New and Future Developments in Microbial Biotechnology and Bioengineering

Recent Advances in Application of Fungi and Fungal Metabolites: Applications in Healthcare

1st Edition - August 19, 2020
Imprint: Elsevier
Editors: Joginder Singh Panwar, Praveen Gehlot
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 0 0 6 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 5 5 5 - 4

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New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Applications in Healthcare presents an account of recent development and applied aspects of fungi and its metabolites in the healthcare sector. Chapters are written by eminent researchers, emphasizing the incredible role of fungi and its metabolites in the field of medicine. This book offers reference material to all mycologists working on the exploration and usage of medicinal aspects of fungi and fungal metabolites.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter 1: Prospective of macrofungal metabolites in human health
Abstract
1.1: Introduction
1.2: Medicinal mushrooms
1.3: Mushroom metabolites
1.4: Mechanism of action
1.5: Medicinal applications
1.6: Conclusions
Chapter 2: Toxins from Fusarium species and their role in animal and plant diseases
Abstract
2.1: Introduction
2.2: Avenacein Y
2.3: Beauvericin
2.4: Butenolide
2.5: Calonectrin
2.6: Deoxynivalenol
2.7: Diacetoxyscirpenol
2.8: Enniatins
2.9: Fructigenin
2.10: Fumonisin B1
2.11: Fusaric acid
2.12: Fusarin
2.13: HT-2 toxin
2.14: Ipomeanine
2.15: Lycomarasmin
2.16: Moniliformin
2.17: Neosolaniol
2.18: Nivalenol
2.19: Sambucynin (sambucinin)
2.20: T-1 toxin (NT-1) and NT-2 toxin
2.21: T-2 toxin
2.22: Yavanicin (Javanicin)
2.23: Zearalenone
2.24: Conclusion and future prospects
Chapter 3: Keratinophilic fungi: Isolation, identification, pathogenicity, characterization, and treatment
Abstract
3.1: Introduction
3.2: Sampling techniques for keratinophilic fungi
3.3: Ecology of keratinophilic fungi
3.4: Identification of keratinophilic fungi
3.5: Nutritional requirements of keratinophilic fungi
3.6: Growth characteristics of keratinophilic fungi
3.7: Effect of environmental factors on keratinophilic fungi
3.8: Infection and transmission
3.9: Treatment of infections caused by keratinophilic fungi
3.10: Antikeratinophilic activity of bioactive compounds from plants
Chapter 4: Endophytic fungi: A new hope for drug discovery
Abstract
4.1: Introduction
4.2: History
4.3: Classification of endophytes
4.4: Endophytes promote the accumulation of bioactive compounds
4.5: The need for endophytes
4.6: Process of drug discovery from endophytes
4.7: Cultivation and extraction of endophytic fungi
4.8: Biopharmaceuticals from endophytes
4.9: Conclusion
Chapter 5: Therapeutic potency of bioactive compounds from fungal endophytes
Abstract
Acknowledgments
5.1: Introduction
5.2: Endophyte-host relationship
5.3: Classification of endophytic fungal metabolites based on their bioactivities
5.4: Conclusion
Chapter 6: Role of fungi in neurodegenerative diseases
Abstract
6.1: Introduction
6.2: Role of fungus in neurological disease
6.3: Treatment of neurodegenerative diseases by nanoformulation of natural compounds
6.4: Conclusion and future perspectives
Chapter 7: Fungal secondary metabolites: A potential source of anticancer compounds
Abstract
7.1: Introduction
7.2: Cancer statistics
7.3: Oyster mushroom
Chapter 8: A promising source of anticancer drug from fungal secondary metabolite
Abstract
8.1: Introduction
8.2: Fungal metabolites as anticancer agents
8.3: Endophytic fungi as a source of anticancer agents
8.4: Anticancer agents from endophytic fungi
8.5: Current challenges and future prospective
Chapter 9: Neoteric research trends in marine fungi as promising and alternate sources of anticancer phytochemicals
Abstract
Acknowledgment
Conflict of interest
9.1: Introduction
9.2: Methodology
9.3: Secondary metabolites obtained from marine endophytic fungi associated with mangrove plants
9.4: Secondary metabolites obtained from algae-associated marine fungi
9.5: Secondary metabolites obtained from sponge-associated marine fungi
9.6: Secondary metabolites isolated from marine sediment-derived fungi
9.7: Secondary metabolites from marine fungi originating in deep-sea sediment
9.8: Metabolites isolated from other types of fungi associated with different organisms or collected from mud or water samples
9.9: Discussion
9.10: Conclusion
Chapter 10: Fungal enzyme inhibitors: Repository of novel cancer therapeutics
Abstract
10.1: Introduction
10.2: Fungi as a source of anticancer agents
10.3: Potential applications of fungal enzyme inhibitors in the management of cancer
10.4: Fungal metabolites in cancer clinical trials
10.5: Synthetic analogues of fungal metabolites in cancer trials
10.6: Fungal metabolites evaluated in vivo in animal models of human cancer
10.7: Conclusion
Chapter 11: Biotechnological approaches for the enhancement of anticancer secondary metabolite production from endophytic fungi
Abstract
11.1: Introduction
11.2: Sources of anticancer compounds
11.3: Biosynthesis of anticancer metabolites
11.4: Improving secondary metabolite production in fungal cell cultures
11.5: Conclusion
Chapter 12: Fungal metabolites—A potential source of antiviral compounds
Abstract
12.1: Introduction
12.2: Fungi as a source of antiviral therapeutic agents
12.3: Classes of antiviral metabolites
12.4: Mechanisms of action of antiviral fungal metabolites
12.5: Fungal metabolites against human and animal viruses
12.6: Fungal metabolites against plant viruses
12.7: Conclusions and future perspectives
Chapter 13: Chitin: Promising biopolymer for biomedical application
Abstract
Acknowledgment
13.1: Introduction
13.2: Chemical structure of chitin
13.3: Chitin sources
13.4: Commercial production of chitin
13.5: Derivatives of chitin
13.6: Properties of chitin
13.7: Applications of chitin polymer
13.8: Conclusion
Chapter 14: Antipathogenic activity of fungal secondary metabolites with special reference to human pathogenic bacteria
Abstract
14.1: Introduction
14.2: Biosynthesis mechanisms of fungal secondary metabolites
14.3: Fungal secondary metabolites in pharmaceutical industries
14.4: Fungal secondary metabolites in cosmeceutical industries
14.5: Fungal secondary metabolites in skin aging
14.6: Fungal metabolites for skin whitening
14.7: Fungal metabolites for acne treatments
Chapter 15: Hypoglycemic potential of mushroom and their metabolites
Abstract
15.1: Introduction
15.2: Diabetes and their pathophysiology
15.3: Mushrooms as hypoglycemic agents
15.4: Conclusions and future scope
Chapter 16: Biomedical applications of 4-hydroxycoumarin as a fungal metabolite and its derivatives
Abstract
16.1: Introduction
16.2: Anticancer activity
16.3: Antibacterial potential of 4HC-based derivatives
16.4: Anti-HIV capabilities
16.5: Antioxidant properties
16.6: Anticoagulant properties of 4HC-based compounds
16.7: Conclusion
Chapter 17: Recombinant Pichia pastoris and its applications in healthcare industry
Abstract
17.1: Introduction
17.2: Pichia pastoris like an expression system
17.3: Pichia pastoris
17.4: Healthcare industry
17.5: Strategies to improve recombinant subunit vaccine production
17.6: Pichia pastoris on human growth hormone
17.7: Advantages
17.8: Drawbacks
17.9: Insulin production for diabetes
17.10: Recombinant protein subunit vaccines
17.11: The custom of Pichia pastoris in recombinant subunit vaccine development
17.12: Evaluation of the existing functional annotation
17.13: Recombinant protein subunit vaccines prepared from Pichia pastoris
17.14: Epstein-Barr infection vaccine
17.15: Dengue infection vaccine
17.16: Pichia pastoris for human cell biology (peroxisome biosynthesis) and diseases
17.17: Use of Pichia pastoris for the diagnosis of allergic diseases
17.18: Future perspectives
Index

