Nanotechnology Principles in Drug Targeting and Diagnosis

1st Edition - July 26, 2023
Editors: Mahendra Rai, Shagufta Khan, Aarti Belgamwar
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 7 6 3 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 3 4 8 - 8

Nanotechnology Principles in Drug Targeting and Diagnosis focuses on the nanotechnology principles and mechanisms involved in drug targeting, nano carriers and target intera… Read more

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Nanotechnology Principles in Drug Targeting and Diagnosis focuses on the nanotechnology principles and mechanisms involved in drug targeting, nano carriers and target interactions associated with particular diseases. The book addresses how phytotherapeutics are effective against solid tumors and how they can be used in designing targeted delivery systems. Also addressed is the use of macrophages as the biomimetic carrier for targeting drugs to different organs. Sections cover the nanotechnology-based concepts in drug targeting, strategies for drug targeting, ways to identify drug carrier-target interaction, the concept of an artificial neural network in identifying drug-target interaction, and more.

The book's final section concentrates on the role of nanotechnology in medical diagnosis, throwing light on nanoscale sensors for the diagnosis of viruses in the bloodstream and biomarkers indicating various cancers. This is an important reference source for materials scientists and pharmaceutical scientists who want to understand how nanotechnology plays an important role in creating more efficient drug targeting and delivery systems.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Section 1: Drug targeting: general principles and strategies
Chapter 1. Drug targeting: nanotechnology principles, future perspectives, and challenges
Abstract
1.1 Introduction
1.2 Nanotechnology-based drug targeting approaches
1.3 Targeted nanoparticulate systems for various disorders
1.4 Future perspectives and challenges
1.5 Conclusion
Acknowledgment
References
Chapter 2. Identifying nanocarrier–target interaction
Abstract
2.1 Introduction
2.2 Potential targets for active targeting
2.3 Surface modification strategies of nanocarriers
2.4 Factors affecting nanocarrier–cell interaction
2.5 Methods to confirm carrier target interaction
2.6 Conclusion and future perspectives
References
Chapter 3. Artificial neural network–based inference of drug–target interactions
Abstract
3.1 Introduction
3.2 Artificial neural networks
3.3 Applications of artificial neural networks to drug–target interactions
3.4 Conclusions and future perspectives
References
Chapter 4. Macrophage-mimetic nanomedicines for the treatment of diseases
Abstract
4.1 Introduction
4.2 Role of macrophages in various disease states
4.3 Application of macrophage-mimetic drug delivery systems
4.4 Conclusions
References
Chapter 5. Biopolymer-based nanosystems for drug targeting
Abstract
5.1 Introduction
5.2 Polymers derived from polysaccharides
5.3 Polymers derived from protein
5.4 Conclusion
References
Chapter 6. Pharmacokinetics of nanomedicine
Abstract
6.1 Introduction
6.2 Current scenario of nanomedicine
6.3 Types of nanomedicine
6.4 Challenges of nanomedicine for alteration of pharmacokinetic properties
6.5 Pharmacokinetic mechanism of action of nanomedicine
6.6 Optimization of nanomedicine
6.7 Conclusion and future prospects
References
Section 2: Nanotechnology approaches for organ/disease specific targeting
Chapter 7. Targeted breast cancer treatment: progress and challenges
Abstract
7.1 Introduction
7.2 Classification of breast cancer
7.3 Biomarkers
7.4 Targets for therapeutic interventions
7.5 Therapeutic tools to treat breast cancer
7.6 Limitations of the conventional therapeutic tools
7.7 Treating breast cancer using biologics and targeted therapies
7.8 Nanocarriers in targeted therapy for breast cancer
7.9 Challenges
7.10 Future prospects
References
Chapter 8. Nanotechnology advances for improved targeting of solid tumors
Abstract
8.1 Introduction
