Nutraceutical Fruits and Foods for Neurodegenerative Disorders

1st Edition - November 21, 2023
Editors: Raj K. Keservani, Rajesh K. Kesharwani, Mila Emerald, Anil K. Sharma
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 5 1 - 7
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 9 5 2 - 4

Nutraceutical Fruits and Foods for Neurodegenerative Disorders presents food-based strategies, specifically related to nutraceuticals, in delaying the onset and slowing down of the… Read more

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Nutraceutical Fruits and Foods for Neurodegenerative Disorders presents food-based strategies, specifically related to nutraceuticals, in delaying the onset and slowing down of the propensity of neuronal devastation. In addition to highlighting the positive effects of nutraceutical fruits and foods on brain health, the book also explores the medicinal properties of fruits, vegetables, berries and nutraceuticals, along with their contribution to environmental factors, potential hazards and the need for specific regulatory actions. This book will be a welcomed reference for nutrition researchers, dieticians, nutritionists and academicians studying related fields.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Role of fruit and food components in brain cognition
Abstract
1.1 Introduction
1.2 Brain food and its components
1.3 The role of micronutrients in the brain
1.4 Conclusion
Acknowledgment
Conflict of interest
References
Chapter 2. Nutraceutical fruits and foods: local wisdoms in Indochina
Abstract
2.1 Introduction
2.2 Nutraceuticals in neurological disorder
2.3 Complementary and alternative medicine and nutraceutical fruits and foods
2.4 Local wisdom on nutraceutical fruits and foods
2.5 Health-care local wisdom in Indochina
2.6 Conclusion
References
Chapter 3. Functional food for mitochondrial dysfunction and autophagy in neurodegenerative diseases
Abstract
3.1 Introduction
3.2 Neurodegenerative disease
3.3 Normal mitochondrial function
3.4 Evidence for mitochondrial dysfunction in neurodegenerative disease
3.5 Functional food
3.6 Conclusion
References
Chapter 4. Fruits and foods to improve kids brain health
Abstract
4.1 Introduction
4.2 Neurodegenerative disease related to kid's brain health
4.3 Types of neurodegenerative disorders
4.4 Nutraceuticals for kid's brain health
4.5 Conclusion
References
Further Reading
Chapter 5. Memory-boosting fruits and foods for elderly
Abstract
5.1 Introduction
5.2 Indian medicine system
5.3 Traditional Chinese medicine system
5.4 Traditional Iranian medicine system
5.5 Herbal drugs used in memory enhancement
5.6 Conclusion
Conflict of interest
References
Chapter 6. Role of functional foods and nutraceuticals for depression, post-traumatic stress disorder, and suicidal behaviors
Abstract
6.1 Introduction
6.2 Mental disorders
6.3 Types of mental disorders
6.4 Mechanisms of mental disorders induction
6.5 Antidepressants and their mode of actions
6.6 Post-traumatic stress disorder and their mode of action
6.7 Suicidal behaviors and their mode of action
6.8 Side effects of existing drugs
6.9 Role of the brain-gut-microbiota axis in mental disorders
6.10 Classification of nutraceuticals
6.11 Other commonly found nutraceuticals
6.12 Nutraceuticals for the management of mental disorders
6.13 Side effects of nutraceutical supplementation
6.14 New treatment regimen: nutraceuticals as gut microbiota modulators
6.15 Conclusion
References
Chapter 7. Nutraceuticals for prevention and management of anxiety
Abstract
7.1 Introduction
7.2 Nutraceuticals: role in anxiety and depression
7.3 Herbal based medicines for prevention of anxiety and stress
7.4 Medicinal plants as an anxiolytic agent
7.5 Nutritional supplements
7.6 Omega 3 adenosyl-methionine
7.7 Conclusions and future directions
Acknowledgments
Conflict of interest
References
Chapter 8. Importance of functional foods in the management of autism
Abstract
8.1 Introduction
8.2 Diet and the development of autism spectrum disorder
8.3 Treatment for autism spectrum disorder
8.4 The gluten-free and casein-free diet
8.5 Conclusion
Conflict of interest
References
Further reading
