New Trends in Smart Nanostructured Biomaterials in Health Sciences

1st Edition - October 7, 2022
Editors: Gil Goncalves, Paula A.A.P. Marques, Joao F. Mano
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 6 7 1 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 5 6 6 - 9

New Trends in Smart Nanostructured Biomaterials in Health Sciences provides guidance on the design and synthesis of nanostructured smart biomaterials, as well as the resultant… Read more

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New Trends in Smart Nanostructured Biomaterials in Health Sciences provides guidance on the design and synthesis of nanostructured smart biomaterials, as well as the resultant therapeutic effects and associated biomedical applications of these novel materials. The book provides readers with a deeper understanding of these novel biomaterials and aids them in making informed decisions when selecting appropriate materials for tissue engineering and cancer therapy applications. It will be of specific interest to materials scientists, biomedical engineers, oncological scientists, tissue engineers and those working in regenerative medicine.

Nanostructured smart materials have the special ability to respond to changes in the cell microenvironment, allowing for robust, biocompatible and rapidly adaptable, therapeutic and restorative action against a range of ailments. These materials are thus ideal candidates for use in tissue engineering and cancer therapy due to the varying nature of the cell microenvironment between persons, tissues and cancers. This book covers the design, synthesis, unique properties and application of smart biomaterials in these two key topic areas of tissue engineering and cancer therapeutics.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Acknowledgment
Section 1. Smart nanostructured materials for oncology
Chapter 1. Smart drug delivery nanostructured systems for cancer therapy
1. Introduction
2. Nanostructured systems for smart drug delivery
3. Conclusions
Chapter 2. Dendrimers and dendrimer-based nano-objects for oncology applications
1. Introduction
2. Dendrimers design: searching for biocompatibility
3. Dendrimers design: overcoming the body barriers and targeting strategies
4. Dendrimers: strategies for cancer treatment and diagnosis
5. Conclusions and perspectives in the field
Chapter 3. Recent advances in tumors-on-chips
1. Basics of tumor-on-a-chip
2. Engineered tumor models
3. Concluding remarks and future perspectives
4. List of abbreviations
Chapter 4. Application of smart materials in biosensors for cancer diagnosis
1. Cancer diagnosis: traditionalism x new perspectives
2. Biosensors
3. Transduction
4. Bioreceptor
5. Enzymes
6. Antibodies
7. Nucleic acids
8. Aptamers
9. Application of smart materials in biosensors for cancer diagnosis
10. Gold nanoparticles
11. Graphene
12. Carbon nanotubes
13. Hydrogels
14. Conclusions
Section 2. Smart nanostructured materials for tissue engineering
Chapter 5. Direct laser biofabrication of scaffolds for neural tissue engineering
1. Methods
2. Neural cell responses
3. Neural cell responses under dynamic conditions
4. Conclusions and future prospects
Chapter 6. Smart biomaterials and constructs for Bone tissue regeneration
1. Introduction
2. Bone composition structure
3. 4D printing
4. Smart constructs
5. Material perspective
6. Designing perspective
7. Conclusion
Chapter 7. Smart biomaterials for skin tissue engineering and health monitoring
1. Smart biomaterials: a general introduction
2. Skin-related applications of smart biomaterials
3. Conclusions
Chapter 8. Smart biomaterials and constructs for cardiac tissue regeneration
1. Introduction
2. Injectable smart biomaterials
3. Injectable smart biomaterials for drug delivery
4. Hydrogel, nanoparticles, and nanogels
5. Injectable smart biomaterials for cell transplantation
6. Cardiac patches
7. Smart biomaterials for TEHV
Chapter 9. The fate of stem cells within smart biomaterials and constructs
1. Introduction
2. Topography
3. Mechanostimulation
4. Electrical stimulation
5. Ligand presentation
6. Conclusion
Chapter 10. 4D printing for tissue engineering of smart constructs
1. Introduction
2. Smart bioinks
3. Tissue engineering evidence
4. Challenges and future perspectives
5. Conclusions
Chapter 11. Bioactive glass nanofibers: synthesis and applications
1. Introduction to bioactive glasses
2. Glass nanofibers: methods of production
3. Bioactive glass nanofibers
4. Summary and outlook
Chapter 12. Graphene: an ally for antibacterial biomaterials
1. Bacterial adhesion and biofilm formation
2. Antimicrobial strategies to fight infection: surface modification
3. Graphene-based materials and their bactericidal action
4. Conclusions
5. Future remarks
Index

