Novel Formulations and Future Trends

Recent and Future Trends in Pharmaceutics, Volume 3

1st Edition - March 25, 2024
Imprint: Academic Press
Editors: Amit Kumar Nayak, Kalyan Kumar Sen
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 8 1 6 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 4 5 - 1

Novel Formulations and Future Trends, Volume Three in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics with an original approach focused… Read more

Purchase options

World Book Day Celebration!

Save up to 30% on books and eBooks!

Shop now

Institutional subscription on ScienceDirect

Request a sales quote

Novel Formulations and Future Trends, Volume Three in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics with an original approach focused on technology, novelties and future trends. It discusses the most important developments in drug delivery, including important and exciting areas such as mucosal, implantable, transdermal, gastroretentive, vaccine and targeted drug delivery systems. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students.

New technologies are also explored including 3D printing and computational pharmaceutics.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Section I: Novel formulations
Chapter 1. Controlled release drug delivery systems: principles and design
Abstract
1.1 Introduction
1.2 Terminology
1.3 Rationale for controlled release drug delivery systems
1.4 Advantages of CRDDS
1.5 Challenges and disadvantages of CRDDS
1.6 Characteristics of drug to be developed as CRDDS
1.7 Factors governing the design of controlled release formulations
1.8 Approaches in designing CRDDS
1.9 Conclusion
References
Chapter 2. Microencapsulation: methodologies and applications
Abstract
2.1 Introduction
2.2 Advantages and disadvantages of microencapsulation
2.3 Microspheres/microcapsules and microparticles
2.4 Methods of microencapsulation
2.5 Applications of microencapsulation
References
Chapter 3. Recent development in mucosal drug delivery system
Abstract
3.1 Introduction
3.2 Physiological characteristics of the mucus layer
3.3 Mucoadhesion-related theories
3.4 Commonly used mucoadhesive polymers
3.5 The absorption pathway of mucosal drug delivery system
3.6 Recent development and formulation considerations in mucosal drug delivery
3.7 Conclusion
References
Chapter 4. Implantable drug delivery systems: design and applications
Abstract
4.1 Introduction
4.2 Classification of implantable drug delivery system
4.3 Mechanisms of drug release from implantable drug delivery systems
4.4 Interaction of the implant composites and immune reaction
4.5 Carrier-free nanocrystals
References
Chapter 5. Transdermal drug delivery systems: principles, design, and applications
Abstract
5.1 Introduction
5.2 Structure of skin and barriers
5.3 Permeation through skin
5.4 Factors affecting permeation
5.5 Permeation enhancers
5.6 Basic components of transdermal drug delivery system
5.7 Formulation approaches and evaluation
5.8 Advantages and disadvantages
5.9 Future prospects
Acknowledgments
References
Chapter 6. Gastroretentive drug delivery approaches for oral bioavailability improvement
Abstract
6.1 Gastroretentive drug delivery systems—a background discussion
6.2 Anatomy and physiological aspects of gastroretentive drug delivery systems
6.3 Prominent factors controlling gastroretention of dosage forms
6.4 Ideal drug candidates for gastroretentive drug delivery systems
6.5 Drugs candidates for gastroretentive drug delivery systems
6.6 Different kinds of gastroretentive drug delivery systems
6.7 Essential excipients for designing gastroretentive drug delivery systems
6.8 Evaluations of gastroretentive drug delivery systems
6.9 Advantages of gastroretentive drug delivery systems
6.10 Disadvantages of gastroretentive drug delivery systems
6.11 Gastroretentive drug delivery systems available in the market
6.12 Conclusion
References
Chapter 7. Nasopulmonary drug delivery system: current status
Abstract
7.1 Introduction
7.2 Nose and pulmonary system: anatomy and physiology
7.3 Anatomy and physiology of lungs: brief view
7.4 Drug delivery through the nasal cavity
7.5 Formulation composition of nasopulmonary delivery system
7.6 Conclusion
Conflict of interest
Acknowledgment
References
Chapter 8. Advancements in ocular drug delivery systems
Abstract
8.1 Introduction
8.2 Anatomy of eye
8.3 Intraocular barriers
8.4 Methods to overcome ocular barrier
8.5 Ocular formulations
8.6 Mechanism of control drug release into the eye
8.7 Formulation methods of Ocuserts
8.8 Evaluation parameters of Ocuserts
8.9 Future prospects of Ocuserts
References
Chapter 9. Targeted drug delivery: concepts, approaches, and applications
Abstract
9.1 Introduction
9.2 Basic principles and applications of targeted drug-delivery systems
9.3 Carrier systems for targeted drug delivery
9.4 Challenges and perspectives
9.5 Conclusions
Acknowledgments
References
