Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood

1st Edition - September 28, 2021
Imprint: Elsevier
Editors: Adil Denizli, Mariappan Rajan, Mohammad Feroz Alam, Khaliqur Rahman, Tuan Anh Nguyen
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 9 7 1 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 1 8 0 - 6

Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood outlines the fundamental design concepts and emerging applications of nanotechnology in hematology, blood tra… Read more

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Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood outlines the fundamental design concepts and emerging applications of nanotechnology in hematology, blood transfusion and artificial blood. This book is an important reference source for materials scientists, engineers and biomedical scientists who are looking to increase their understanding of how nanotechnology can lead to more efficient blood treatments. Sections focus on how nanotechnology could offer new routes to address challenging and pressing issues facing rare blood diseases and disorders and how nanomaterials can be used as artificial cell-like systems (compartmentalized biomimetic nanocontainers), which are especially useful in drug delivery.

For artificial blood, the nanotechnological approach can fabricate artificial red blood cells, platelet substitutes, and white blood cell substitutes with their inherent enzyme and other supportive systems. In addition, nanomaterials can promote blood vessel growth and reserve red blood cells at a positive temperature.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Foreword
Chapter 1. Blood–nanomaterials interactions
Abstract
1.1 Introduction
1.2 Nanoparticle uptake pathways
1.3 Nanoparticles in blood plasma: biological identity
1.4 Platelets and coagulation system
1.5 Immune system response: leukocytes
1.6 Red blood cell–nanoparticle interaction
1.7 Factors influencing nanoparticles biodistribution
1.8 Summary
References
Chapter 2. Extracorporeal affinity systems and immunoadsorption therapies
Abstract
2.1 Introduction
2.2 Extracorporeal therapy for autoimmune diseases
2.3 Extracorporeal affinity adsorbents for bilirubin removal
2.4 Affinity adsorbents for metal ion removal
2.5 Conclusion
References
Chapter 3. Physical chemistry of dispersed nanostructures in blood
Abstract
3.1 Consequences of structural surface
3.2 Size distribution
3.3 Dispersion stability
3.4 Mechanical stability
3.5 Applications of nuclear magnetic resonance spectroscopy
3.6 Conclusion
References
Chapter 4. Electromagnetic Casson blood flow in multistenosed porous artery using Caputo–Fabrizio fractional derivatives
Abstract
4.1 Introduction
4.2 Methodology
4.3 Results and discussions
4.4 Conclusions
Acknowledgment
References
Chapter 5. Mathematical modeling to the motion control of magnetic nano/microrobotic tools performing in bodily fluids, especially blood/plasma
Abstract
5.1 Introduction
5.2 State of the art
5.3 Swimming in the circulatory system
5.4 Motion control
5.5 Conclusion
References
Chapter 6. Effects of nanoparticles on the blood coagulation system (nanoparticle interface with the blood coagulation system)
Abstract
6.1 Introduction
6.2 Interaction of nanoparticles with the blood coagulation system—the underlying mechanisms
6.3 Common in vitro methods to evaluate the effect of nanoparticles on blood coagulation
6.4 Factors affecting nanoparticle–blood coagulation system interactions
6.5 Two-side effect of engineered nanoparticles on the blood coagulation system
6.6 Conclusion and prospects
References
Chapter 7. Red blood cells under externally induced stressors probed by micro-Raman spectroscopy
Abstract
7.1 Red blood cells and hemoglobin
7.2 Raman spectroscopy of human blood
7.3 Raman Tweezers—an optical approach to single-cell spectroscopy
7.4 Raman Tweezers instrumentation
7.5 Exogenous stress on red blood cells
7.6 Conclusions
Acknowledgment
References
Chapter 8. Drug delivery systems based on blood cells
Abstract
8.1 Introduction
8.2 Conventional drug delivery systems and their challenges
8.3 Cell-mediated drug delivery systems
8.4 Erythrocyte-based delivery systems
8.5 Covalent conjugation onto surface markers
8.6 Erythrocytes bioreactors for low-molecular-weight metabolites utilization
8.7 Carrier erythrocytes with a gradual release of the pharmacological agent
8.8 Morphine encapsulation into erythrocytes
8.9 Platelet-based delivery systems
8.10 Leukocyte-based delivery systems
8.11 The leukocyte-based carriers
8.12 Advantages of blood cell-based drug delivery systems
8.13 Disadvantages of blood cell-based drug delivery systems
8.14 Conclusions and future prospects
References
Chapter 9. Nanosensors for medical diagnosis
Abstract
9.1 Introduction
9.2 Medical diagnosis needs
9.3 Nanosensors for diagnosis
9.4 Conclusion and vision for future
References
Chapter 10. Applications of nanotechnology in biological systems and medicine
Abstract
10.1 Introduction to nanomedicine and nanoparticles
10.2 Types of nanoparticles
10.3 Interaction of blood components with nanoparticles
10.4 Emerging applications of nanoparticles in biological systems and medicine
10.5 Conclusion
References
Chapter 11. Lab-on-a-chip (lab-on-a-phone) for analysis of blood and diagnosis of blood diseases
Abstract
11.1 Introduction
11.2 On-chip whole blood analysis and disease diagnosis
11.3 Smartphone-based platform for blood analysis and disease diagnosis
11.4 Conclusion and perspective
Abbreviations
References
Chapter 12. Lab-on-a-chip for analysis of blood
Abstract
12.1 Introduction to microfluidics science
12.2 Basic principles
12.3 Microfabrication technologies and methods
12.4 Microfluidic technology for blood and cells testing applications
12.5 Basic and complete metabolic panel
12.6 Sexually transmitted disease tests
References
Chapter 13. Nanotechnology for blood test to predict the blood diseases/blood disorders
Abstract
13.1 Introduction
13.2 Blood disorders
13.3 Current diagnostic and therapeutic strategies for blood disorders
13.4 Nanodiagnostic approaches to detect blood disorders
13.5 Nanomedicines for treatment of blood diseases
13.6 Future perspectives and conclusion
References
Chapter 14. Advanced methods for clearing blood clots using mechanical thrombectomy devices and untethered microrobots
Abstract
14.1 Introduction
14.2 Thrombolysis
14.3 Mechanical thrombectomy
14.4 Using untethered helical robots in clearing clogged blood vessels
14.5 Conclusions and future work
References
Chapter 15. Nanotechnology for stroke treatment
Abstract
15.1 Introduction
15.2 Principles for improving thrombolytic efficiency
15.3 Passive nanoparticle treatment
15.4 Improved stroke treatment with enhanced mass transport
15.5 Other strategies
15.6 Conclusions and perspectives
References
Chapter 16. Nanofiltration for blood products
Abstract
16.1 Introduction
16.2 Literature review
16.3 Learning objectives
16.4 Methods and techniques
16.5 Applications
16.6 Conclusion
References
Chapter 17. Artificial red blood cells
Abstract
17.1 Introduction
17.2 General requirements for an ideal artificial oxygen carriers
17.3 Perfluorocarbon-based oxygen carriers
17.4 Stem cell-derived oxygen carriers
17.5 Fate/biodistribution of artificial oxygen carriers in the body
17.6 Biomedical applications of artificial oxygen carriers beyond emergency medicine
17.7 Role of artificial oxygen carriers in viral infections, for example, in lung diseases
17.8 Outlook
Further reading referring to Tables 26.1, 26.2 and 26.3
References
Chapter 18. Platelet substitutes
Abstract
18.1 Platelet physiology
18.2 Artificial platelets
18.3 Platelet membrane cloaking for drug delivery
18.4 Limitations of artificial hemostats
References
Chapter 19. Artificial white blood cells—WBC substitute
Abstract
19.1 Leukocyte physiology
19.2 Artificial leukocytes
19.3 Limitations of artificial leukocytes
19.4 Conclusion
References
Index

