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Natural Polymers in Wound Healing and Repair

From Basic Concepts to Emerging Trends

1st Edition - June 23, 2022

Editors: Mahesh K. Sah, Naresh Kasoju, Joao F. Mano

Paperback ISBN:

9 7 8 - 0 - 3 2 3 - 9 0 5 1 4 - 5

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 0 5 1 5 - 2

Natural Polymers in Wound Healing and Repair: From Basic Concepts to Emerging Trends presents comprehensive coverage on the development and application of natural polymers in… Read more

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Natural Polymers in Wound Healing and Repair: From Basic Concepts to Emerging Trends presents comprehensive coverage on the development and application of natural polymers in wound healing and repair, including fundamental concepts, traditional approaches, cutting-edge methods and emerging trends. The application of natural polymers has evolved from their use in the simplest wound management material, to drug eluting matrices, to cell-laden constructs, and to 3D bio-printed skin equivalents. This book reflects the remarkable progress that has been made in recent years in this innovative field.

This is an essential resource for researchers, scientists, and advanced students across polymer science, biomaterials, bio-based and sustainable materials, biomedicine, biomedical engineering, pharmaceuticals, and materials science and engineering. It will also be valuable to R&D professionals, scientists, technologists and all those working in a medical setting who are interested in the latest developments in advanced materials for wound management, healing and repair.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editors
Preface
Introduction
Chapter 1. Fundamentals of skin wound healing and repair: A brief review on cellular and molecular pathophysiologic basis of wound healing
Abstract
Chapter Outline
1.1 Introduction
1.2 Roles of epidermal T cells during tissue repair
1.3 Other possible abnormal (pathological) tissue repair processes that frequently occur and are clinically relevant
1.4 Few basic experimental methods used for investigating the pathophysiology of wound healing
1.5 What the future holds in the experimental pathophysiology of skin wound healing
1.6 Concluding remarks
Acknowledgment and dedication
References
Chapter 2. Traditional and advanced wound dressings: physical characterization and desirable properties for wound healing
Abstract
Chapter Outline
2.1 Introduction
2.2 Traditional and advanced wound dressings
2.3 Physical characterization of wound dressings
2.4 Ideal properties for the wound dressings
2.5 Conclusion
References
Chapter 3. Natural-based biomaterials for drug delivery wound healing patches
Abstract
Chapter Outline
3.1 Introduction
3.2 Transdermal drug delivery patches
3.3 Hydrogels versus nonhydrogels polymeric patches
3.4 Patches based on biopolymers
3.5 Conclusions
References
Chapter 4. Controlled drug delivery system for wound healing: formulations and delivery required therapeutic agents
Abstract
Chapter Outline
4.1 Introduction
4.2 Routes of delivery for wound healing
4.3 Route-specific drug delivery mechanisms
4.4 Drug delivery mediums
4.5 Therapeutic agents for wound healing
4.6 Conclusion
References
Chapter 5. Artificial skin: current advanced methods of fabrication and development
Abstract
Chapter Outline
5.1 Introduction
5.2 Why do we need alternatives to the skin graft?
5.3 Advanced tissue engineering approaches to regenerate skin
5.4 Modification of polymers for fabrication of artificial skin
5.5 Modern tissue engineering approaches to regenerate skin
5.6 Animal models to test tissue engineered fabricated skin
5.7 Current commercially available skin grafts in market
5.8 Advantages and disadvantages of artificially fabricated skin
5.9 Development of current fabrication technologies of artificial skin
5.10 Conclusion
References
Chapter 6. Natural polymer based hydrogel systems for wound management
Abstract
Chapter Outline
6.1 Introduction
6.2 Polysaccharide biomaterials for wound dressing
6.3 Protein biomaterials for wound dressing
6.4 Conclusion
References
Chapter 7. Natural polymer based electrospun systems for wound management
Abstract
Chapter Outline
7.1 Introduction
7.2 Fabrication of electrospun system for wound healing
7.3 Natural polymers–based electrospun system for wound management
7.4 Important natural polymers for nanofibrous system for wound healing
7.5 Commercially available natural polymer–based electrospun systems for wound management
7.6 Conclusions and future prospects
Abbreviations
References
Chapter 8. Three-dimensional bioprinting of skin tissue equivalents using natural polymers as bioinks for potential applications in wound repair
Abstract
Chapter Outline
8.1 Introduction
8.2 Skin physiology and pathophysiology
8.3 Regenerative strategies for skin wound healing and repair
8.4 Three-dimensional bioprinting for biofabrication of skin constructs
8.5 Bioinks for three-dimensional bioprinting of skin tissue equivalents
8.6 Summary, challenges, and prospects
Acknowledgments
References
Chapter 9. Blood-derived products in wound healing and repair
Abstract
Chapter Outline
9.1 Introduction
9.2 Wound healing process and role of blood components
9.3 Blood components, preparation, and translational potential
9.4 Summary and conclusion
Acknowledgments
References
Chapter 10. Natural antimicrobial and bioactive agents as additives in wound dressings
Abstract
Chapter Outline
10.1 Introduction
10.2 Modern wound dressing
10.3 Bioactive wound dressing
10.4 Wound infections and natural antimicrobials
10.5 Requirement of antimicrobial wound dressing
10.6 Conclusion
References
Chapter 11. Curcumin-based strategies in wound healing and skin tissue regeneration
Abstract
Chapter Outline
11.1 Introduction: wounds and healing process
11.2 Wound healing efficacy of curcumin
11.3 Limitations in the use of CUR and recent adaptations
11.4 Wound healing efficacy of CUR-based nanoformulations
11.5 Summary and conclusion
Acknowledgment
Conflict of interest
References
Chapter 12. Collagen-based strategies in wound healing and skin tissue engineering
Abstract
Chapter Outline
12.1 Introduction
12.2 History of collagen in biomedical use
12.3 Collagen types
12.4 Sources of collagen
12.5 Things to know before collagen extraction and use
12.6 General procedure for type I collagen extraction
12.7 Reconstitution of collagen
12.8 Collagen cross-linking
12.9 Sterilization methods
12.10 Role of collagen in wound healing
12.11 Application of collagen in wound healing
12.12 Collagen in skin tissue engineering
12.13 Conclusion and remarks
References
Chapter 13. Silk fibroin and silk sericin in skin tissue engineering and wound healing: retrospect and prospects
Abstract
Chapter Outline
13.1 Introduction
13.2 Skin physiology
13.3 Skin pathophysiology and wound healing
13.4 Silk biomaterials
13.5 Silk fibroin in skin tissue engineering and wound healing
13.6 Silk sericin in skin tissue engineering and wound healing
13.7 Molecular insights into silk biomaterials in a wound healing context
13.8 Trends in clinical investigations and commercialization of silk-based wound healing biomaterials
13.9 Summary, challenges, and prospects
Acknowledgment
References
Chapter 14. Chitin- and chitosan-based strategies in wound healing
Abstract
Chapter Outline
14.1 Introduction
14.2 Chitin
14.3 Chitosan
14.4 Application of chitin and chitosan as wound dressings
14.5 Conclusion
Acknowledgments
References
Acronyms
Chapter 15. Alginate-based wound dressings for skin healing and regeneration
Abstract
Chapter Outline
15.1 Introduction
15.2 Alginate properties and commercially available alginate wound dressings
15.3 Alginate-based wound dressings
15.4 Alginate-based hydrogels in skin regeneration
15.5 Conclusion
Acknowledgment
References
Chapter 16. Eggshell membrane in skin tissue engineering and wound healing
Abstract
Chapter Outline
16.1 Introduction
16.2 Eggshell membrane and its processed forms
16.3 Eggshell membrane in wound healing and skin tissue engineering
16.4 Conclusions and future perspectives
Acknowledgment
Conflict of interest
Abbreviations
References
Chapter 17. Decellularized extracellular matrices–based strategies in wound healing and skin tissue engineering
Abstract
Chapter Outline
17.1 Introduction
17.2 Tissue engineering approach to repair skin defects
17.3 Extracellular matrix-based biomaterials and substitutes: wound healing and skin regeneration
17.4 Translational challenges associated with decellularized matrices
References
Chapter 18. Innovative approaches and future perspectives of natural polymers in wound healing and repair
Abstract
Chapter Outline
18.1 Introduction
18.2 Electrospinning in advanced wound care
18.3 Three-dimensional printing in advanced wound care
18.4 Artificial skin and latest advances
18.5 Personalized wound care products
18.6 Challenges and future perspectives
Acknowledgment
References
Index

