Nuclear Cardiology and Multimodal Cardiovascular Imaging
A Companion to Braunwald's Heart Disease
- 1st Edition - November 17, 2021
- Imprint: Elsevier
- Editor: Marcelo Fernando Di Carli
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 6 3 0 3 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 6 3 0 4 - 2
Recent years have seen numerous advances in cardiovascular nuclear medicine technology, leading to more precise diagnoses and treatment and an expanded understanding of the… Read more
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Request a sales quoteRecent years have seen numerous advances in cardiovascular nuclear medicine technology, leading to more precise diagnoses and treatment and an expanded understanding of the molecular basis for cardiac disease. Nuclear Cardiology and Multimodal Cardiovascular Imaging is a one-stop, comprehensive guide to the diagnostic and clinical implications of this complex and increasingly important technology. Part of the Braunwald family of renowned cardiology references, it provides cutting-edge coverage of multimodal cardiac imaging along with case vignettes and integrated teaching content—ideal for cardiologists, cardiology fellows, radiologists, and nuclear medicine physicians.
Features all the latest cardiovascular nuclear medicine studies with practical, evidence-based implications for personalized patient evaluation and treatment.
Presents a consistent, patient-centered approach using integrated case vignettes correlated with specific nuclear medicine imaging findings. Discusses patient assessment criteria, risk factor criteria, pathology, evaluation criteria, outcomes, and other clinical implications.
Covers a full range of imaging technologies, including SPECT/CT, PET/CT, and CT/MR hybrid radionuclide cardiovascular imaging studies.
Addresses emerging clinical applications of nuclear imaging techniques for precision-based medicine, including targeted molecular imaging and cell therapies.
Includes sections on instrumentation/principles of imaging; protocols and interpretation; applications in coronary artery disease, special populations, and heart failure; artificial intelligence, and more.
Contains guidelines and appropriate use documents to provide appropriate context for clinicians.
Features hundreds of high-quality figures including multimodal cardiac imaging studies, anatomic illustrations, and graphs.
Provides Key Point summaries, 50 procedural videos, and 100 multiple-choice questions and answers to reinforce understanding and facilitate review.
Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
Cardiologists and cardiology fellows, cardio-oncologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Video contents
- Braunwald’s heart disease family of books
- List of Tables
- List of Illustrations
- Section I. Instrumentation and Principles of Imaging
- 1. Single photon emission computed tomography
- Introduction
- Detectors
- Collimators
- System designs for cardiac SPECT imaging
- Factors affecting image quality
- Reconstruction
- Cardiac gating
- Future developments
- Questions
- References
- 2. Positron emission tomography
- Introduction
- PET physics fundamentals
- PET imaging technology
- PET data acquisition
- PET image reconstruction
- PET image quality
- Emerging technologies
- Questions
- References
- 3. Principles of myocardial blood flow quantification with SPECT and PET imaging
- Introduction
- Myocardial blood flow measurements with PET and SPECT
- Myocardial blood flow assessment with SPECT
- Questions
- References
- Section II. Imaging Protocols and Interpretation
- 4. Radiopharmaceuticals for clinical SPECT and PET and imaging protocols
- Introduction
- Current radiotracers for cardiac imaging
- Imaging protocols for cardiac SPECT and PET
- Radiation exposure
- Guidelines
- Questions
- References
- 5. Recognizing and preventing artifacts with SPECT and PET imaging
- Introduction
- SPECT imaging
- PET imaging
- Conclusion
- Questions
- References
- 6. Approaches to minimize patient dose in nuclear cardiology
- Introduction
- New technology to limit patient dose
- Best practices to limit patient dose
- Conclusions
- Questions
- References
- Section III. Applications of Nuclear Cardiology in Coronary Artery Disease
- 7. Patients with new-onset stable chest pain syndromes
- Introduction
- Initial assessment of patients with new-onset chest pain
- Incremental value of imaging tests
- Diagnostic value of radionuclide imaging
- Added value of coronary artery calcium score
- Applications of radionuclide imaging in patients with new-onset stable chest pain syndrome
- Questions
- References
- 8. Applications of nuclear cardiology in known stable coronary artery disease
- Introduction
- Role of non-invasive imaging in patients with stable coronary artery disease
- Patient-centered applications of radionuclide MPI in patients with known coronary artery disease: Case-based discussion
- New developments for radionuclide myocardial perfusion imaging
- Questions
- References
- 9. Patient with prior revascularization
- Introduction
- Approach to patient evaluation and test selection
- Patient-centered clinical applications
- Future directions and emerging applications
- Questions
- References
- 10. Preoperative risk evaluation: When and how?