Chapter 10. Recent developments in pediatric and geriatric dosage forms
Abstract
10.1 Introduction
10.2 Pediatric population
10.3 Geriatric population
10.4 Advanced oral formulation technologies
10.5 Rectal formulations
10.6 Topical dosage forms
10.7 Patient centric Pharmaceutical drug product design (PCDPD)
10.8 Conclusions
References
Chapter 11. Protein and peptide drug delivery system
Abstract
11.1 Introduction
11.2 Current formulation of delivery systems of proteins and peptides
11.3 Evaluation of protein and peptide drug formulations
11.4 Barriers for protein and peptide delivery
11.5 Regulatory consideration of protein and peptide drug
11.6 Clinical trials for protein and peptide drugs
11.7 Future prospects
11.8 Applications of protein and peptide drug delivery
References
Chapter 12. Nucleic acid-based therapeutic delivery system
Abstract
12.1 Introduction
12.2 Viral and nonviral vectors
12.3 Mechanism of gene delivery
12.4 Factors affecting transfection
12.5 Future consideration
12.6 Conclusions
References
Chapter 13. Vaccine delivery systems for immunization
Abstract
13.1 Introduction
13.2 Vaccine delivery systems
13.3 Conclusion
References
Section II: Future trends in pharmaceutics
Chapter 14. Computational pharmaceutics
Abstract
14.1 Introduction
14.2 History of computers in pharmaceutical research and development
14.3 Statistical modeling in pharmaceutical research and development
14.4 Computational modeling of drug disposition
14.5 Computer simulation in pharmacokinetics and pharmacodynamics
14.6 Artificial intelligence in pharmaceutics
14.7 Pharmaceutical automation
14.8 Conclusion
Consent for publication
Conflict of interest
Acknowledgments
References
Chapter 15. Application of artificial intelligence in pharmaceutical development
Abstract
15.1 Introduction
15.2 A conceptual assessment framework
15.3 Conclusions
References
Chapter 16. Computational fluid dynamics in pharmaceutical formulation development
Abstract
16.1 Introduction
16.2 Modeling approaches
16.3 Computational fluid dynamics modeling and its applications in pharmaceutics
References
Chapter 17. Predictive tools for cocrystal formation
Abstract
17.1 Introduction
17.2 Solid forms of active pharmaceutical ingredients
17.3 Molecular salts and cocrystals: from design to application
17.4 Rational cocrystal design
17.5 Conclusions
References
Chapter 18. 3D printing technology in drug delivery
Abstract
18.1 Introduction
18.2 Pharmaceutics and 3D printing
18.3 Rationale for the development of 3D-printed drug products
18.4 Common 3D printing techniques in the pharmaceutical sector
18.5 Materials and considerations for 3D printing of pharmaceutical products
18.6 Applications of 3D printing in the pharmaceutical field
18.7 Limitations and outlook of 3D printing in the pharmaceutical sector
18.8 Conclusion
Acknowledgment
References
Chapter 19. Targeted drug delivery using aptamers as molecular probes
Abstract
19.1 Introduction
19.2 Aptamers: an overview
19.3 Aptamers as bioaffinity molecules
19.4 Aptameric formulations
19.5 Aptamer-based targeted delivery approaches
19.6 Future outlook
19.7 Conclusions
References
Further reading
Chapter 20. Bioinspired drug delivery therapeutics
Abstract
20.1 Introduction
20.2 Synthetic drug carriers
20.3 Cell-based systems
20.4 Concluding remarks
References
Chapter 21. Stimuli-responsive nanosystems for smart drug delivery
Abstract
21.1 Introduction
21.2 Different stimuli-responsive drug delivery nanosystems
21.3 Multi stimuli-responsive drug delivery system
21.4 Conclusion and future outlook
Acknowledgments
References
Chapter 22. Ultrasound-based drug delivery system
Abstract
22.1 Biomass polymeric matrix medicines
22.2 Advantageous stimuli therapy of ultrasound
22.3 Efficacy of ultrasound in drug delivery
22.4 Ultrasonic effect of biomass hydrogels
22.5 Conclusion
References
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Kalyan Kumar Sen

Dr. Kalyan Kumar Sen (MPharm, PhD) has over 38 years of teaching and industrial and research experience in the field of pharmaceutics, especially in the development and characterization of novel drug delivery systems. He has earned his PhD in pharmacy from Jadavpur University, India. Currently, Dr. Sen is working as a principal and professor of Gupta College of Technological Sciences, Asansol, India. Till date, he has authored several publications in various journals of international repute. He has authored several book chapters. He already has edited two books and co-authored one book. He has been the permanent reviewer of many international journals of high repute. Dr. Sen has participated and presented his research work at several conferences in India. Dr. Sen is a life member of the APTI and several professional bodies.

Affiliations and expertise

Department of Pharmaceutics, Principal of Gupta College of Technological Sciences, Asansol, W.B, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health