Natural Biopolymers in Drug Delivery and Tissue Engineering

1st Edition - August 14, 2023
Imprint: Woodhead Publishing
Editors: Rangasamy Jayakumar, Vishnu Priya Murali
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 8 2 7 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 4 8 - 9

Natural Biopolymers in Drug Delivery and Tissue Engineering systematically examines a broad range of natural polymers and their applications in drug delivery and tissue engine… Read more

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Natural Biopolymers in Drug Delivery and Tissue Engineering systematically examines a broad range of natural polymers and their applications in drug delivery and tissue engineering. The book thoroughly collates the most relevant and up-to-date research on natural biopolymers, covering a variety of key natural polymer types such as chitin, chitosan, alginate, guar gum and collagen. It is divided into two sections, covering drug delivery and tissue engineering applications. Each section focuses on natural biopolymers in the form of scaffolds, membranes, films, gels and nanoparticles, thus helping the reader select not only the most appropriate polymer type, but also the most relevant structure.

This comprehensive resource is ideal for materials scientists, biomedical engineers, tissue engineers, pharmaceutical scientists and anyone interested in developing novel materials for biomedical applications.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Section 1: Drug delivery applications of natural biopolymers
Chapter 1. Natural biopolymers in drug delivery—role, challenges and clinical applications
Abstract
1.1 Introduction
1.2 Formulations and applications of natural polymers for drug delivery
1.3 Disadvantages and challenges
1.4 Future direction and conclusion
References
2. Alginates in drug delivery systems
Abstract
2.1 Introduction
2.2 Properties
2.3 Derivatives
2.4 Pharmaceutical and biomedical applications
2.5 Conclusion
References
3. Carrageenan for drug delivery and biomedical applications
Abstract
3.1 Introduction
3.2 General properties of carrageenan
3.3 Biomedical applications of carrageenan
3.4 Wound healing
3.5 Conclusion
References
4. Cellulose and cellulose derivatives in drug delivery
Abstract
4.1 Introduction
4.2 Classification of cellulose and its derivatives
4.3 Application of cellulose and cellulose derivatives in drug delivery
4.4 Conclusion
Acknowledgement
Conflict of interest
References
5. Chitin in drug delivery
Abstract
5.1 Introduction
5.2 Sources of chitin
5.3 Properties of chitin
5.4 Structure
5.5 Extraction of chitin
5.6 Chitin in drug delivery
5.7 Conclusion
References
6. Chitosan as potential carrier for drug delivery
Abstract
6.1 Introduction
6.2 Physicochemical and biological properties of chitosan
6.3 Methods of preparation of chitosan
6.4 Characteristics of chitosan drug delivery systems
6.5 Chitosan-based drug delivery system
6.6 Advantages and disadvantages of the chitosan drug delivery system
6.7 Conclusion
References
7. Collagen for drug delivery applications
Abstract
7.1 Introduction
7.2 Triple helix structure of collagen
7.3 Drug delivery using collagen-based biomaterials
7.4 Conclusion
References
8. Cyclodextrin in drug delivery
Abstract
8.1 Introduction
8.2 Derivatives of cyclodextrin
8.3 History
8.4 Production of cyclodextrins
8.5 Nature of the action of cyclodextrin
8.6 Complexation efficiency and factors hindering efficiency
8.7 Binding affinity of drug–cyclodextrin complex
8.8 Preparation of drug–cyclodextrin complex
8.9 Cyclodextrin in drug delivery
8.10 Cyclodextrin-based novel drug delivery systems
8.11 Properties of cyclodextrin
8.12 Conclusion
8.13 Future perspectives
References
9. Dextran-based engineering: a leap in novel drug delivery
Abstract
9.1 Introduction
9.2 Dextran
9.3 Synthesis of dextran conjugate
9.4 Pharmacokinetics of dextran
9.5 Application of dextran in drug delivery
9.6 Future perspectives
9.7 Conclusion
References
10. Progress of guar gum-based biomaterials as drug delivery carriers
Abstract
10.1 Introduction
10.2 Guar gum-based materials in drug delivery
10.3 Conclusion
References
11. Hyaluronic acid-based drug delivery systems for targeted cancer therapy
Abstract
11.1 Introduction
11.2 Hyaluronic acid: biology and physiochemical properties
11.3 Hyaladherins/hyaluronic acid receptors—biology and its significance in carcinogenesis
11.4 Hyaluronic aci-based nanomedicines for active tumor targeting
11.5 Conclusion and future directions
References
12. Pectin-based drug delivery systems for biomedical applications
Abstract
12.1 Introduction
12.2 General properties of pectin
12.3 Chemical structure
12.4 Use of pectin for drug delivery
12.5 Conclusion
References
13. Role of starch-based drug delivery system and its pharma applications
Abstract
13.1 Introduction to starch
13.2 History of starch
13.3 Chemistry of starch
13.4 Natural source of starch materials
13.5 Pharmaceutical application of starch
13.6 Conclusion
References
14. Natural biopolymers in ophthalmology
Abstract
Abbreviations
14.1 Introduction
14.2 Barriers to ocular drug delivery
14.3 Natural biopolymers for ocular delivery
14.4 Properties of natural biopolymers for ocular delivery
14.5 Classification of natural biopolymers
14.6 Conclusion
References
Section 2: Tissue engineering applications of natural biopolymers
15. Natural biopolymers in tissue engineering—role, challenges, and clinical applications
Abstract
15.1 Introduction
15.2 Commonly used natural biopolymers in tissue engineering and wound healing
15.3 Formulations and applications of natural polymers for tissue engineering and wound healing
15.4 Challenges and future direction
15.5 Conclusion
References
16. Alginate-based biomaterials for tissue engineering applications
Abstract
16.1 Introduction
16.2 Tissue engineering
16.3 Bone tissue engineering
16.4 Additive manufacturing
16.5 Extruder-based three-dimensional printed alginate composites
16.6 Fused deposition model–based three-dimensional printed alginate composites
16.7 Pneumatic-based three-dimensional printed alginate composites
16.8 Conclusion
Acknowledgments
References
17. Carrageenan in tissue engineering and biomedical applications
Abstract
17.1 Introduction
17.2 Tissue engineering and biomedical applications
17.3 Future perspectives and conclusion
References
18. Cellulose in tissue engineering
Abstract
18.1 Introduction
18.2 Cellulose in tissue engineering
18.3 Cellulose nanoform and its application in tissue engineering
18.4 Cellulose in orthopedic grafts
18.5 Cellulose in skin tissue grafts and wound healing application
18.6 Other biological applications related to tissue engineering
18.7 Conclusion
References
19. Chitin biopolymer in tissue engineering
Abstract
19.1 Introduction
19.2 Applications of chitin in tissue engineering
19.3 Advantages of using chitin in tissue engineering and the key challenges
19.4 Conclusion
References
20. Tissue engineering and chitosan: a wonder biomaterial
Abstract
20.1 Introduction
20.2 Chitosan in bone tissue engineering
20.3 Chitosan in skin tissue engineering
20.4 Chitosan in cartilage tissue engineering
20.5 Chitosan in neural tissue engineering
20.6 Chitosan in dental tissue engineering
20.7 Chitosan in wound healing
20.8 Chitosan in cardiovascular tissue engineering
20.9 Chitosan in liver tissue engineering
20.10 Conclusion
References
21. Collagen-based biomaterials for tissue engineering applications
Abstract
21.1 Introduction
21.2 Collagen: structure, classification and source
21.3 Cross-linking of collagen
21.4 Host response and biocompatibility
21.5 Recent regenerative applications of collagen-based scaffolds
21.6 Conclusion and future perspective
Acknowledgements
Conflict of interest
References
22. Advances in guar gum-based materials in biomedical applications with special reference to tissue engineering applications
Abstract
22.1 Introduction
22.2 Physicochemical properties of guar gum
22.3 Processing of guar gum
22.4 Guar gum in tissue engineering
22.5 Conclusions
References
23. Hyaluronic acid in tissue engineering
Abstract
23.1 Introduction
23.2 Hyaluronic acid–cell interaction
23.3 Chemical modifications
23.4 Different forms of hyaluronic acid scaffolds
23.5 Various tissue engineering approaches
23.6 Conclusions
Acknowledgments
References
24. Pectin in tissue engineering
Abstract
24.1 Introduction
24.2 Pectin—a natural biopolymer
24.3 Pectin in tissue engineering application
24.4 Conclusion
References
25. Silk and silk fibroin in tissue engineering
Abstract
25.1 Introduction
25.2 Silk as a biomaterial
25.3 Processing of silk for tissue engineering applications
25.4 Silk and silk fibroin for organoid platforms
25.5 Summary and future directions
Acknowledgments
Conflict of interest
References
Index