- Introduction
- Risk assessment
- Noninvasive testing for preoperative risk assessment
- Patient-centered approach to preoperative risk assessment
- Questions
- References
- 11. Imaging in patients with acute chest pain in the emergency department
- Scope of the problem
- Evaluation of patients with chest pain in the emergency department
- The ischemic cascade and the rationale for use of noninvasive imaging
- Patient-centered applications of noninvasive imaging in patients with suspected acute cardiac ischemia
- Conclusion
- Questions
- References
- 12. Assessing the biology of high-risk plaque features with molecular imaging
- Introduction
- Rationale for high-risk plaque imaging
- 18F-FDG PET imaging of vascular inflammation
- 18F-NaF imaging of active calcification
- Other radionuclide probes for plaque imaging
- Imaging plaque biology and composition using pet/mri
- Summary
- Questions
- References
- Section IV. Applications of Nuclear Cardiology in Select Populations
- 13. Patients with suspected coronary microvascular dysfunction
- Introduction
- Evaluation of suspected coronary microvascular dysfunction
- Patient-centered clinical applications
- Emerging applications
- Questions
- References
- 14. Patient with cardiometabolic disease
- Introduction
- Technical considerations
- Patient-centered clinical applications
- Questions
- References
- 15. Patient with chronic kidney disease
- Introduction
- Patient-centered clinical applications of radionuclide and multimodality imaging in patients with CKD
- Questions
- References
- 16. Women with suspected ischemic heart disease
- Introduction
- Sex differences in ischemic heart disease
- Moving beyond obstructive coronary artery disease
- Patient-centered clinical applications of imaging in women
- Patient selection for testing
- Extended algorithm of diagnostic testing strategies
- Questions
- References
- 17. Key concepts in risk stratification and cost-effectiveness using nuclear scintigraphy in stable coronary artery disease
- Introduction
- Risk stratification and incremental prognostic value
- Principles of prognostication and risk stratification
- Post-MPI resource utilization and implications for risk assessment
- Radionuclide MPI and patient management
- Cost effectiveness of radionuclide MPI and its relationship to alternative strategies and modalities
- Questions
- References
- Section V. Applications of Nuclear Cardiology in Heart Failure
- 18. The patient with new-onset heart failure
- Introduction
- Patient-centered applications of multimodality imaging in patients with new-onset heart failure
- Questions
- References
- 19. Metabolic remodeling in heart failure
- Introduction
- Basic concepts on myocardial metabolism
- Methods for measuring substrate metabolism in the human heart
- Assessing key myocardial metabolic pathways
- Risk factors for heart failure
- Myocardial metabolic phenotypes in cardiomyopathy and heart failure
- Myocardial metabolic effects of standard heart failure therapies
- Myocardial metabolic modulation in heart failure
- Future directions
- Questions
- References
- 20. Patient with ischemic heart failure: Ischemia and viability assessment and management
- Introduction
- Ischemic heart failure
- Imaging techniques for the evaluation of ischemia and viability
- Patient-centered imaging applications in ischemic heart failure
- Critical appraisal of the evidence regarding the use of myocardial ischemia and viability testing to guide patient management
- Questions
- References
- 21. Novel approaches for the evaluation of arrhythmic risk
- Introduction
- Risk stratification of arrhythmic risk
- Patient-centered applications of radionuclide and multimodality imaging for the evaluation of arrhythmic risk
- Potential role for radionuclide imaging to guide arrhythmia ablation
- Questions
- References
- 22. Screening for transplant vasculopathy
- Introduction
- Clinical aspects of cardiac allograft vasculopathy
- Noninvasive imaging approaches for screening of cardiac allograft vasculopathy
