Oncogenic Viruses Volume 1

Fundamentals of Oncoviruses

1st Edition - September 14, 2022
Editor: Moulay Mustapha Ennaji
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 1 5 2 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 1 3 - 4

Oncogenic Viruses: Fundamentals of Oncoviruses provides an overview of the history of human oncoviruses, how to discover and define an oncovirus, how viruses cause cancer in genera… Read more

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Oncogenic Viruses: Fundamentals of Oncoviruses provides an overview of the history of human oncoviruses, how to discover and define an oncovirus, how viruses cause cancer in general, their oncogenic mechanisms and epidemiology, and the cancer biology of oncoviruses. The book is organized into five main parts that include history and discovery of virus-tumor complications, taxonomy and classification of oncoviruses, oncoviruses around the world, including epidemiology statistics and current methods. Finally, the book looks at the molecular epidemiology of DNA and RNA viruses and their role in the pathogenesis of human cancers.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editor
Preface
Acknowledgments
Chapter 1. General introduction oncogenic viruses: recent knowledge
Abstract
References
Chapter 2. Hepatocellular carcinoma associated with hepatitis B virus and environmental factors
Abstract
2.1 Introduction
2.2 Hepatocellular carcinoma
2.3 Anatomopathological characteristics
2.4 Nature and history of liver carcinogenesis
2.5 Molecular mechanism of hepatocarcinogenesis
2.6 Hepatitis B virus
2.7 Virological data
2.8 Natural history of hepatitis B virus infection
2.9 Antiviral treatment for hepatitis B
2.10 Hepatocellular carcinoma associated with hepatitis B virus
2.11 The link between hepatitis B virus and hepatic tumorigenesis
2.12 Molecular mechanisms of hepatocarcinogenesis induced by hepatitis B virus
2.13 Hepatocellular carcinoma associated with environmental factors
2.14 Metabolic and environmental risk factors
2.15 Nutritional risk factors for hepatocellular carcinoma
2.16 Prevention of risk factors
2.17 Synergy between hepatitis B virus and environmental factors in the etiology of hepatocellular carcinoma
2.18 Conclusion
Acknowledgments
References
Chapter 3. General principals and mechanisms of viral oncogenic and associated cancers (cytomegalovirus, papillomaviruses, and RNA oncogenic virus)
Abstract
3.1 Introduction
3.2 General information on oncogenic viruses:cytomegalovirus, papillomaviruses, and RNA oncogenic virus
3.3 Conclusion
Acknowledgments
References
Chapter 4. Infection of HPV and MMTV oncovirus in breast cancer tissues in women
Abstract
4.1 Introduction
4.2 Infection with human papillomavirus
4.3 Mouse mammary tumor virus infection
4.4 Discussion
4.5 Conclusion
References
Further reading
Chapter 5. MicroRNAs associated with Helicobacter pylori and Epstein-Barr virus infections in gastric cancer
Abstract
5.1 Introduction
5.2 Discovery and origin of microRNAs
5.3 Biogenesis of microRNAs
5.4 MicroRNAs in gastric cancer
5.5 Conclusion
References
Chapter 6. Breast cancer: epidemiology and viral ethology associated with human papillomavirus and mouse mammary tumor virus
Abstract
6.1 Introduction
6.2 Breast cancer epidemiology
6.3 Risk factors for breast cancer
6.4 Human papillomaviruses and mouse mammary tumor virus in breast cancer
6.5 Conclusion
References
Chapter 7. Human papillomavirus infections and cervical cancer
Abstract
7.1 Virology of human papillomavirus
7.2 Molecular architecture of human papillomavirus and features of viral pro-oncogenes and oncoproteins
7.3 Infection cell cycle and replication
7.4 Transmission mode and risk factors
7.5 Pathophysiology, evolution, and natural history of human papillomavirus infection
7.6 Cervical cancer: a preventable disease
References
Chapter 8. Covid-19 and cancer: impact on diagnosis, care and therapy
Abstract
8.1 Introduction
8.2 Coronavirus disease
8.3 Factors affecting the pathogenesis of the virus
8.4 The impact of the COVID-19 pandemic on cancer care
8.5 The different types of anti-SARS-CoV-2 vaccine
8.6 SARS-CoV-2 vaccines in cancer patients
8.7 Conclusion
Acknowledgments
References
Chapter 9. The role of DNA oncoviruses and its association with human cancer
Abstract
9.1 Introduction
9.2 History, discovery, and types
9.3 Epidemiology
9.4 Viral proteins involved
9.5 General mechanism by which oncovirus induces cancer in DNA
9.6 Mechanism of action for each oncoviruses
9.7 Genome and structure of viruses
9.8 Cancers associated with DNA oncoviruses
9.9 Therapeutic options for DNA oncoviruses
9.10 Conclusion
Acknowledgment
References