Mahesh K. Sah

Dr. Mahesh K. Sah is Assistant Professor at the Department of Biotechnology, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India. Dr. Mahesh received his PhD from Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Odisha, India in 2013. After gaining post-doctoral training from Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, he joined at Department of Biotechnology, National Institute of Technology, Andhra Pradesh, and since January 2018 he is serving Department of Biotechnology, National Institute of Technology Jalandhar, Punjab. He has been awarded Bharat Vikas Award-2016 and Green Thinkerz Award-2019 for his contribution in the area of biotechnology. He is working on development of natural based biomaterials for tissue regeneration equipped with advanced tools and techniques in the field aiming for green materials and techniques for tissue engineering.

Affiliations and expertise

Assistant Professor, Department of Biotechnology, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar, Punjab, India

Naresh Kasoju

Dr. Kasoju obtained Ph.D. from Department of Biotechnology, Indian Institute of Technology, Guwahati, India in 2012, followed by post-doctoral training from Institute of Macromolecular Chemistry, Prague, Czech Republic, Department of Zoology, as well as Institute of Biomedical Engineering, University of Oxford, Oxford, UK, before joining Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India in October 2017. His areas of research interests include fabrication of novel biomaterial structures, understanding cell – material interactions and development of tissue engineered constructs.

Affiliations and expertise

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India

Joao F. Mano

João F. Mano (CEng, PhD, DSc) is a Full Professor at the Chemistry Department of University of Aveiro, Portugal, where he is directing both the MSc and PhD programs of Biotechnology. He is the founder and director of the COMPASS Research Group, from the Associated Laboratory CICECO – Aveiro Institute of Materials. His research interests include the use of advanced biomaterials and cells towards the progress of transdisciplinary concepts to be employed in regenerative and personalised medicine. In particular, he has been applying biomimetic and nano/micro-technology approaches to polymer-based biomaterials and surfaces in order to develop biomedical devices with improved structural and (multi-)functional properties, or in the engineering of microenvironments to control cell behaviour and organization, to be exploited clinically in advanced therapies or in drug screening. João Mano is the Editor-in-Chief of Materials Today Bio (Elsevier). He has been coordinating or involved in many national and European research projects, including Advanced and Proof-of-Concept Grants from the European Research Council. João Mano is an elected fellow of the European Academy of Sciences.

Affiliations and expertise

Full Professor, CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campo Universitario de Santiago, Aveiro, Portugal