Neuroinflammation, Resolution, and Neuroprotection in the Brain
- 1st Edition - September 15, 2021
- Imprint: Academic Press
- Author: Akhlaq A. Farooqui
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 8 4 6 0 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 4 6 1 - 7
Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of… Read more
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Request a sales quoteNeuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects.
- Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection
- Examines the role of diet and exercise on neuroinflammatory diseases
- Provides cutting-edge research on signal transduction processes
- Explores the treatment of neurological disorders caused by neuroinflammation
Researchers, clinicians and advanced graduate students in neuroscience, neurochemistry, and neuropharmacology
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- About the author
- Preface
- Acknowledgments
- Abbreviations
- Chapter 1: Molecular aspects of neuroinflammation: Contribution of eicosanoids, cytokines, and chemokines
- Abstract
- Introduction
- Molecular mechanisms of inflammation
- Involvement of microglia in neuroinflammation
- Involvement of astrocytes in neuroinflammation
- Acute neuroinflammation
- Chronic neuroinflammation
- Conclusion
- References
- Chapter 2: Contribution of bioactive lipid mediators in neuroinflammation, resolution, and neuroprotection
- Abstract
- Introduction
- Contribution of arachidonic acid-derived bioactive molecules in neuroinflammation
- Contribution of EPA-derived bioactive molecules in prevention of neuroinflammation
- Contribution of DHA-derived bioactive molecules in prevention of neuroinflammation
- Contribution of PAF in neuroinflammation
- Contribution of sphingolipid-derived mediators in neuroinflammation
- Contribution of 7-ketocholesterol in neuroinflammation
- Conclusion
- References
- Chapter 3: Contribution of protein-derived bioactive molecules (cytokines and chemokines) in neuroinflammation, resolution, and neuroprotection
- Abstract
- Introduction
- Cytokine receptors and their involvement in neuroinflammation
- Chemokine receptors and their involvement in neuroinflammation
- Contribution of TNF-α and its receptor in neuroinflammation
- Contribution of interleukins and their receptors in neuroinflammation
- Involvement of IL-10 and its receptors in neuroinflammation
- Contribution of toll-like receptors in neuroinflammation
- Effect of cytokines on neurovascular unit
- Effects of cytokines on blood-brain barrier permeability
- Contribution of cytokines and chemokines in resolution of neuroinflammation
- Contribution of cytokines and chemokines in neuroprotection
- Conclusion
- References
- Chapter 4: Contribution of neuroinflammation, resolution, and neuroprotection in neurotraumatic diseases
- Abstract
- Introduction
- Molecular mechanisms contributing to the pathogenesis of stroke
- Interplay between neuroinflammation and oxidative stress in ischemic injury
- Contribution of gut microbiota in the pathogenesis of stroke
- Resolution of neuroinflammation in stroke
- Contribution of annexins in resolution of neuroinflammation
- Contribution of galectins in the resolution of neuroinflammation
- Contribution of hydrogen sulfide in resolution of neuroinflammation
- Contribution of microbiota in resolution of neuroinflammation
- Contribution of adenosine in resolution of neuroinflammation
- Resolution of neuroinflammation in traumatic brain and spinal cord injuries
- Neuroprotection in neurotraumatic diseases
- Conclusion
- References
- Chapter 5: Contribution of neuroinflammation, resolution, and neuroprotection in neurodegenerative diseases
- Abstract
- Introduction
- Contribution of neuroinflammation in neurodegenerative diseases
- Alzheimer's disease
- Contribution of neuroinflammation in Alzheimer's disease
- Resolution of neuroinflammation in Alzheimer's disease
- Parkinson's disease
- Contribution of neuroinflammation in Parkinson's disease
- Resolution of neuroinflammation in Parkinson's disease
- Huntington's disease
- Neurodegeneration in Huntington's disease
- Neuroinflammation in Huntington's disease
- Resolution of inflammation in Huntington's disease
- Amyotrophic lateral sclerosis
- Contribution of neuroinflammation in ALS
- Resolution of neuroinflammation in amyotrophic lateral sclerosis
- Neuroprotection in neurodegenerative diseases
- Conclusion
- References
- Chapter 6: Contribution of neuroinflammation, resolution, and neuroprotection in neuropsychiatric diseases
- Abstract
- Introduction
- Depression
- Contribution of neuroinflammation the pathogenesis of depression
- Bipolar disorder
- Contribution of neuroinflammation in bipolar disorder
- Schizophrenia
- Contribution of neuroinflammation in schizophrenia
- Autism spectrum disorder
- Contribution of neuroinflammation in autism spectrum disorder
- Resolution of neuroinflammation in neuropsychiatric diseases
- Neuroprotection in neuropsychiatric diseases
- Conclusion
- References
- Chapter 7: Regulation of neuroinflammation, resolution, and neuroprotection by diet and gut microbiota
- Abstract
- Introduction
- Contribution of gut microbiota in cardiovascular diseases
- Contribution of gut microbiota in the pathogenesis of stroke
- Effect of diet on gut microbiota and brain
- Effect of diet on gut microbiota and metabolic diseases
- Beneficial effects of gut microbiota in metabolism
- Effects of long-term consumption of Western diet in humans
- Effect of long-term consumption of Mediterranean diet in humans
- Effects of long-term consumption of vegetarian diet in humans
- Effects of long-term consumption of ketogenic diet in humans
- Resolution of neuroinflammation by diet
- Conclusion
- References
- Chapter 8: Regulation of neuroinflammation, resolution, and neuroprotection by aerobic exercise, yoga, and Tai Chi
- Abstract
- Introduction
- Beneficial effects of exercise in peripheral tissues
- Beneficial effects of exercise on human brain
- Effect of aerobic exercise on neuroinflammation
- Resolution of neuroinflammation by regular aerobic exercise
- Effect of yoga practice on neuroinflammation
- Resolution of neuroinflammation by yoga practice
- Molecular mechanisms underlying Tai Chi practice
- Resolution of neuroinflammation by Tai Chi practice
- Conclusion
- References
- Chapter 9: Prevention of neuroinflammation and resolution by phytochemicals
- Abstract
- Introduction
- Prevention of neuroinflammation by green tea
- Prevention of neuroinflammation by curcumin
- Prevention of neuroinflammation by resveratrol
- Prevention of neuroinflammation by garlic constituents
- Ginseng and its biological effects
- Prevention of neuroinflammation by ginseng
- Prevention of neuroinflammation by flaxseeds
- Prevention of neuroinflammation by Ginkgo biloba
- Prevention of neuroinflammation by cinnamon
- Resolution of neuroinflammation by phytochemicals
- Conclusion
- References
- Chapter 10: Effects of dietary patterns, exercise on neuroinflammation: Perspective and future studies
- Abstract
- Introduction
- Effect of lifestyle factors on chronic neuroinflammation
- Effects of dietary patterns on neuroinflammation
- Effects of exercise on neuroinflammation
- Future studies on the effects of diet and exercise on neuroinflammation
- Conclusion
- References
- Index
- Edition: 1
- Published: September 15, 2021
- Imprint: Academic Press
- No. of pages: 332
- Language: English
- Paperback ISBN: 9780323884600
- eBook ISBN: 9780323884617
AF
Akhlaq A. Farooqui
Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.
Affiliations and expertise
Research Scientist, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USARead Neuroinflammation, Resolution, and Neuroprotection in the Brain on ScienceDirect