Non-Canonical Autophagy

Chapter 1. Introduction: canonical vs non-canonical autophagy

Chapter 2. Overview of Canonical Autophagy 

2.1 Introduction 

2.2 Overview of the main autophagic processes 

2.3 Molecular components of the autophagy core machinery and signaling pathways 

2.4 Autophagosomes formation, maturation and fusion 

Chapter 3. Overview of Non-Canonical Autophagy

3.1 Introduction

3.2 ULK-1-independent autophagy

3.3 Beclin 1-indipendent, VSPS34-independent and VPS34/VPS15-independent Autophagy

3.4 Ubiquitin-like conjugation actors-independent autophagy

3.5 Non-canonical mitophagy

3.5 The unconventional functions of ATG proteins

Chapter 4. LC3-associated phagocytosis (LAP)

4.1 Introduction 

4.2 Molecular divergences between canonical autophagy and LAP 

4.3 Role of LAP in immunity and inflammation 

4.4 Role of LAP in anti-cancer immune response 

Chapter 5. Autophagy-dependent cell death (ADCD) 

5.1 Introduction 

5.2 Types of ADCD and their distinguishing features: excessive autophagy, excessive mitophagy and autosis 

5.3 The key signals regulating ADCD 

5.4 Role of ADCD in physiological and pathophysiological conditions 

5.5 Induction of ADCD by anti-cancer agents. Facts and controversies

Chapter 6. Therapeutic targeting of non-conventional autophagy: potential benefits and pitfalls  

6.1 Introduction 

6.2 Therapeutic targeting of autophagy in neurodegenerative disease 

6.3 Targeting autophagy in aging and cardiovascular diseases 

6.4 Autophagy as a therapeutic target for autoimmune disorders 

6.5 Targeting autophagy in cancer