Chapter 9. Role of probiotics in brain health
Abstract
9.1 Introduction
9.2 Probiotics
9.3 Probiotics and brain health
9.4 Role of probiotics on major neurological diseases
9.5 Conclusion
List of abbreviations
Author contributions
Acknowledgments
References
Chapter 10. Nutraceutical’s potentials in neurodegenerative disease
Abstract
10.1 Introduction
10.2 Neurodegenerative disease
10.3 Mechanism of neurotoxicity
10.4 Nutraceuticals in neurodegenerative disease
10.5 Role of various nutraceuticals in neurodegenerative diseases
10.6 Conclusion and future perspectives
References
Chapter 11. Neuroprotective effect of dietary polyphenols
Abstract
11.1 Introduction
11.2 Classes of polyphenols
11.3 Signaling pathways
11.4 Future prospects
11.5 Conclusion
References
Chapter 12. Herbal nutraceuticals in health and neurodegenerative diseases
Abstract
12.1 Herbal nutraceuticals and brain function in health and neurodegenerative diseases
12.2 Herbal nutraceutical
12.3 Chief constituents of herbal extract
12.4 The chief component of herbal nutraceutical and neurodegenerative diseases, any link?
12.5 Conclusion
References
Chapter 13. Effect of nutrients on brain function
Abstract
13.1 Introduction
13.2 Nutrition’s influence on brain function
13.3 Food calories and mental performance
13.4 Antioxidant foods
13.5 Epigenetics and diet
13.6 Future prospects
13.7 Conclusion
Acknowledgement
Conflict of interest
References
Chapter 14. Effect of plant-based diets on the brain
Abstract
14.1 Introduction
14.2 Neurodegenerative disorders
14.3 Types of neurodegenerative and cardiovascular disorders
14.4 Nutraceutical products: a promising medication source for neurodegenerative diseases
14.5 Conclusion
References
Further reading
Chapter 15. Role of dietary fibers in the management of hypertension and its association with neurodegeneration
Abstract
15.1 Introduction
15.2 Mechanisms of development of neurodegenerative diseases
15.3 Hypertension
15.4 Types of hypertensions
15.5 Secondary hypertension
15.6 Some other types of hypertension
15.7 Resistant hypertension
15.8 Malignant hypertension
15.9 Isolated systolic hypertension
15.10 Hypertension and neurodegeneration
15.11 Dietary fiber
15.12 Applications
15.13 Dietary fibers used in management of hypertension
15.14 Risk factors and prevention of hypertension
15.15 Modifiable risk factors for hypertension
15.16 Role of dietary fiber in the management of hypertension
15.17 Conclusion
References
Chapter 16. Potentials of berries and pomegranate in management of the neurodegenerative disorders
Abstract
16.1 Introduction
16.2 Constituents of pomegranate and berries
16.3 Role of berries and pomegranate in neurodegenerative disorders
16.4 Effect of pomegranate on Parkinson's disease
16.5 Athero-preventive effects of blueberries
16.6 Influencing gut microbiota
16.7 Multiple sclerosis
16.8 EPILEPSY
16.9 Neurobehavioral abnormalities
16.10 Conclusion
References
Chapter 17. Effect of green tea on human brain health
Abstract
17.1 Introduction
17.2 Chemical constituents
17.3 Green tea effects on neurodegenerative diseases
17.4 Neuroprotective action of green tea
17.5 Commercial and clinical perspective
17.6 Future perspective
17.7 Conclusion
References
Chapter 18. Role of garlic and onion for better cognition and maintenance of neurodegenerative diseases
Abstract
18.1 Introduction
18.2 Neurodegeneration
18.3 Phytochemical constituents present in garlic
18.4 Pathophysiology and pharmacology
18.5 Toxicological studies
18.6 Onion and its phytoconstituents
18.7 Conclusion
References
Chapter 19. Role of antioxidants in neutralizing oxidative stress
Abstract
19.1 Introduction
19.2 Oxidants
19.3 Reactive oxygen species
19.4 Reactive nitrogen species
19.5 Generation of free radicals
19.6 Endogenous sources of oxidants
19.7 Exogenous source of oxidants
19.8 Exercises
19.9 Cigarette smoke
19.10 Ozone exposure
19.11 Hyperoxia
19.12 Ionizing radiation
19.13 Heavy metal ions
19.14 Oxidative stress
19.15 Mechanisms of cell signaling mediated by reactive oxygen species/reactive nitrogen specie
19.16 Antioxidants
19.17 Enzymatic antioxidants
19.18 Nutritional antioxidants
19.19 Vitamin C
19.20 Vitamin E
