Nanotechnology for Oral Drug Delivery

From Concept to Applications

1st Edition - July 27, 2020
Imprint: Academic Press
Editors: João Pedro Martins, Hélder A. Santos
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 0 3 8 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 0 3 9 - 6

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers… Read more

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Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.

Cover image
Title page
Table of Contents
Copyright
Contributors
Foreword
Part I: Biological aspects and properties of nanomaterials for oral drug delivery
Chapter 1: Oral drug delivery: Overview
Abstract
1: Introduction
Chapter 2: Organization of the intestinal mucosa and barriers to oral drug delivery
Abstract
Acknowledgments
1: Introduction
2: Structure of the small intestine
3: Metabolizing enzymes
4: Efflux pumps
5: Transporters for transcytosis
6: Mechanism of crossing the intestinal mucosal barrier
7: Models to study intestinal absorption
8: Conclusions
Chapter 3: Nanomaterials for oral drug administration
Abstract
1: Introduction
2: The rational design of nanocarriers for oral drug formulation
3: Types of nanomaterials
4: Emerging trends in oral nanoformulation: Hybrid, protein and stimuli-responsive nanocarriers
5: Nanomaterials for the targeting of specific GIT regions
6: Conclusions and future perspectives
Chapter 4: Mucoadhesive and mucus-penetrating polymers for drug delivery
Abstract
1: Introduction
2: Definitions and fundamentals
3: Mucoadhesive and mucus-penetrating materials
4: Oral mucosal drug delivery systems
5: Safety and toxicity
6: Regulatory status
7: Patenting and market
8: Conclusions and future perspectives
Chapter 5: Size, shape and surface charge considerations of orally delivered nanomedicines
Abstract
Acknowledgments
1: Introduction to nanomedicine for oral drug delivery
2: Challenges associated with oral nDDS
3: Size, shape and surface chemistry considerations for orally delivered nanomedicine
4: Summary
Chapter 6: Modified drug release: Current strategies and novel technologies for oral drug delivery
Abstract
1: Part 1: Evolution of oral modified release dosage forms
2: Part 2: Current oral formulation strategies for modified release
3: Novel technologies for modified drug release
4: Conclusions and future perspectives
Chapter 7: Delivery platforms for oral drug administration
Abstract
1: Introduction
2: Delivery platforms for oral administration of (bio)pharmaceuticals
3: Conclusions
Chapter 8: (Trans)buccal drug delivery
Abstract
1: Introduction
2: Oral cavity: Anatomic and physiologic features
3: Buccal mucosa as barrier for drug penetration/permeation
4: Strategies to target the buccal mucosa
5: The advantages of nanoparticles for buccal delivery
6: Dosage forms for the buccal delivery of nanoparticles
7: Final remarks
Part II: Advanced technologies for oral delivery applications
Chapter 9: Spray-drying for the formulation of oral drug delivery systems
Abstract
Acknowledgments
1: Introduction
2: Spray-drying
3: Formulation of drugs/drug delivery systems for oral administration using the spray-drying technology
4: Conclusions and future perspectives
Chapter 10: Microdevices to successfully deliver orally administered drugs
Abstract
Acknowledgments
1: Introduction
2: Design of microdevices
3: Materials for the fabrication of microdevices
4: Methods for microfabrication of oral drug delivery devices
5: Loading techniques for drug formulations
6: Lid formation on the cavity of microdevices
7: In vitro and ex vivo studies
8: In vivo testing and applications
9: Future perspectives
10: Conclusion
Chapter 11: Batch and microfluidic reactors in the synthesis of enteric drug carriers
Abstract
1: Introduction
2: Nanotechnology in oral drug delivery
3: Delivery to the systemic circulation—Passage through the intestinal barrier
4: pH-dependent and pH-independent targeted delivery to specific sites of the intestine
5: Microfluidics for the synthesis of micro and nanocarriers in oral delivery
6: Conclusions
Chapter 12: 3D printing in oral drug delivery
Abstract
1: Oral delivery
2: Personalized medicine
3: Introduction to additive manufacturing
4: Regulatory challenges
5: Future perspective
6: Concluding remarks
Part III: Methods for the evaluation of oral drug delivery systems
Chapter 13: 3D intestinal models towards a more realistic permeability screening
Abstract
Acknowledgments
1: Introduction
2: 3D intestinal models
3: Limitations and future perspectives
4: Conclusion
Chapter 14: In vitro relevant information for the assessment of nanoparticles for oral drug administration
Abstract
1: General considerations of oral drug delivery
2: Barriers to oral drug delivery
3: Understanding the biological-material interface
4: Nanoparticles for oral drug delivery: In vitro characterization techniques
5: Conclusions and future perspectives
Chapter 15: In vivo testing of orally delivered nanoparticles
Abstract
Acknowledgment
1: Introduction
2: Selection of animal models
3: Administration technique
4: Experimental techniques
5: In vitro-In vivo correlation
6: Ethical considerations
7: Conclusion
Part IV: Pharmaceutical industry perspective
Chapter 16: Industrial perspectives and future of oral drug delivery
Abstract
1: Introduction: Oral nano-drug delivery
2: Current market status
3: Challenges
4: Regulatory aspects: Regulations and guidelines
5: Conclusions and future perspectives
Annex I. Existing guidance documents expected to be applied for nano-enabled pharmaceutical products
Index

João Pedro Martins

João Pedro Martins graduated in Biomedical Engineering at the Faculty of Engineering of the University of Porto (FEUP) in collaboration with the Institute of Biomedical Engineering (INEB), Porto, Portugal. Currently, he is a fourth-year PhD student at the Faculty of Pharmacy of the University of Helsinki, Finland. In the framework of his PhD, J.P. Martins is developing advanced drug delivery systems with the aim of making oral administration of nanomedicines carrying anti-diabetic drugs a reality. So far, he has authored/co-authored 12 scientific publications (original and review articles), 2 book chapters, and 1 conference proceedings, and has given 8 oral communications and 13 poster presentations in scientific meetings. J.P. Martins has more than 150 citations (Google Scholar 190; h-index = 8), and has also served as a reviewer for 7 international peer-reviewed scientific journals.

Affiliations and expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland

Hélder A. Santos

Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the "Talent Prize in Science" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021.

Affiliations and expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health