Neurobiology of Epilepsy

Chapter 1: Multimodal investigation of epileptic networks: The case of insular cortex epilepsy

• Abstract
• 1 Epilepsy as a Systems Disease
• 2 Investigating the Epileptic Networks: Clinical Practice
• 3 Investigating the Epileptic Networks: Perspectives
• 4 Conclusion

Chapter 2: Genetic investigations of the epileptic encephalopathies: Recent advances

• Abstract
• 1 Background
• 2 CNVs in Epilepsy
• 3 Massively Parallel Sequencing in Epilepsy
• 4 Genetic Heterogeneity in EE
• 5 Expanding the Phenotypic Spectrum
• 6 Next Steps in Mutation Discovery
• 7 Precision Diagnostics for Precision Therapies
• 8 Conclusions and Future Directions
• Acknowledgments

Chapter 3: mTOR signaling pathway genes in focal epilepsies

• Abstract
• 1 GATOR1 Complex Acts as a Repressor of the mTORC1 Signaling Pathway
• 2 DEPDC5 Mutations in Focal Epilepsy Syndromes
• 3 DEPDC5 Mutations in Malformations of Cortical Development
• 4 Clinical Features of Families with GATOR1 Complex Gene Mutations
• 5 The Singularities of GATOR1-Related Epilepsies
• 6 How Are GATOR1 Mutations Related to Defects in the mTORC1 Pathway?
• 7 Animal Models of GATOR1 Deficiency
• 8 Brain Somatic Mutations in MTOR
• 9 Conclusions
• Acknowledgments

Chapter 4: Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy

• Abstract
• 1 Introduction
• 2 Cortical Interneuron Diversity
• 3 Cell-Type Specification
• 4 Migration
• 5 Maturation and Cell Survival
• 6 Neuronal Excitability
• 7 Synaptic Connectivity
• 8 Functional Networks
• 9 Perspectives
• Acknowledgments

Chapter 5: Organization and control of epileptic circuits in temporal lobe epilepsy

• Abstract
• 1 Organization and Reorganization of Microcircuits: Anatomical Changes in Temporal Lobe Epilepsy
• 2 From Organization to Control of Neuronal Circuits: Introduction to Graph Theory
• 3 Beginning to Control Microcircuits: Using Graph Theory to Control Circuits In Silico
• 4 Further Control of Microcircuits: Can We Learn to Control a Pathological Circuit in Order to Treat Epilepsy?
• 5 Network Organization at the Macrocircuit Level: Applications of Graph Theory at a Larger Scale
• 6 Conclusions
• Acknowledgments

Chapter 6: Normal and epilepsy-associated pathologic function of the dentate gyrus

• Abstract
• 1 Introduction
• 2 Activity in the DG Is Sparse
• 3 What Functions Are Served by Sparsely Activating DGCs?
• 4 Dentate Gating: A secondary Consequence of the DG’s Sparse code
• 5 Which Mechanisms Contribute to the DG Gate Breakdown in Epilepsy?
• 6 Conclusions

Chapter 7: Antiepileptic drug treatment strategies in neonatal epilepsy

• Abstract
• 1 Introduction
• 2 Treatment Approaches
• Acknowledgments

Chapter 8: Advancing epilepsy treatment through personalized genetic zebrafish models

• Abstract
• 1 Zebrafish as a Vertebrate Model for Epilepsy
• 2 Modeling Genetic Epilepsies in Zebrafish
• 3 Electrophysiological Recordings in Zebrafish Larvae
• 4 Tracking Locomotion and Convulsive Behavior
• 5 Cardiac Monitoring in Zebrafish Larvae
• 6 Discovering New AEDs for Genetic Epilepsies
• 7 Personalized Treatments for Genetic Epilepsy
• 8 Conclusion

Chapter 9: Antiepileptogenic repair of excitatory and inhibitory synaptic connectivity after neocortical trauma

• Abstract
• 1 Introduction
• 2 Excitatory Axonal Sprouting and Synaptogenesis in Models of Cortical Injury
• 3 Structural and Functional Alterations in GABAergic Interneurons in Injured Cortex
• 4 Summary and Conclusions
• Acknowledgment