Rangasamy Jayakumar

Rangasamy Jayakumar is a Professor at the Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (Deemed University), Kerala, India. He received his PhD degree in polymer chemistry from Anna University, Chennai, India (2002) and MSc degree from Bharathidasan University.

Affiliations and expertise

Professor, Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (Deemed University), Kerala, India

Vishnu Priya Murali

Clinical Research Project Manager, MicroPort Orthopedics Inc.,Arlington, Tennessee, USA Dr. Vishnu Priya Murali has extensive research experience in the field of biomedical engineering, exploring a number of polymers, ceramics and metals for regenerative medicine. Her work has driven improvements in the fabrication and characterization of polymer-based hydrogels, nanogels and nanoparticles for bone tissue engineering, development, and characterization of polymeric scaffolds for drug delivery, and the fabrication of nanoparticle-loaded polymeric surface coatings for gene delivery. She is currently involved in translational research where she develops strategies and monitors research progress of ceramic and metallic orthopedic products that are ready to be commercialized. She has a PhD in Biomedical Engineering from the University of Memphis, USA (2019), where she received the 2019 Steven Slack Fellowship and Herff College of Engineering Felllowship (2015-2019). She did her PostDoctoral training at Florida State University, USA (2019-2021) and was selected for the AAAS/Science Program for Excellence in Science, 2019. She has published 10 peer-reviewed journal articles in prestigious journals like Acta Biomaterialia and Carbohydrate Polymers and 3 book chapters for Wiley, Springer and Woodhead Publishing. She has around 650 citations and a i10 Index and h-index of 9, each. She has been invited as a guest speaker in multiple international forums and is a reviewer for several international journals of Elsevier, MDPI and Springer.

Affiliations and expertise

Research Scientist, Florida State University, USA

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health