NK Cells in Cancer Immunotherapy: Successes and Challenges

1. Introduction and basic biology of NK cells; history, basic biology, mode of function, Innate Lymphoid Cells (ILCs), mouse models of human cancer, NK cells in metastatic cancer and targeting cancer stem cells and use in Immunotherapy2. Immunotherapy using CAR/NK with and without CAR/T: What we have learned from Trials and where are we heading3. Immunotherapy using NK cells with and without T cells and Tumor infiltrating lymphocytes as well as NK/T cells : Different sources of NK cells (cord blood derived NK cells, iPSC derived NK cells, NK cell lines, different feeder cell expanded peripheral blood NK cells), types of activation and expansion and Successes and Challenges of each source4. Autologous vs allogeneic sources of NK and T cell effectors; Studies of patients’ NK and T cell function and the challenges of using autologous sources5. Reversing NK inhibitory tumor microenvironment by targeting suppressive immune effectors; Multiparameter analyses of data, Reference tools for immune fitness analyses. Immunogenetic analyses of immune cells and Correlates with tumor cell profiling6. Check point inhibitors: Novel approaches for use with NK cell immunotherapy7. Combination of NK immunotherapy with chemotherapy and radiation: The rationale and background8. NK cell immunotherapy using ADCC inducing antibodies9. Oncolytic viruses and NK cell immunotherapy: successes and challenges10. NK cell diagnostics; Different tests to assess patient NK function11. Novel cell delivery systems; Intravenous vs. intraperitoneal and intracranial