Chapter 10. RNA oncoviruses and their association with cancer implications
Abstract
10.1 Introduction
10.2 Oncoviruses and their variants
10.3 Timeline of oncoviruses
10.4 Endogenous and exogenous retroviruses
10.5 Viral carcinogenesis
10.6 Reverse transcription and recognition of proto-oncogenes
10.7 Human T cell lymphotropic virus 1
10.8 Hepatitis C virus
10.9 Human immunodeficiency virus
10.10 Conclusion
Abbreviation
Acknowledgment
References
Chapter 11. Evolution of viruses: tumor complications
Abstract
11.1 Introduction
11.2 Oncovirus and its prevalence
11.3 Epidemiology
11.4 Discovery of oncovirus and its timeline
11.5 Mechanism of oncovirus
11.6 Classification of oncoviruses
11.7 Genes associated with oncogenes and virus tumor complications
11.8 Causes and prevention
11.9 Therapies and treatment
11.10 Conclusion
Acknowledgment
References
Chapter 12. HPV oncovirus: molecular biology and mechanism of action
Abstract
12.1 Introduction
12.2 Recent progress
12.3 Discussion
References
Chapter 13. Oncogenic viruses and mechanism of oncogenesis: study of oncogenic characteristics of HTLV-1 and HHV-8 viruses
Abstract
13.1 Introduction
13.2 Molecular aspects of human herpesvirus 8 and associated tumors
13.3 Molecular aspects of human T-lymphotropic virus type 1 and associated tumors
13.4 Conclusion
References
Chapter 14. Hepatitis C virus and hepatocellular carcinoma
Abstract
14.1 Introduction
14.2 The drug target of hepatitis C virus
14.3 Progression from hepatitis C virus to hepatocellular carcinoma
14.4 Hepatocellular carcinoma
14.5 Drugs and drug targets in hepatocellular carcinoma
14.6 Diagnosis of hepatitis C virus
14.7 Tests for liver damage
14.8 Conclusion
References
Chapter 15. Prostate cancer and viral infections: epidemiological and clinical indications
Abstract
15.1 Introduction
15.2 Prostate cancer: clinical aspects
15.3 Viral Infections as a risk factor for prostate cancer
References
Chapter 16. Oncogenic human virus associated with prostate cancer: molecular epidemiology of Human Papillomavirus and Epstein-Barr virus
Abstract
16.1 Introduction
16.2 Conclusion
References
Chapter 17. Epidemiology of gynecological and mammary cancers in Africa: viral etiology and risk factors
Abstract
17.1 Introduction
17.2 Generalities about cancer
17.3 Epidemiology of gynecomammary cancers in Africa
17.4 Overview of the molecular oncogenesis of gynecomammary cancer
17.5 Oncoviruses associated with gynecomammary cancer
Acknowledgments
References
Chapter 18. Involvement of BK polyomavirus in genitourinary cancers
Abstract
18.1 Introduction
18.2 The Polyomaviridae family
18.3 BK polyomavirus
18.4 Involvement of BK in genitourinary cancer
18.5 The kidney
18.6 Conclusion
Acknowledgments
References
Chapter 19. Kidney cancer associated with Epstein-Barr virus
Abstract
19.1 Introduction
19.2 Epstein-Barr virus
19.3 The association between kidney cancer and Epstein-Barr virus
19.4 Conclusion
Acknowledgments
References
Further reading
Chapter 20. The involvement of human papillomavirus in breast cancer in general and the different prognostic biomarkers in triple-negative breast cancer
Abstract
20.1 Introduction
20.2 Anatomy of the mammary gland
20.3 Epidemiology
20.4 Human papillomavirus
20.5 Triple-negative breast cancer
20.6 Conclusion
Acknowledgments
References
Chapter 21. Hypermethylation of tumor suppressor genes associated with Helicobacter pylori and Epstein–Barr virus infections in gastric cancer
Abstract
21.1 Introduction
21.2 DNA methylation in gastric carcinogenesis
21.3 Helicobacter pylori and Epstein–Barr virus inducing aberrant methylation in the promoter of tumor suppressor genes
21.4 Helicobacter pylori coinfection with Epstein–Barr virus inducing aberrant methylation
21.5 Conclusion
References
Chapter 22. Etiology of human papillomavirus in cervical cancer and infection mechanism
Abstract
22.1 Introduction
22.2 Human papillomavirus cervical cancer risk factors
22.3 Viral etiology of cervical cancer
22.4 Biology of papillomavirus
22.5 Interaction between E6 and p53 in the cancer pathway
22.6 Consequences of the E6 and p53 interaction
22.7 Interaction between E7 and pRb in the cancer pathway
22.8 Assessment of the joint action of oncoproteins E6 and E7
22.9 Vaccination is a way to fight against cervical cancer
22.10 Conclusion
References
Chapter 23. In vivo gene therapy with p53 or p21 adenovirus for prostate cancer
Abstract
23.1 Introduction
23.2 Protein P53
23.3 Cell cycle arrest
23.4 Protein P21
23.5 Adenovirus
23.6 In vivo gene therapy with P53 or P21 adenovirus for prostate cancer
23.7 Conclusion
References
Index

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health