Neuro-Urology Research
A Comprehensive Overview
- 1st Edition - May 8, 2023
- Imprint: Academic Press
- Editor: Anne M.J. Verstegen
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 5 5 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 5 6 - 4
**Selected for Doody’s Core Titles® 2024 in Urology**Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field including the latest… Read more
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Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field including the latest discoveries, explains in detail some of the neuroscience tools that can be used when studying the neural control of the lower urinary tract, and discusses potential future directions for research. The first section, Neuroscience in Urology Research, reviews neuro-regulators and the important anatomical brain sites. It also provides an overview of voluntary versus reflex micturition control and describes how bladder physiology readout is a useful tool in research. The second section, Fundamental and Translational Neuro-Urology Research, discusses the translational potential of basic research for patients and the impact of neuro-urology research on clinical practice. Chapters in this section provide more insight into pathologies endemic to specific patient populations and areas for treatment development opportunities. The third section, Neurobiological Tools Applied to Neuro-Urology Research, supplements the ‘A Quick Guide to the "Neuroscience Toolbox"’ and introduces research techniques such as RNA sequencing and calcium imaging of neural activity. The fourth and final section, aptly titled Research Directions and Research Opportunities, covers research directions that remain underexplored or have high therapeutic potential. Research in neuro-urology presents a route to understanding how bladder function is controlled and how urinary continence is maintained. This book provides a platform for researchers to initiate collaborations on the many underexplored research topics and to consolidate knowledge, ultimately lending itself to a coordinated and multi-center research approach that will benefit the field.
- Presents a comprehensive overview of research studies in the field of neuro-urology
- Discusses approaches to conducting neuro-urology research, including models of lower urinary tract dysfunction and methods of tracking bladder physiology
- Proposes areas of research opportunity that, if explored, could yield effective treatment options for those affected by lower urinary tract disorders
- Includes an introductory guide to useful research tools and the "Neuroscience Toolbox", as well as chapters specifically about RNA sequencing techniques and imaging bladder-associated neural circuits
Urology and neuro-urology researchers because of the emphasis on and synthesis of urology and neuroscience. Clinicians and researchers who are less familiar with the neuro-urology field. Clinical urologists may appreciate the detailed explanation of basic research techniques. Healthcare practitioners in patient-facing settings as most chapters elaborate on how research may relate to human patients
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- About the editor
- Preface
- Acknowledgments
- Chapter 1. Neuro-urology research: a comprehensive overview
- Outline
- Introduction to neuro-urology
- Section I. Neuroscience in urology research
- Chapter 2. Barrington's nucleus: a century of progress identifying neurons that control micturition
- Introduction
- The micturition reflex
- Neuroanatomical landscape surrounding Barrington's nucleus
- Discovery and characterization of the neurons in Barrington's nucleus
- Efferent projections of Bar neurons
- Afferent projections to Bar neurons
- Conclusion
- Chapter 3. Voluntary versus reflex micturition control
- Introduction
- Neural circuits involved in reflex micturition control
- Neural circuits involved in voluntary micturition control
- Neurotransmitters in cortical and subcortical controls of micturition
- Conclusion
- Chapter 4. The bladder as a readout in neuroscience research
- Introduction
- Bladder function as a readout in basic neuroscience studies Electrical stimulation of the brain and measurement of bladder physiology
- Recording of neural activity within the brain during physiological changes in bladder activity
- Optogenetics and pharmacological manipulation of brain circuits with measurement of bladder function
- Bladder function as a readout in clinical neuroscience including developmental, regenerative, and degenerative neuroscience
- The autonomic nervous system and bladder control
- The bladder as a readout in affective and social neuroscience: understanding the cognition of voiding
- Conclusion
- Section II. Fundamental and translational neuro-urology research
- Chapter 5. How treatment of lower urinary tract symptoms can benefit from basic research
- Introduction
- Afferent bladder pathways
- Afferent neurons in bladder reflexes
- Conclusion
- Chapter 6. “Translational effects of neuro-urology research on clinical practice”; Patient population–specific lower urinary tract symptoms
- Brain–bladder axis in health
- Nomenclature
- Localization-related symptoms in patients with neurological disease
- Neurological populations with frequent lower urinary tract dysfunction
- Idiopathic urinary retention: Fowler's syndrome and functional urological disorders
- Treatment options for patients with neurological disorders
- Conclusion
- Chapter 7. Effect of androgens and estrogens on bladder/lower urinary tract function
- Sex differences in bladder histology
- Sex differences in anatomy and physiology
- Sex differences in histology
- Impact of testosterone and estradiol on smooth muscle physiology
- Testosterone and estradiol in benign bladder diseases
- LUTS, testosterone and estradiol, and innervation
- Testosterone as a therapy for LUTS
- Stress incontinence
- Estrogens and innervation
- Overactive bladder
- Environmental factors that mediate changes in testosterone and estradiol concentrations
- Summary and conclusions
- Chapter 8. Transcriptomic identification of cell types in the lower urinary tract
- Bulk transcriptional profiling
- Single-cell transcriptional profiling
- Conclusion
- Section III. Neurobiological tools applied to neuro-urology research
- Chapter 9. Exploring urinary bladder neural circuitry through calcium imaging
- Traditional means of recording neuronal function
- Overview of calcium signaling as it applies to neuronal function
- Using imaging to measure neuronal function
- Exploring urinary bladder neural circuitry through calcium imaging
- Beyond calcium: new frontiers to measure neuronal function
- Summary
- Chapter 10. The periaqueductal gray and control of bladder function
- Introduction
- Anatomy and neural network of the PAG
- Functional cell populations in the PAG
- Human functional magnetic resonance imaging study on the PAG in bladder control as part of functional brain imaging
- PAG and recent research with lower urinary tract function
- Conclusions and future directions
- Section IV. Research directions and research opportunities
- Chapter 11. Impact of spinal neuromodulation on spinal neural networks controlling lower urinary tract function
- Neurophysiology of the lower urinary tract
- Current options to alter LUT function after SCI
- Chapter 12. Neural control of continence
- Introduction
- Central nervous nystem pathways
- The role of human brain imaging in understanding neural circuits of continence
- Overview of peripheral innervation
- Disruptions in neural control of voiding and associated clinical findings
- Future research directions
- Index
- Edition: 1
- Published: May 8, 2023
- No. of pages (Paperback): 258
- No. of pages (eBook): 258
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128224557
- eBook ISBN: 9780128224564
AV
Anne M.J. Verstegen
Dr. Verstegen has a broad background in research and with specific training in key areas of molecular and cellular biology, behavioral and systems neuroscience, and with expertise in stereotaxic surgery techniques, design and execution of experimental paradigms coupled with optogenetics, and mouse genetics. She graduated in Experimental and Clinical Neuroscience at Utrecht University (NL) and obtained a Ph.D. degree at the Italian Institute of Technology (IIT). Her current research projects aim to identify the neural networks that control urine storage and voiding. Because disturbances in the brain control of the bladder and sphincter can cause or contribute to LUTS, understanding these control circuits may lead to potential therapies. Besides unraveling and mapping the neural circuitry, she is interested in understanding which neuro-regulators are involved and in associating function with distinct neuron subpopulations in aspects of bladder control.
Affiliations and expertise
Medicine Department, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, MassachusettsRead Neuro-Urology Research on ScienceDirect