8.2 Challenges and failures of primary approaches to cancer treatment
8.3 Novel approaches for tumor treatment
8.4 Molecular targets of solid tumors
8.5 Targeting strategies using nanotechnology: active and passive targeting
8.6 Applications of nanotechnology for delivery of phytoconstituent in cancer treatment
8.7 Conclusion
References
Chapter 9. Solid lipid nanoparticles: the enhanced and targeted potential treatment of colorectal cancer
Abstract
9.1 Introduction
9.2 Solid lipid nanoparticles
9.3 Conclusion and future perspectives
References
Chapter 10. Targeted therapy for aggressive lung cancer
Abstract
Abbreviations
10.1 Introduction
10.2 Principles of targeting and nanotechnology
10.3 Targeting lung cancer using different types of nanoparticles
10.4 Inhalation route in targeting lung cancer
10.5 Conclusions and perspectives
References
Chapter 11. Molecular targets for the treatment of angina pectoris
Abstract
11.1 Introduction
11.2 Pathogenesis of angina pectoris
11.3 Clinical manifestation of angina pectoris
11.4 Molecular targets for traditional antianginal drug therapy
11.5 Molecular targets for novel antianginal drug therapy
11.6 Molecular targets for investigational antianginal drug therapy
11.7 Conclusion
References
Chapter 12. Nanocarriers: the enhanced potential treatment of age-related macular degeneration
Abstract
12.1 Introduction
12.2 Types of age-related macular degeneration
12.3 Mechanism of age-related macular degeneration development
12.4 Risk factors for macular degeneration
12.5 Detection of age-related macular degeneration
12.6 Treatments for age-related macular degeneration
12.7 Challenges in age-related macular degeneration treatment
12.8 Role of nanocarriers in enhancing age-related macular degeneration treatment
12.9 Investigations on nanocarriers for the treatment of age-related macular degeneration
12.10 Conclusions and future perspectives
References
Chapter 13. Nanotechnology-based drug targeting to infectious diseases
Abstract
13.1 Introduction
13.2 Advantages of a nanobased system
13.3 Nanotechnology-based drug targeting approaches—general aspects
13.4 Designing nanomaterials for drug targeting
13.5 Types of nanocarriers for drug targeting
13.6 Concluding remark and future perspectives
Acknowledgments
References
Chapter 14. Nanotechnological strategies for drug delivery and treatment of COVID-19
Abstract
14.1 Introduction
14.2 Treatments for COVID-19
14.3 Vaccine developed for COVID-19
14.4 Nanotechnology in drug delivery
14.5 Direct role of nanotechnology in COVID-19 management
14.6 Future perspectives
14.7 Conclusions
Acknowledgments
References
Section 3: Nanotechnology based techniques for medical diagnosis
Chapter 15. Nanotechnological tools for the diagnosis and treatment of cancer
Abstract
15.1 Introduction
15.2 Nanotechnology for the diagnosis of cancer
15.3 Nanotechnology for the treatment of cancer
15.4 Conclusion
References
Chapter 16. Nanodiagnostics and targeted drug delivery: integrated technologies
Abstract
16.1 Introduction
16.2 Role of nanoparticles in diagnostics and drug delivery
16.3 In vitro nanodiagnostic devices
16.4 Nanotechnology-based targeted drug delivery for treatment of diseases
16.5 Application of nanotechnology in cancer diagnosis and treatment
16.6 Nanotechnology-mediated imaging for diagnosis
16.7 Challenges
16.8 Conclusion
Acknowledgment
References
Chapter 17. Classification of clinically actionable genetic mutations in cancer patients using machine learning-based precision diagnostics
Abstract
17.1 Introduction
17.2 Impact of genetics and genomics on cancer science
17.3 Related work
17.4 Proposed approach
17.5 Results of experiment
17.6 Conclusion
References
Chapter 18. Nanotheranostic applications in the detection and treatment of cervical cancer
Abstract
18.1 Introduction
18.2 Etiology and risk factors
18.3 Classification of cervical cancer
18.4 Current approaches to diagnosis and treatment
18.5 Nanotheranostics in cervical cancer
18.6 Conclusions and future prospects
References
Index

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Mahendra Rai

Shagufta Khan

Aarti Belgamwar