Nutrition in the Control of Inflammation

Emerging Roles for the Microbiome and Epigenome

1st Edition - November 22, 2024
Editors: Bradley S. Ferguson, Steven Frese
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 7 9 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 8 0 - 7

Nutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome is a comprehensive guide that delves into the intricate relationship between diet and… Read more

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Nutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome is a comprehensive guide that delves into the intricate relationship between diet and inflammation to regulate inflammatory diseases. Divided into five insightful sections, this book provides an introduction to the microbiome and epigenome in nutrition, exploring the impact of diet, lifestyle, and the microbiome on the development of inflammatory diseases. With a focus on nutrition and the epigenome in metabolic and cardiovascular diseases, the chapters tackle crucial topics such as histone modifications, DNA methylation, and non-coding RNAs in disease progression. Addressing health disparities in diet, epigenetics, and gut microbes, this book is a valuable resource for nutrition researchers, nutritionists, postgraduate students, and professionals in related fields. From the multifactorial microbial networks shaping aging to practical applications for diet and lifestyle improvements, this book offers practical insights for enhancing microbial and epigenetic health.

Title of Book
Cover image
Title page
Table of Contents
Copyright
List of contributors
Section 1: Introduction
Chapter 1. Introduction: nutrition, the microbiome, and the epigenome in human health and disease
Abstract
Outline
1.1 Introduction
1.2 Epigenetics and inflammatory diseases
1.3 Microbiome and inflammatory diseases
1.4 The cross-section of the microbiome-epigenome axis in inflammation
1.5 Conclusion
References
Section 2: Diet, lifestyle and the microbiome in development and inflammatory diseases
Chapter 2. Multifactorial microbial networks shape aging and neurodegeneration
Abstract
Outline
2.1 Introduction
2.2 Microbiome changes with healthy aging
2.3 Microbiome-based treatments to rejuvenate the aging gut
2.4 The microbiome in Alzheimer’s disease
2.5 Nicotinamide adenine dinucleotide+ as a microbiome-associated regulator of aging
2.6 Epigenetics and microbial regulation in aging and neurodegeneration
2.7 Conclusions
Acknowledgments
References
Chapter 3. The microbiome in infant gut health and development
Abstract
outline
3.1 Introduction
3.2 Origin, dynamics and stabilization of the human gut microbiome
3.3 Factors affecting infant’s gut microbiome
3.4 Importance of the gut microbiome and immune system in early life
3.5 Reshaping the gut microbiome to improve health
3.6 Conclusions
References
Chapter 4. Fiber and the gut microbiome and its impact on inflammation
Abstract
Outline
4.1 Introduction
4.2 Gut microbiota in health and diseases
4.3 Prebiotics and dietary fibers
4.4 Fibers, metabolites and impacts on inflammation
4.5 Conclusion and future remarks
References
Chapter 5. Diet-specific impacts on the gut microbiome and their relation to health and inflammation
Abstract
Outline
5.1 Introduction
5.2 The intestinal microbiome in health and disease
5.3 Interaction between diet, microbiome, and inflammatory bowel diseases
5.4 Carbohydrates
5.5 Fiber
5.6 Fats
5.7 Nutritional approaches for the treatment of inflammatory bowel disease
5.8 Additional nutritional therapies in inflammatory bowel disease
5.9 Conclusion
References
Chapter 6. Hypertension, obesity, and the microbiome in cardiovascular disease
Abstract
Outline
6.1 Introduction
6.2 Metabolic pathways: mechanisms of gut microbiome function in the host at the molecular level
6.3 Trimethylamine N-oxide
6.4 Short-chain fatty acids
6.5 Bile acids
6.6 Lipopolysaccharides
6.7 Phenylacetylglutamine
6.8 Gut microbiota and hypertension
6.9 Gut microbiome and atherosclerotic cardiovascular disease
6.10 The intersection between aging and gut microbiota
6.11 Aging, inflammation, and gut microbiota
6.12 Aging, gut permeability, and immune function
6.13 Modulation of gut microbiota as a therapeutic strategy
6.14 Dietary strategies: probiotics, prebiotics, and other strategies
6.15 Dietary strategies: different dietary patterns and gut microbiota modulation
6.16 Very low carbohydrate ketogenic diet
6.17 High protein-low carbohydrate diet
6.18 Vegetarian diets
6.19 Other strategies to modulate gut microbiota
6.20 Conclusions
References
Section 3: Nutrition and the epigenome in metabolic and cardiovascular diseases
Chapter 7. Obesity, histone acetylation, and insulin resistance
Abstract
Outline
7.1 Introduction
7.2 Concluding remarks
Acknowledgments
References
Chapter 8. Diet, histone modifications and cardiovascular diseases
Abstract
outline
8.1 Introduction
8.2 Obesity, inflammation and cardiovascular diseases
8.3 Histone modifications
8.4 Fiber and cardiovascular health
8.5 Phytochemicals, inflammation and cardiovascular disease
8.6 Summary
References
Chapter 9. Diet, DNA methylation, and cardiovascular disease
Abstract
OUTLINE
9.1 Introduction
9.2 Methyl nutrients, DNA methylation, and cardiovascular disease
9.3 Diet quality and DNA methylation and cardiovascular diseases
9.4 Epigenetic signatures of diet and lifestyle habits for cardiovascular disease
9.5 DNA methylation and cardiovascular disease
9.6 Considerations for statistical modeling of DNA methylation data
9.7 Dietary intervention to change epigenetic status to prevent cardiovascular disease risk
9.8 Future perspectives
References
Chapter 10. Obesity and noncoding RNAs in epigenetic inheritance of metabolic disease
Abstract
Outline
10.1 Introduction
10.2 Obesity
10.3 Epigenetic inheritance and noncoding RNAs
10.4 MircoRNAs, inflammation, and obesity/obesity-related metabolic diseases
10.5 Long noncoding RNAs
10.6 Conclusion and further perspective
Abbreviations
References
Chapter 11. Caloric restriction in the epigenetic regulation of aging and longevity
Abstract
Outline
11.1 Introduction
11.2 Variations in caloric restriction
11.3 Calorie restriction
11.4 Alternate-day fasting
11.5 Time restricted eating
11.6 Dietary restriction and aging/healthspan
11.7 Caloric restriction and aging/healthspan
11.8 Alternate-day fasting and aging/heathspan
11.9 Time-restricted eating and aging/healthspan
11.10 Caloric restriction and epigenetics
11.11 Caloric restriction and DNA methylation
11.12 Caloric restriction and histone acetylation/deacetylation
11.13 Caloric restriction and microRNAs
11.14 Alternate-day fasting, time-restricted eating, and epigenetics
11.15 Alternate-day fasting, time-restricted eating, histone methylation, and DNA methylation
11.16 Alternate-day fasting, time-restricted eating, and histone acetylation
11.17 Alternate-day fasting, time-restricted eating, and microRNAs
11.18 Conclusion
References
Section 4: Diet, epigenetics, and the microbiome in inflammatory disease
Chapter 12. Gut microbiome, epigenetics, and neuro-inflammatory disease
Abstract
Outline
12.1 Introduction
12.2 The gut-brain axis, inflammation, and neuroinflammation
12.3 Microbiome–gut–brain communication
12.4 Neuroinflammation
12.5 Microbial alterations in neuropathology
12.6 Human microbiome and epigenetic studies
12.7 Nutritional interventions for neuroinflammation
12.8 Therapeutic Interventions
12.9 Generalizability of microbiome research findings
References
Chapter 13. Obesity, gut bacteria, and the epigenetic control of metabolic disease
Abstract
OUTLINE
13.1 Introduction
13.2 Gut microbiota
13.3 Gut microbiota, obesity, and metabolic disorders
13.4 Environmental factors that affect gut microbiota in obesity and cardiometabolic diseases
13.5 Exploring mechanisms: the potential underlying mechanism on how gut microbiota may influence the etiology of obesity and cardiometabolic diseases
13.6 Conclusions
References
Chapter 14. Dietary impact on the gut microbiome and epigenome and regulation of gut inflammation
Abstract
Outline
14.1 Introduction
14.2 Dietary impact on the gut microbiome and host epigenetics
14.3 Diet, epigenetics, and gut inflammation
14.4 Conclusion
References
Section 5: Conclusions: practical applications for diet in inflammation
Chapter 15. Practical applications for diet and lifestyle to improve microbial and epigenetic health
Abstract
OUTLINE
15.1 Introduction
15.2 Microbial and epigenetic health
15.3 Dietary strategies for improving microbial health
15.4 Dietary strategies for improving epigenetic health
15.5 Lifestyle strategies for improving microbial and epigenetic health
15.6 Conclusion
References
Index

