Nanostructures for Oral Medicine

1st Edition - April 11, 2017
Imprint: Elsevier
Editors: Ecaterina Andronescu, Alexandru Mihai Grumezescu
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 4 7 7 2 0 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 4 7 7 2 1 - 5

Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressin… Read more

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Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry.

The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed.

This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field.

Chapter 1: Bacterial polyester nanoparticles for drug delivery
Sung Chul Yoon

Abstract
1. Introduction
2. Amphiphlic Block Copolymers
3. Polymeric Nanoparticles in Drug-Delivery Applications
4. Biodegradable Bacterial Polyesters Poly(R)-Hydroxyalkanoic Acids
5. Targeting Drug Delivery using Ligand-Conjugated PHA Nanoparticles (Active Targeting)
6. Chemical Modification of PHA Polymers for Drug Delivery (Passive Targeting)
7. Synthesis of Surface Modified PHB-mPEG Diblock Copolymer
8. Self-Assembly of Diblock Copolymer Into Nanoparticles
9. Characterization of PHA–mPEG Nanoparticles
10. Drawbacks and Challenges
11. Conclusions and Future Perspectives

Chapter 2: A novel approach to the oral delivery of bionanostructures for systemic disease
Sung Chul Yoon

Abstract
1. Introduction
2. NanoStructures for Oral Drug Delivery
3. The Gastrointestinal Mucus Barriers
4. Strategies for Effective Oral Delivery of Drugs
5. Challenges in the Oral Delivery Route
6. Characteristics of the Transporter Used in Oral Delivery Nanostructures
7. Therapeutic Applications of Oral Delivery Nanostructures
8. Synthesis of Nanoparticles
9. Characterization of Nanoparticles
10. Conclusions

Chapter 3: Biodegradable polymeric nanostructures: design and advances in oral drug delivery for neurodegenerative disorders
Andreza Maria Ribeiro

Abstract
1. Introduction
2. Biodegradable Polymeric Materials
3. Nanocarriers Technology and Recent Modifications to Improve Their Specificity
4. Advances in Polymeric Nanocarriers as Vehicles for Oral-Delivery Systems
5. New Approaches and Clinical Applications in Neurodegenerative Disorders
6. Future Perspectives

Chapter 4: Nanostructured systems for transbuccal drug delivery
Eneida de Paula

Abstract
1. Introduction
2. Oral Mucosa
3. Buccal Mucosa Chemical Permeation Enhancers: Chemical Structure, Mechanisms, and Biopharmaceutical Applications
4. Nanoparticles and Nanostructures for Transbuccal Drug Delivery
5. Limitations
6. Conclusions
Acknowledgments

Chapter 5: Trends in orally viral vector gene delivery and therapy
Ruian Xu

Abstract
1. Introduction
2. Nanoparticles and Microparticles Applications in Oral Delivery of Drug Molecules and Therapeutic Genes
3. The Crucial Intake Site of the Absorption of Nanoparticles and Microparticles in the Gastrointestinal Tract
4. The Characteristics of Particles and the Effect of Intake In Vivo
5. Protein Transduction and the Absorption of Nanoparticles
6. Ways to Promote the Absorption of Particles
7. The Feasibility of Oral Gene Delivery
8. The Oral Gene Delivery Vector System
9. The Uptake of Oral Viral Vector
10. The Selection of Viral Vectors Suitable for Oral Delivery
11. The Digestion Circumstance of Oral Gene Delivery
12. The Transmission, Distribution, and Transgenic Product Pharmacokinetics of Oral Viral Vectors
13. Potential, Problems, and Prospects
14. Conclusions

Chapter 6: Nanostructures for oral delivery of therapeutic nucleic acids
Virginie Escriou

Abstract
1. Introduction
2. Oral Delivery of Therapeutic Nucleic Acids
3. Oral Delivery Systems for Nucleic Acid Administration (Table 6.2)
4. Conclusions

Chapter 7: Challenges in oral drug delivery: a nano-based strategy to overcome
Pragasam Viswanathan

Abstract
1. Introduction
2. Biopharmaceutical Classification of Drugs
3. Measurement of Parameters Determining Bioavailability
4. Transport Mechanism in GIT
5. Gastrointestinal Luminal Milieu and Drug Absorption
6. Improving Drug Bioavailability
7. Pharmaceutics Approach Enabling Physical Modification of Drugs
8. Improving Stability of Oral Drugs
9. Nanostructures in Oral Drug Delivery
10. Conclusions
Acknowledgment
Conflict of Interest

Chapter 8: Oral pellets loaded with nanoemulsions
Thierry F. Vandamme

Abstract
1. Pellets
2. Nanoemulsions
3. Biopharmaceutical Classification System (BSC) and Applications of Pellet to Improve Dissolution Rate of Drugs in BCS Class II
4. Case Study
5. Conclusions

