Novel Platforms for Drug Delivery Applications

1st Edition - November 8, 2022
Imprint: Woodhead Publishing
Editors: Sangita Das, Sabu Thomas, Partha Pratim Das
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 3 7 6 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 3 7 8 - 2

Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book compre… Read more

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Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials and molecular platforms for drug delivery, from hydrogels, nanocarriers and metal-organic-frameworks, to ꞵ-cyclodextrin and polyphosphazene. Each chapter discusses the benefits and limitations of each drug delivery system, as well as toxicological and safety implications. This book offers an interdisciplinary approach to this fast-moving topic, bridging the disciplines of materials science and pharmacology.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Introduction: state of the art, new challenges, and opportunities for drug delivery and its application
Abstract
1.1 Introduction
1.2 Conclusion
References
Chapter 2. Drug delivery application: an outlook on past and present technologies
Abstract
2.1 Introduction
2.2 Tissue engineering generators
2.3 Importance of engineered nanocomposite materials as drug delivery vehicles
2.4 Carbohydrate-based amphiphilic delivery system
2.5 Self-assembled materials: drug delivery perspectives
2.6 Conclusion
References
Chapter 3. General mechanisms of drug loading and sustained release
Abstract
3.1 Introduction
3.2 Biological factors affecting oral sustained-release design of dose form
3.3 Physicochemical features affecting oral sustained-release design of dose form
3.4 Systems
3.5 Types of matrices
3.6 Hydrophobic drugs in hydrogels
3.7 Conclusions and future perspective
References
Chapter 4. Supramolecular hydrogels as drug delivery systems for nerve regeneration and wound healing
Abstract
4.1 Introduction
4.2 Structure of hydrogel
4.3 Classification/types of hydrogels
4.4 Characterization of hydrogels
4.5 Application of hydrogels in drug delivery system
4.6 Supramolecular hydrogels in nerve regeneration
4.7 Inclusion of hydrogels in wound healing
4.8 Conclusion
References
Chapter 5. Molecularly imprinted polymeric carriers for controlled drug release
Abstract
5.1 Introduction
5.2 Molecular imprinting technique
5.3 Drug release system
5.4 Applications of controlled drug release
5.5 Conclusions and perspectives
References
Chapter 6. Engineered extracellular vesicles as drug delivery systems for the next generation of nanomedicine
Abstract
6.1 Introduction
6.2 Origin, composition, and function of extracellular vesicles
6.3 Preparation and characterization of extracellular vesicles
6.4 Engineering strategies for extracellular vesicles
6.5 Recent advances in extracellular vesicles in drug delivery applications
6.6 Opportunities and challenges
6.7 Summary and prospect
References
Chapter 7. Polyelectrolyte multilayer films for cancer therapy
Abstract
7.1 Introduction
7.2 Polyelectrolyte multilayers as anticancer drug delivery vehicles
7.3 Polyelectrolyte multilayers as DNA delivery vehicles
7.4 Polyelectrolyte multilayers as protein delivery vehicles
7.5 Polyelectrolyte multilayers as inorganic nanoparticles delivery vehicles
7.6 Characterization methods for layer by layer assemblies
7.7 Conclusions
References
Chapter 8. Porous metal–organic framework nanoscale carriers as a potential platform for drug delivery
Abstract
8.1 Introduction
8.2 Role of metal–organic frameworks in drug delivery
8.3 Classification of metal–organic frameworks
8.4 Advanced Systems for metal–organic frameworks modification
8.5 Synthesis of nano-metal–organic frameworks
8.6 Functionalization of nano-metal–organic frameworks for drug delivery
8.7 Pharmacokinetics of nano-metal–organic frameworks
8.8 Pharmacokinetics of drug-loaded nano-metal–organic frameworks
8.9 Conclusion
References
Chapter 9. Stimulus-responsive liposomes as smart nanocarriers for drug delivery applications
Abstract
9.1 Introduction
9.2 Lipophilic drugs
9.3 Stimulus responsive liposomes
9.4 Dual- or- multiresponsive liposomes
9.5 Conclusions
References
Chapter 10. Hybrid platforms for drug delivery applications
Abstract
10.1 Introduction
10.2 Ideal conditions for drug delivery system
10.3 Drug delivery triggers for controlled release
10.4 Synthesis of hybrid nanoparticles
10.5 Classification of hybrid materials
10.6 Conclusion and outlook
References
Chapter 11. Self-nanoemulsifying drug delivery systems with bioavailability potential
Abstract
11.1 Introduction
11.2 Self-emulsifying drug delivery system
11.3 Intestinal perfusion
11.4 Oral bioavailability of biopharmaceutical classification system compounds
11.5 Conclusion
References