19.21 Prooxidant agents
19.22 Ascorbic acid
19.23 Polyphenols
19.24 Flavonoids and essential oils
19.25 Flavanols flavanones isoflavones
19.26 Gingerols gingerenone
19.27 Genistein
19.28 Genistein
19.29 Aesculetin
19.30 Aesculetin
19.31 Curcumin
19.32 Resveratrol
19.33 Resveratrol
19.34 Selenium
19.35 Radiation therapy
19.36 Conclusions
References
Chapter 20. Nutraceutical interventions in Alzheimer's disease
Abstract
20.1 Introduction
20.2 Factors responsible for neurodegenerative disorder
20.3 Progression of neurodegenerative disease stages
20.4 Retrogenesis
20.5 Cognitive dysfunction
20.6 Gait abnormality
20.7 Nutraceuticals to prevent or mitigate neurodegeneration
20.8 Alzheimer’s disease
20.9 Etiology and pathophysiology of Alzheimer’s disease
20.10 Current treatments and remedies
20.11 Flavonoids
20.12 Saffron and its constituents
20.13 Adjuvant therapy in Alzheimer disease
20.14 Bacosides
20.15 Quercetin
20.16 Ashwagandha
20.17 Omega 3 denosyl-methionine
20.18 Parkinson’s disease
20.19 Vitamins
20.20 Polyphenol stilbenes
20.21 Resveratrol
20.22 Oxyresveratrol
20.23 Phytoestrogens
20.24 Ginsenoside
20.25 Genistein
20.26 Polyphenolic compounds
20.27 Catechins in green tea
20.28 Curcuminoids
20.29 Baicalein
20.30 Adjuvant therapy in Parkinsonism disease
20.31 Omega-3 fatty acids
References
Chapter 21. Nutraceuticals and gutbiota-brain axis
Abstract
21.1 Introduction
21.2 Mechanism involved in the microbiota-gut-brain axis
21.3 Effect of antibiotics on gut bacteria
21.4 Dietary nutrients and their effect on gut-brain axis
21.5 Omega 3-fatty acids
21.6 Probiotics
21.7 Conclusion
References
Chapter 22. Nutraceuticals regulation: an overview of the regulatory frameworks in USA, EU, and Japan
Abstract
22.1 Introduction
22.2 Nutraceuticals regulations in the USA
22.3 Nutraceutical regulations in the EU
22.4 Nutraceuticals regulations in Japan
References
Chapter 23. Nutraceuticals in the management of Parkinson’s disease and dementia
Abstract
23.1 Introduction
23.2 Conclusion
References
Chapter 24. Scrutinizing the landscape of DNA methylation epigenetic face(s) in glioblastomas
Abstract
24.1 Introduction
24.2 Part 1
24.3 Part 2
24.4 Perspective
24.5 Future prospective
Acknowledgment
Author contributions
Funding
Conflicts of interest
Availability of data and materials
Declaration of interest
Compliance with ethical standards/Ethics approval
Consent to participate
Consent to publish
Abbreviations
References
Chapter 25. Role of protein-rich diet in brain functions
Abstract
25.1 Introduction
25.2 Sensitivity to protein contained in diet
25.3 A high-protein diet sends signals to the nucleus tractus solitarius
25.4 Dietary protein and brain centers of homeostatic regulation
25.5 The role of reward centers in protein regulation
25.6 Mechanism by which proteins can control the reward and food intake
25.7 Cognitive effects of vagal nerve stimulation
25.8 Nutrient effects on cognition
25.9 Caloric intake and cognition
25.10 Control of protein intake
25.11 Conclusion and future prospects
Acknowledgement
References
Chapter 26. Therapeutic potential of nutraceuticals for the management of neurodegenerative disorders
Abstract
26.1 Introduction
26.2 Polyphenolic flavonoid
26.3 Nonflavonoid polyphenols as neuroprotective agents
26.4 Phenolic acids and diterpenes having significant neuroprotective properties
26.5 Organosulfur compounds and conjugated polyenes as neuroprotective agents
26.6 Amino acid derivative as neuroprotective agent
26.7 Conclusions
References
Chapter 27. Nutraceuticals and anxiety
Abstract
27.1 Introduction
27.2 Types of anxiety
27.3 Causes of anxiety disorder
27.4 Drugs used in treatment of anxiety
27.5 Mechanisms involved in anxiety
27.6 Role of neurotransmitters in some neurological (mental) disorder
27.7 Nutraceuticals as potential anxiolytics
27.8 Side effects of nutraceuticals
References
Chapter 28. Pomegranate and berries as source of bioactive compounds for neurodegenerative disorders
Abstract
28.1 Introduction
28.2 Pomegranate fruit
28.3 Boysenberries
28.4 Choqueberries
28.5 Cloudberries
28.6 Cranberries
28.7 Bilberries
28.8 Elderberries
28.9 Goji berries
28.10 Final remarks
References
Index

