Table of Contents (revised after reviewer’s comments and AE’s recommendations):
Part I - Foundations of Neuroinfection
1. Anatomical organization of CNS
2. The enteric nervous system's (ENS) impact on the neurobiology of infectious diseases
3. The role of the microbiota-gut-brain axis on the neurobiology of infectious diseases
4. The role and function of specialized blood-neuronal barriers: blood-CSF, blood-retinal, blood-spinal cord, blood-labyrinth, blood-nerve, and BBB barriers.
5. The glymphatic system: What is it, and its function on the neurobiology of infectious diseases?
6. Neuro-immune interactions in health and disease
7. The routes and mechanisms of microbial translocation to the CNS
Part II - Bacterial Infections Of CNS
8. Brain infections, encephalitis, and meningitis: Streptococcus pneumoniae
9. Brain infections, encephalitis, and meningitis: Neisseria meningitidis
10. Brain infections, encephalitis, and meningitis: Mycobacterium tuberculosis
11. Brain infections, encephalitis, and meningitis: Neurosyphilis
12. Brain infections, encephalitis, and meningitis: Lyme disease - Lyme Borreliosis
13. Brain infections, encephalitis, and meningitis: Brucelosis
14. Brain infections, encephalitis, and meningitis: Listeria monocytogenesis - Listeriosis
15. Sepsis-associated-encephalopathy: understanding the brain dysfunction in sepsis.
Part III - Parasitic Infections Of CNS
16. Human trypanosomiasis: Trypanosoma brucei, Trypanosoma cruzes
17. Cerebral Malaria: understanding the parasite pathogenesis in the brain.
18. Neurocysticercosis and other CNS helminthic infections
19. Free-Living Ameba: the protozoa, the pathogenesis, and the CNS disease.
20. Pathophysiological mechanisms of Toxoplasma gondii infection in the CNS
21. Neurologic manifestations of Leishmania spp.
Part IV - Virus Infections Of CNS
22. HIV-infected human brain: implications in HIV infection and immune response.
23. SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation.
24. Epstein-Barr virus infections of the central nervous system (CNS)
25. Herpes Simplex Virus, Varicella-zoster: infection of the Central Nervous System (CNS).
26. Rhabdoviridae virus: infection of the Central Nervous System (CNS).
27. Paramyxoviridae: infection of the Central Nervous System (CNS).
28. Zika virus: infection of the Central Nervous System (CNS).
29. Yellow Fever: infection of the Central Nervous System (CNS).
30. Dengue Fever: infection of the Central Nervous System (CNS).
31. Japanese encephalitis virus (JEV): infection of the Central Nervous System (CNS).
32. West Nile viruses: infection of the Central Nervous System (CNS).
33. Tick-borne Encephalitis (TBE)
34. La Crosse encephalitis and Omsk hemorrhagic fever virus: infection of the Central Nervous System (CNS).
35. HTLVs: infection of the Central Nervous System (CNS).
36. Chikungunya virus (CHIKV): infection of the Central Nervous System (CNS).
Part V– Fungal Infections Of CNS
37. Brain infections, encephalitis, and meningitis: Cryptococcus sp.
38. Brain infections, encephalitis, and meningitis: Histoplasma capsulatum
39. Brain infections, encephalitis, and meningitis: Hyphae - fungus
40. Brain infections, encephalitis, and meningitis: Coccidioides sp.
41. Brain infections, encephalitis, and meningitis: Candida sp.
Part VI – Proteins And Other Peripheral Mediators That Affect The CNS
42. CNS and Prions disease: α-synuclein, amyloid-β, and others.
43. Creutzfeldt-Jakob disease (CJD), Variant CJD, and Kuru Variably protease-sensitive prionopathy (VPSPr)
44. Antineutrophil cytoplasmic antibody (ANCA), Sydenham chorea, PANDAS, and PANDAS variants.