Chapter 12. Graphene-based nanomaterials for targeted drug delivery and tissue engineering
Abstract
12.1 Introduction
12.2 Conclusion and future recommendation
References
Chapter 13. Bionanocomposites as a new platform for drug delivery systems
Abstract
13.1 Nanotechnology: a new avenue in drug delivery
13.2 Bionanocomposites
13.3 Synthesis of bionanocomposites
13.4 Bionanocomposites-based drug delivery
13.5 Fundamentals of drug delivery
13.6 Monitoring of in vitro drug release
13.7 Applications for drug delivery
13.8 Conclusion
References
Chapter 14. Nanotube platforms for effective drug delivery applications
Abstract
14.1 Introduction
14.2 Nanoencapsulation
14.3 Nanoemulsion
14.4 Liposomes
14.5 Micelles
14.6 Dendrimers
14.7 Nanocrystals
14.8 Nanogels
14.9 TiO2 nanotubes
14.10 Titania nanotubes
14.11 Carbon nanotubes
14.12 Conclusion
References
Chapter 15. Biodegradable polymeric nanoparticle drug for oral delivery applications
Abstract
15.1 Introduction
15.2 Polymeric nanoparticles in oral drug delivery
15.3 Nanoparticle targeting
15.4 Oral drug delivery and role of gastrointestinal tract
15.5 Nanoparticle delivery systems in gene therapy
15.6 Applications
15.7 Conclusions
References
Chapter 16. Delivery of radiopharmaceuticals and theranostic agents: targeted alpha therapy
Abstract
16.1 Introduction: targeted alpha therapy—history and prospective
16.2 Radiation therapy: methods of action
16.3 Production and purification considerations for α emitters
16.4 Key considerations for the delivery and transport of α emitters
16.5 Pathophysiological effects and their mitigation
16.6 Outlook
References
Further reading
Chapter 17. Controlled drug release and drug delivery applications from mesoporous nanoparticles
Abstract
17.1 Introduction
17.2 3D porous crystalline polyimide for drug delivery
17.3 Mesoporous silica nanoparticles
17.4 Bone tissue regeneration based on mesoporous silica nanoparticles
17.5 Microfluidic-templated encapsulation
17.6 Multifunctional nano-in-micro drug delivery
17.7 Conclusion
17.8 Future aspects
References
Chapter 18. Porous nanostructured metal oxides as potential scaffolds for drug delivery
Abstract
18.1 Introduction
18.2 Controlled drug release system
18.3 Metal oxide nanoparticles chemistry
18.4 Applications of metal oxide nanoparticles as drug delivery matrices
18.5 Conclusions and future perspectives
References
Chapter 19. Thin films as an emerging platform for drug delivery
Abstract
19.1 Introduction
19.2 Types of thin films
19.3 Advantages of thin films as an emerging dosage form
19.4 Major drawbacks of thin films
19.5 Polymers used in the fabrication of thin films
19.6 Technologies for manufacturing thin films
19.7 Critical quality attributes of thin films
19.8 Packaging of thin films
19.9 Routes for the administration of thin films
19.10 Future scope of development and conclusion
Acknowledgement
References
Chapter 20. Modeling and simulation in drug delivery
Abstract
20.1 Introduction
20.2 Modeling drug administration routes
20.3 Modeling of drug delivery systems
References
Chapter 21. In-vivo drug release studies
Abstract
21.1 In-vitro versus in-vivo
21.2 Principles of pharmacokinetics
21.3 Pharmacodynamics
21.4 Effectors
21.5 Therapeutic window
References
Chapter 22. Toxicity measurement and toxicity studies of drug delivery
Abstract
22.1 Introduction
22.2 Toxicity assessment assays and measurement methods
22.3 Toxicity assessment in different organ systems
22.4 Biocompatible drug delivery and excretion methods
22.5 Conclusion
Acknowledgement
References
Chapter 23. Nasal and pulmonary routes of drug delivery
Abstract
23.1 Introduction
23.2 Nasal and pulmonary drug delivery
23.3 Research for novel drug delivery systems
23.4 Concluding remarks
References
Chapter 24. “Gene therapy”: ethical and regulatory issues
Abstract
24.1 Introduction
24.2 Gene-editing tools
24.3 Types of gene therapies
24.4 Gene delivery mechanism
24.5 Development of gene therapy
24.6 Risks and benefits of gene therapy
24.7 Gene therapy regulatory issues and biosafety
24.8 Gene therapy regulatory framework and professional guidelines
24.9 Conclusion
References
Chapter 25. New challenges in drug discovery
Abstract
25.1 Historical and contemporary drug discovery status
25.2 Common challenges in drug design
25.3 Pharmaceutical Industry challenges for drug discovery
25.4 Challenges in drug discovery from natural products
25.5 Challenges in SBDD discovery
25.6 Challenges at preclinical stages of drug discovery
25.7 Challenges at clinical stages of drug discovery
25.8 Challenges for small molecule drug design
25.9 Challenges for anticancer drug discovery
25.10 Challenges in drug discovery via engineered nanoparticles
25.11 Conclusion and future prospective
References
Index