Raj K. Keservani

Raj K. Keservani, MPharm, is a Faculty of B. Pharmacy, CSM Group of Institutions, Allahabad, India. He has more than 12 years of academic (teaching) experience from various institutes of India in pharmaceutical education. He has published 31 peer-reviewed papers in the field of pharmaceutical sciences in national and international journals, 43 book chapters, three co-authored books, and 18 edited books. He is also active as a reviewer for several international scientific journals. Mr. Keservani graduated with a pharmacy degree from the Department of Pharmacy, Kumaun University, Nainital (Uttarakhand), India. He received his Master of Pharmacy (MPharm) (specialization in pharmaceutics) from the School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India. Mr. Keservani is a life member of Society of Pharmaceutical Education and Research (SPER). His research interests include nutraceutical and functional foods, novel drug delivery systems (NDDS), transdermal drug delivery/drug delivery, health science, cancer biology, and neurobiology.

Affiliations and expertise

Faculty of B. Pharmacy, CSM Group of Institutions India, India

Rajesh K. Kesharwani

Rajesh K. Kesharwani, PhD, MTech, has more than 10 years of research and eight years of teaching experience at various institutes of India, imparting bioinformatics, and biotechnology education. He has received several awards, including the NASI-Swarna Jayanti Puruskar by The National Academy of Sciences of India. He has supervised PhD, postgraduate, and undergraduate students for their research work and has authored over 40 peer-reviewed articles, 20 book chapters, and 11 edited books with international publishers. Dr. Kesharwani received his PhD from the Indian Institute of Information Technology, Allahabad, India, and worked at NIT Warangal. He has been a recipient of the Ministry of Human Resource Development (India) Fellowship and Senior Research Fellowship from the Indian Council of Medical Research, India. His research fields of interest are medical informatics, protein structure and function prediction, computer-aided drug designing, structural biology, drug delivery, cancer biology, nano-biotechnology, and biomedical sciences.

Affiliations and expertise

Nehru Gram Bharati, India

Mila Emerald

Prof. Mila Emerald, Ph.D., Dr. Sc., President and CEO at PHYTOCEUTICALS International ™ & NOVOTEK Global Solutions ™, Ph.D. in Cellular Biochemistry and Molecular Biophysics, Dr. Science in Neuroscience, and professorship from the Cornell University, dedicated her life to research of nutraceuticals and natural products, their therapeutic properties, and applications. Her work, business, and research are dedicated to the role of natural nanomaterials and novel drugs delivery systems, in nutraceuticals, fermented products, functional foods, probiotics, essential oils and natural extracts complexes, and their crucial role in human wellbeing and health. She is also focused on the natural compounds, which can potentially be used in prevention and maintenance of bacterial, fungal, as well as viral pathogens, including SARS-COV2. Dr. M. Emerald is honoured to be one of the winners in the International Challenge called: “Next Great Impossible” on Nanotechnology, by Sigma-Aldrich/Merck, one of the most viewed profiles on the LinkedIn.

Affiliations and expertise

Phytoceuticals International, Canada

Anil K. Sharma

Anil K. Sharma, PhD, MPharm, is working as an assistant professor at the Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Gurugram, India. He has more than ten years of academic experience in pharmaceutical sciences. He has published 35 peer-reviewed papers in the field of pharmaceutical sciences in national and international journals as well as 28 book chapters. In addition, he has edited 16 books with reputable publishers. He received a bachelor’s degree in pharmacy from the University of Rajasthan, Jaipur, India, and a Master of Pharmacy degree from the School of Pharmaceutical Sciences, Rajiv Gandhi ProudyogikiVishwavidyalaya, Bhopal, India, with a specialization in pharmaceutics. He earned his PhD in pharmacy from the University of Delhi, India.His research interests encompass nutraceutical and functional foods, novel drug delivery systems (NDDS), drug delivery, nanotechnology, health science/life science, and biology/cancer biology/neurobiology.

Affiliations and expertise

Assistant professor, Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Gurugram, India

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health

Nutraceutical Fruits and Foods for Neurodegenerative Disorders

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Raj K. Keservani

Rajesh K. Kesharwani

Mila Emerald

Anil K. Sharma