Novel Drug Delivery Systems in the management of CNS Disorders

1st Edition - September 1, 2024
Editors: Pooja A Chawla, Raimar Loebenberg, Kamal Dua, Vinay Parikh, Viney Chawla
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 4 7 4 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 4 7 5 - 3

Novel Drug Delivery Systems in the Management of CNS Disorders provides a single source for information on drug delivery to the central nervous system. Written at graduate… Read more

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Novel Drug Delivery Systems in the Management of CNS Disorders provides a single source for information on drug delivery to the central nervous system. Written at graduate level, the book covers an extensive range of CNS disorders, including epilepsy, Parkinson’s, Alzheimer’s, Huntington’s, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others. The book also presents the foundations of drug delivery to the brain and its challenges in the introductory part. The book’s final part is dedicated to clinical trials, and future prospects of the presented technologies.

This book is a complete reference on overcoming the Brain-Blood Barrier and targeted drug delivery to the CNS. Drug delivery researchers in academia and corporate environments will benefit the most of this comprehensive reference.

Part I Introduction to Drug delivery to the CNS

1. General physiology and function of brain

2. Formulator’s challenges for delivering drugs to the brain

3. Possible targets in the management of various CNS disorders

4. Antioxidants and their possible benefits in neurodegeneration

5. Prodrug approaches for delivering CNS active agents

6. Traditional practices in CNS drug delivery

7. Emerging need of Novel Drug Delivery Systems in management of CNS disorders

8. Nose to brain drug delivery through advanced Drug Delivery Systems

9. PBPK modeling for CNS Delivery

Part II Novel Drug Delivery Systems to specific CNS Disorders

10: Novel Drug Delivery Systems in treating epilepsy

11. Novel Drug Delivery Systems in the management of Parkinson’s Disease

12. Role of Novel Drug Delivery Systems in managing Alzheimer’s Disease

13. Novel Drug Delivery Systems in the management of Huntington’s Disease

14. Novel Drug Delivery Systems in the management of multiple sclerosis

15. Role of Novel Drug Delivery Systems in delivering antidepressant drugs to the brain

16. Delivering cancer chemotherapeutics to the brain through Novel Drug Delivery Systems

17. Novel Drug Delivery Systems in the management of Schizophrenia

18. Prospects of Novel Drug Delivery Systems in treating cerebral palsy

19. Targeting phytoconstituents to the brain through Novel Drug Delivery Systems

20. Novel Drug Delivery Systems in managing autism

21. Novel Drug Delivery Systems in amyotrophic lateral sclerosis

22. Novel Drug Delivery Systems in cerebral vascular disorders, transient ischemic attack and stroke interventions

23. Treating meningitis through Novel Drug Delivery Systems

24. Treatment of CNS infections in AIDS positive patients through Novel Drug Delivery Systems

25. Novel Drug Delivery Systems in the management of myasthenia gravis

26. Managing Concussions and traumatic brain injury through NDDS

27. Trends in delivery of drugs to brain for treatment of neuropathy

28. Delivery of antimigraine drugs to brain through Novel Drug Delivery Systems

29. Treatment of heavy metal induced neurotoxicity via advanced drug delivery systems

Part III Clinical Trials and Future Prospects

30. Exploring the potential of artificial intelligence in drug delivery to brain

31. Clinical trials in drug discovery for treatment of CNS disorders

32. Future prospects and Challenges to CNS drug delivery

Pooja A Chawla

Dr. Pooja A Chawla is a Professor, Department of Pharmaceutical Chemistry, ISF College Of Pharmacy Moga, India. She Has 19 Years of Experience in the Research, Discovery And Development Of Biologically Active Pharmaceuticals. Dr. Chawla Holds a Ph D Degree In Medicinal Chemistry and Has Published 3 Books, 5 Book Chapters and More Than 60 Papers In National/International Journals and Is serving as reviewer for international journals of repute. Dr. Chawla Is also Privileged to serve as guest editor of two reputed journals of Bentham Sciences. She has guided 47 Post Graduate Projects And Her Research Team Consists Of 3 Master And 4 Doctoral Research Scholars. Her area of research Interest focuses on the design And synthesis of various heterocyclic moieties.