Sangita Das

Dr. Sangita Das is working as Newton International Fellow at Durham University, England, United Kingdom. She also works as a visiting professor in the Department of Energy Science in Mahatma Gandhi University, Kerala, India. She received her B. Sc. degree with honors in chemistry in 2008 from the University of Calcutta, Kolkata, West Bengal, India. She obtained her M. Sc. degree in chemistry with organic specialization in 2010 from the same university. She had qualified the all India (CSIR–JRF) NET, and then she joined “The Goswami Group,” Department of Chemistry, IIEST for her doctoral work under the supervision of Prof. Shyamaprosad Goswami. She got Ph.D. in 2016. Her areas of research interest include molecular recognition; design of fluorescence chemosensors; and characterization of fluorescence probe (detection of metal ions, anions, reactive oxygen species, nerve gas, and other environmentally hazardous species, etc.); aggregation-induced emission dyes and solid-state emitters, and synthesis of compounds with antidiabetic activity. She is now working as a Newton International Fellow in the United Kingdom. Her current research activities include the development of compounds as HDAC inhibitors, experimental and theoretical investigations of electronic structure of transition metal complexes with redox noninnocent ligands, and computational chemistry (DFT, TDDFT calculations).

Affiliations and expertise

Royal Society Newton International Fellow, Department of Chemistry, Durham University, Durham, United Kingdom Post-doctoral research fellow, Durham University, England, UK

Sabu Thomas

Prof. Sabu Thomas is a Professor of Polymer Science and Engineering and the Director of the School of Energy Materials at Mahatma Gandhi University, India. Additionally, he is the Chairman of the Trivandrum Engineering Science & Technology Research Park (TrEST Research Park) in Thiruvananthapuram, India. He is the founder director of the International and Inter-university Centre for Nanoscience and Nanotechnology at Mahatma Gandhi University and the former Vice-Chancellor of the same institution.

Prof. Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields. Dr. Thomas has been conferred with Honoris Causa (DSc) by the University of South Brittany, France.

Affiliations and expertise

Professor and Director, International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, India

Partha Pratim Das

Dr. Partha Pratim Das is presently working as a postdoctoral researcher in Seoul National University, South Korea. He previously worked in the Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea, as a postdoctoral researcher. He has completed both the B.Sc. (2008) and M.Sc. (2010) in chemistry from Calcutta University, India. He has received Ph.D. in science (chemistry) in 2016 from Jadavpur University, India. His working laboratories during Ph.D. are CSIR-CGCRI, Kolkata, and CSIR-NCL, Pune, India. His research area is focused on nanotechnology, synthesis, and structure–properties correlation studies of different multifunctional nanomaterials under various conditions for mainly clean and sustainable energy and environmental applications. He has published several high-impact papers in peer-reviewed journals. Moreover, his research works have been acclaimed in many national and international conferences and journal societies.

Affiliations and expertise

Postdoctoral researcher, Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Novel Platforms for Drug Delivery Applications

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