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Nontuberculous Mycobacterial Pulmonary Disease, An Issue of Clinics in Chest Medicine
- 1st Edition, Volume 44-4 - October 26, 2023
- Editors: Shannon Kasperbauer, Rachel Thomson
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 3 9 1 1 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 3 9 1 2 - 6
In this issue of Clinics in Chest Medicine, guest editors Drs. Shannon Kasperbauer and Rachel Thomson bring their considerable expertise to the topic of Nontuberculous… Read more
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Contains 15 practice-oriented topics including novel antimicrobial agents in nontuberculous pulmonary disease; host directed therapy in nontuberculous pulmonary disease; cystic fibrosis related nontuberculous mycobacterial pulmonary disease; surgical resection in nontuberculous mycobacterial pulmonary disease; and more.
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Provides in-depth clinical reviews on nontuberculous mycobacterial pulmonary disease, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Environmental Sources and Transmission of Nontuberculous Mycobacteria
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Disclosure
- Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease: A Review
- Key points
- Introduction
- Epidemiology of nontuberculous mycobacterial isolation and disease by global region
- Systematic review and meta-analysis—global
- Summary and research gaps
- Clinics care points
- Disclosure
- Host Susceptibility to Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Clinical features of nontuberculous mycobacteria infections
- Rare variants versus common variants
- Pathophysiology of nontuberculous mycobacteria disease
- Genes responsible for Mendelian susceptibility to mycobacterial disease
- Disseminated nontuberculous mycobacteria due to neutralizing anti-IFNγ autoantibodies
- Familial clustering of pulmonary nontuberculous mycobacteria disease
- Whole-exome sequencing of nontuberculous mycobacteria-pulmonary disease
- Genome wide association studies of nontuberculous mycobacteria-pulmonary disease
- Future directions
- Funding source
- Clinics care points
- Disclosure
- Investigation and Management of Bronchiectasis in Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Definition of bronchiectasis
- Investigation into etiology
- Management
- Bronchiectasis exacerbations
- Clinics care points
- Disclosure
- Culture, Identification, and Antimicrobial Susceptibility Testing of Pulmonary Nontuberculous Mycobacteria
- Key points
- Background
- Sample Collection and Processing
- Microscopy
- Classification of nontuberculous mycobacteria
- Culture
- Methods of identification
- Strain typing
- Phenotypic Antimicrobial Susceptibility Testing
- Gene-based antimicrobial susceptibility testing
- Disclosure
- Diagnostic Criteria and the Decision to Treat Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Summary
- Clinics care points
- Disclosure
- Treatment of Mycobacterium avium Complex Pulmonary Disease: When Should I Treat and What Therapy Should I Start?
- Key points
- Introduction
- What therapy should I start?
- Composition of the regimen
- Administration of the regimen
- Surgery
- Outcomes of treatment of Mycobacterium avium complex pulmonary disease
- Managing treatment refractory disease
- Macrolide-resistant disease
- Monitoring for treatment response
- Monitoring for adverse effects
- Drugs in development
- Clinics care points
- Disclosure
- Treatment Approaches to Mycobacterium abscessus Pulmonary Disease
- Key points
- Introduction
- Clinical significance of M abscessus and decision to treat
- Antibiotic susceptibility and resistance mechanisms
- Current principles of pharmacotherapy
- Macrolides
- Amikacin (parenteral and inhaled)
- Tigecycline
- Imipenem-cilastatin and cefoxitin
- Clofazimine
- Other oral agents
- Emerging therapies
- Rifabutin
- Bedaquiline
- Novel tetracycline analogues
- Tedizolid
- Dual beta-lactams
- Inhaled antibiotics
- Nonantibiotic agents
- Surgery
- Summary
- Clinics care points
- Disclosure
- Treatment of the Less Common Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Evaluation of patients with suspected nontuberculous mycobacterial pulmonary disease
- General treatment principles
- Antimycobacterial therapy initiation and drug susceptibility testing
- Adjunctive surgery
- Summary
- Clinics care points
- Appendix 1. Less Common NTM Appendix
- Medications and Monitoring in Treatment of Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Summary
- Clinics care points
- Disclosure
- Nontuberculous Mycobacterial Pulmonary Disease in the Immunocompromised Host
- Key points
- Background
- Epidemiology
- Immunosuppressive states
- Immunosuppressive therapies
- Management in the Setting of Immunosuppression
- Summary
- Clinics care point
- Potential conflicts of interest
- Host-Directed Therapy in Nontuberculous Mycobacterial Pulmonary Disease: Preclinical and Clinical Data Review
- Key points
- Introduction
- Predominant Host Defenses to Pulmonary Mycobacterial Infection
- Augmenting Host Mechanical Defenses to NTM
- Augmenting Host Immunologic Defenses to NTM
- NTM-PD HDT Pipeline
- Summary
- Clinics care points
- Disclosure
- Cystic Fibrosis-Related Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Epidemiology
- Risk factors for nontuberculous mycobacteria acquisition
- Acquisition of nontuberculous mycobacteria
- Diagnosis and screening
- Treatment
- Emerging therapies for nontuberculous mycobacteria
- Lung transplantation and surgery
- Summary
- Clinics care points
- Disclosure
- Surgical Resection in Nontuberculous Mycobacterial Pulmonary Disease
- Key points
- Introduction
- Summary
- Clinics care points
- Disclosure
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 44-4
- Published: October 26, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323939119
- eBook ISBN: 9780323939126
SK
Shannon Kasperbauer
RT