Joginder Singh Panwar

Prof. Joginder Singh is a Professor at the Department of Botany, Nagaland University, Lumami, Nagaland, India. Previously, he worked as a Professor in the School of Bioengineering and Biosciences, Lovely Professional University and also as a Young Scientist at Microbial Biotechnology and Biofertilizer Laboratory, Department of Botany, Jai Narain Vyas University on a research project funded by the Department of Science and Technology, Government of India. He is an active member of various scientific societies and organizations, including the Association of Microbiologists of India, the Indian Society of Salinity Research Scientists, the Indian Society for Radiation Biology, and the European Federation of Biotechnology. He has published extensively with Elsevier and Springer both in journals and books. He serves as a reviewer for many prestigious journals, including Current Research in Engineering, Science and Technology; Journal of Cleaner Production; Science of the Total Environment; Environmental Monitoring and Assessment; Pedosphere; Soil and Sediment Contamination; Symbiosis; International Journal of Phytoremediation; Ecotoxicology and Environmental Safety; Annals of Agricultural Sciences; and Annals of the Brazilian Academy of Sciences.

Affiliations and expertise

Professor, Department of Botany, Nagaland University, Nagaland, India

Praveen Gehlot

Dr. Praveen Gehlot is Associate Professor, Department of Botany, Jai Narain Vyas University Jodhpur. He did his PhD from JNV University Jodhpur, under the able guidance of Prof. D.K. Purohit. He has about 18 years of teaching and research experience. He has been an awardee of Young Scientist under FAST Track Scheme by Department of Science and Technology, New Delhi and later worked as a Pool-Officer of Council of Scientific and Industrial Research, New Delhi. Earlier, he taught at Budha Institute of Technology and Science Research College, Jodhpur and Government Bangor PG College, Pali, Rajasthan and subsequently served as an Associate Professor and Head, Department of Microbiology, Maharaja Ganga Singh University, Bikaner, Rajasthan. Dr. Gehlot worked out three major research projects sponsored by UGC, DST and CSIR, New Delhi. He has published more than 80 research papers, book chapters and review articles in journals of international and national repute and has edited three book entitled “Pyrenomycetes Fungi”, “Arbuscular Mycorrhizal Fungi” and “Microbes: In Action” published by AgroBios, India and “Fungi and their Role in Sustainable Development: Current Perspectives” published by Springer International. He attended several International and National Seminars, Symposia, Conferences and chaired technical sessions and presented papers in some of them. He is an active member Mycological Society of India, Society of Mycology and Plant Pathology, India, Association of Microbiologists of India, Indian Science Congress Association, etc.

Affiliations and expertise

Associate Professor, Department of Botany, Jai Narain Vyas University Jodhpur, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health