Neonatal Respiratory Distress

1st Edition - January 1, 1982
Editor: Philip M Farrell
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 2 4 9 7 0 2 - 5
Paperback ISBN:
9 7 8 - 1 - 4 8 3 2 - 3 8 6 6 - 1
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 6 9 1 2 - 2

Lung Development: Biological and Clinical Perspectives, Volume II: Neonatal Respiratory Distress is a collection of papers that addresses the needs of small infants who have… Read more

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Lung Development: Biological and Clinical Perspectives, Volume II: Neonatal Respiratory Distress is a collection of papers that addresses the needs of small infants who have respiratory diseases. This volume deals with fetal lung development with emphasis on hyaline membrane disease. This book also presents basic information on pulmonary surfactant in the clinical area, particularly in 1) diagnosis and movement of neonatal respiratory distress; 2) prenatal assessment of fetal lung maturity; and 3) prevention of hyaline membrane disease with corticosteroid therapy. One paper reviews the essential clinical aspects of hyaline membrane disease, while another paper discusses data of the physiology of surfactant from a patient with hyaline membrane disease. Another paper examines the radiology of hyaline membrane disease, transient tachypnea of the newborn, and bronchopulmonary dysplasia; this paper also describes the radiographic techniques to be applied on infants. Other papers cite a treatment using antepartum glucocorticoid, as well as other clinical trials involving antenatal corticosteroid. One paper proposes a design and organization of a multicenter clinical trial that will study the effects of corticosteroid in the development of the human lung. This book can prove useful for pediatricians, specialists in respiratory diseases, and researchers whose work involves cardiovascular medicine and radiology.

Contributors

Foreword

Preface

Terminology

Contents of Volume I

I Clinical Aspects of Hyaline Membrane Disease

1 Historical Perspective: Past and Present Approaches to Therapy of Hyaline Membrane Disease

Text

References

2 Clinical Relevance of Pulmonary Surfactant

I. Introduction

II. The Clinical Physiology of Surfactant during Health

III. The History of the Discovery of Pulmonary Surfactant

IV. Hyaline Membrane Disease as a Model for Surfactant Deficiency

V. Lung Stability of Immature Lungs

VI. Role of Surfactant in Lung Liquid Balance

VII. Clinical Function Summary

References

3 Overview of Hyaline Membrane Disease

I. Introduction

II. Clinical Presentation

III. Diagnostic Criteria

IV. Differential Diagnosis

V. Consequences of Hyaline Membrane Disease

VI. Epidemiology

VII. Pathogenesis in Relationship to Pulmonary Surfactant Deficiency

VIII. Summary

References

4 Radiology of Hyaline Membrane Disease, Transient Tachypnea of the Newborn, and Bronchopulmonary Dysplasia

I. Radiographic Evaluation of the Infant Chest

II. Hyaline Membrane Disease

III. Transient Tachypnea of the Newborn

IV. Bronchopulmonary Dysplasia

References

5 Pulmonary Function Abnormalities in Hyaline Membrane Disease and Bronchopulmonary Dysplasia

I. Introduction

II. Clinical Evaluation of Pulmonary Function

III. Direct Assessment of Pulmonary Function

IV. Bronchopulmonary Dysplasia: Long-Term Pulmonary Function Sequel of HMD

References

6 Therapy of Hyaline Membrane Disease

I. Introduction

II. Supportive Care

III. Respiratory Management

IV. Maintenance and Recovery Phase

V. Perspective

References

7 Long-Term Consequences of Hyaline Membrane Disease

I. Introduction to Follow-Up Studies

II. General Observations

III. Neurologic Sequel

IV. Pulmonary Status of Children Surviving HMD

V. Summary and Conclusions

References

II Prevention of Hyaline Membrane Disease

8 Introduction to the Preventative Approach in Perinatal Care

I. Introduction

II. Need for Prevention of Hyaline Membrane Disease

III. Investigation of the Preventative Approach in Perinatology

References

9 Amniocentesis

I. Introduction

II. Indications

III. Technique

IV. Risks

V. Technical Complications

VI. Ultrasound

References

10 Prenatal Assessment of Fetal Lung Maturation: A Critical Review of Amniotic Fluid Phospholipid Tests

I. Introduction

II. Methodology

III. Clinical Interpretation

IV. Summary and Recommendations

References

11 Hormonal Aspects of Fetal Lung Development

I. Introduction

II. Effects of Administered Hormones

III. Physiologic Role of Endogenous Hormones

IV. Hormone Binding in Lung

References

12 The New Zealand Study of Antepartum Glucocorticoid Treatment

I. Introduction

II. Design

III. Findings

IV. Adverse Effects

V. Conclusions

VI. Implications

References

13 Design and Organization of a Multicenter Clinical Trial for the Study of Corticosteroid Effects on Human Lung Development

I. Background

II. Initiation and Conduct of the Study

III. Quality Control

IV. Summary of Advantages and Disadvantages of the Multicenter Approach

References

14 The NIH Multicenter Study and Miscellaneous Clinical Trials of Antenatal Corticosteroid Administration

I. Introduction and Objectives

II. Clinical Trials Using Antepartum Corticosteroids

III. The NIH Collaborative Study

IV. Summary

References

15 Current Recommendations for Use of Prenatal Corticosteroids Based on Assessment of the Risk-Benefit Relationship

Text

Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Neonatal Respiratory Distress

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Philip M Farrell