Nontuberculous Mycobacterial Pulmonary Disease, An Issue of Clinics in Chest Medicine

1st Edition, Volume 44-4 - October 26, 2023
Editors: Shannon Kasperbauer, Rachel Thomson
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 9 1 1 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 9 1 2 - 6

In this issue of Clinics in Chest Medicine, guest editors Drs. Shannon Kasperbauer and Rachel Thomson bring their considerable expertise to the topic of Nontuberculous… Read more

Nontuberculous Mycobacterial Pulmonary Disease, An Issue of Clinics in Chest Medicine

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In this issue of Clinics in Chest Medicine, guest editors Drs. Shannon Kasperbauer and Rachel Thomson bring their considerable expertise to the topic of Nontuberculous Mycobacterial Pulmonary Disease. Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a challenging infection which is becoming increasingly prevalent, particularly in the elderly, for reasons which are unknown. In this issue, top experts discuss topics such as environmental sources and transmission of nontuberculous mycobacteria; global epidemiology; host susceptibility; investigation and management of bronchiectasis in nontuberculous mycobacterial pulmonary disease; and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Environmental Sources and Transmission of Nontuberculous Mycobacteria
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosure
Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease: A Review
Key points
Introduction
Epidemiology of nontuberculous mycobacterial isolation and disease by global region
Systematic review and meta-analysis—global
Summary and research gaps
Clinics care points
Disclosure
Host Susceptibility to Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Clinical features of nontuberculous mycobacteria infections
Rare variants versus common variants
Pathophysiology of nontuberculous mycobacteria disease
Genes responsible for Mendelian susceptibility to mycobacterial disease
Disseminated nontuberculous mycobacteria due to neutralizing anti-IFNγ autoantibodies
Familial clustering of pulmonary nontuberculous mycobacteria disease
Whole-exome sequencing of nontuberculous mycobacteria-pulmonary disease
Genome wide association studies of nontuberculous mycobacteria-pulmonary disease
Future directions
Funding source
Clinics care points
Disclosure
Investigation and Management of Bronchiectasis in Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Definition of bronchiectasis
Investigation into etiology
Management
Bronchiectasis exacerbations
Clinics care points
Disclosure
Culture, Identification, and Antimicrobial Susceptibility Testing of Pulmonary Nontuberculous Mycobacteria
Key points
Background
Sample Collection and Processing
Microscopy
Classification of nontuberculous mycobacteria
Culture
Methods of identification
Strain typing
Phenotypic Antimicrobial Susceptibility Testing
Gene-based antimicrobial susceptibility testing
Disclosure
Diagnostic Criteria and the Decision to Treat Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Summary
Clinics care points
Disclosure
Treatment of Mycobacterium avium Complex Pulmonary Disease: When Should I Treat and What Therapy Should I Start?
Key points
Introduction
What therapy should I start?
Composition of the regimen
Administration of the regimen
Surgery
Outcomes of treatment of Mycobacterium avium complex pulmonary disease
Managing treatment refractory disease
Macrolide-resistant disease
Monitoring for treatment response
Monitoring for adverse effects
Drugs in development
Clinics care points
Disclosure
Treatment Approaches to Mycobacterium abscessus Pulmonary Disease
Key points
Introduction
Clinical significance of M abscessus and decision to treat
Antibiotic susceptibility and resistance mechanisms
Current principles of pharmacotherapy
Macrolides
Amikacin (parenteral and inhaled)
Tigecycline
Imipenem-cilastatin and cefoxitin
Clofazimine
Other oral agents
Emerging therapies
Rifabutin
Bedaquiline
Novel tetracycline analogues
Tedizolid
Dual beta-lactams
Inhaled antibiotics
Nonantibiotic agents
Surgery
Summary
Clinics care points
Disclosure
Treatment of the Less Common Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Evaluation of patients with suspected nontuberculous mycobacterial pulmonary disease
General treatment principles
Antimycobacterial therapy initiation and drug susceptibility testing
Adjunctive surgery
Summary
Clinics care points
Appendix 1. Less Common NTM Appendix
Medications and Monitoring in Treatment of Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Summary
Clinics care points
Disclosure
Nontuberculous Mycobacterial Pulmonary Disease in the Immunocompromised Host
Key points
Background
Epidemiology
Immunosuppressive states
Immunosuppressive therapies
Management in the Setting of Immunosuppression
Summary
Clinics care point
Potential conflicts of interest
Host-Directed Therapy in Nontuberculous Mycobacterial Pulmonary Disease: Preclinical and Clinical Data Review
Key points
Introduction
Predominant Host Defenses to Pulmonary Mycobacterial Infection
Augmenting Host Mechanical Defenses to NTM
Augmenting Host Immunologic Defenses to NTM
NTM-PD HDT Pipeline
Summary
Clinics care points
Disclosure
Cystic Fibrosis-Related Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Epidemiology
Risk factors for nontuberculous mycobacteria acquisition
Acquisition of nontuberculous mycobacteria
Diagnosis and screening
Treatment
Emerging therapies for nontuberculous mycobacteria
Lung transplantation and surgery
Summary
Clinics care points
Disclosure
Surgical Resection in Nontuberculous Mycobacterial Pulmonary Disease
Key points
Introduction
Summary
Clinics care points
Disclosure

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Nontuberculous Mycobacterial Pulmonary Disease, An Issue of Clinics in Chest Medicine

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Shannon Kasperbauer

Rachel Thomson