Nicotinic Acetylcholine Receptors in Health and Disease
- 1st Edition - March 14, 2023
- Imprint: Academic Press
- Author: R. Thomas Boyd
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 9 5 8 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 4 1 8 - 4
Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, includ… Read more
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Request a sales quoteNicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders.
- Describes the roles, expression and function of nicotinic receptors
- Includes receptor involvement, both inside and outside the nervous system
- Details nicotinic receptor involvement in Alzheimer’s, Parkinson’s, Cancer, Schizophrenia, and more
- Emphasizes future treatment prospects of disorders via modulation of nAChR signaling
Undergraduate and graduate students in medicine, health sciences, and biological sciences, neuroscientists, clinicians, post-doctoral fellows, and researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- About the author
- Preface
- Chapter One: nAChR structure
- Abstract
- 1.1: Early structural studies on muscle and Torpedo nAChRs
- 1.2: Diversity of neuronal nAChRs
- 1.3: Structure of individual nAChR subunits
- References
- Chapter Two: Neuronal nAChR localization, subtype diversity, and evolution
- Abstract
- 2.1: Subtype diversity
- 2.2: Subunit genes
- 2.3: Subtype assemblies
- 2.4: Subtypes present in vivo
- 2.5: Regional localization
- 2.6: Cellular localization
- 2.7: Summary
- References
- Further reading
- Chapter Three: Function and pharmacology of neuronal nAChRs
- Abstract
- 3.1: Introduction
- 3.2: Function
- 3.3: Pharmacology overview
- 3.4: Agonists
- 3.5: Antagonists
- 3.6: Allosteric modulators
- 3.7: Summary
- References
- Further reading
- Chapter Four: Nicotine addiction: The role of specific nAChR subtypes and treatments
- Abstract
- 4.1: Introduction
- 4.2: Nicotine metabolism
- 4.3: Presentation of nicotine addiction in humans and in animal models
- 4.4: Reward pathways for nicotine
- 4.5: Genetic involvement in nicotine addiction
- 4.6: nAChR subtypes involved in the effects of nicotine on reward and aversion
- 4.7: Pharmacotherapy for nicotine addiction
- 4.8: Other potential candidates for smoking cessation
- References
- Chapter Five: Disease associations—Alzheimer’s disease, schizophrenia, Parkinson’s disease, autism, and cancer
- Abstract
- 5.1: Alzheimers’ disease
- 5.2: Schizophrenia
- 5.3: Autism
- 5.4: Parkinson’s disease
- 5.5: Cancer
- References
- Chapter Six: Role of neuronal nAChRs in normal development and plasticity
- Abstract
- 6.1: Acetylcholine and receptors are present and function before and early in nervous system development
- 6.2: Timing and location of nAChR subtypes during development
- 6.3: The role of nAChRs in specific developmental events
- 6.4: Additional developmental effects
- References
- Chapter Seven: Developmental, epigenetic, and possible transgenerational effects of smoking and vaping
- Abstract
- 7.1: Effects of maternal nicotine exposure on various organ systems
- 7.2: Nervous system effects of prenatal nicotine exposure
- 7.3: Nervous system effects of adolescent nicotine exposure
- 7.4: Role of specific nAChR subtypes and possible mechanisms
- 7.5: Vaping: Prenatal and adolescent effects
- 7.6: Epigenetic effects of nicotine exposure
- 7.7: Intergenerational and transgenerational effects
- References
- Chapter Eight: Expression and function of nonneuronal nAChRs
- Abstract
- 8.1: Expression of nAChRs and a cholinergic system in nonneuronal cells
- 8.2: Nonneuronal cholinergic system overview
- 8.3: Cholinergic system in immune cells
- 8.4: Cholinergic system in skin cells
- References
- Chapter Nine: Regulation of nAChR expression: Posttranscriptional regulation of nAChRs
- Abstract
- 9.1: Assembly of NMJ nAChRs
- 9.2: Assembly and trafficking of neuronal nAChRs
- 9.3: NACHO
- 9.4: 14-3-3η and adenomatous polyposis coli (APC)
- 9.5: ly6/uPAR prototoxins
- 9.6: Menthol
- 9.7: Upregulation by nicotine: An important role in addiction
- 9.8: MicroRNA (miRNA)
- References
- Chapter Ten: Nonmammalian models for studying nAChRs; zebrafish, fruit fly, and worm. What have we learned?
- Abstract
- 10.1: Danio rerio (D. rerio)
- 10.2: Caenorhabditis elegans (C. elegans)
- 10.3: Drosophila melanogaster (D. melanogaster)
- References
- Index
- Edition: 1
- Published: March 14, 2023
- No. of pages (Paperback): 290
- No. of pages (eBook): 290
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128199589
- eBook ISBN: 9780128204184
RB
R. Thomas Boyd
Associate Professor in the Department of Neuroscience at Ohio State University. Involved in undergraduate and graduate education for most of his career, he served on the Neuroscience Graduate Studies Program Graduate Studies Committee for many years and is currently on the Biomedical Sciences Graduate Programs Graduate Studies Committee (BSGP). He was involved in the development of the Neuroscience major at Ohio State and has taught a large undergraduate Neuroscience class for more than 10 years. Research activities in the Boyd laboratory emphasize a molecular biological analysis of neuronal nicotinic acetylcholine receptors (nAChRs) and were the first to clone the zebrafish neuronal nAChR genes and determine its expression pattern during development. The information derived from these studies is being used to develop zebrafish as a model for studying the role of nAChRs in normal development of the nervous system and the mechanisms by which nicotine perturbs this.
Affiliations and expertise
Ohio State University Wexner Medical Center, USARead Nicotinic Acetylcholine Receptors in Health and Disease on ScienceDirect