Affiliations and expertise

Professor, Department of Pharmaceutical Chemistry, ISF College of Pharmacy, India

Raimar Loebenberg

Dr. Löbenberg holds a BSc in pharmacy from the Johannes Gutenberg-University in Mainz, Germany. He received his PhD in pharmaceutics from the Johann Wolfgang Goethe-University in Frankfurt in 1996. He joined the University of Alberta in 2000. His research interests are in Biopharmaceutics to predict the oral performance of drugs and botanicals and inhalable nanoparticles to treat lung diseases like cancer or tuberculosis. He is founder and director of the Drug Development and Innovation Centre at the University of Alberta. He was president of the Canadian Society for Pharmaceutical Sciences 2014 & 2015. He is member of the United States Pharmacopeia Dietary Supplement Expert Committee. He is Vice Chair of the Specialty Committee of Traditional Chinese Medicine in Pharmaceutics of the World Foundation of Chinese Medicine Science. He is member of the Health Canada Scientific Advisory Committee on Pharmaceutical Sciences and Clinical Pharmacology.

Affiliations and expertise

Professor, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Canada

Kamal Dua

Dr Kamal Dua is an award-winning pharmaceutics and drug delivery researcher who has deep roots in teaching, research and industry spanning three nations and two continents. He holds dual expertise in Pharmaceutical Sciences and Immunology & Microbiology and has also completed four professional diplomas in the areas of clinical research, product development, drug regulation, and documentation and intellectual property rights. In his role as a senior lecturer in the Graduate School of Health at UTS, Kamal leads a suite of Good Manufacturing Practice (GMP) courses where, as a Program Coordinator, his responsibilities include coordinating the academic and research activities for those courses. Drawing on his experience with various pharmacy schools in Australia and overseas, he has blended different modes of innovative teaching with traditional teaching modes to create a flexible, student-centred and engaging approach to pedagogy.

Affiliations and expertise

Adjunct Assistant Professor, Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Canada

Vinay Parikh

Dr Vinay Parikh, is an Associate Professor in the Cognition and Neuroscience area of the Department of Psychology at Temple University. Dr. Parikh also holds an affiliated faculty appointment in the Center for Substance Abuse Research at Lewis Katz School of Medicine. Previously, he served as the Director of Neuroscience Program in the College of Liberal Arts and provided strategic leadership, direction, and guidance for all educational and professional activities in the program. Dr. Parikh’s research interests broadly focus on neuromodulation of cognition in health and disease. For many years, his laboratory is engaged in delineating the contributions of cholinergic and glutamatergic signaling in modulation of distinct cognitive processes, specifically those involved in attention and executive functions. His research has also focused on the role of neurotrophins as key regulators of neurochemical circuit adaptations and cognitive functioning in aging and psychiatric disorders such as drug addiction and schizophrenia.

Affiliations and expertise

Department of Psychology and Neuroscience Program, Temple University, USA

Viney Chawla

Dr. Viney Chawla is working as Professor and Principal at University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Punjab, India, He has 23 years of experience In the research, formulation and development of solid lipid nanoparticles, microspheres, nanostructured lipid carriers. Dr. Chawla Holds a Ph. D Degree In Pharmaceutics And Has Published 1 Book, 21 Book Chapters And More Than 60 Papers In National/International Journals And Is Serving as A Reviewer For International Journals Of Repute. Dr. Chawla delivered An Oral Talk at World Chemistry Congress, Dubai 2019. He Has Guided 40 Post Graduate Projects And his Research Team Consists Of 4 Master And 3 Doctoral Research Scholars.

Affiliations and expertise

University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, India