Chapter 9: Oral drug delivery potential of dendrimers
Dr. Umesh Gupta

Abstract
1. Introduction
2. Oral Route and its Implication
3. Nanocarriers in Oral Delivery
4. Dendrimers in Oral Drug Delivery
5. Synthetic Approaches of Dendrimer
6. Unique Properties of Dendrimers
7. Host Guest Interactions of Dendrimers and Bioactives
8. Drugs Delivered Through Oral Route Using Dendrimers as a Nanocarrier
9. Conclusions and Future Prospects
10. Abbreviations

Chapter 10: Nanovaccines for oral delivery-formulation strategies and challenges
Sandeep Prakash Patankar

Abstract
1. Introduction
2. Oral Vaccine Delivery
3. Intestinal Immune Response
4. Challenges in Oral Vaccine Delivery
5. Nanocarrier Based Oral Vaccine Delivery
6. Nanocarrier Formulation Strategies
7. Regulatory Aspects of Oral Nanovaccines
8. Future Prospects

Chapter 11: Nanosystems for oral delivery of immunomodulators
Vandana Bharat Patravale

Abstract
1. Introduction
2. Oral Route for Immunomodulators
3. Need of Nanosystems for Immunomodulators
4. Oral Nanosystems for Immunomodulators
5. Methods for Characterization of Nanosystems
6. Fate of Immunomodulators After Oral Delivery
7. Future Prospects
8. Conclusions
Abbreviations

Chapter 12: Tannic acid modification of metal nanoparticles: possibility for new antiviral applications
Malgorzata Krzyzowska

Abstract
1. Introduction
2. Syntheses and Characterization of Metallic Nanoparticles Colloids (AuNPs, AgNPs, Ag/CuNPs) with Tannic Acid
3. Toxicity and Antiviral Properties of Tannic Acid Modifies Metallic Nanoparticles Colloids (AuNPs, AgNPs, Ag/CuNPs)
4. Conclusions
Acknowledgments

Chapter 13: Polyelectrolyte-drug ionic complexes as nanostructured drug carriers to design solid and liquid oral delivery systems
María Eugenia Olivera

Abstract
1. Introduction
2. Pharmaceutical Polyelectrolytes
3. Polyelectrolyte-Drug Complexes in Aqueous Dispersion
4. Polyelectrolyte-Drug Complexes in the Solid State
5. Conclusions
Abbreviations

Chapter 14: Polysaccharide based nano/microformulation: an effective and versatile oral drug delivery system
Yong-kyu Lee

Abstract
1. Introduction
2. Chitosan
3. Hyaluronic Acid
4. Chondroitin Sulfate
5. Heparin
6. Cyclodextrins
7. Other Polysaccharides
8. Polysaccharide Blends (PSB) in Oral Drug Delivery
9. Conclusion and Future Prospects

Chapter 15: Recent advancements in oral delivery of insulin: from challenges to solutions
A.K Bajpai

Abstract
1. Introduction
2. Diabetes Mellitus
3. Diagnosis Test for Diabetes
4. Insulin Therapy
5. Plants Used in the Treatment of Diabetes
6. Diabetes in World Scenario
7. Insulin
8. Action of Insulin
9. Oral Delivery of Insulin
10. Problems in Oral Delivery
11. Strategies to Improve Oral Delivery of Insulin
12. Recent Breakthroughs in Oral Insulin Delivery
13. Commercialization
14. Recent Challenges and Future Prospects

Chapter 16: Nanotechnology for oral delivery of anticancer drugs: an insight potential
Nagendra Singh Chauhan

Abstract
1. Introduction
2. Remarkable Addressing Issues Concerns for Challenging of Oral Chemotherapy
3. Specific Consideration of Anticancer Drugs Appropriate for Oral Delivery
4. Nanocarrier System for Oral Delivery of Cancer Therapeutics
5. Concluding Remarks

Chapter 17: Nanomaterials: promising structures for the management of oral cancer
Aylin Türel Ermertcan

Abstract
1. Oral Cancer
2. Nanoparticles in Cancer Treatment and Diagnosis
3. Nanomaterials in Early Diagnosis of Oral Cancer
4. Nanotherapeutics in Oral Cancer
5. Nanomaterials in Tumor Imaging of Oral Cancer
6. Conclusions

Chapter 18: Therapeutic potential of solubilized nanolignin against oral diseases
Hiroshi Sakagami

Abstract
1. Studies of Nanostructure of Lignin
2. Biological Activity
3. Efficient Utilization of Plant Resources by Alkaline Extraction
4. Utilization of Lignin and Its Components
5. Clinical Application
6. Future Direction
Acknowledgments

Chapter 19: Novel lipid nanostructures for delivery of natural agents with antioxidant, antiinflammatory and antistroke potential: perspectives and outcomes
Anil Kumar Dwivedi

Abstract
1. Introduction
2. Stroke
3. Oxidative Stress Inflammation, Antioxidants, and Their Mechanism of Action
4. Bioactives with Potential Antioxidant, Antiinflammatory, and Antistroke Effects
5. Limitations of Bioactives to Elicit the Desired Therapeutic Response
6. Novel Lipid Nanostructures
7. Conclusions: Way Ahead with LNs
Acknowledgement