Gil Goncalves

Gil Gonçalves received his PhD in Mechanical Engineering at the University of Aveiro with a thesis dedicated to nanocomposite materials for biomedical applications. He worked as a Researcher at the Institute of Material Science of Barcelona-High Council of Spanish Research (ICMAB-CSIC) under the Marie Skłodowska-Curie Actions. He was a short-term visitor on various occasions at University of Trieste and Laboratory of Applied Nuclear Energy (LENA, University of Pavia).Currently, he is working as Assistant Researcher at TEMA Centre for Mechanical Technology and Automation (Portugal), on the development of novel carbon-based nanocomposite materials with application in water remediation (Environment), three-dimensional graphene scaffolds for biomedical applications (Biomaterials), and carbon dots-based nanoplatforms for detection and therapy of cancer (Theranostic agents).

Affiliations and expertise

TEMA - Centre for Mechanical Technology and Automation Mechanical Engineering Department, University of Aveiro, Campo Universitário de Santiago, Aveiro, Portugal

Paula A.A.P. Marques

Paula Marques graduated in Chemistry in the Universidade de Aveiro (UA) in 1993, completing her Master’s in Chemistry and Physics Teaching in 1997 and the PhD degree in Materials Science Engineering (Biomaterials specialization) in 2003 in the same institution. Paula’s research interests are the engineering and development of carbon-based nanostructured composites for health and environmental applications. She published +80 papers in international peer reviewed journals, seven book chapters, three books and has one patent registered and three requested. The quality of her work is expressed by the number of citations (+3800) and h-index of 33. Paula participated in 25 R&D projects with 9 in progress, being presently the coordinator of a H2020-FETOPEN project (A step forward to spinal cord injury repair using innovative stimulated nanoengineered scaffolds - No 829060). Paula is responsible for teaching the course “Carbon Nanostructures” of the PhD program in Nanoscience and Nanotechnology, Technologies and Processes at Nano-Scale of the 5th year of Mechanical Engineering Master and is also supporting recurrent teaching activities in Materials Science Engineering. She has completed the supervision of 7 post-doctoral researchers, 5 PhD and 9 MSc, and is currently supervising 7 PhD and 2 MSc students.

Affiliations and expertise

TEMA - Centre for Mechanical Technology and Automation Mechanical Engineering Department, University of Aveiro, Campo Universitário de Santiago, Aveiro, Portugal

Joao F. Mano

João F. Mano (CEng, PhD, DSc) is a Full Professor at the Chemistry Department of University of Aveiro, Portugal, where he is directing both the MSc and PhD programs of Biotechnology. He is the founder and director of the COMPASS Research Group, from the Associated Laboratory CICECO – Aveiro Institute of Materials. His research interests include the use of advanced biomaterials and cells towards the progress of transdisciplinary concepts to be employed in regenerative and personalised medicine. In particular, he has been applying biomimetic and nano/micro-technology approaches to polymer-based biomaterials and surfaces in order to develop biomedical devices with improved structural and (multi-)functional properties, or in the engineering of microenvironments to control cell behaviour and organization, to be exploited clinically in advanced therapies or in drug screening. João Mano is the Editor-in-Chief of Materials Today Bio (Elsevier). He has been coordinating or involved in many national and European research projects, including Advanced and Proof-of-Concept Grants from the European Research Council. João Mano is an elected fellow of the European Academy of Sciences.

Affiliations and expertise

Full Professor, CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campo Universitario de Santiago, Aveiro, Portugal

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New Trends in Smart Nanostructured Biomaterials in Health Sciences

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Gil Goncalves

Paula A.A.P. Marques

Joao F. Mano