Bradley S. Ferguson

Bradley S. Ferguson is an Associate Professor of Nutrition at the University of Nevada, Reno, Nevada. His lab adopts integrative, translational research approaches that encompass bioinformatics, in vitro cell culture, and in vivo animal models to elucidate dietary food components that act as epigenetic modifiers, as well as the role of dietary epigenetic modifiers on pathological cardiac signaling, gene expression, and remodeling. He also seeks to understand how sarcomere protein acetylation links metabolic disease (obesity and diabetes) to pathological cardiac remodeling and skeletal muscle dysfunction. Dr. Ferguson has published his findings across a wide range of peer-reviewed journals, including Scientific Reports, Journal of Animal Science, American Journal of Physiology, Cell Reports, PNAS, and the Journal of Molecular and Cellular Cardiology.

Affiliations and expertise

Department of Nutrition, University of Nevada, Reno, NV, United States; Center of Biomedical Research Excellence for Molecular and Signal Transduction in the Cardiovascular System, University of Nevada, Reno, NV, United States

Steven Frese

Steven Frese is an Assistant Professor of Nutrition at the University of Nevada, Reno, Nevada and holds an appointment as an Adjunct Assistant Professor at the Department of Food Science and Technology at the University of Nebraska, Lincoln. His research applies principles of microbial ecology and evolutionary biology to develop rational interventions to improve human health via the gut microbiome. This includes applying advanced techniques including bioinformatics, DNA/RNA sequencing, and mass spectrometry to determine strain- and ecosystem-level interactions both in vitro and in human clinical trials. His work has primarily focused on the gut microbiome in early life, and the role of diet and the microbiome in shaping infant health and development. Dr. Frese’s work has been published in a variety of broad interest peer-reviewed journals including Cell, Science Translational Medicine, Cell Host & Microbe, and PLoS Genetics, as well as audience-specific journals including Pediatric Research, Glycobiology, and Bioinformatics.

Affiliations and expertise

Assistant Professor, Department of Nutrition, University of Nevada, Reno, NV, United States; University of Nevada, Reno School of Medicine, Reno, NV United States

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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