Chapter 20: Chitosan-based nanoparticulate systems for oral drug delivery
Sougata Jana

Abstract
1. Introduction
2. Novel Technologies for Chitosan-Based Nanoparticles
3. Oral Chitosan Nanosystems: Key Findings
4. Conclusions

Chapter 21: Phytonanoconjugates in oral medicine
Vijaya Padma. V

Abstract
1. Introduction
2. Mechanism of Polyphenol Protection
3. Nanostructures in Oral Delivery
4. Mechanism of Absorption of Phytonanoconjugates in Epithelial Cells Via Endocytotic Cellular Uptake
5. Biofate and Pharmacokinetics of the Nanocarriers in the GI Tract After Oral Administration
6. Phytonanoparticles in Oral Medicine
7. Other Phytonanoconjugates
8. Remarks and Future Perceptions

Chapter 22: Design and development of pharmaceutical microprocesses in the production of nanomedicine
Norma Angélica Noguez

Abstract
1. Microfluidics: Origins, Present, and Future
2. Lyotropic Liquid Crystals as Drug Delivery Systems
3. Lipid-Carrying Systems
4. Microspheres
5. Polymerosomes
6. Conclusions

Chapter 23: Mesoporous materials and technologies for development of oral medicine
Shou-Cang Shen

Abstract
1. Introduction
2. Development of Mesoporous Materials as Potential Drug Carriers
3. Drug-Loading Techniques
4. Characterization and Stabilities Studies of Poorly Soluble Oral Drug Formulation
5. Application of Functional Mesoporous Materials in Smart Oral Dosage Form
6. Summary and Outlook

Chapter 24: Nanodentistry: novel approaches
Prakash Singh Bisen

Abstract
1. Introduction
2. Types and Properties of Nanostructures Used in Dentistry
3. Nanotechnology in Dentistry
4. Preventive Nanodentistry
5. Challenges Faced by Nanodentistry
6. Conclusions

Chapter 25: The role of nanomedicine, nanotechnology, and nanostructures on oral bone healing, modeling, and remodeling
Mohamadreza Baghaban Eslaminejad

Abstract
1. Introduction
2. Nanomedicine
3. TERM and Nanomedicine
4. Fabrication Methods for Nanomaterials and Nanostructures
5. Application of Nanotechnology in Dentistry
6. Application of Nanomedicine in Oral Bone Regeneration
7. Nanotechnology and Cell Therapy in Oral Bone Regeneration
8. Current Challenges and Future Directions

Chapter 26: Therapeutic applications of nanotechnology in dentistry
Muhammad Sohail Zafar

Abstract
1. Introduction
2. Origin of Nanotechnology Concept and History
3. Nature and Timeline of Nanomaterials
4. Synthesis, Characteristics, and Classifications of Nanomaterials
5. Nanobiomaterials in Dentistry
6. Conclusive Remarks

Chapter 27: Oral nanomedicine and the emergent process of clinical translation
Elaine Del-Bel

Abstract
1. Introduction
2. Understanding Clinical Trials
3. Overview of Oral Nanomedicine and Clinical Trials
4. Analyzing Selected Trials
5. Final Considerations
6. Appendix

Chapter 28: Carbon-based nanostructures for electrochemical analysis of oral medicines
Sibel A. Özkan

Abstract
1. Introduction
2. Oral Drugs
3. Voltammetric Methods for Electrochemical Analysis of Oral Medicines Using Carbon-Based Nanostructures
4. Carbon-Based Nanostructures in Electrochemical Analysis of Oral Medicines
5. Conclusions
Abbreviations

Chapter 29: Scientometric overview regarding oral cancer nanomedicine
Ozcan Konur

Abstract
1. Overview
2. The Citation Classics in Oral Cancer Nanomedicine
3. Conclusions

Ecaterina Andronescu

Ecaterina Andronescu is Professor at UPB, Faculty of Applied Chemistry and Material Science, Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica, Romania. He has been the coordinator for more than 80 research projects with national and international funding and author of more than 330 papers (more than 150 in lSI-ranked journals). Her specific fields of interest are biomaterials, nanomaterials and nanotechnologies; anti-microbial anti-biofilm, and drug delivery systems. Prof. Andronescu has received several honorary titles, including Doctor Honoris Causa – from several universities. She is a member of the Register of Assessors of ARACIS, Commission for Chemistry and Materials Science Founder and President of the Romanian Society of Materials; Founder of the Romanian Society of Biomaterials; Founder and member of the Romanian Society of Ceramics; Founder of the Romanian Society of Chemistry; and Member of the European Society of Ceramics.

Affiliations and expertise

Professor at UPB, Faculty of Applied Chemistry and Material Science, Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica, Romania

Alexandru Mihai Grumezescu

Dr. Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biomaterials, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, and Biomaterials and Tissue Engineering Bulletin. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 6 co-authored books and 11 edited books.

Affiliations and expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science and Faculty of Medical Engineering, Politehnica University of Bucharest, Romania

Life Sciences

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