Non-Canonical Autophagy
Mechanisms and Pathophysiological Implications
- 1st Edition - April 21, 2021
- Editors: Giulia Petroni, Lorenzo Galluzzi
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 5 3 8 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 9 1 1 - 0
Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discov… Read more
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Request a sales quoteNon-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies.
- Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy
- Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes
- Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
Researchers, graduate students, and professionals actively working in the field of autophagy research across molecular biology, biochemistry, cell biology, and biomedical sciences. Medical researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Chapter 1. Canonical versus noncanonical autophagy
- Chapter 2. AMPK: the energy sensor that regulates autophagy and a potential therapeutic target for neurodegenerative diseases
- 2.1. Introduction
- 2.2. Conclusion
- Chapter 3. Overview of noncanonical autophagy
- 3.1. Introduction
- 3.2. The canonical autophagic pathway
- 3.3. Noncanonical autophagy
- 3.4. Is noncanonical autophagy relevant in pathophysiology?
- 3.5. Conclusion
- Chapter 4. LC3-associated phagocytosis: molecular mechanisms and pathological consequences
- 4.1. Introduction
- 4.2. Molecular mechanisms of LAP
- 4.3. Pathologies associated with LAP
- 4.4. Conclusion
- Chapter 5. Autophagy-dependent cell death; therapeutic target or chance encounter? Recent insights into the mechanisms of death by self-consumption
- Abbreviations
- 5.1. Introduction
- 5.2. Autophagy
- 5.3. Autophagy and cell death signaling
- 5.4. Autophagy-dependent cell death and autosis
- 5.5. Molecular mechanisms of autophagy-dependent cell death and autosis—lessons learnt from therapeutic interventions
- 5.6. The importance of accurately reporting ADCD
- 5.7. Conclusion and future outlook
- Chapter 6. Noncanonical use of the autophagy machinery in antigen presentation
- 6.1. Introduction on the macroautophagy machinery
- 6.2. MHC-restricted antigen presentation
- 6.3. LC3-associated phagocytosis in MHC class II–restricted antigen presentation
- 6.4. MHC class I internalization by the autophagic machinery
- 6.5. Antigen exocytosis for efficient cross-presentation on MHC class I molecules
- 6.6. Conclusions and future direction
- Chapter 7. Metabolic aspects of canonical versus noncanonical autophagy
- 7.1. Introduction
- 7.2. Canonical versus noncanonical autophagy: molecular mechanisms
- 7.3. Metabolic control of canonical versus noncanonical autophagy
- 7.4. Metabolic regulation of alternative autophagy routes
- 7.5. Metabolic control of mitophagy
- 7.6. Concluding remarks
- Index
- No. of pages: 182
- Language: English
- Edition: 1
- Published: April 21, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128205389
- eBook ISBN: 9780128209110
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Giulia Petroni
Giulia Petroni is a PhD Fellow at the Department of Experimental and Clinical Medicine, University of Florence. Giulia does research in Oncology, focusing on the ion channels' role in Colorectal Cancer. She has also an expertise in Clinical Immunology and Immunogenicity. She has published over 15 articles in international peer-reviewed journals.
Affiliations and expertise
Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyLG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USARead Non-Canonical Autophagy on ScienceDirect