Adil Denizli

Adil Denizli is Professor at Hacettepe University, Department of Chemistry, Ankara, Turkey. His main research fields are molecular imprinting technologies, purification of biomolecules by chromatographic methods, detection of molecules by sensors, production of polymers with different surface and bulk properties, shape and geometries, and application of these polymers in different applications.

Affiliations and expertise

Professor, Hacettepe University, Department of Chemistry, Ankara, Turkey

Mariappan Rajan

Mariappan Rajan is currently working as an Assistant Professor in the Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, India. He is an experienced researcher and is mainly interested in the development of biodegradable polymeric nanocarrier systems, nanogels, nanoparticles, nanocomposite scaffolds, bio-ceramic materials and mineral substituted scaffold for Tissue engineering, Drug Delivery and Wound Dressing applications.

Affiliations and expertise

Assistant Professor, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, India

Mohammad Feroz Alam

Mohammad Feroz Alam M.D (Pathology) is an Assistant Professor at J.N Medical College, AMU. He has an experience of nearly 16 years in Teaching and Research work.His areas of interest are Hematology, Histopathology, Cancer research and Nanomedicine

Affiliations and expertise

Assistant Professor, Department of Pathology, J.N Medical College, Aligarh Muslim University, Aligarh, India. Area of interest are Hematology, Histopathology, Cancer research and Nanomedicine

Khaliqur Rahman

Khaliqur Rahman is an Associate Professor in the Hematology Laboratory at Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. His areas of research are molecular diagnostic of hematolymphoid neoplasm and advancement in flow cytometric immunophenotyping and minimal residual disease evaluation.

Affiliations and expertise

Associate Professor, Hematology Laboratory, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

Tuan Anh Nguyen

Tuan Anh Nguyen is a Senior Principal Research Scientist at the Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam. He received a BS in physics from Hanoi University in 1992, a BS in economics from Hanoi National Economics University in 1997, and a PhD in chemistry from the Paris Diderot University, France, in 2003. He was a Visiting Scientist at Seoul National University, South Korea, in 2004, and the University of Wollongong, Australia, in 2005. He then worked as a Postdoctoral Research Associate and Research Scientist at Montana State University, United States in 2006-09. In 2012 he was appointed as the Head of the Microanalysis Department at the Institute for Tropical Technology. His research areas of interest include smart sensors, smart networks, smart hospitals, smart cities, complexiverse, and digital twins. He has edited more than 74 books for Elsevier, 12 books for CRC Press, 1 book for Springer, 1 book for RSC, and 2 books for IGI Global. He is the Editor-in-Chief of Kenkyu Journal of Nanotechnology & Nanoscience.

Affiliations and expertise

Senior Principal Research Scientist, Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood

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Adil Denizli

Mariappan Rajan

Mohammad Feroz Alam

Khaliqur Rahman

Tuan Anh Nguyen

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