a potential target for antitumor therapy
- 9.8 Targeting the MYC–Max interaction with small molecule inhibitors
- 9.9 Indirect targeting of the MYC
- 9.10 Targeting MYC transcription
- 9.11 Targeting of MYC expression
- 9.12 Targeting MYC stability
- 9.13 Synthetic lethality with MYC
- 9.14 G-quadruplexes and expression of c-MYC
- 9.15 Conclusions and perspective
- Acknowledgments
- References
- Chapter 10. Current status of viral biomarkers for oncogenic viruses
- Abstract
- 10.1 Introduction
- 10.2 Epstein-Barr virus
- 10.3 Hepatitis B virus and hepatitis C virus
- 10.4 Human T-cell lymphotropic virus-1
- 10.5 Human Herpesvirus-8
- 10.6 Human papillomavirus
- 10.7 Conclusions
- References
- Chapter 11. Bioinformatics serving oncoviral studies
- Abstract
- 11.1 Biological database
- 11.2 Sequence analysis
- 11.3 Molecular dynamics simulations
- 11.4 Computer-aided drug discovery
- 11.5 Systems biology approach
- 11.6 Artificial intelligence approaches
- 11.7 Conclusion
- References
- Chapter 12. QSAR approach for combating cancer cells
- Abstract
- 12.1 Introduction
- 12.2 Handling and curation of chemical and biological data
- 12.3 Structures drawing and database building
- 12.4 Molecular descriptors
- 12.5 Multivariate analysis
- 12.6 Multiple linear regression analysis
- 12.7 Principal component regression
- 12.8 Partial least squares
- 12.9 Kernel partial least squares
- 12.10 Artificial neural network
- 12.11 Other methods
- 12.12 Classification-based QSAR approaches
- 12.13 QSAR model generation
- 12.14 Model examination and validation
- 12.15 Internal validation
- 12.16 External validation
- 12.17 Applicability domain
- 12.18 Model application for the prediction of compounds activity
- References
- Chapter 13. Human papillomaviruses and their carcinogens effect
- Abstract
- 13.1 Introduction
- 13.2 Epidemiology of human papillomaviruse
- 13.3 Human papillomaviruse classification
- 13.4 Human papillomavirus transmission
- 13.5 Structure, genomic organization, and viral proteins
- 13.6 Human papillomavirus replication cycle
- 13.7 Infection evolution
- 13.8 Molecular mechanisms of HPV-induced carcinogenesis
- 13.9 Mechanisms of cell transformation
- 13.10 Conclusion
- Acknowledgments
- References
- Chapter 14. Progress in the development of vaccines against human papillomavirus
- Abstract
- 14.1 Introduction
- 14.2 Virus-like particle vaccination strategy
- 14.3 Vaccines prophylactic against human papillomavirus
- 14.4 Immunization procedures and doses
- 14.5 Efficacy and safety of human papillomavirus vaccines
- 14.6 L2-based human papillomavirus prophylactic vaccines
- 14.7 Human papillomavirus vaccine coverage
- 14.8 Factors influencing vaccination coverage
- 14.9 Therapeutic vaccines
- 14.10 Conclusion
- References
- Chapter 15. Development and characterization of an electrochemical sensor using molecularly imprinted polymer based on a gold screen-printed electrode for the detection of creatinine and glucose in human urine and saliva
- Abstract
- 15.1 Introduction
- 15.2 Urine and saliva as noninvasive sources of biomarkers
- 15.3 Biomarkers in the bloodstream can infiltrate the acini and eventually be secreted into the saliva
- 15.4 Current electrochemical sensor devices
- 15.5 Applications of gas sensors in oncology or virology as tools for the detection of biomarkers
- 15.6 Experimental
- 15.7 Results and discussion
- 15.8 Conclusion
- Acknowledgments
- Declaration of competing interest
- References
- Chapter 16. Detection of triclosan and sodium lauryl sulfate in environmental samples and cosmetic product by electrochemical sensor based on biomimetic recognition combined with electronic nose
- Abstract
- 16.1 Introduction
- 16.2 Experimental
- 16.3 Results and discussion
- 16.4 Conclusion
- Acknowledgments
- Declaration of competing interest
- Appendix A
- References
- Index
- Edition: 1
- Published: September 14, 2022
- Imprint: Academic Press
- No. of pages: 414
- Language: English
- Paperback ISBN: 9780128241561
- eBook ISBN: 9780323859165
ME
Moulay Mustapha Ennaji
Dr. Moulay Mustapha Ennaji, Professor in Virology and Oncology at the University of Casablanca and Director of the Quality and Medical Biotechnologies Team at Laboratory of Virology Microbiology, Hassan II University Mohammedia of Casablanca, Morocco He is currently a Professor in Virology and Oncology at the University of Casablanca, and since 2010, he has been the Director of the Quality and Medical Biotechnologies Team at the Laboratory of Virology Microbiology, Quality, Biotechnologies. He received a MSc in 1986 and a PhD in virology in 1993 from Armand Frappier Institute, University of Quebec (Canada). He has published dozens of journals articles and is an editorial board member of the journal, Infectious Agents and Cancer. Throughout his career, Dr. Ennaji has been rewarded several awards. At present, he is the vice president of the three Moroccan societies of Biosafety, Cancer, and Microbiology.
Affiliations and expertise
Professor, Virology and Oncology, University of Casablanca, Morocco; Director, Quality and Medical Biotechnologies Team, Laboratory of Virology Microbiology, Quality, Biotechnologies/Eco-Toxicology and Biodiversity; Faculty, Sciences and Techniques, Hassan II University Mohammedia of Casablanca, MoroccoRead Oncogenic Viruses Volume 2 on ScienceDirect