- Patient-centered applications of radionuclide imaging and multimodality imaging in patients after heart transplantation
- Questions
- References
- 23. Patient with known or suspected cardiac sarcoidosis
- Introduction
- Diagnosis of cardiac sarcoidosis
- Role of imaging in cardiac sarcoidodis
- Patient-centered evaluation of suspected or known cardiac sarcoidosis
- Questions
- References
- 24. Patients with known or suspected amyloidosis
- Introduction
- Epidemiology
- Clinical presentation
- Radionuclide imaging
- 99mTechnetium imaging protocols
- Patient-centered applications of imaging in cardiac amyloidosis
- Future directions
- Questions
- References
- 25. Patients undergoing cancer treatment
- Introduction
- Patient-centered applications of multimodality imaging in cardio-oncology
- Questions
- References
- 26. Molecular imaging of myocardial infarction and remodeling
- Introduction
- Molecular repair mechanisms after acute myocardial infarction: Inflammation, fibrosis, and angiogenesis
- Multimodality imaging after acute myocardial infarction
- Future challenges
- Questions
- References
- 27. Patient with mechanical dyssynchrony
- Introduction
- Imaging methods to assess mechanical dyssynchrony
- Clinical applications
- Questions
- References
- Section VI. Emerging Clinical Applications
- 28. Aortic stenosis and bioprosthetic valve degeneration
- Introduction
- Computed tomography
- Positron emission tomography
- Left ventricular remodeling and the role of positron emission tomography imaging
- Image optimization and current state of the art
- Applications of 18F-Fluoride positron emission tomography
- End point in clinical trials
- Patient management
- Bioprosthetic valve degeneration
- Patient-centered clinical applications
- Acknowledgments
- Questions
- References
- 29. Infective endocarditis
- Introduction
- Technical considerations
- Image interpretation
- Clinical applications of 18F-FDG-PET/CCTA
- Additional benefits of whole-body positron emission tomography/computed tomography
- Diagnostic challenges
- Other nuclear imaging techniques
- Role of nuclear imaging in the multimodality evaluation of infective endocarditis
- Future directions
- Summary
- Questions
- References
- 30. Large-vessel vasculitis
- Introduction
- Classification and diagnosis of large-vessel vasculitides
- Multimodality imaging of large-vessel vasculitides
- Patient-centered clinical applications
- Emerging applications of large-vessel vasculitis imaging
- Questions
- References
- 31. Peripheral arterial disease
- Epidemiology and the natural history of peripheral arterial disease
- Compartments of peripheral arterial disease: Macrovasculature, microvasculature, angiosomes, and collateral vessels
- Standard noninvasive evaluation of peripheral arterial disease
- Questions
- References
- Section VII. Artificial Intelligence in Nuclear Cardiology
- 32. Artificial intelligence in nuclear cardiology
- Introduction
- Using artificial intelligence to improve image processing
- Using artificial intelligence to improve image quality
- Using artificial intelligence to improve the diagnosis of coronary artery disease
- Using artificial intelligence to improve risk prediction
- Using artificial intelligence to quantify and integrate coronary artery calcium information
- Epicardial adipose tissue quantification with artificial intelligence
- Development and evaluation of artificial intelligence
- Explainable artificial intelligence
- Clinical implementation
- Questions
- References
- Answer key
- Index
- Edition: 1
- Published: November 17, 2021
- Imprint: Elsevier
- No. of pages: 496
- Language: English
- Hardback ISBN: 9780323763035
- eBook ISBN: 9780323763042
MD
Marcelo Fernando Di Carli
Affiliations and expertise
Seltzer Family Professor of Radiology and Medicine, Harvard Medical School, Executive Director, Cardiovascular Imaging, Chief, Division of Nuclear Medicine and Molecular Imaging, Brigham and Women’s Hospital, Boston, Massachusetts